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The map label for this gene is era [H]

Identifier: 188585831

GI number: 188585831

Start: 1274227

End: 1275120

Strand: Direct

Name: era [H]

Synonym: Nther_1205

Alternate gene names: 188585831

Gene position: 1274227-1275120 (Clockwise)

Preceding gene: 188585830

Following gene: 188585832

Centisome position: 40.25

GC content: 35.23

Gene sequence:

>894_bases
ATGGAGGAGGAAATTTTCTATTCTGGCTTTGTCTCAGTTATCGGAAGACCAAATGCCGGCAAGTCAACTTTGATCAATTA
TATATTAGGTGAAAAAGTAGTAATTACAAGTGACAAGCCCCAGACAACCAGAAATAAAATTCAATGTGTTTATAATGGTG
AAAACAGTCAAATCATATTTCTTGATACGCCAGGGATGCACAAACCCAAGCATAAATTGGGAGAAAAAATGGTAAAAGCA
GTTGATGAAAGTCTGAACGAAATGGATGCCATTTTATTTGTAATTGATGTATCCGTTCCCTTTGGAAAGGGAGAAACTAT
GTTAGTTGAAAGACTAGCGCGTCTATCAACTCCAGTTATTTTAGTAATGAATAAAATGGATCTGGTTGATGAAGACTTGG
CCAGGGAAAAGACAGAGAAAATTAAGGAAAAATTGTCTCCTGAAAGTATTCACTATATATCTGCACTGTATGGGAACAAT
TTAGTTGACTTATTAGGAGAGCTTGAGAATTTAATGCCAGAAGGCCCGAAATACTATCCGGAAGATCAACTTATAGACCA
GCCTGAGAGATTTGTAGTTTCCGAATTAATCAGGGAAAAACTTTTAAACTATACACAAGAAGAGATACCCCATTCTGTAG
CTGTAGAAATTATGTTGATGGAAAATCGGGAAGATCAGGATTTAATAGATATAGAAGCGGTAATATATGTGGAACGTGAA
TCACAAAAAAAGATAGTTATCGGACGAAGAGGAAAATTACTAAAAAAGGTTGGTCAAGAAGCTCGACGCGATATTGAGAA
TTTATTAGGTTCTCAGATATACTTAGATTTATGGGTTAAAAATCAAAAAGATTGGCGAAACAGAGAAAGATTTTTAAGAG
AGTTGGGGTATTAA

Upstream 100 bases:

>100_bases
ATATGTGCAAAAGGAATATATTTGGGATTCAATTTAAATAAACTTTGATTAAATAGGGTAATGTATTTAATAATATGAAT
TTTAAGGGGTGAACCAAAAT

Downstream 100 bases:

>100_bases
AGATGTGTGCTCTGTATAATTCGGATGCGGTGGTTATTAGAAGCCGTGATTATAGAGATTATGACAAGATAATAAATCTG
TTCACCCCTTATTATGGAAG

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MEEEIFYSGFVSVIGRPNAGKSTLINYILGEKVVITSDKPQTTRNKIQCVYNGENSQIIFLDTPGMHKPKHKLGEKMVKA
VDESLNEMDAILFVIDVSVPFGKGETMLVERLARLSTPVILVMNKMDLVDEDLAREKTEKIKEKLSPESIHYISALYGNN
LVDLLGELENLMPEGPKYYPEDQLIDQPERFVVSELIREKLLNYTQEEIPHSVAVEIMLMENREDQDLIDIEAVIYVERE
SQKKIVIGRRGKLLKKVGQEARRDIENLLGSQIYLDLWVKNQKDWRNRERFLRELGY

Sequences:

>Translated_297_residues
MEEEIFYSGFVSVIGRPNAGKSTLINYILGEKVVITSDKPQTTRNKIQCVYNGENSQIIFLDTPGMHKPKHKLGEKMVKA
VDESLNEMDAILFVIDVSVPFGKGETMLVERLARLSTPVILVMNKMDLVDEDLAREKTEKIKEKLSPESIHYISALYGNN
LVDLLGELENLMPEGPKYYPEDQLIDQPERFVVSELIREKLLNYTQEEIPHSVAVEIMLMENREDQDLIDIEAVIYVERE
SQKKIVIGRRGKLLKKVGQEARRDIENLLGSQIYLDLWVKNQKDWRNRERFLRELGY
>Mature_297_residues
MEEEIFYSGFVSVIGRPNAGKSTLINYILGEKVVITSDKPQTTRNKIQCVYNGENSQIIFLDTPGMHKPKHKLGEKMVKA
VDESLNEMDAILFVIDVSVPFGKGETMLVERLARLSTPVILVMNKMDLVDEDLAREKTEKIKEKLSPESIHYISALYGNN
LVDLLGELENLMPEGPKYYPEDQLIDQPERFVVSELIREKLLNYTQEEIPHSVAVEIMLMENREDQDLIDIEAVIYVERE
SQKKIVIGRRGKLLKKVGQEARRDIENLLGSQIYLDLWVKNQKDWRNRERFLRELGY

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=322, Percent_Identity=27.3291925465839, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1788919, Length=294, Percent_Identity=38.7755102040816, Blast_Score=206, Evalue=1e-54,
Organism=Escherichia coli, GI87082120, Length=166, Percent_Identity=28.9156626506024, Blast_Score=72, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24646434, Length=306, Percent_Identity=25.4901960784314, Blast_Score=91, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 34312; Mature: 34312

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEEIFYSGFVSVIGRPNAGKSTLINYILGEKVVITSDKPQTTRNKIQCVYNGENSQIIF
CCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCEEEEECCCCCCCCCCEEEEEECCCCEEEE
LDTPGMHKPKHKLGEKMVKAVDESLNEMDAILFVIDVSVPFGKGETMLVERLARLSTPVI
EECCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCHHHHHHHHHHHCCCEE
LVMNKMDLVDEDLAREKTEKIKEKLSPESIHYISALYGNNLVDLLGELENLMPEGPKYYP
EEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCC
EDQLIDQPERFVVSELIREKLLNYTQEEIPHSVAVEIMLMENREDQDLIDIEAVIYVERE
CCHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEECCCCCCCCEEEEEEEEEEEC
SQKKIVIGRRGKLLKKVGQEARRDIENLLGSQIYLDLWVKNQKDWRNRERFLRELGY
CCCEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEEEIFYSGFVSVIGRPNAGKSTLINYILGEKVVITSDKPQTTRNKIQCVYNGENSQIIF
CCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCEEEEECCCCCCCCCCEEEEEECCCCEEEE
LDTPGMHKPKHKLGEKMVKAVDESLNEMDAILFVIDVSVPFGKGETMLVERLARLSTPVI
EECCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCHHHHHHHHHHHCCCEE
LVMNKMDLVDEDLAREKTEKIKEKLSPESIHYISALYGNNLVDLLGELENLMPEGPKYYP
EEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCC
EDQLIDQPERFVVSELIREKLLNYTQEEIPHSVAVEIMLMENREDQDLIDIEAVIYVERE
CCHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEECCCCCCCCEEEEEEEEEEEC
SQKKIVIGRRGKLLKKVGQEARRDIENLLGSQIYLDLWVKNQKDWRNRERFLRELGY
CCCEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]