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The map label for this gene is der

Identifier: 188586247

GI number: 188586247

Start: 1710425

End: 1711747

Strand: Reverse

Name: der

Synonym: Nther_1630

Alternate gene names: 188586247

Gene position: 1711747-1710425 (Counterclockwise)

Preceding gene: 188586248

Following gene: 188586246

Centisome position: 54.07

GC content: 35.07

Gene sequence:

>1323_bases
ATGTCAGTAAAAGCTACAGTAGCTTTAGTAGGAAGACCTAATGTAGGTAAATCTGCTCTATTTAATAGAATTGTTGGTCA
GAGAATTTCCATTGTAGACGATACCCCTGGAGTTACTAGAGATCGAATAGACGGTAAAGGTGAATGGAGTGGACATTCTT
TTAATCTAATAGACACTGGGGGAATTTTTGACGAGGAAGATGACATTTTAAAACAGGTTGTTATACAAGCTGAAGTTGCT
ATTGATGAGGCAGATGTAATTGTTTTTGTGACAGATGGACGAGATGGAATAACTCCAGCTGATGAAGAGGTGGCTGCTAC
TTTAAGAAAAACCAAAAAACCCGTCCTTGTCGCTGTCAACAAAAGTGAAGGAAACTACGACCAATATGCTATGGAATTTT
ATCAACTTGGTTTTGAACAAGTAATATCAATATCAGCATTGCATGGTACAAATACCGGCCAATTACTGGATGAAATTGTT
GAATTGTTACCGGAACAGGAATACGAAGAACTAAATTATCATGAAGACGATATTATGCTCTCTGTAATTGGTAGACCAAA
TGTAGGGAAGTCTTCTCTGATTAATAAGATCTTGAATAAAGAACGTTTGATTGTTAGTAATATGCCTGGTACAACTAGAG
ACGCAATTGACACTGTTATTGAAAGGGAAGACCAAAAGTATGTCTTTATTGACACAGCAGGGTTGAGGAAAAAATCTAAA
ATTGATGAAAGGTTAGAAAAGTATAGTGTCATTAGAAGTATCAAAGGAATGGAAAGAAGTAATATTGCATTGTTATTAAT
TGATGTTACTAAAGGAATTTTAGAACAAGATAAAAAAATTGCCGGCTTAGCTGAAGAAAAAGGGAAAGGTTTAATAATCC
TATTAAATAAATGGGATGCCATTGAAAAAGATGGTAAAGCTGGTGACAAGTATTATGAAACAGTCAGGCTAGAGCTACCT
AGTGTTAATTATGCACCGATAATGTTTTTATCTGCTCAAACTGGTAAAAATGTTGAGAAAATATTTCCTGTAATTGATAA
AGTATCAAAAGAACACAGTAAAAGGATAACCACTGCTGATGTAAACCGTGTCATTGAGGATGCCGTCAATTATACTCCAC
CGCCATCTAAAAAGGGAAAAAGATTAAAAATATATTATGCTACCCAAGTGCGTACACGGCCTCCAACTTTTGTATTGTTT
GTTAACAATCCAGAACTAATGAAAAATTCTTATAAGAGATATCTTCAGAATCAATTAAGAAGGGCTTTTGGATTTGAAGG
AACTCCTATTCGCATCCTAGAAAGAGTGAAACAGAGGAGGTAA

Upstream 100 bases:

>100_bases
GCTAGATATTAAAACTATAATTGTTCCTGTTAACGGTGAAAAATTTGTAAAGACCCTAAGAGATTTTTACTATACTGGCC
TCTAGAAGGAGTTGATAAAA

Downstream 100 bases:

>100_bases
TAAAATGTGGTTAATTCTTTTAGCCTATTTATTAGGGTCTATACCCGGTGGTTATATAATAGGAAAATTAACTCAAGGAA
TCGATATTCGCAATTATGGT

Product: small GTP-binding protein

Products: NA

Alternate protein names: GTP-binding protein EngA

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MSVKATVALVGRPNVGKSALFNRIVGQRISIVDDTPGVTRDRIDGKGEWSGHSFNLIDTGGIFDEEDDILKQVVIQAEVA
IDEADVIVFVTDGRDGITPADEEVAATLRKTKKPVLVAVNKSEGNYDQYAMEFYQLGFEQVISISALHGTNTGQLLDEIV
ELLPEQEYEELNYHEDDIMLSVIGRPNVGKSSLINKILNKERLIVSNMPGTTRDAIDTVIEREDQKYVFIDTAGLRKKSK
IDERLEKYSVIRSIKGMERSNIALLLIDVTKGILEQDKKIAGLAEEKGKGLIILLNKWDAIEKDGKAGDKYYETVRLELP
SVNYAPIMFLSAQTGKNVEKIFPVIDKVSKEHSKRITTADVNRVIEDAVNYTPPPSKKGKRLKIYYATQVRTRPPTFVLF
VNNPELMKNSYKRYLQNQLRRAFGFEGTPIRILERVKQRR

Sequences:

>Translated_440_residues
MSVKATVALVGRPNVGKSALFNRIVGQRISIVDDTPGVTRDRIDGKGEWSGHSFNLIDTGGIFDEEDDILKQVVIQAEVA
IDEADVIVFVTDGRDGITPADEEVAATLRKTKKPVLVAVNKSEGNYDQYAMEFYQLGFEQVISISALHGTNTGQLLDEIV
ELLPEQEYEELNYHEDDIMLSVIGRPNVGKSSLINKILNKERLIVSNMPGTTRDAIDTVIEREDQKYVFIDTAGLRKKSK
IDERLEKYSVIRSIKGMERSNIALLLIDVTKGILEQDKKIAGLAEEKGKGLIILLNKWDAIEKDGKAGDKYYETVRLELP
SVNYAPIMFLSAQTGKNVEKIFPVIDKVSKEHSKRITTADVNRVIEDAVNYTPPPSKKGKRLKIYYATQVRTRPPTFVLF
VNNPELMKNSYKRYLQNQLRRAFGFEGTPIRILERVKQRR
>Mature_439_residues
SVKATVALVGRPNVGKSALFNRIVGQRISIVDDTPGVTRDRIDGKGEWSGHSFNLIDTGGIFDEEDDILKQVVIQAEVAI
DEADVIVFVTDGRDGITPADEEVAATLRKTKKPVLVAVNKSEGNYDQYAMEFYQLGFEQVISISALHGTNTGQLLDEIVE
LLPEQEYEELNYHEDDIMLSVIGRPNVGKSSLINKILNKERLIVSNMPGTTRDAIDTVIEREDQKYVFIDTAGLRKKSKI
DERLEKYSVIRSIKGMERSNIALLLIDVTKGILEQDKKIAGLAEEKGKGLIILLNKWDAIEKDGKAGDKYYETVRLELPS
VNYAPIMFLSAQTGKNVEKIFPVIDKVSKEHSKRITTADVNRVIEDAVNYTPPPSKKGKRLKIYYATQVRTRPPTFVLFV
NNPELMKNSYKRYLQNQLRRAFGFEGTPIRILERVKQRR

Specific function: GTPase that plays an essential role in the late steps of ribosome biogenesis

COG id: COG1160

COG function: function code R; Predicted GTPases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH-like domain

Homologues:

Organism=Escherichia coli, GI87082120, Length=453, Percent_Identity=39.514348785872, Blast_Score=330, Evalue=9e-92,
Organism=Escherichia coli, GI1788919, Length=252, Percent_Identity=30.952380952381, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI2367268, Length=121, Percent_Identity=34.7107438016529, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17507259, Length=118, Percent_Identity=31.3559322033898, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6323665, Length=228, Percent_Identity=31.5789473684211, Blast_Score=90, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DER_NATTJ (B2A4M9)

Other databases:

- EMBL:   CP001034
- RefSeq:   YP_001917792.1
- ProteinModelPortal:   B2A4M9
- SMR:   B2A4M9
- GeneID:   6314777
- GenomeReviews:   CP001034_GR
- KEGG:   nth:Nther_1630
- HOGENOM:   HBG592135
- OMA:   TRDRTYQ
- GO:   GO:0005622
- HAMAP:   MF_00195
- InterPro:   IPR016484
- InterPro:   IPR015946
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- PIRSF:   PIRSF006485
- TIGRFAMs:   TIGR03594
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF01926 MMR_HSR1

EC number: NA

Molecular weight: Translated: 49602; Mature: 49470

Theoretical pI: Translated: 8.52; Mature: 8.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVKATVALVGRPNVGKSALFNRIVGQRISIVDDTPGVTRDRIDGKGEWSGHSFNLIDTG
CCCEEEEEEEECCCCCHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEECC
GIFDEEDDILKQVVIQAEVAIDEADVIVFVTDGRDGITPADEEVAATLRKTKKPVLVAVN
CCCCCHHHHHHHHHHHHHHEECCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEEE
KSEGNYDQYAMEFYQLGFEQVISISALHGTNTGQLLDEIVELLPEQEYEELNYHEDDIML
CCCCCHHHHHHHHHHHCHHHHHEEHEECCCCHHHHHHHHHHHCCCCHHHHCCCCCCCEEE
SVIGRPNVGKSSLINKILNKERLIVSNMPGTTRDAIDTVIEREDQKYVFIDTAGLRKKSK
EEECCCCCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCHHHH
IDERLEKYSVIRSIKGMERSNIALLLIDVTKGILEQDKKIAGLAEEKGKGLIILLNKWDA
HHHHHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHCHHHHCCHHHCCCEEEEEEECCCC
IEKDGKAGDKYYETVRLELPSVNYAPIMFLSAQTGKNVEKIFPVIDKVSKEHSKRITTAD
CCCCCCCCCCEEEEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHH
VNRVIEDAVNYTPPPSKKGKRLKIYYATQVRTRPPTFVLFVNNPELMKNSYKRYLQNQLR
HHHHHHHHHCCCCCCCCCCCEEEEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHHHHHH
RAFGFEGTPIRILERVKQRR
HHHCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SVKATVALVGRPNVGKSALFNRIVGQRISIVDDTPGVTRDRIDGKGEWSGHSFNLIDTG
CCEEEEEEEECCCCCHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEECC
GIFDEEDDILKQVVIQAEVAIDEADVIVFVTDGRDGITPADEEVAATLRKTKKPVLVAVN
CCCCCHHHHHHHHHHHHHHEECCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEEE
KSEGNYDQYAMEFYQLGFEQVISISALHGTNTGQLLDEIVELLPEQEYEELNYHEDDIML
CCCCCHHHHHHHHHHHCHHHHHEEHEECCCCHHHHHHHHHHHCCCCHHHHCCCCCCCEEE
SVIGRPNVGKSSLINKILNKERLIVSNMPGTTRDAIDTVIEREDQKYVFIDTAGLRKKSK
EEECCCCCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCHHHH
IDERLEKYSVIRSIKGMERSNIALLLIDVTKGILEQDKKIAGLAEEKGKGLIILLNKWDA
HHHHHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHCHHHHCCHHHCCCEEEEEEECCCC
IEKDGKAGDKYYETVRLELPSVNYAPIMFLSAQTGKNVEKIFPVIDKVSKEHSKRITTAD
CCCCCCCCCCEEEEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHH
VNRVIEDAVNYTPPPSKKGKRLKIYYATQVRTRPPTFVLFVNNPELMKNSYKRYLQNQLR
HHHHHHHHHCCCCCCCCCCCEEEEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHHHHHH
RAFGFEGTPIRILERVKQRR
HHHCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA