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The map label for this gene is dxs

Identifier: 188586311

GI number: 188586311

Start: 1769695

End: 1771590

Strand: Reverse

Name: dxs

Synonym: Nther_1694

Alternate gene names: 188586311

Gene position: 1771590-1769695 (Counterclockwise)

Preceding gene: 188586312

Following gene: 188586310

Centisome position: 55.96

GC content: 36.6

Gene sequence:

>1896_bases
ATGACTAAATTATTGAGTTATATTAATACATCAGAAGATTTAAAACATCTATCAACAGAAGATTTGAACAAGCTGGCTGA
GGAACTCAGGGAATTTTTAATAAGCTCTATTTCTATAACGGGTGGTCACCTTGCACCTAATTTAGGGGTAGTGGAACTGA
CTCTTGCTATTCATAAGGTGTTTTCACCTATACAAGACAAAATTGTTTGGGATGTAGGTCATCAATCTTATATCCACAAA
ATATTGACTGGGAGAAAAGAGCAATTTTCAACCCTGAGACAGTTTGGAGGATTATCCGGCTTTCCTAAACCTGAAGAAAG
TCGTTATGACGCTTTCGGTACTGGACATAGCAGCACCTCGATTTCAGCAGCTCTTGGTATGGCAAAGGCTAGAGACTTAC
AAGGAAGTAATGAAGAAGTCTTGGCTGTAATCGGAGACGGTGCAATGACTGGTGGAATGGCCTTTGAAGCCATGAACCAT
GCTGGCCATGAACAAGCAAATATGACAGTAATTTTAAATGATAATGAAATGTCAATCGGAACAAATGTAGGTGCTCTGTC
TTCATATTTATCTCGATTAAGAACTGATCCTAAATACCACAGAATTAAAGAAGATGTAGAGTTTCTGTTAAAACGAATCC
CAGCCATTGGCGGTAAAATGATGAAATCAGTTGAACGGGTTAAAGATAGCATGAAATATTTGATGGTATCGGGAATGTTG
TTTGAAGAATTAGGTTTTACTTATATTGGACCTATTGATGGTCATAATATTCCTCAACTCATGGAAGTACTAAACAATGC
CAAGGATAAAAATGGCCCAGTCCTTGTTCATGTAATCACCAAAAAAGGTAAGGGATACGAACCTGCCGAGAAATTTCCCG
ATAAATTTCACGGAACTGGTCCCTTTGAGATTGAAACGGGTAATGCTCCGAAAAAGGCAGAAACTGCACCAAGTTACTCT
AAAGTTTTTGGAGATACTATCTCAGAAATTGCCAGGAAAAATGAATCGGTTGTTGCGATTACAGCAGCTATGAAGGATGG
AACCGGTTTAACTAATTTTGCTAGAGAATTTCCTGAAAGATTTTTTGATGTAGGGATTGCAGAACAACATGCAATTACTT
TTGCAGCAGGTTTAGCTCGTAAAGGGTTTAAACCAGTAGTTGCTATATATTCAACTTTTTTACAAAGAGCATACGATCAA
ATTATCCATGATGTTTGTATGCAAGATAATCCTGTGATTTTTGCAATTGATAGAGCTGGTATAGTTGGAGGAGATGGAGA
AACCCATCAAGGTTTATACGATTTATCGTACCTTAGAAGCATACCAAATTTGATAGTGATGGCACCTAAAGATGAAGCTG
AATTACAAAGAATGTTAAATACAGCAGTTAACATCAATAAACCTGTAGCTATAAGATATCCTAGAGGAAAAGGTGAAGGT
GTAACTCTTTGGGAGAATATGACACCTATTCCTTTGTATAAAGGAGAGACTATACGAGAAGGATCCCAAGTAGCAATGAT
TGGAGTAGGGAAGATGGTACCTGACATGCTTGAAGTGGCTGATATGCTGAAAAAAGAAGGTATTGAACCCACAGTTTTCA
ATGCTAGATTTGTTAAACCTTTAGACGAAAGTTCAATTCTTGAAATAGCTCAAAAACACGAATACATTTACACTTTCGAA
GAAAATACAGAATTAGGAGGATTTGGTTCCCAAGTATTGGAATGCTTATCTAAACATGGTCTAGCACATAAATTAATTGA
TAGATTTTGTTTACCTGATGAATATATTCCGCATGGTGATAGATCTAAAGTACTAAGTCAATATAGTTTACATTCCCAGG
AATTAATAAATAAAATATTAAATCGCCTTAGAGGTGAACAGATTGAGCAAGGATAA

Upstream 100 bases:

>100_bases
GACAGACATTATTTTTTTAGTAGGCGTTGTATTAACAAAACTTGAAGACCTACTTGTTTTTCCCAAAAAACACATTAAAA
ATGTGAAGTGAGGGATATAA

Downstream 100 bases:

>100_bases
AAATCGACTCGACCAATTGCTAGTAGATAAAGGTTATTTCGCATCAAGGGAGCAGGCCAAGCGCAATATTATGGCTGGTT
TAGTTTTTGTCGATAATCAA

Product: 1-Deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 631; Mature: 630

