Click here to switch to the map view.

The map label for this gene is ispA [C]

Identifier: 188586314

GI number: 188586314

Start: 1772775

End: 1773668

Strand: Reverse

Name: ispA [C]

Synonym: Nther_1697

Alternate gene names: 188586314

Gene position: 1773668-1772775 (Counterclockwise)

Preceding gene: 188586315

Following gene: 188586313

Centisome position: 56.03

GC content: 35.35

Gene sequence:

>894_bases
ATGTCTTTAGATGTTTTTATGAAAAATAACAAAAATTTAGTGGATCAAAAGTTACAGGAATACCTTCCCAATAAATCTGA
ATATCCTACTGCAATCCATGAAGCCATGCATTACAGCGTTTTTGCTGGTGGCAAGAGATTACGTCCACTTTTAACTCTTG
CAGCAGGAGACTTATTTGGAGCTAATAAAAAAACTATTTTACCATTTGCTTGTGCCATAGAATTAATTCATACTTATTCC
TTAATTCATGACGATTTACCTGCCCTGGATAATGATGATTTGAGACGAGGTAAATCAACTAATCATGTAGTTTTTGGTGA
AGATATAGCTATCCTAGCAGGCGATGCATTGTTAAATTATGCTTTTGAATTAATGACTTCTAAGGGGGTTGAAAACTTCA
CAGACGCTAGAACGCCACTATGGGCAATAAGTGAAGTTGCTAAAGCATCTGGCACTAAAGGTATGATAGGAGGACAAGTA
GTAGATATAAAAAGTGAGAAAAATGCGGATATTGATCTAGAAACAGTTTCATATATCCATAAACACAAGACAGGTGCCTT
ATTTACTGCTAGTATCAGAATAGGAGCTATTTTATCACAAGCTAGTCAAGCCGATTTAGAAAAACTGACAACATACGCCC
AAAAACTTGGTTTAGCATTTCAAGTTGTTGATGACATTTTAGATATTGAAGGGGATGAACAAAAACTTGGTAAAACAGTT
GGAAAAGATGATGACAATGAAAAAGCCACATACCCTAAGATTATGGGCTTAAAGGAATCCCATGAATATGCCTCTCGTTT
ACATCATGAAGCTTTAACGGCTATTTCTGATTATGGGGAAGAAGCTAATATTTTACGGGAATTGGCTAACAAAATAGTCA
ACAGGGAAAAATAG

Upstream 100 bases:

>100_bases
AGAAATTAAAACAGGCAGAAAAACAAATTGAAAAATTGACAAAGGATGAGGAAACAGGTGAATTAAAGTTTGAGCCAGTT
GATTTTGAGGAGGAATAATC

Downstream 100 bases:

>100_bases
GATTAACATCAGTTAGTAGGAAGTTACTATAGAAAGGCGGATAATAGTTTGATTTTAAATGAACTTTTATCAAATATTTA
TTTGATATCAGCTTTAATAG

Product: farnesyl-diphosphate synthase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MSLDVFMKNNKNLVDQKLQEYLPNKSEYPTAIHEAMHYSVFAGGKRLRPLLTLAAGDLFGANKKTILPFACAIELIHTYS
LIHDDLPALDNDDLRRGKSTNHVVFGEDIAILAGDALLNYAFELMTSKGVENFTDARTPLWAISEVAKASGTKGMIGGQV
VDIKSEKNADIDLETVSYIHKHKTGALFTASIRIGAILSQASQADLEKLTTYAQKLGLAFQVVDDILDIEGDEQKLGKTV
GKDDDNEKATYPKIMGLKESHEYASRLHHEALTAISDYGEEANILRELANKIVNREK

Sequences:

>Translated_297_residues
MSLDVFMKNNKNLVDQKLQEYLPNKSEYPTAIHEAMHYSVFAGGKRLRPLLTLAAGDLFGANKKTILPFACAIELIHTYS
LIHDDLPALDNDDLRRGKSTNHVVFGEDIAILAGDALLNYAFELMTSKGVENFTDARTPLWAISEVAKASGTKGMIGGQV
VDIKSEKNADIDLETVSYIHKHKTGALFTASIRIGAILSQASQADLEKLTTYAQKLGLAFQVVDDILDIEGDEQKLGKTV
GKDDDNEKATYPKIMGLKESHEYASRLHHEALTAISDYGEEANILRELANKIVNREK
>Mature_296_residues
SLDVFMKNNKNLVDQKLQEYLPNKSEYPTAIHEAMHYSVFAGGKRLRPLLTLAAGDLFGANKKTILPFACAIELIHTYSL
IHDDLPALDNDDLRRGKSTNHVVFGEDIAILAGDALLNYAFELMTSKGVENFTDARTPLWAISEVAKASGTKGMIGGQVV
DIKSEKNADIDLETVSYIHKHKTGALFTASIRIGAILSQASQADLEKLTTYAQKLGLAFQVVDDILDIEGDEQKLGKTVG
KDDDNEKATYPKIMGLKESHEYASRLHHEALTAISDYGEEANILRELANKIVNREK

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=265, Percent_Identity=26.4150943396226, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786623, Length=287, Percent_Identity=43.205574912892, Blast_Score=198, Evalue=4e-52,
Organism=Escherichia coli, GI1789578, Length=221, Percent_Identity=33.4841628959276, Blast_Score=125, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17505681, Length=261, Percent_Identity=27.2030651340996, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24651612, Length=232, Percent_Identity=24.5689655172414, Blast_Score=71, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32762; Mature: 32630

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLDVFMKNNKNLVDQKLQEYLPNKSEYPTAIHEAMHYSVFAGGKRLRPLLTLAAGDLFG
CCEEEEECCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
ANKKTILPFACAIELIHTYSLIHDDLPALDNDDLRRGKSTNHVVFGEDIAILAGDALLNY
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCEEEECCCEEEHHHHHHHHH
AFELMTSKGVENFTDARTPLWAISEVAKASGTKGMIGGQVVDIKSEKNADIDLETVSYIH
HHHHHHHCCCCHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCHHHHHHHH
KHKTGALFTASIRIGAILSQASQADLEKLTTYAQKLGLAFQVVDDILDIEGDEQKLGKTV
HHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHC
GKDDDNEKATYPKIMGLKESHEYASRLHHEALTAISDYGEEANILRELANKIVNREK
CCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SLDVFMKNNKNLVDQKLQEYLPNKSEYPTAIHEAMHYSVFAGGKRLRPLLTLAAGDLFG
CEEEEECCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
ANKKTILPFACAIELIHTYSLIHDDLPALDNDDLRRGKSTNHVVFGEDIAILAGDALLNY
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCEEEECCCEEEHHHHHHHHH
AFELMTSKGVENFTDARTPLWAISEVAKASGTKGMIGGQVVDIKSEKNADIDLETVSYIH
HHHHHHHCCCCHHHHCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCHHHHHHHH
KHKTGALFTASIRIGAILSQASQADLEKLTTYAQKLGLAFQVVDDILDIEGDEQKLGKTV
HHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHC
GKDDDNEKATYPKIMGLKESHEYASRLHHEALTAISDYGEEANILRELANKIVNREK
CCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]