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The map label for this gene is ribD [H]

Identifier: 188584764

GI number: 188584764

Start: 145566

End: 146708

Strand: Direct

Name: ribD [H]

Synonym: Nther_0122

Alternate gene names: 188584764

Gene position: 145566-146708 (Clockwise)

Preceding gene: 188584763

Following gene: 188584765

Centisome position: 4.6

GC content: 39.02

Gene sequence:

>1143_bases
ATGGATAACTGGATAAAAAAGGACCGCCAGTACATGGATCGGGCGCTGGATTTAGCTTGGAAAGGTTGGGGGAAAACTAA
TCCTAATCCCCTAGTAGGTGCAGTACTAGTAAAGAACGATGATATAGTTGCCCAAGGTTATCATGGTAGATTAGGAGGGC
CTCACGCAGAAGCTGTTGCTTTAGAAAAAGCCGGTAGAGAAGCTTCGGGAACGACAATGTATGTTACCCTTGAACCTTGT
TGTCATTACGGGAAAACACCTCCATGCACAGATAAAATTATTGAAGCTGGTGTTAAAAGGGTTGTAATTGCTTCTCTAGA
TCCACACGAAAAAATGGCAGGAAAAGGTGTTAAAAAATTAAGGCAAGCAGGAATTAAAGTAGAAGTTGGACTAAAAAAAG
CTGAAGCTGAGAAGCAAAATGAAATATTCAGAAAATATATAGTAACAGGTTTGCCTTATATGATTGGCAAATGGGGGATG
AGTTTAGATGGAAAGATTGCTACTCATACCGGTGATTCTCGTTGGATTACATCGGAAAAAGCCAGATTTGACACTCATCG
ACTTAGGGCGAGAGTAGCGGCTATTATGGTGGGAATCGGAACTGTAAAAGCTGATGACCCTCTCCTAACATGTAGGCATC
CTAATTACCCTGGACAGCACCCAGTAAGAATCGTTGTAGATTCTCATCTCAGATTATCTTTACAAAGCAAAGTATTAGAA
AAAATTTCTGAGACTCCAACTATTATAGCTACCTCAGAAGAAATCAAGCACAAATCAAAAGAAATGGAAATTGCTAAACA
GATTGAAAATTTAGGAGGAGAAGTACTTTACTTGCCCCAAACTTCTACAGGAAAAGTGGATATATTTGAACTGGTGAAAC
TTTTGGGTCAAAGAGGGCTAGATAGCGTGCTTGTTGAAGGTGGAGAAACTCTTCATGGATCTTTAATAGAAGCTAATTAC
TATGATAAGTATATTGTTTATCTCGGGAACTTGGTAATTGGAGGTACTAACTCACCTACACCGGTTGGTGGAAAAGGTTT
TCAAGCGCTAAAAGACAGCGTGATGTTAAATAATATGGAATATGAATATTTTGGTGATTCTATCAGGATTGAAGCGTATC
CATTTCTAGAAAACCAAAGATGA

Upstream 100 bases:

>100_bases
AAGATTGGAAACTGCTGATTAGCATCTTAGTACGATCAGTAACCGATCTTCCCTGGGGGTACAGGGAAGATTTTTTATTT
TATAAGAAAGGGTGCGATAA

Downstream 100 bases:

>100_bases
AAGTAGGTGGTAACTTGTTTACCGGCATTGTAGAAGAAGTTGGAAAAGTATTGTCTGTTAATCAAGGCCCAAATTCTATT
AGTTTGAATATTCAAGCTGA

Product: riboflavin biosynthesis protein RibD

Products: NA

Alternate protein names: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; DRAP deaminase; Riboflavin-specific deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; HTP reductase [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MDNWIKKDRQYMDRALDLAWKGWGKTNPNPLVGAVLVKNDDIVAQGYHGRLGGPHAEAVALEKAGREASGTTMYVTLEPC
CHYGKTPPCTDKIIEAGVKRVVIASLDPHEKMAGKGVKKLRQAGIKVEVGLKKAEAEKQNEIFRKYIVTGLPYMIGKWGM
SLDGKIATHTGDSRWITSEKARFDTHRLRARVAAIMVGIGTVKADDPLLTCRHPNYPGQHPVRIVVDSHLRLSLQSKVLE
KISETPTIIATSEEIKHKSKEMEIAKQIENLGGEVLYLPQTSTGKVDIFELVKLLGQRGLDSVLVEGGETLHGSLIEANY
YDKYIVYLGNLVIGGTNSPTPVGGKGFQALKDSVMLNNMEYEYFGDSIRIEAYPFLENQR

Sequences:

>Translated_380_residues
MDNWIKKDRQYMDRALDLAWKGWGKTNPNPLVGAVLVKNDDIVAQGYHGRLGGPHAEAVALEKAGREASGTTMYVTLEPC
CHYGKTPPCTDKIIEAGVKRVVIASLDPHEKMAGKGVKKLRQAGIKVEVGLKKAEAEKQNEIFRKYIVTGLPYMIGKWGM
SLDGKIATHTGDSRWITSEKARFDTHRLRARVAAIMVGIGTVKADDPLLTCRHPNYPGQHPVRIVVDSHLRLSLQSKVLE
KISETPTIIATSEEIKHKSKEMEIAKQIENLGGEVLYLPQTSTGKVDIFELVKLLGQRGLDSVLVEGGETLHGSLIEANY
YDKYIVYLGNLVIGGTNSPTPVGGKGFQALKDSVMLNNMEYEYFGDSIRIEAYPFLENQR
>Mature_380_residues
MDNWIKKDRQYMDRALDLAWKGWGKTNPNPLVGAVLVKNDDIVAQGYHGRLGGPHAEAVALEKAGREASGTTMYVTLEPC
CHYGKTPPCTDKIIEAGVKRVVIASLDPHEKMAGKGVKKLRQAGIKVEVGLKKAEAEKQNEIFRKYIVTGLPYMIGKWGM
SLDGKIATHTGDSRWITSEKARFDTHRLRARVAAIMVGIGTVKADDPLLTCRHPNYPGQHPVRIVVDSHLRLSLQSKVLE
KISETPTIIATSEEIKHKSKEMEIAKQIENLGGEVLYLPQTSTGKVDIFELVKLLGQRGLDSVLVEGGETLHGSLIEANY
YDKYIVYLGNLVIGGTNSPTPVGGKGFQALKDSVMLNNMEYEYFGDSIRIEAYPFLENQR

Specific function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate [H]

COG id: COG0117

COG function: function code H; Pyrimidine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HTP reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786616, Length=373, Percent_Identity=40.4825737265416, Blast_Score=258, Evalue=6e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193
- InterPro:   IPR004794
- InterPro:   IPR011549
- InterPro:   IPR002734 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1; PF01872 RibD_C [H]

EC number: =3.5.4.26; =1.1.1.193 [H]

Molecular weight: Translated: 42055; Mature: 42055

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNWIKKDRQYMDRALDLAWKGWGKTNPNPLVGAVLVKNDDIVAQGYHGRLGGPHAEAVA
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCEEEECCCCCCCCCHHHHHH
LEKAGREASGTTMYVTLEPCCHYGKTPPCTDKIIEAGVKRVVIASLDPHEKMAGKGVKKL
HHHCCCCCCCCEEEEEECHHHCCCCCCCHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHH
RQAGIKVEVGLKKAEAEKQNEIFRKYIVTGLPYMIGKWGMSLDGKIATHTGDSRWITSEK
HHCCCEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCEEEECCCCCCEEECCH
ARFDTHRLRARVAAIMVGIGTVKADDPLLTCRHPNYPGQHPVRIVVDSHLRLSLQSKVLE
HHHHHHHHHHHHHHHHHCCCCEECCCCEEEEECCCCCCCCCEEEEECCCHHHHHHHHHHH
KISETPTIIATSEEIKHKSKEMEIAKQIENLGGEVLYLPQTSTGKVDIFELVKLLGQRGL
HHHCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEHHHHHHHHHHCCC
DSVLVEGGETLHGSLIEANYYDKYIVYLGNLVIGGTNSPTPVGGKGFQALKDSVMLNNME
HHHHHCCCCEEECEEEECCCCCEEEEEEECEEECCCCCCCCCCCCHHHHHHHHHHHCCCC
YEYFGDSIRIEAYPFLENQR
CEEECCEEEEEEECCCCCCC
>Mature Secondary Structure
MDNWIKKDRQYMDRALDLAWKGWGKTNPNPLVGAVLVKNDDIVAQGYHGRLGGPHAEAVA
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCEEEECCCCCCCCCHHHHHH
LEKAGREASGTTMYVTLEPCCHYGKTPPCTDKIIEAGVKRVVIASLDPHEKMAGKGVKKL
HHHCCCCCCCCEEEEEECHHHCCCCCCCHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHH
RQAGIKVEVGLKKAEAEKQNEIFRKYIVTGLPYMIGKWGMSLDGKIATHTGDSRWITSEK
HHCCCEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCEEEECCCCCCEEECCH
ARFDTHRLRARVAAIMVGIGTVKADDPLLTCRHPNYPGQHPVRIVVDSHLRLSLQSKVLE
HHHHHHHHHHHHHHHHHCCCCEECCCCEEEEECCCCCCCCCEEEEECCCHHHHHHHHHHH
KISETPTIIATSEEIKHKSKEMEIAKQIENLGGEVLYLPQTSTGKVDIFELVKLLGQRGL
HHHCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEHHHHHHHHHHCCC
DSVLVEGGETLHGSLIEANYYDKYIVYLGNLVIGGTNSPTPVGGKGFQALKDSVMLNNME
HHHHHCCCCEEECEEEECCCCCEEEEEEECEEECCCCCCCCCCCCHHHHHHHHHHHCCCC
YEYFGDSIRIEAYPFLENQR
CEEECCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8522537 [H]