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The map label for this gene is aroE [H]

Identifier: 188586349

GI number: 188586349

Start: 1798780

End: 1799697

Strand: Reverse

Name: aroE [H]

Synonym: Nther_1732

Alternate gene names: 188586349

Gene position: 1799697-1798780 (Counterclockwise)

Preceding gene: 188586350

Following gene: 188586348

Centisome position: 56.85

GC content: 37.58

Gene sequence:

>918_bases
ATGAATTTAATAGAAAATGGTGGTGAGATTATGGTTAAAAATCCCAAAGGTTTACTGGCTTTGATTGGTAATCCAGTGGG
GCACTCTCTTTCTCCTGTGATGCACAATGCCGCTTTCCACGAGATGGGGCTAAATTGGTGTTATCATGCGTTTAATGTAG
AATCTATTCAGTTGGCCGAAGCGATTCATGGACTGAAAGCTTTAAATTTTAATGGAGGAAATGTAACCTCTCCGTACAAA
GAGCAGGTTATACCTTACTTAGATAATTTGACTTGGGAAGCTAAGATAGCAGGTGCTGTTAATACTTTGATTTTGGATGA
TCTAGAGGGGAGCATTACAGGGGACAATACAGACGGAGATGGGTTTGTAACTTATTTAGAAAAGGAAAAGAACTTCACTC
TTAAAAATAAAGACATATGTGTTATAGGAGCAGGTGGAGCTGCCAGGGCTATCTGTATGGGAATGTTAAAAAGAGCACCA
AATAGCATTGTCATAGTTAATCGAAACTTAAATAGAGCAGATAAATTAGTAGAGAGATTAAATCAAGCAATAACAGAAGA
TCAATTCAAAAAACTGTATGGACATGTAAAAACCCATTTAAAAGCTGTTTCATTGGAACCCAGTTGTCTTATTGGAGTTT
TAAAAGAAAGCAATTTGATCATTAATTCTATACCGACTGACCCGCCCGAGTATATTGTGCAAAGTTTACAAACTCTTGAA
ACAATTGATACAAGAACAGCAGTGGTCGATTTACGCTATGGCGAACAACTGGGTCCCTATCTACAGCAAATAGCTAGACC
TGGTATAGAAATATCCGATGGCTCGGGGATGCTTTTATATCAGGGTATATTGTCTTTTGAAAAATGGACCGGAGAAGAAG
CTCCTGTTAAGATCATGAAAAAAGCTCTAAATTGGTAA

Upstream 100 bases:

>100_bases
TTTTGTATTCTTTATTTATATGGATTGGTTTGGGTTTAATATATTTTAAAATTAGACAATATTATGCTAAAACAAAAGGC
TATCAAAACTTTTATGGATA

Downstream 100 bases:

>100_bases
TTTAGAGCTTTTTTTTTTATTTTTAGAGTAAAGAGGGTTTTGGAAAATTATGTAGAATAAAGTATTACTTTCACTTGTCG
GAGGTGCATAACAATTTCAA

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MNLIENGGEIMVKNPKGLLALIGNPVGHSLSPVMHNAAFHEMGLNWCYHAFNVESIQLAEAIHGLKALNFNGGNVTSPYK
EQVIPYLDNLTWEAKIAGAVNTLILDDLEGSITGDNTDGDGFVTYLEKEKNFTLKNKDICVIGAGGAARAICMGMLKRAP
NSIVIVNRNLNRADKLVERLNQAITEDQFKKLYGHVKTHLKAVSLEPSCLIGVLKESNLIINSIPTDPPEYIVQSLQTLE
TIDTRTAVVDLRYGEQLGPYLQQIARPGIEISDGSGMLLYQGILSFEKWTGEEAPVKIMKKALNW

Sequences:

>Translated_305_residues
MNLIENGGEIMVKNPKGLLALIGNPVGHSLSPVMHNAAFHEMGLNWCYHAFNVESIQLAEAIHGLKALNFNGGNVTSPYK
EQVIPYLDNLTWEAKIAGAVNTLILDDLEGSITGDNTDGDGFVTYLEKEKNFTLKNKDICVIGAGGAARAICMGMLKRAP
NSIVIVNRNLNRADKLVERLNQAITEDQFKKLYGHVKTHLKAVSLEPSCLIGVLKESNLIINSIPTDPPEYIVQSLQTLE
TIDTRTAVVDLRYGEQLGPYLQQIARPGIEISDGSGMLLYQGILSFEKWTGEEAPVKIMKKALNW
>Mature_305_residues
MNLIENGGEIMVKNPKGLLALIGNPVGHSLSPVMHNAAFHEMGLNWCYHAFNVESIQLAEAIHGLKALNFNGGNVTSPYK
EQVIPYLDNLTWEAKIAGAVNTLILDDLEGSITGDNTDGDGFVTYLEKEKNFTLKNKDICVIGAGGAARAICMGMLKRAP
NSIVIVNRNLNRADKLVERLNQAITEDQFKKLYGHVKTHLKAVSLEPSCLIGVLKESNLIINSIPTDPPEYIVQSLQTLE
TIDTRTAVVDLRYGEQLGPYLQQIARPGIEISDGSGMLLYQGILSFEKWTGEEAPVKIMKKALNW

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787983, Length=296, Percent_Identity=31.4189189189189, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1789675, Length=278, Percent_Identity=32.0143884892086, Blast_Score=100, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320332, Length=310, Percent_Identity=29.0322580645161, Blast_Score=105, Evalue=9e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 33499; Mature: 33499

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS00012 PHOSPHOPANTETHEINE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLIENGGEIMVKNPKGLLALIGNPVGHSLSPVMHNAAFHEMGLNWCYHAFNVESIQLAE
CCCCCCCCEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHCHHHHHHHCCCCHHHHHH
AIHGLKALNFNGGNVTSPYKEQVIPYLDNLTWEAKIAGAVNTLILDDLEGSITGDNTDGD
HHHHHEEEECCCCCCCCCHHHHHHHHHHCCEEEEEEHHHHHHHEEECCCCCCCCCCCCCC
GFVTYLEKEKNFTLKNKDICVIGAGGAARAICMGMLKRAPNSIVIVNRNLNRADKLVERL
CEEEEEECCCCCEECCCCEEEEECCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHH
NQAITEDQFKKLYGHVKTHLKAVSLEPSCLIGVLKESNLIINSIPTDPPEYIVQSLQTLE
HHHHHHHHHHHHHHHHHHHHEEECCCCHHHEEEECCCCEEEECCCCCCHHHHHHHHHHHH
TIDTRTAVVDLRYGEQLGPYLQQIARPGIEISDGSGMLLYQGILSFEKWTGEEAPVKIMK
HHCCCEEEEEECCCHHCCHHHHHHHCCCCEEECCCCEEHHHHHHHHHHHCCCCCHHHHHH
KALNW
HHHCC
>Mature Secondary Structure
MNLIENGGEIMVKNPKGLLALIGNPVGHSLSPVMHNAAFHEMGLNWCYHAFNVESIQLAE
CCCCCCCCEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHCHHHHHHHCCCCHHHHHH
AIHGLKALNFNGGNVTSPYKEQVIPYLDNLTWEAKIAGAVNTLILDDLEGSITGDNTDGD
HHHHHEEEECCCCCCCCCHHHHHHHHHHCCEEEEEEHHHHHHHEEECCCCCCCCCCCCCC
GFVTYLEKEKNFTLKNKDICVIGAGGAARAICMGMLKRAPNSIVIVNRNLNRADKLVERL
CEEEEEECCCCCEECCCCEEEEECCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHH
NQAITEDQFKKLYGHVKTHLKAVSLEPSCLIGVLKESNLIINSIPTDPPEYIVQSLQTLE
HHHHHHHHHHHHHHHHHHHHEEECCCCHHHEEEECCCCEEEECCCCCCHHHHHHHHHHHH
TIDTRTAVVDLRYGEQLGPYLQQIARPGIEISDGSGMLLYQGILSFEKWTGEEAPVKIMK
HHCCCEEEEEECCCHHCCHHHHHHHCCCCEEECCCCEEHHHHHHHHHHHCCCCCHHHHHH
KALNW
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014 [H]