Protein sequence:

>631_residues
MTKLLSYINTSEDLKHLSTEDLNKLAEELREFLISSISITGGHLAPNLGVVELTLAIHKVFSPIQDKIVWDVGHQSYIHK
ILTGRKEQFSTLRQFGGLSGFPKPEESRYDAFGTGHSSTSISAALGMAKARDLQGSNEEVLAVIGDGAMTGGMAFEAMNH
AGHEQANMTVILNDNEMSIGTNVGALSSYLSRLRTDPKYHRIKEDVEFLLKRIPAIGGKMMKSVERVKDSMKYLMVSGML
FEELGFTYIGPIDGHNIPQLMEVLNNAKDKNGPVLVHVITKKGKGYEPAEKFPDKFHGTGPFEIETGNAPKKAETAPSYS
KVFGDTISEIARKNESVVAITAAMKDGTGLTNFAREFPERFFDVGIAEQHAITFAAGLARKGFKPVVAIYSTFLQRAYDQ
IIHDVCMQDNPVIFAIDRAGIVGGDGETHQGLYDLSYLRSIPNLIVMAPKDEAELQRMLNTAVNINKPVAIRYPRGKGEG
VTLWENMTPIPLYKGETIREGSQVAMIGVGKMVPDMLEVADMLKKEGIEPTVFNARFVKPLDESSILEIAQKHEYIYTFE
ENTELGGFGSQVLECLSKHGLAHKLIDRFCLPDEYIPHGDRSKVLSQYSLHSQELINKILNRLRGEQIEQG

Sequences:

>Translated_631_residues
MTKLLSYINTSEDLKHLSTEDLNKLAEELREFLISSISITGGHLAPNLGVVELTLAIHKVFSPIQDKIVWDVGHQSYIHK
ILTGRKEQFSTLRQFGGLSGFPKPEESRYDAFGTGHSSTSISAALGMAKARDLQGSNEEVLAVIGDGAMTGGMAFEAMNH
AGHEQANMTVILNDNEMSIGTNVGALSSYLSRLRTDPKYHRIKEDVEFLLKRIPAIGGKMMKSVERVKDSMKYLMVSGML
FEELGFTYIGPIDGHNIPQLMEVLNNAKDKNGPVLVHVITKKGKGYEPAEKFPDKFHGTGPFEIETGNAPKKAETAPSYS
KVFGDTISEIARKNESVVAITAAMKDGTGLTNFAREFPERFFDVGIAEQHAITFAAGLARKGFKPVVAIYSTFLQRAYDQ
IIHDVCMQDNPVIFAIDRAGIVGGDGETHQGLYDLSYLRSIPNLIVMAPKDEAELQRMLNTAVNINKPVAIRYPRGKGEG
VTLWENMTPIPLYKGETIREGSQVAMIGVGKMVPDMLEVADMLKKEGIEPTVFNARFVKPLDESSILEIAQKHEYIYTFE
ENTELGGFGSQVLECLSKHGLAHKLIDRFCLPDEYIPHGDRSKVLSQYSLHSQELINKILNRLRGEQIEQG
>Mature_630_residues
TKLLSYINTSEDLKHLSTEDLNKLAEELREFLISSISITGGHLAPNLGVVELTLAIHKVFSPIQDKIVWDVGHQSYIHKI
LTGRKEQFSTLRQFGGLSGFPKPEESRYDAFGTGHSSTSISAALGMAKARDLQGSNEEVLAVIGDGAMTGGMAFEAMNHA
GHEQANMTVILNDNEMSIGTNVGALSSYLSRLRTDPKYHRIKEDVEFLLKRIPAIGGKMMKSVERVKDSMKYLMVSGMLF
EELGFTYIGPIDGHNIPQLMEVLNNAKDKNGPVLVHVITKKGKGYEPAEKFPDKFHGTGPFEIETGNAPKKAETAPSYSK
VFGDTISEIARKNESVVAITAAMKDGTGLTNFAREFPERFFDVGIAEQHAITFAAGLARKGFKPVVAIYSTFLQRAYDQI
IHDVCMQDNPVIFAIDRAGIVGGDGETHQGLYDLSYLRSIPNLIVMAPKDEAELQRMLNTAVNINKPVAIRYPRGKGEGV
TLWENMTPIPLYKGETIREGSQVAMIGVGKMVPDMLEVADMLKKEGIEPTVFNARFVKPLDESSILEIAQKHEYIYTFEE
NTELGGFGSQVLECLSKHGLAHKLIDRFCLPDEYIPHGDRSKVLSQYSLHSQELINKILNRLRGEQIEQG

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=619, Percent_Identity=23.4248788368336, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI4507521, Length=619, Percent_Identity=23.4248788368336, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI133778974, Length=392, Percent_Identity=26.530612244898, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI225637461, Length=510, Percent_Identity=23.7254901960784, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI225637463, Length=510, Percent_Identity=23.7254901960784, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI225637459, Length=510, Percent_Identity=23.7254901960784, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI156564403, Length=235, Percent_Identity=23.4042553191489, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1786622, Length=616, Percent_Identity=48.8636363636364, Blast_Score=602, Evalue=1e-173,
Organism=Caenorhabditis elegans, GI17539652, Length=639, Percent_Identity=24.2566510172144, Blast_Score=112, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6319698, Length=255, Percent_Identity=27.4509803921569, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI45551847, Length=672, Percent_Identity=23.9583333333333, Blast_Score=135, Evalue=1e-31,
Organism=Drosophila melanogaster, GI45550715, Length=672, Percent_Identity=23.9583333333333, Blast_Score=135, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24666278, Length=593, Percent_Identity=26.1382799325464, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24645119, Length=625, Percent_Identity=23.68, Blast_Score=130, Evalue=4e-30,
Organism=Drosophila melanogaster, GI21358145, Length=286, Percent_Identity=24.1258741258741, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24650940, Length=286, Percent_Identity=24.1258741258741, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_NATTJ (B2A526)

Other databases:

- EMBL:   CP001034
- RefSeq:   YP_001917856.1
- ProteinModelPortal:   B2A526
- SMR:   B2A526
- GeneID:   6314337
- GenomeReviews:   CP001034_GR
- KEGG:   nth:Nther_1694
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 69809; Mature: 69678

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKLLSYINTSEDLKHLSTEDLNKLAEELREFLISSISITGGHLAPNLGVVELTLAIHKV
CCHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
FSPIQDKIVWDVGHQSYIHKILTGRKEQFSTLRQFGGLSGFPKPEESRYDAFGTGHSSTS
HHHHHHHHEEECCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCH
ISAALGMAKARDLQGSNEEVLAVIGDGAMTGGMAFEAMNHAGHEQANMTVILNDNEMSIG
HHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCCCEEEEECCCCEECC
TNVGALSSYLSRLRTDPKYHRIKEDVEFLLKRIPAIGGKMMKSVERVKDSMKYLMVSGML
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
FEELGFTYIGPIDGHNIPQLMEVLNNAKDKNGPVLVHVITKKGKGYEPAEKFPDKFHGTG
HHHCCCEEECCCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCHHHHCCHHHCCCC
PFEIETGNAPKKAETAPSYSKVFGDTISEIARKNESVVAITAAMKDGTGLTNFAREFPER
CEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHH
FFDVGIAEQHAITFAAGLARKGFKPVVAIYSTFLQRAYDQIIHDVCMQDNPVIFAIDRAG
HHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
IVGGDGETHQGLYDLSYLRSIPNLIVMAPKDEAELQRMLNTAVNINKPVAIRYPRGKGEG
EECCCCCCCCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCC
VTLWENMTPIPLYKGETIREGSQVAMIGVGKMVPDMLEVADMLKKEGIEPTVFNARFVKP
EEEECCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHCCCCCEEECCCCCCC
LDESSILEIAQKHEYIYTFEENTELGGFGSQVLECLSKHGLAHKLIDRFCLPDEYIPHGD
CCHHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCC
RSKVLSQYSLHSQELINKILNRLRGEQIEQG
HHHHHHHHHHHHHHHHHHHHHHHCCHHCCCC
>Mature Secondary Structure 
TKLLSYINTSEDLKHLSTEDLNKLAEELREFLISSISITGGHLAPNLGVVELTLAIHKV
CHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
FSPIQDKIVWDVGHQSYIHKILTGRKEQFSTLRQFGGLSGFPKPEESRYDAFGTGHSSTS
HHHHHHHHEEECCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCH
ISAALGMAKARDLQGSNEEVLAVIGDGAMTGGMAFEAMNHAGHEQANMTVILNDNEMSIG
HHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCCCEEEEECCCCEECC
TNVGALSSYLSRLRTDPKYHRIKEDVEFLLKRIPAIGGKMMKSVERVKDSMKYLMVSGML
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
FEELGFTYIGPIDGHNIPQLMEVLNNAKDKNGPVLVHVITKKGKGYEPAEKFPDKFHGTG
HHHCCCEEECCCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCHHHHCCHHHCCCC
PFEIETGNAPKKAETAPSYSKVFGDTISEIARKNESVVAITAAMKDGTGLTNFAREFPER
CEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHH
FFDVGIAEQHAITFAAGLARKGFKPVVAIYSTFLQRAYDQIIHDVCMQDNPVIFAIDRAG
HHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
IVGGDGETHQGLYDLSYLRSIPNLIVMAPKDEAELQRMLNTAVNINKPVAIRYPRGKGEG
EECCCCCCCCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCC
VTLWENMTPIPLYKGETIREGSQVAMIGVGKMVPDMLEVADMLKKEGIEPTVFNARFVKP
EEEECCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHCCCCCEEECCCCCCC
LDESSILEIAQKHEYIYTFEENTELGGFGSQVLECLSKHGLAHKLIDRFCLPDEYIPHGD
CCHHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCC
RSKVLSQYSLHSQELINKILNRLRGEQIEQG
HHHHHHHHHHHHHHHHHHHHHHHCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA