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The map label for this gene is hemD [H]

Identifier: 188585751

GI number: 188585751

Start: 1192196

End: 1193746

Strand: Direct

Name: hemD [H]

Synonym: Nther_1125

Alternate gene names: 188585751

Gene position: 1192196-1193746 (Clockwise)

Preceding gene: 188585750

Following gene: 188585752

Centisome position: 37.66

GC content: 39.26

Gene sequence:

>1551_bases
GTGTCAGGGAGAGTATATTTAATAGGTGCGGGCCCAGGAGATGAAGGCCTAATTACTGTCAAAGGCCTAAACTGTGTCAA
AGAAGCTAATGTAATTGTTTATGACCGGCTTATTCCCCAAGCTTTATTGCGATATGCACCTTCTACTGCCGAGTTTATAT
TTGTGGGCAAAAGCCCTGAAAAACATACTTTAACACAAGAAGAAATAAATGATTTATTAATTGAACAAGCTGAGCAAGGT
AAAATTATTGCAAGATTAAAGGGCGGTGATCCCTTTGTATTTGGCAGGGGAGGTGAGGAGGTCATAGCTTTAAAAGAACA
TAATATACCTTTTGAAGTGGTACCTGGTATAACTTCAGCAGTAGCAGCTCCTATGTATGCAGGAATACCAGTTACTCACC
GAGGACTAAGTTCAAGTTTTGCGGTCATAACCGGTCATGAGGATCCGGACAAAGCTGAAAGTTCTATCTCATGGCAAGAC
TTAGCCTTAGAAAGTGGAACTTTGTGTTTCTTGATGGGAGTGGGTAACCTCTCCAGAATAGTTGATAACTTGCTGGCCCA
TGGAAAAGATTCTGAAACCCCTATAGCTTTAGTTAGATGGGGGACTCGCCCCTATCAGAAAACCCTGACCGGTACCCTAT
CGAATATAGTAGAAAAAGCAAAGAGCGAAAACTTTAAATCACCGGCGGTAATCATAATTGGTGAAGTGGTAAATTTACGA
GAACAACTGGCTTGGTTTGAAAAGAAGCCCTTTTTTAATAAAAATATTCTAGTTACTAGGGCGAGAAGTCAGGCTAGTGA
ACTTTCATATAAAATTTCCCAACTGGGTGGTCAACCTGTGGAGTTCCCCACAATTAAAATAGAAAAACCTGATACATACC
AACCCCTGGATGAAGCTATTAAAAAATTGGCTGAATATAACTGGCTGGTTTTTACTAGTGTTAACGGGGTGAAACACTTT
TTTAATAGATTAGAAAATTTAGATTATGATTGTAGACAACTCGCCGGCTTAAAAACTTGTGCTATTGGTTCTAAAACTAA
AGAATCTTTAGAAGAGAAGGGTATAAAGGCTGATGTAGTGCCCCAAGAATATAGAGCTGAAGCATTGATCGACTTAATGA
AAGAGCAAGTTAAATCAGGTGATCGTGTCCTAATTCCCCGTGCAAAAGAAGCTAGAGAAGTACTGCCGGAAGCTTTAAGG
GAGCAGGGCTTAAAAGTGGATGTAATTACTGCTTATGAAACAGTAAAAGACACTAAAGACACAGAAAAAGTCCGGAAAAT
GTTAAAACAAAATGAGTTAGACGCCATCACATTCACTAGTTCTTCTACGGTAAAAAATTTTGTGGAAGTGTTAGAATTAA
ATGTAGGGTTAAATGAACCAGGCGCCGTACTAGCTAACACTCATATTGCATGTATCGGCCCTATCACTGCTAGTACTTGC
CAACAGTATGGTATAGAAGTTAATTCAATTGCCAATGAATATACAATTCCAGGTCTGGTAGAATCCTTGATAGATAATCT
GGATGAGAACGTGGAGGAGGAGTTTAAATGA

Upstream 100 bases:

>100_bases
ATAATAACAAAATACCATCTACATTGGGAAATGACCTGGCTGAAGAGCTGATAGAGTTAGGAGCAAATAAAATATTGTCA
GAACTTAAGGAGGGGTAGAT

Downstream 100 bases:

>100_bases
TTAGTGTAACTAAATTATTAATGCAGGACAGTGATCATTATGGAGATGGTCTTAGATATCACAAGGATTCAGGAAAAACA
GTTCATGGAACTCGTAAAGG

Product: uroporphyrinogen-III C-methyltransferase, uroporphyrinogen-III synthase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Uroporphyrinogen-III synthase; UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 516; Mature: 515

Protein sequence:

>516_residues
MSGRVYLIGAGPGDEGLITVKGLNCVKEANVIVYDRLIPQALLRYAPSTAEFIFVGKSPEKHTLTQEEINDLLIEQAEQG
KIIARLKGGDPFVFGRGGEEVIALKEHNIPFEVVPGITSAVAAPMYAGIPVTHRGLSSSFAVITGHEDPDKAESSISWQD
LALESGTLCFLMGVGNLSRIVDNLLAHGKDSETPIALVRWGTRPYQKTLTGTLSNIVEKAKSENFKSPAVIIIGEVVNLR
EQLAWFEKKPFFNKNILVTRARSQASELSYKISQLGGQPVEFPTIKIEKPDTYQPLDEAIKKLAEYNWLVFTSVNGVKHF
FNRLENLDYDCRQLAGLKTCAIGSKTKESLEEKGIKADVVPQEYRAEALIDLMKEQVKSGDRVLIPRAKEAREVLPEALR
EQGLKVDVITAYETVKDTKDTEKVRKMLKQNELDAITFTSSSTVKNFVEVLELNVGLNEPGAVLANTHIACIGPITASTC
QQYGIEVNSIANEYTIPGLVESLIDNLDENVEEEFK

Sequences:

>Translated_516_residues
MSGRVYLIGAGPGDEGLITVKGLNCVKEANVIVYDRLIPQALLRYAPSTAEFIFVGKSPEKHTLTQEEINDLLIEQAEQG
KIIARLKGGDPFVFGRGGEEVIALKEHNIPFEVVPGITSAVAAPMYAGIPVTHRGLSSSFAVITGHEDPDKAESSISWQD
LALESGTLCFLMGVGNLSRIVDNLLAHGKDSETPIALVRWGTRPYQKTLTGTLSNIVEKAKSENFKSPAVIIIGEVVNLR
EQLAWFEKKPFFNKNILVTRARSQASELSYKISQLGGQPVEFPTIKIEKPDTYQPLDEAIKKLAEYNWLVFTSVNGVKHF
FNRLENLDYDCRQLAGLKTCAIGSKTKESLEEKGIKADVVPQEYRAEALIDLMKEQVKSGDRVLIPRAKEAREVLPEALR
EQGLKVDVITAYETVKDTKDTEKVRKMLKQNELDAITFTSSSTVKNFVEVLELNVGLNEPGAVLANTHIACIGPITASTC
QQYGIEVNSIANEYTIPGLVESLIDNLDENVEEEFK
>Mature_515_residues
SGRVYLIGAGPGDEGLITVKGLNCVKEANVIVYDRLIPQALLRYAPSTAEFIFVGKSPEKHTLTQEEINDLLIEQAEQGK
IIARLKGGDPFVFGRGGEEVIALKEHNIPFEVVPGITSAVAAPMYAGIPVTHRGLSSSFAVITGHEDPDKAESSISWQDL
ALESGTLCFLMGVGNLSRIVDNLLAHGKDSETPIALVRWGTRPYQKTLTGTLSNIVEKAKSENFKSPAVIIIGEVVNLRE
QLAWFEKKPFFNKNILVTRARSQASELSYKISQLGGQPVEFPTIKIEKPDTYQPLDEAIKKLAEYNWLVFTSVNGVKHFF
NRLENLDYDCRQLAGLKTCAIGSKTKESLEEKGIKADVVPQEYRAEALIDLMKEQVKSGDRVLIPRAKEAREVLPEALRE
QGLKVDVITAYETVKDTKDTEKVRKMLKQNELDAITFTSSSTVKNFVEVLELNVGLNEPGAVLANTHIACIGPITASTCQ
QYGIEVNSIANEYTIPGLVESLIDNLDENVEEEFK

Specific function: May catalyze sequential reactions to synthesize uroporphyrinogen III from hydroxymethylbilane (HMB) and then precorrin-2, which are intermediate compounds in both vitamin B12 and siroheme biosyntheses [H]

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=244, Percent_Identity=47.1311475409836, Blast_Score=231, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6322922, Length=236, Percent_Identity=32.6271186440678, Blast_Score=139, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR003754
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF02602 HEM4; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =4.2.1.75 [H]

Molecular weight: Translated: 56890; Mature: 56758

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00839 SUMT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGRVYLIGAGPGDEGLITVKGLNCVKEANVIVYDRLIPQALLRYAPSTAEFIFVGKSPE
CCCEEEEEECCCCCCCEEEEECCCHHHHCCEEEEHHHHHHHHHHHCCCCCEEEEEECCCC
KHTLTQEEINDLLIEQAEQGKIIARLKGGDPFVFGRGGEEVIALKEHNIPFEVVPGITSA
CCCCCHHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCCEEEEEECCCCCEEECCCCHHH
VAAPMYAGIPVTHRGLSSSFAVITGHEDPDKAESSISWQDLALESGTLCFLMGVGNLSRI
HHHHHHCCCCCCCCCCCCCEEEEECCCCCCHHHCCCCHHHHEECCCCEEEEEECCCHHHH
VDNLLAHGKDSETPIALVRWGTRPYQKTLTGTLSNIVEKAKSENFKSPAVIIIGEVVNLR
HHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHH
EQLAWFEKKPFFNKNILVTRARSQASELSYKISQLGGQPVEFPTIKIEKPDTYQPLDEAI
HHHHHHHCCCCCCCCEEEEECHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHHH
KKLAEYNWLVFTSVNGVKHFFNRLENLDYDCRQLAGLKTCAIGSKTKESLEEKGIKADVV
HHHHHCCEEEEEECHHHHHHHHHHHCCCHHHHHHCCCHHCCCCCHHHHHHHHCCCEECCC
PQEYRAEALIDLMKEQVKSGDRVLIPRAKEAREVLPEALREQGLKVDVITAYETVKDTKD
CHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHCCCEEEEEEHHHHHHCCHH
TEKVRKMLKQNELDAITFTSSSTVKNFVEVLELNVGLNEPGAVLANTHIACIGPITASTC
HHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCEEECCEEEEECCCCHHHH
QQYGIEVNSIANEYTIPGLVESLIDNLDENVEEEFK
HHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SGRVYLIGAGPGDEGLITVKGLNCVKEANVIVYDRLIPQALLRYAPSTAEFIFVGKSPE
CCEEEEEECCCCCCCEEEEECCCHHHHCCEEEEHHHHHHHHHHHCCCCCEEEEEECCCC
KHTLTQEEINDLLIEQAEQGKIIARLKGGDPFVFGRGGEEVIALKEHNIPFEVVPGITSA
CCCCCHHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCCEEEEEECCCCCEEECCCCHHH
VAAPMYAGIPVTHRGLSSSFAVITGHEDPDKAESSISWQDLALESGTLCFLMGVGNLSRI
HHHHHHCCCCCCCCCCCCCEEEEECCCCCCHHHCCCCHHHHEECCCCEEEEEECCCHHHH
VDNLLAHGKDSETPIALVRWGTRPYQKTLTGTLSNIVEKAKSENFKSPAVIIIGEVVNLR
HHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHH
EQLAWFEKKPFFNKNILVTRARSQASELSYKISQLGGQPVEFPTIKIEKPDTYQPLDEAI
HHHHHHHCCCCCCCCEEEEECHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHHH
KKLAEYNWLVFTSVNGVKHFFNRLENLDYDCRQLAGLKTCAIGSKTKESLEEKGIKADVV
HHHHHCCEEEEEECHHHHHHHHHHHCCCHHHHHHCCCHHCCCCCHHHHHHHHCCCEECCC
PQEYRAEALIDLMKEQVKSGDRVLIPRAKEAREVLPEALREQGLKVDVITAYETVKDTKD
CHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHCCCEEEEEEHHHHHHCCHH
TEKVRKMLKQNELDAITFTSSSTVKNFVEVLELNVGLNEPGAVLANTHIACIGPITASTC
HHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCEEECCEEEEECCCCHHHH
QQYGIEVNSIANEYTIPGLVESLIDNLDENVEEEFK
HHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7665501 [H]