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The map label for this gene is menA [H]

Identifier: 188585790

GI number: 188585790

Start: 1232471

End: 1233340

Strand: Direct

Name: menA [H]

Synonym: Nther_1164

Alternate gene names: 188585790

Gene position: 1232471-1233340 (Clockwise)

Preceding gene: 188585789

Following gene: 188585791

Centisome position: 38.93

GC content: 31.61

Gene sequence:

>870_bases
ATGAAATCAACATTATATTTCAGAGCTTTAAGACCTTTTTCTTTCCCTACCTCTATTATTCCTATTACAATAGGTACTTT
CTGGGAGATAGGAAGTGGTGTTAATTGGCCAATTTATTTGATAACTTTATTATGCGGGATAGCTATACATGGTGGTACTA
ATTTAACTAACGATTATTATGATTTTATACGAGGAGTAGATACTGTAAATTCCTTTGGGTCAAGTAAACTTTTGCCATTA
CAAATTATTCCTCCCAGAAACATATTAATATTCGCAGTTATGTCTTTTAGTTTTGCATTTATTCTTAGTCTAATTCTTGG
TATATTAACTTCATATAAAGTAACTGTTATTGCTGTCATAGGAATTCTAGCTGGTTATTTTTATACAGGGTTTCCGTTAC
AACTGAAATATCGGGCTTTAGGTCCAGTTCTAGTTTTTTTAATGATGGGCCCATTGTTAGTAAAAGCTGGGGGTTTGACA
CAACTGGGTTATTCAGATTGGGATTTAATTTTGATTAGTATTCCCATTGCATGTTTAGTATCTATTATTTTACAAGCGAA
TGATCTGAGGGATAAAAGATGGGATAAAAGAAGTGGTGTAACTACTTTTGCTATTTTGTTTGGCTACTCAATGGCATGTA
AAATTTTTACAATAACTGGATTGGTAGCTTTTTTACTAATCCCCATATTCGTCAGTCAAGGATTACTTCCATATTTTACA
ATGATTACATGGTTGTTACTGCCTAAATTTTTTGCAGTTAATCGCAAAATTTACAAGGGGACTTCCTCTCTTATGTTGAA
TATTGATATAGAGATGACTAAACTATATTCCCTGTTTGGTGTAATAATTATATTTTCCATATTAATATAG

Upstream 100 bases:

>100_bases
AGAATTAGATTTAATTTAAATAATAAAGTAAATAATATTGTAAAATATAAATTTCAACAACGAAACATAAAAGCGCTAAA
TTTTAAAAGGAGTTGCTACA

Downstream 100 bases:

>100_bases
GGTACTGGAGGTGAAGATTTGAAAGCACCAGATGTATTATACAAAGATGTACTTGATGCTTTAGATGAAGGTGTACACGT
GGTCGATGCCAATGGTCAAA

Product: UbiA prenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MKSTLYFRALRPFSFPTSIIPITIGTFWEIGSGVNWPIYLITLLCGIAIHGGTNLTNDYYDFIRGVDTVNSFGSSKLLPL
QIIPPRNILIFAVMSFSFAFILSLILGILTSYKVTVIAVIGILAGYFYTGFPLQLKYRALGPVLVFLMMGPLLVKAGGLT
QLGYSDWDLILISIPIACLVSIILQANDLRDKRWDKRSGVTTFAILFGYSMACKIFTITGLVAFLLIPIFVSQGLLPYFT
MITWLLLPKFFAVNRKIYKGTSSLMLNIDIEMTKLYSLFGVIIIFSILI

Sequences:

>Translated_289_residues
MKSTLYFRALRPFSFPTSIIPITIGTFWEIGSGVNWPIYLITLLCGIAIHGGTNLTNDYYDFIRGVDTVNSFGSSKLLPL
QIIPPRNILIFAVMSFSFAFILSLILGILTSYKVTVIAVIGILAGYFYTGFPLQLKYRALGPVLVFLMMGPLLVKAGGLT
QLGYSDWDLILISIPIACLVSIILQANDLRDKRWDKRSGVTTFAILFGYSMACKIFTITGLVAFLLIPIFVSQGLLPYFT
MITWLLLPKFFAVNRKIYKGTSSLMLNIDIEMTKLYSLFGVIIIFSILI
>Mature_289_residues
MKSTLYFRALRPFSFPTSIIPITIGTFWEIGSGVNWPIYLITLLCGIAIHGGTNLTNDYYDFIRGVDTVNSFGSSKLLPL
QIIPPRNILIFAVMSFSFAFILSLILGILTSYKVTVIAVIGILAGYFYTGFPLQLKYRALGPVLVFLMMGPLLVKAGGLT
QLGYSDWDLILISIPIACLVSIILQANDLRDKRWDKRSGVTTFAILFGYSMACKIFTITGLVAFLLIPIFVSQGLLPYFT
MITWLLLPKFFAVNRKIYKGTSSLMLNIDIEMTKLYSLFGVIIIFSILI

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=294, Percent_Identity=27.891156462585, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17737429, Length=297, Percent_Identity=25.9259259259259, Blast_Score=98, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 32239; Mature: 32239

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSTLYFRALRPFSFPTSIIPITIGTFWEIGSGVNWPIYLITLLCGIAIHGGTNLTNDYY
CCCCEEEEEECCCCCCCCEEEEEHHHHHHHCCCCCHHHHHHHHHHHHEECCCCCCCHHHH
DFIRGVDTVNSFGSSKLLPLQIIPPRNILIFAVMSFSFAFILSLILGILTSYKVTVIAVI
HHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GILAGYFYTGFPLQLKYRALGPVLVFLMMGPLLVKAGGLTQLGYSDWDLILISIPIACLV
HHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
SIILQANDLRDKRWDKRSGVTTFAILFGYSMACKIFTITGLVAFLLIPIFVSQGLLPYFT
HHHHHHCCCHHHHCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
MITWLLLPKFFAVNRKIYKGTSSLMLNIDIEMTKLYSLFGVIIIFSILI
HHHHHHHHHHHHHCCHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MKSTLYFRALRPFSFPTSIIPITIGTFWEIGSGVNWPIYLITLLCGIAIHGGTNLTNDYY
CCCCEEEEEECCCCCCCCEEEEEHHHHHHHCCCCCHHHHHHHHHHHHEECCCCCCCHHHH
DFIRGVDTVNSFGSSKLLPLQIIPPRNILIFAVMSFSFAFILSLILGILTSYKVTVIAVI
HHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GILAGYFYTGFPLQLKYRALGPVLVFLMMGPLLVKAGGLTQLGYSDWDLILISIPIACLV
HHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
SIILQANDLRDKRWDKRSGVTTFAILFGYSMACKIFTITGLVAFLLIPIFVSQGLLPYFT
HHHHHHCCCHHHHCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
MITWLLLPKFFAVNRKIYKGTSSLMLNIDIEMTKLYSLFGVIIIFSILI
HHHHHHHHHHHHHCCHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]