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The map label for this gene is pdp [H]

Identifier: 188586282

GI number: 188586282

Start: 1741302

End: 1742636

Strand: Reverse

Name: pdp [H]

Synonym: Nther_1665

Alternate gene names: 188586282

Gene position: 1742636-1741302 (Counterclockwise)

Preceding gene: 188586283

Following gene: 188586281

Centisome position: 55.05

GC content: 37.0

Gene sequence:

>1335_bases
ATGCGAGCTTATGAAGTCATTGTAAAAAAACGTGAAGGTGGAGAATTATCTTCTAGTGAAATCGACTTTTTAGTACAAGG
ATATACTAGGGGTGAAATACCTGACTATCAGATGTCATCCTTTTTAATGGCAGCTTTTTTACAGGGATTGAATAGCCAAG
AAACTGCCCAATTAACTAAATCTATGGTACACTCAGGTGAAGTTTTAGATCTTAGCAGGATTTCCGGTATCAAGGTTGAC
AAACACAGTACTGGTGGAGTAGGGGATAAAACTACACTTGCACTTGCTCCTCTGGTAGCATCAGCAGATCTCAACGTGGC
AAAGATGTCTGGTAGAGGTCTAGGTCATTCTGGTGGAACCATTGACAAATTAGAAGCATTTTTGGGTTTTACCCCTGAAC
TGTCAATGGAAAACTTTATTGAACAGGTACAAAAGCATAACCTAGCTATTGTGGGGCAAACAAAACAGCTGGCTCCAGCT
GATGGCAAAATTTATTCGTTAAGAGATGTAACTGCTACTGTAGATTCAATTCCGTTAATAGCAAGCTCAATAATGAGTAA
AAAACTTGCAGCTGGTACCAATATGATTGTATTGGATGTAAAAGTAGGCAAAGGGGCTTTTATGGAGAATCTTGAAGATG
CAACTGCCCTCGGACATGAGATGGTTAATATCGGCAAAAATTTAGGAAGAAAAACGGTGGCAGTGATTAGTGATATGAAC
CAGCCTTTGGGAAGAAAGGTTGGAAATTCCTTAGAAGTACAAGAAGCCATCGCTACATTGAAGGGCAATGGACCAGAAGA
TTTTAAAGAATTATGTCTCAATTTAGGAGCCATCTTATTGAATATGGCCGAAAAAGTTACCACAGTTACAGAAGGCAAAA
AGTTATTATCAAATAAAATAAACAGTGGAGAGGCTTTAGCTAAGCTCGAGCAATTAGTAAAGGCTCAGAATGGAGATACA
TCAGGTATACATAATACAGAAAATCTGCCTCAAGCCAAGCACTATAAAATATTAACAGCAGATAAATCTGGATTTATTAC
AAATTTAGATGCTAAAAAAGTAGGACTAGCCAGTGTAAATTTAGGAGCTGGCAGGGCAACCAAAGAAGATAAAATTGACT
TATCCGTTGGGATAGAATTAAATAAAAAACTAGGTGATGAAGTTAGTACAGGTGATGAATTAGCAAAAATATGGTATAAC
GATGAAGATAAATTATTACAAGCCGCACCTATTCTAGAAGATGCTTTTGATATTTCAGAAAGTGCTTCAGGAAAGTCACT
TATTTATGGCATGATAACTGAAAATACAAATCCAGGTGAATTAGATAGCATTTAA

Upstream 100 bases:

>100_bases
TAAGAAAAGTGTTAGCATCAATGTAAATTTACTATAACAACTGCTATTAAAGGAAATATTCAAACTACTTGAGATGGCGT
TATTACAGGGAGGCCTTAGA

Downstream 100 bases:

>100_bases
ATTGATACCATACAACAAAATCATCAGAATTTTCATGTTATAACTTGTAATAAAAGGTCTCAATTACCAGAGACCTTTTA
TTTTTTTTGCGCATTTTTTT

Product: thymidine phosphorylase

Products: NA

Alternate protein names: PYNP [H]

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MRAYEVIVKKREGGELSSSEIDFLVQGYTRGEIPDYQMSSFLMAAFLQGLNSQETAQLTKSMVHSGEVLDLSRISGIKVD
KHSTGGVGDKTTLALAPLVASADLNVAKMSGRGLGHSGGTIDKLEAFLGFTPELSMENFIEQVQKHNLAIVGQTKQLAPA
DGKIYSLRDVTATVDSIPLIASSIMSKKLAAGTNMIVLDVKVGKGAFMENLEDATALGHEMVNIGKNLGRKTVAVISDMN
QPLGRKVGNSLEVQEAIATLKGNGPEDFKELCLNLGAILLNMAEKVTTVTEGKKLLSNKINSGEALAKLEQLVKAQNGDT
SGIHNTENLPQAKHYKILTADKSGFITNLDAKKVGLASVNLGAGRATKEDKIDLSVGIELNKKLGDEVSTGDELAKIWYN
DEDKLLQAAPILEDAFDISESASGKSLIYGMITENTNPGELDSI

Sequences:

>Translated_444_residues
MRAYEVIVKKREGGELSSSEIDFLVQGYTRGEIPDYQMSSFLMAAFLQGLNSQETAQLTKSMVHSGEVLDLSRISGIKVD
KHSTGGVGDKTTLALAPLVASADLNVAKMSGRGLGHSGGTIDKLEAFLGFTPELSMENFIEQVQKHNLAIVGQTKQLAPA
DGKIYSLRDVTATVDSIPLIASSIMSKKLAAGTNMIVLDVKVGKGAFMENLEDATALGHEMVNIGKNLGRKTVAVISDMN
QPLGRKVGNSLEVQEAIATLKGNGPEDFKELCLNLGAILLNMAEKVTTVTEGKKLLSNKINSGEALAKLEQLVKAQNGDT
SGIHNTENLPQAKHYKILTADKSGFITNLDAKKVGLASVNLGAGRATKEDKIDLSVGIELNKKLGDEVSTGDELAKIWYN
DEDKLLQAAPILEDAFDISESASGKSLIYGMITENTNPGELDSI
>Mature_444_residues
MRAYEVIVKKREGGELSSSEIDFLVQGYTRGEIPDYQMSSFLMAAFLQGLNSQETAQLTKSMVHSGEVLDLSRISGIKVD
KHSTGGVGDKTTLALAPLVASADLNVAKMSGRGLGHSGGTIDKLEAFLGFTPELSMENFIEQVQKHNLAIVGQTKQLAPA
DGKIYSLRDVTATVDSIPLIASSIMSKKLAAGTNMIVLDVKVGKGAFMENLEDATALGHEMVNIGKNLGRKTVAVISDMN
QPLGRKVGNSLEVQEAIATLKGNGPEDFKELCLNLGAILLNMAEKVTTVTEGKKLLSNKINSGEALAKLEQLVKAQNGDT
SGIHNTENLPQAKHYKILTADKSGFITNLDAKKVGLASVNLGAGRATKEDKIDLSVGIELNKKLGDEVSTGDELAKIWYN
DEDKLLQAAPILEDAFDISESASGKSLIYGMITENTNPGELDSI

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=426, Percent_Identity=37.793427230047, Blast_Score=269, Evalue=4e-72,
Organism=Homo sapiens, GI4503445, Length=426, Percent_Identity=37.793427230047, Blast_Score=269, Evalue=4e-72,
Organism=Homo sapiens, GI166158922, Length=426, Percent_Identity=37.793427230047, Blast_Score=269, Evalue=4e-72,
Organism=Escherichia coli, GI1790842, Length=406, Percent_Identity=40.8866995073892, Blast_Score=283, Evalue=2e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.2 [H]

Molecular weight: Translated: 47376; Mature: 47376

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAYEVIVKKREGGELSSSEIDFLVQGYTRGEIPDYQMSSFLMAAFLQGLNSQETAQLTK
CCHHEEEEEECCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHH
SMVHSGEVLDLSRISGIKVDKHSTGGVGDKTTLALAPLVASADLNVAKMSGRGLGHSGGT
HHHHCCCEEEHHHCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCCC
IDKLEAFLGFTPELSMENFIEQVQKHNLAIVGQTKQLAPADGKIYSLRDVTATVDSIPLI
HHHHHHHHCCCCCCCHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEEHHHHHHHHHHHHH
ASSIMSKKLAAGTNMIVLDVKVGKGAFMENLEDATALGHEMVNIGKNLGRKTVAVISDMN
HHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
QPLGRKVGNSLEVQEAIATLKGNGPEDFKELCLNLGAILLNMAEKVTTVTEGKKLLSNKI
CHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NSGEALAKLEQLVKAQNGDTSGIHNTENLPQAKHYKILTADKSGFITNLDAKKVGLASVN
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEECCCCCCCEEEEE
LGAGRATKEDKIDLSVGIELNKKLGDEVSTGDELAKIWYNDEDKLLQAAPILEDAFDISE
CCCCCCCCCCCEEEEEEEEECHHCCCCCCCCHHHHHEEECCHHHHHHHHHHHHHHHCCCC
SASGKSLIYGMITENTNPGELDSI
CCCCCEEEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MRAYEVIVKKREGGELSSSEIDFLVQGYTRGEIPDYQMSSFLMAAFLQGLNSQETAQLTK
CCHHEEEEEECCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHH
SMVHSGEVLDLSRISGIKVDKHSTGGVGDKTTLALAPLVASADLNVAKMSGRGLGHSGGT
HHHHCCCEEEHHHCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCCC
IDKLEAFLGFTPELSMENFIEQVQKHNLAIVGQTKQLAPADGKIYSLRDVTATVDSIPLI
HHHHHHHHCCCCCCCHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEEHHHHHHHHHHHHH
ASSIMSKKLAAGTNMIVLDVKVGKGAFMENLEDATALGHEMVNIGKNLGRKTVAVISDMN
HHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
QPLGRKVGNSLEVQEAIATLKGNGPEDFKELCLNLGAILLNMAEKVTTVTEGKKLLSNKI
CHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NSGEALAKLEQLVKAQNGDTSGIHNTENLPQAKHYKILTADKSGFITNLDAKKVGLASVN
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEECCCCCCCEEEEE
LGAGRATKEDKIDLSVGIELNKKLGDEVSTGDELAKIWYNDEDKLLQAAPILEDAFDISE
CCCCCCCCCCCEEEEEEEEECHHCCCCCCCCHHHHHEEECCHHHHHHHHHHHHHHHCCCC
SASGKSLIYGMITENTNPGELDSI
CCCCCEEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA