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The map label for this gene is selA [H]

Identifier: 188585788

GI number: 188585788

Start: 1230422

End: 1231852

Strand: Direct

Name: selA [H]

Synonym: Nther_1162

Alternate gene names: 188585788

Gene position: 1230422-1231852 (Clockwise)

Preceding gene: 188585787

Following gene: 188585789

Centisome position: 38.87

GC content: 35.22

Gene sequence:

>1431_bases
TTGAAGCAATTGTTACGAGCTATCCCATCTGTCAATGAATTAGTGGCAGAAACTGAAATTCAGCAATATTTAAATTTTTA
TAATCGAGAAATGATTGTAGATATAGTTAGAGAAGAACAGGATAAACTTAGAAACGCAATTATTAATCATGATCAGGATT
TAACTAAATTTATGGTTGATTATCAAGATGAAACAAAGGGTATCAAAGAATATCTGATAAATAAAATCTATCAAATGATC
CAATCAAGAACGGAAGCCAAATTTAAGCGGGTAATAAATTGTACGGGAACTGTATTACACACCAATTTGGGACGTGCTCC
TCTTTCATCGGGTATCATGGAGAAACTTACAGAAACTGTTTCAAACTATAGTAATTTAGAATATGATTTGGACCAAGGTT
CAAGGGGTAGCAGATATGATCATATAGAAGATTTGATTACTACTCTTACAGGTGCTGAAAGTGCTATGGTGGTAAACAAC
AATGCAGCCGCAGTCATGCTTGTCTTGAAAGCATTGGCACAGGACAAAGAAGTGATACTTTCGAGAGGTGAACTCGTAGA
GATTGGTGGTAGCTTTAGAATTCCTGAAGTAATGAAACAAAGTGGTGCTCATTTAGTAGAAGTTGGCACTACCAATAAGA
CTCATTTAAAAGATTATGAACAGGCAATTTCAGAAGAAACAGGGTTGATTATGAAGGTACACACCTCTAATTATGAAATA
ATTGGCTTTACAGACAGCGTTTCTCGCAGTGAACTGGTGGAAATGTCACACAATAATGGGATCACAGTAGTGGAAGACTT
AGGAAGTGGGCTTTTTCTAGACTTAACAGAGTACGGTTTAGATAATGAACCTACTATAAAAGAAGTTTTAGATACTGGTG
TTGATTTGGTAACATTTAGTGGAGATAAACTACTGGGAGGACCACAAACTGGAATAATAGCTGGAAGAAGAGAGCTGATT
CAACTTTTAAAACAAGACCAATTAACAAGGGCTCTTCGAGTTGATAAACTATCATTAAAAGCGCTAGAGGAAACCTTACG
TTTATATTTACAGCCAGAACAAGCCAGGGAAAAGATACCAGTTCTGAATATGCTGACAATATCTCAGGATGAAATCAAAA
CACGTGCAAAATTACTTTACGATAAACTTTCGGAATTTATCACCAAAGAATATAAATTAGAAATTGAATCTAATATTTCT
AGGGTAGGAGGAGGGGCTATGCCAACCCAGGAATTACCGACTTGGGTAGTTACTTTAACTTGTTCATCAACTGATCTTCA
TAAAATTTGGGATCAATTGAGACAACAAAACCCTCCTATAGTTACAAGATTGCAAAAAGATAAATTGGTGTTTGACTTGC
GAACAGTTTCAATTAAAGAAATAGACATAGTAGCTTCTAAAGTTACTAAAGTTATTATAAAGGGAGAGTGA

Upstream 100 bases:

>100_bases
TAAAGAGAGTTTTGCAATCATCTACAAATTTAGGTTATAATTGAGTTCAATGAAAAACATTTGTATATTTAGCTGACCAG
TTAGAATAGAGGTGATTAAG

Downstream 100 bases:

>100_bases
TAAAGTGAAGAGCAAAATTATTTGGAAAGACAATATGGCTTTTTATGGAGAAGGTGAAAATAGTACTAACCAAGTAGTCT
TTGATGCAACATCGGGGGTT

Product: L-seryl-tRNA(Sec) selenium transferase

Products: NA

Alternate protein names: Selenocysteine synthase; Sec synthase; Selenocysteinyl-tRNA(Sec) synthase [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MKQLLRAIPSVNELVAETEIQQYLNFYNREMIVDIVREEQDKLRNAIINHDQDLTKFMVDYQDETKGIKEYLINKIYQMI
QSRTEAKFKRVINCTGTVLHTNLGRAPLSSGIMEKLTETVSNYSNLEYDLDQGSRGSRYDHIEDLITTLTGAESAMVVNN
NAAAVMLVLKALAQDKEVILSRGELVEIGGSFRIPEVMKQSGAHLVEVGTTNKTHLKDYEQAISEETGLIMKVHTSNYEI
IGFTDSVSRSELVEMSHNNGITVVEDLGSGLFLDLTEYGLDNEPTIKEVLDTGVDLVTFSGDKLLGGPQTGIIAGRRELI
QLLKQDQLTRALRVDKLSLKALEETLRLYLQPEQAREKIPVLNMLTISQDEIKTRAKLLYDKLSEFITKEYKLEIESNIS
RVGGGAMPTQELPTWVVTLTCSSTDLHKIWDQLRQQNPPIVTRLQKDKLVFDLRTVSIKEIDIVASKVTKVIIKGE

Sequences:

>Translated_476_residues
MKQLLRAIPSVNELVAETEIQQYLNFYNREMIVDIVREEQDKLRNAIINHDQDLTKFMVDYQDETKGIKEYLINKIYQMI
QSRTEAKFKRVINCTGTVLHTNLGRAPLSSGIMEKLTETVSNYSNLEYDLDQGSRGSRYDHIEDLITTLTGAESAMVVNN
NAAAVMLVLKALAQDKEVILSRGELVEIGGSFRIPEVMKQSGAHLVEVGTTNKTHLKDYEQAISEETGLIMKVHTSNYEI
IGFTDSVSRSELVEMSHNNGITVVEDLGSGLFLDLTEYGLDNEPTIKEVLDTGVDLVTFSGDKLLGGPQTGIIAGRRELI
QLLKQDQLTRALRVDKLSLKALEETLRLYLQPEQAREKIPVLNMLTISQDEIKTRAKLLYDKLSEFITKEYKLEIESNIS
RVGGGAMPTQELPTWVVTLTCSSTDLHKIWDQLRQQNPPIVTRLQKDKLVFDLRTVSIKEIDIVASKVTKVIIKGE
>Mature_476_residues
MKQLLRAIPSVNELVAETEIQQYLNFYNREMIVDIVREEQDKLRNAIINHDQDLTKFMVDYQDETKGIKEYLINKIYQMI
QSRTEAKFKRVINCTGTVLHTNLGRAPLSSGIMEKLTETVSNYSNLEYDLDQGSRGSRYDHIEDLITTLTGAESAMVVNN
NAAAVMLVLKALAQDKEVILSRGELVEIGGSFRIPEVMKQSGAHLVEVGTTNKTHLKDYEQAISEETGLIMKVHTSNYEI
IGFTDSVSRSELVEMSHNNGITVVEDLGSGLFLDLTEYGLDNEPTIKEVLDTGVDLVTFSGDKLLGGPQTGIIAGRRELI
QLLKQDQLTRALRVDKLSLKALEETLRLYLQPEQAREKIPVLNMLTISQDEIKTRAKLLYDKLSEFITKEYKLEIESNIS
RVGGGAMPTQELPTWVVTLTCSSTDLHKIWDQLRQQNPPIVTRLQKDKLVFDLRTVSIKEIDIVASKVTKVIIKGE

Specific function: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis [H]

COG id: COG1921

COG function: function code E; Selenocysteine synthase [seryl-tRNASer selenium transferase]

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the selA family [H]

Homologues:

Organism=Escherichia coli, GI2367248, Length=458, Percent_Identity=41.703056768559, Blast_Score=345, Evalue=3e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR018319
- InterPro:   IPR004534 [H]

Pfam domain/function: PF03841 SelA [H]

EC number: =2.9.1.1 [H]

Molecular weight: Translated: 53673; Mature: 53673

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQLLRAIPSVNELVAETEIQQYLNFYNREMIVDIVREEQDKLRNAIINHDQDLTKFMVD
CHHHHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
YQDETKGIKEYLINKIYQMIQSRTEAKFKRVINCTGTVLHTNLGRAPLSSGIMEKLTETV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHH
SNYSNLEYDLDQGSRGSRYDHIEDLITTLTGAESAMVVNNNAAAVMLVLKALAQDKEVIL
HHHCCCEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCHHHHH
SRGELVEIGGSFRIPEVMKQSGAHLVEVGTTNKTHLKDYEQAISEETGLIMKVHTSNYEI
CCCCEEEECCCCCCHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCEEE
IGFTDSVSRSELVEMSHNNGITVVEDLGSGLFLDLTEYGLDNEPTIKEVLDTGVDLVTFS
EEECCCCCHHHHHHHHCCCCEEEEECCCCCEEEEHHHCCCCCCCCHHHHHHCCCCEEEEC
GDKLLGGPQTGIIAGRRELIQLLKQDQLTRALRVDKLSLKALEETLRLYLQPEQAREKIP
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCC
VLNMLTISQDEIKTRAKLLYDKLSEFITKEYKLEIESNISRVGGGAMPTQELPTWVVTLT
EEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHEEHHHCHHHCCCCCCCCCCCCEEEEEEE
CSSTDLHKIWDQLRQQNPPIVTRLQKDKLVFDLRTVSIKEIDIVASKVTKVIIKGE
ECCCHHHHHHHHHHHCCCCCEEEECCCCEEEEEEECCHHHHHHHHHHHHEEEEECC
>Mature Secondary Structure
MKQLLRAIPSVNELVAETEIQQYLNFYNREMIVDIVREEQDKLRNAIINHDQDLTKFMVD
CHHHHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
YQDETKGIKEYLINKIYQMIQSRTEAKFKRVINCTGTVLHTNLGRAPLSSGIMEKLTETV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHH
SNYSNLEYDLDQGSRGSRYDHIEDLITTLTGAESAMVVNNNAAAVMLVLKALAQDKEVIL
HHHCCCEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCHHHHH
SRGELVEIGGSFRIPEVMKQSGAHLVEVGTTNKTHLKDYEQAISEETGLIMKVHTSNYEI
CCCCEEEECCCCCCHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCEEE
IGFTDSVSRSELVEMSHNNGITVVEDLGSGLFLDLTEYGLDNEPTIKEVLDTGVDLVTFS
EEECCCCCHHHHHHHHCCCCEEEEECCCCCEEEEHHHCCCCCCCCHHHHHHCCCCEEEEC
GDKLLGGPQTGIIAGRRELIQLLKQDQLTRALRVDKLSLKALEETLRLYLQPEQAREKIP
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCC
VLNMLTISQDEIKTRAKLLYDKLSEFITKEYKLEIESNISRVGGGAMPTQELPTWVVTLT
EEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHEEHHHCHHHCCCCCCCCCCCCEEEEEEE
CSSTDLHKIWDQLRQQNPPIVTRLQKDKLVFDLRTVSIKEIDIVASKVTKVIIKGE
ECCCHHHHHHHHHHHCCCCCEEEECCCCEEEEEEECCHHHHHHHHHHHHEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA