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The map label for this gene is ribBA [H]

Identifier: 188584766

GI number: 188584766

Start: 147503

End: 148741

Strand: Direct

Name: ribBA [H]

Synonym: Nther_0124

Alternate gene names: 188584766

Gene position: 147503-148741 (Clockwise)

Preceding gene: 188584765

Following gene: 188584767

Centisome position: 4.66

GC content: 39.55

Gene sequence:

>1239_bases
ATGACTTTAAGTACCATTAAAGAAGCACTGGAAGATTTAAAAAATGGAAAAATGGTCATCGTAGTTGATGATGAGGATAG
AGAAAACGAAGGTGACTTGGTAATTCCCGCAGAAAAAGCAACTCCCCAGGCAGTTAACTTTATGGCTAAGTACGGAAGAG
GCCTTATCTGTATGCCGATGAAGGAGGAAAGGTTACAGGAGCTCGACATTCCTTTGATGGTAAATGACAACACCGATGAA
ATGGGAACGGCTTTCACAGTATCGGTAGATTATAAAGATTGTCATACAGGCATATCTGCCTACGAAAGGGCAATGACAGT
TACTAAATTAATAAAAGAAGACAGCAAACCAGAGGATTTTAATAGGCCTGGGCATATATTTCCTCTTGCGGCTCGTCAGG
GTGGTGTTCTAAAGAGGGCCGGCCATACAGAGGCTGCTATTGACTTGGCTTATTTAGCAGGTTGTTACCCCGCTGGTGTT
ATATGTGAAATAATGTCTGATGATGGAACTATGGCCAGGTTACCTGAATTAGAACAATTTGCTAGAGAGCACGACCTTAA
AATTATATCAATTGCCGACTTAATTTCTTACAGGAGAAACTCAGAACAGCTTATCGAAGCAGTTGCTGATATTAATTTAC
CAACAAAGTACGGAGAGTTTCAAGGAAAATTATATCAAGATACAATTTCTGGAGAGCATCACTTGGCAATAATTAAAGGT
GAACCTGATAAAGAAAAGGAGCCGGTTTTGGTTCGAGTGCATTCGGAATGTTTGACCGGTGATGTTCTAGGGTCAATGAG
ATGTGATTGTGGAGATCAATTGGCTAGCGCTATGCAGAAAATAGAAGAGGAAGGTGTAGGAGTAGTACTTTATATGCGTC
AGGAAGGTCGTGGCATTGGTCTGGCAAATAAATTAAAGGCCTATGAACTTCAAGATCAGGGGAAGGATACTGTGGAAGCC
AATGAACTGTTAGGTTTTCCTGCTGATTTAAGAGATTACGGAATTGGTGCTCAAATTTTAAAAGATCTAGGACTAACCAA
GATTTTATTGATGACTAATAACCCCAAGAAAATTATTGGTTTAAAAGGCTATGGCCTAGAAGTGGAACAGAGATTAGCCT
TGGAGGCTGAGGTTACACCTCACAATAAATGTTATTTACAAACTAAGCAAGACAAACTGGGACATATATTAAATGTCCAG
CAACAAAATGACAACAAGGAGGAAAATTATTATGAGTAA

Upstream 100 bases:

>100_bases
CTTAAGAGAGCTTGGTTATTAACAGTTCCACTATCAAACTCAAGAGGCAATTGAGTTCTAGAATAATTAATTAACCTTGA
TACAAGAGGGGTGAATATAA

Downstream 100 bases:

>100_bases
AATTTATGAAGGTCAACTAAAAGCTGAAGGTCTTAAAATCGGAATAGTAGTATCTAGGTTCAATGAATTAATTACTAATA
AACTACTGGGAGGCGCCATG

Product: 3,4-dihydroxy-2-butanone 4-phosphate synthase, GTP cyclohydrolase II

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MTLSTIKEALEDLKNGKMVIVVDDEDRENEGDLVIPAEKATPQAVNFMAKYGRGLICMPMKEERLQELDIPLMVNDNTDE
MGTAFTVSVDYKDCHTGISAYERAMTVTKLIKEDSKPEDFNRPGHIFPLAARQGGVLKRAGHTEAAIDLAYLAGCYPAGV
ICEIMSDDGTMARLPELEQFAREHDLKIISIADLISYRRNSEQLIEAVADINLPTKYGEFQGKLYQDTISGEHHLAIIKG
EPDKEKEPVLVRVHSECLTGDVLGSMRCDCGDQLASAMQKIEEEGVGVVLYMRQEGRGIGLANKLKAYELQDQGKDTVEA
NELLGFPADLRDYGIGAQILKDLGLTKILLMTNNPKKIIGLKGYGLEVEQRLALEAEVTPHNKCYLQTKQDKLGHILNVQ
QQNDNKEENYYE

Sequences:

>Translated_412_residues
MTLSTIKEALEDLKNGKMVIVVDDEDRENEGDLVIPAEKATPQAVNFMAKYGRGLICMPMKEERLQELDIPLMVNDNTDE
MGTAFTVSVDYKDCHTGISAYERAMTVTKLIKEDSKPEDFNRPGHIFPLAARQGGVLKRAGHTEAAIDLAYLAGCYPAGV
ICEIMSDDGTMARLPELEQFAREHDLKIISIADLISYRRNSEQLIEAVADINLPTKYGEFQGKLYQDTISGEHHLAIIKG
EPDKEKEPVLVRVHSECLTGDVLGSMRCDCGDQLASAMQKIEEEGVGVVLYMRQEGRGIGLANKLKAYELQDQGKDTVEA
NELLGFPADLRDYGIGAQILKDLGLTKILLMTNNPKKIIGLKGYGLEVEQRLALEAEVTPHNKCYLQTKQDKLGHILNVQ
QQNDNKEENYYE
>Mature_411_residues
TLSTIKEALEDLKNGKMVIVVDDEDRENEGDLVIPAEKATPQAVNFMAKYGRGLICMPMKEERLQELDIPLMVNDNTDEM
GTAFTVSVDYKDCHTGISAYERAMTVTKLIKEDSKPEDFNRPGHIFPLAARQGGVLKRAGHTEAAIDLAYLAGCYPAGVI
CEIMSDDGTMARLPELEQFAREHDLKIISIADLISYRRNSEQLIEAVADINLPTKYGEFQGKLYQDTISGEHHLAIIKGE
PDKEKEPVLVRVHSECLTGDVLGSMRCDCGDQLASAMQKIEEEGVGVVLYMRQEGRGIGLANKLKAYELQDQGKDTVEAN
ELLGFPADLRDYGIGAQILKDLGLTKILLMTNNPKKIIGLKGYGLEVEQRLALEAEVTPHNKCYLQTKQDKLGHILNVQQ
QNDNKEENYYE

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=199, Percent_Identity=48.7437185929648, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI1787533, Length=194, Percent_Identity=50, Blast_Score=194, Evalue=6e-51,
Organism=Saccharomyces cerevisiae, GI6320695, Length=204, Percent_Identity=42.156862745098, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6319438, Length=170, Percent_Identity=43.5294117647059, Blast_Score=127, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 45878; Mature: 45747

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLSTIKEALEDLKNGKMVIVVDDEDRENEGDLVIPAEKATPQAVNFMAKYGRGLICMPM
CCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCEEEECC
KEERLQELDIPLMVNDNTDEMGTAFTVSVDYKDCHTGISAYERAMTVTKLIKEDSKPEDF
CHHHHHHCCCCEEECCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
NRPGHIFPLAARQGGVLKRAGHTEAAIDLAYLAGCYPAGVICEIMSDDGTMARLPELEQF
CCCCCEEEECCCCCCCEEECCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHH
AREHDLKIISIADLISYRRNSEQLIEAVADINLPTKYGEFQGKLYQDTISGEHHLAIIKG
HHHHCCEEEEHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCEEEEEEEC
EPDKEKEPVLVRVHSECLTGDVLGSMRCDCGDQLASAMQKIEEEGVGVVLYMRQEGRGIG
CCCCCCCCEEEEEECHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCC
LANKLKAYELQDQGKDTVEANELLGFPADLRDYGIGAQILKDLGLTKILLMTNNPKKIIG
CHHHHEEEECCCCCCCCCCHHHHCCCCCHHHHCCCHHHHHHHCCCEEEEEEECCCCEEEE
LKGYGLEVEQRLALEAEVTPHNKCYLQTKQDKLGHILNVQQQNDNKEENYYE
ECCCCCCHHHHEEEEEECCCCCEEEEEECHHHCCCEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
TLSTIKEALEDLKNGKMVIVVDDEDRENEGDLVIPAEKATPQAVNFMAKYGRGLICMPM
CHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCEEEECC
KEERLQELDIPLMVNDNTDEMGTAFTVSVDYKDCHTGISAYERAMTVTKLIKEDSKPEDF
CHHHHHHCCCCEEECCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
NRPGHIFPLAARQGGVLKRAGHTEAAIDLAYLAGCYPAGVICEIMSDDGTMARLPELEQF
CCCCCEEEECCCCCCCEEECCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHH
AREHDLKIISIADLISYRRNSEQLIEAVADINLPTKYGEFQGKLYQDTISGEHHLAIIKG
HHHHCCEEEEHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCEEEEEEEC
EPDKEKEPVLVRVHSECLTGDVLGSMRCDCGDQLASAMQKIEEEGVGVVLYMRQEGRGIG
CCCCCCCCEEEEEECHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCC
LANKLKAYELQDQGKDTVEANELLGFPADLRDYGIGAQILKDLGLTKILLMTNNPKKIIG
CHHHHEEEECCCCCCCCCCHHHHCCCCCHHHHCCCHHHHHHHCCCEEEEEEECCCCEEEE
LKGYGLEVEQRLALEAEVTPHNKCYLQTKQDKLGHILNVQQQNDNKEENYYE
ECCCCCCHHHHEEEEEECCCCCEEEEEECHHHCCCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA