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The map label for this gene is cysK [H]

Identifier: 188586337

GI number: 188586337

Start: 1789398

End: 1790306

Strand: Reverse

Name: cysK [H]

Synonym: Nther_1720

Alternate gene names: 188586337

Gene position: 1790306-1789398 (Counterclockwise)

Preceding gene: 188586338

Following gene: 188586336

Centisome position: 56.56

GC content: 38.17

Gene sequence:

>909_bases
ATGGTTGCTAATAATATCATTAACTCAATTGGGGATACTCCCATGGTTGCACTTGCCGGTAACGATGGAGCCCAAATTTA
TGCTAAGTTAGAATACTTTAATCCAGGGGGAAGTGTAAAAGATAGGATTTCTTTAAGTATGGTACAAGCTGGTGAGGAAA
AAGGTAAGATTGATTCGGAAACAACTATTATAGAACCAACTAGTGGAAACACAGGTATTGGTCTAGCAATAGTGGCTGCT
TCAAAGGGATATAGATTACAACTTGTTATGCCTGATTCTATGAGTTTAGAGAGAAGAGGGTTACTGGCAGGATTAGGAGC
TGAACTAGTTTTAACCCCTGGCAATGAAGGCATGGGTGGAGCAGTTAAAAAAGCTCAAGAACTACAGGAAGAGTATCTTA
AAAGTTTTATGCCTCAACAATTTGATAATCCAGAAAACCCTAAAATTCATTATCATACAACTGGCCGTGAAATAATTGCA
AACCTTGGAGATATTGAGCCAGATTTTTTTGTGGCTGGAGTTGGTACAGGAGGTACTATTACCGGTGTGGGACAGGCTTT
AAAAGCAAAATTTCCCAAAATCAAAAATATTGCAATAGAGCCACAAAAATCACAAGTGCTTACAGGAAAAGATCCTGCTC
CCCACAAAATCCAGGGAATTGGTGCTGGTTTTATTCCTAAAGTCTTGGATTTTAATATAATAGACGAAATTATACCAGTT
AGTGATCAAGATGCCATTGATAGTGCAAAATTATTATCTAAACAACATGGTATATTGACTGGTATTTCAGCTGGAGCGGC
TTATTTCGCTGCCCAAGAAATTGCCAGTCGGTACCCTGGATCCAAAATAGTAACTGTTTTACCAGATACTGGGGAACGCT
ATCTATCAACTCAATTATTTCAGGATTAA

Upstream 100 bases:

>100_bases
GACCATTTAATATGGACTGATAAGTTAACTCCTCAAGAAGTTGCTAATCAAATTTACAGTAAATTATACTCTAATGGCTA
TATGTATAGGAGTGATTTAA

Downstream 100 bases:

>100_bases
TAAATTATTAAAATTAGGTCATTTGAGAAGCGAATAACTAGTGATCATAAAAGGAGGCTGACTGTTTGAAAATCTATGTC
ATCCACGGCCCTAATATTAA

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MVANNIINSIGDTPMVALAGNDGAQIYAKLEYFNPGGSVKDRISLSMVQAGEEKGKIDSETTIIEPTSGNTGIGLAIVAA
SKGYRLQLVMPDSMSLERRGLLAGLGAELVLTPGNEGMGGAVKKAQELQEEYLKSFMPQQFDNPENPKIHYHTTGREIIA
NLGDIEPDFFVAGVGTGGTITGVGQALKAKFPKIKNIAIEPQKSQVLTGKDPAPHKIQGIGAGFIPKVLDFNIIDEIIPV
SDQDAIDSAKLLSKQHGILTGISAGAAYFAAQEIASRYPGSKIVTVLPDTGERYLSTQLFQD

Sequences:

>Translated_302_residues
MVANNIINSIGDTPMVALAGNDGAQIYAKLEYFNPGGSVKDRISLSMVQAGEEKGKIDSETTIIEPTSGNTGIGLAIVAA
SKGYRLQLVMPDSMSLERRGLLAGLGAELVLTPGNEGMGGAVKKAQELQEEYLKSFMPQQFDNPENPKIHYHTTGREIIA
NLGDIEPDFFVAGVGTGGTITGVGQALKAKFPKIKNIAIEPQKSQVLTGKDPAPHKIQGIGAGFIPKVLDFNIIDEIIPV
SDQDAIDSAKLLSKQHGILTGISAGAAYFAAQEIASRYPGSKIVTVLPDTGERYLSTQLFQD
>Mature_302_residues
MVANNIINSIGDTPMVALAGNDGAQIYAKLEYFNPGGSVKDRISLSMVQAGEEKGKIDSETTIIEPTSGNTGIGLAIVAA
SKGYRLQLVMPDSMSLERRGLLAGLGAELVLTPGNEGMGGAVKKAQELQEEYLKSFMPQQFDNPENPKIHYHTTGREIIA
NLGDIEPDFFVAGVGTGGTITGVGQALKAKFPKIKNIAIEPQKSQVLTGKDPAPHKIQGIGAGFIPKVLDFNIIDEIIPV
SDQDAIDSAKLLSKQHGILTGISAGAAYFAAQEIASRYPGSKIVTVLPDTGERYLSTQLFQD

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=315, Percent_Identity=41.9047619047619, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI295821200, Length=315, Percent_Identity=41.9047619047619, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI4557415, Length=315, Percent_Identity=41.9047619047619, Blast_Score=217, Evalue=1e-56,
Organism=Escherichia coli, GI1788754, Length=308, Percent_Identity=48.3766233766234, Blast_Score=239, Evalue=1e-64,
Organism=Escherichia coli, GI2367138, Length=295, Percent_Identity=37.9661016949153, Blast_Score=207, Evalue=7e-55,
Organism=Caenorhabditis elegans, GI17535051, Length=300, Percent_Identity=46, Blast_Score=241, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI115535073, Length=300, Percent_Identity=50, Blast_Score=238, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI17562970, Length=302, Percent_Identity=43.7086092715232, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI32566674, Length=295, Percent_Identity=44.0677966101695, Blast_Score=221, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI17561720, Length=301, Percent_Identity=43.8538205980066, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17534315, Length=321, Percent_Identity=36.4485981308411, Blast_Score=167, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI25147552, Length=319, Percent_Identity=35.7366771159875, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI32566672, Length=216, Percent_Identity=42.5925925925926, Blast_Score=165, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17561716, Length=118, Percent_Identity=40.6779661016949, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17539800, Length=336, Percent_Identity=26.1904761904762, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321594, Length=317, Percent_Identity=39.1167192429022, Blast_Score=203, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6321449, Length=324, Percent_Identity=37.3456790123457, Blast_Score=139, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24643623, Length=309, Percent_Identity=39.1585760517799, Blast_Score=188, Evalue=3e-48,
Organism=Drosophila melanogaster, GI20129101, Length=309, Percent_Identity=39.1585760517799, Blast_Score=188, Evalue=3e-48,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32024; Mature: 32024

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVANNIINSIGDTPMVALAGNDGAQIYAKLEYFNPGGSVKDRISLSMVQAGEEKGKIDSE
CCCHHHHHHCCCCCEEEEECCCCEEEEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCC
TTIIEPTSGNTGIGLAIVAASKGYRLQLVMPDSMSLERRGLLAGLGAELVLTPGNEGMGG
CEEEECCCCCCCCEEEEEEECCCCEEEEECCCCCCHHHCCCEEECCCEEEEECCCCCCCH
AVKKAQELQEEYLKSFMPQQFDNPENPKIHYHTTGREIIANLGDIEPDFFVAGVGTGGTI
HHHHHHHHHHHHHHHHCHHHCCCCCCCEEEEEECHHHHHHHCCCCCCCEEEEECCCCCCH
TGVGQALKAKFPKIKNIAIEPQKSQVLTGKDPAPHKIQGIGAGFIPKVLDFNIIDEIIPV
HHHHHHHHHCCCCCCCEEECCCCCEEEECCCCCCCEEEECCCCHHHHHHHHHHHHHHCCC
SDQDAIDSAKLLSKQHGILTGISAGAAYFAAQEIASRYPGSKIVTVLPDTGERYLSTQLF
CCCCHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHC
QD
CC
>Mature Secondary Structure
MVANNIINSIGDTPMVALAGNDGAQIYAKLEYFNPGGSVKDRISLSMVQAGEEKGKIDSE
CCCHHHHHHCCCCCEEEEECCCCEEEEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCC
TTIIEPTSGNTGIGLAIVAASKGYRLQLVMPDSMSLERRGLLAGLGAELVLTPGNEGMGG
CEEEECCCCCCCCEEEEEEECCCCEEEEECCCCCCHHHCCCEEECCCEEEEECCCCCCCH
AVKKAQELQEEYLKSFMPQQFDNPENPKIHYHTTGREIIANLGDIEPDFFVAGVGTGGTI
HHHHHHHHHHHHHHHHCHHHCCCCCCCEEEEEECHHHHHHHCCCCCCCEEEEECCCCCCH
TGVGQALKAKFPKIKNIAIEPQKSQVLTGKDPAPHKIQGIGAGFIPKVLDFNIIDEIIPV
HHHHHHHHHCCCCCCCEEECCCCCEEEECCCCCCCEEEECCCCHHHHHHHHHHHHHHCCC
SDQDAIDSAKLLSKQHGILTGISAGAAYFAAQEIASRYPGSKIVTVLPDTGERYLSTQLF
CCCCHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHC
QD
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA