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The map label for this gene is ndk [H]

Identifier: 188586222

GI number: 188586222

Start: 1682177

End: 1682596

Strand: Reverse

Name: ndk [H]

Synonym: Nther_1605

Alternate gene names: 188586222

Gene position: 1682596-1682177 (Counterclockwise)

Preceding gene: 188586223

Following gene: 188586221

Centisome position: 53.15

GC content: 37.38

Gene sequence:

>420_bases
ATGTCATCACAAAATGAACAAACCTTTGTTATGGTTAAACCCGATGGGGTAGAGAGGGGATTAGTCGGAGAGATAATTTC
TCGACTAGAGAATAAGAGATTGAACTTAAGGAAGATAACCATGTTAGAAGTCTCTAAAGAGTTAGCCCAAACCCATTATC
AAGAACATAGGGACAAACCCTTTTTTAACGATTTAATCAATTACATAACAAGTGGACCAGTGGTTGCTATGGTATGGGAG
GGAGATAATGTCATTGAGGTTGTTCGTAAGTTGATAGGGGATACGGACCCTAAAAAAGCTGCACCAGGTACCATTAGAGG
TGATTTAGCTTTAGATATAACTTATAACTTAGTTCACGGGTCTGATAGTGAAGATACTGCAAAAAGAGAAATTAATTTAT
TTTTTCGACCGACGAACTAA

Upstream 100 bases:

>100_bases
GTTACAATTTAATGAAACACTATTGGTTATAATTATTAAAAAGACAGCGAGACACAATTTTAAACACTAATCCTACATAA
CAGTTAAGGAGGTTTTTTGA

Downstream 100 bases:

>100_bases
TGCATAGAACTGAGTATGATCAGTAGGGAGAGGAGAGATTCATAATTGACTGATACAGCTTTTGAAACATTTAAATCTAA
AGTTTATCAAAAAACAGGAA

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 139; Mature: 138

Protein sequence:

>139_residues
MSSQNEQTFVMVKPDGVERGLVGEIISRLENKRLNLRKITMLEVSKELAQTHYQEHRDKPFFNDLINYITSGPVVAMVWE
GDNVIEVVRKLIGDTDPKKAAPGTIRGDLALDITYNLVHGSDSEDTAKREINLFFRPTN

Sequences:

>Translated_139_residues
MSSQNEQTFVMVKPDGVERGLVGEIISRLENKRLNLRKITMLEVSKELAQTHYQEHRDKPFFNDLINYITSGPVVAMVWE
GDNVIEVVRKLIGDTDPKKAAPGTIRGDLALDITYNLVHGSDSEDTAKREINLFFRPTN
>Mature_138_residues
SSQNEQTFVMVKPDGVERGLVGEIISRLENKRLNLRKITMLEVSKELAQTHYQEHRDKPFFNDLINYITSGPVVAMVWEG
DNVIEVVRKLIGDTDPKKAAPGTIRGDLALDITYNLVHGSDSEDTAKREINLFFRPTN

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=136, Percent_Identity=50.7352941176471, Blast_Score=157, Evalue=2e-39,
Organism=Homo sapiens, GI38045913, Length=135, Percent_Identity=48.8888888888889, Blast_Score=154, Evalue=2e-38,
Organism=Homo sapiens, GI4557797, Length=135, Percent_Identity=48.8888888888889, Blast_Score=154, Evalue=2e-38,
Organism=Homo sapiens, GI66392227, Length=132, Percent_Identity=50.7575757575758, Blast_Score=153, Evalue=5e-38,
Organism=Homo sapiens, GI66392205, Length=132, Percent_Identity=50.7575757575758, Blast_Score=153, Evalue=5e-38,
Organism=Homo sapiens, GI4505409, Length=132, Percent_Identity=50.7575757575758, Blast_Score=153, Evalue=5e-38,
Organism=Homo sapiens, GI66392192, Length=132, Percent_Identity=50.7575757575758, Blast_Score=153, Evalue=5e-38,
Organism=Homo sapiens, GI66392203, Length=132, Percent_Identity=50.7575757575758, Blast_Score=153, Evalue=5e-38,
Organism=Homo sapiens, GI4826862, Length=137, Percent_Identity=50.3649635036496, Blast_Score=149, Evalue=5e-37,
Organism=Homo sapiens, GI37574614, Length=138, Percent_Identity=34.0579710144928, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI7019465, Length=138, Percent_Identity=34.0579710144928, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI5031951, Length=133, Percent_Identity=37.593984962406, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788866, Length=130, Percent_Identity=42.3076923076923, Blast_Score=118, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17506807, Length=134, Percent_Identity=49.2537313432836, Blast_Score=148, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI71995094, Length=137, Percent_Identity=32.8467153284672, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17507605, Length=80, Percent_Identity=43.75, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=50.7352941176471, Blast_Score=157, Evalue=6e-40,
Organism=Drosophila melanogaster, GI45549037, Length=135, Percent_Identity=49.6296296296296, Blast_Score=154, Evalue=2e-38,
Organism=Drosophila melanogaster, GI18860097, Length=133, Percent_Identity=30.8270676691729, Blast_Score=77, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15757; Mature: 15626

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSQNEQTFVMVKPDGVERGLVGEIISRLENKRLNLRKITMLEVSKELAQTHYQEHRDKP
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
FFNDLINYITSGPVVAMVWEGDNVIEVVRKLIGDTDPKKAAPGTIRGDLALDITYNLVHG
HHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCEECCEEEEEEEEEEEC
SDSEDTAKREINLFFRPTN
CCCCCCCCEEEEEEEEECC
>Mature Secondary Structure 
SSQNEQTFVMVKPDGVERGLVGEIISRLENKRLNLRKITMLEVSKELAQTHYQEHRDKP
CCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
FFNDLINYITSGPVVAMVWEGDNVIEVVRKLIGDTDPKKAAPGTIRGDLALDITYNLVHG
HHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCEECCEEEEEEEEEEEC
SDSEDTAKREINLFFRPTN
CCCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]