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The map label for this gene is fhs

Identifier: 188584725

GI number: 188584725

Start: 100248

End: 101918

Strand: Direct

Name: fhs

Synonym: Nther_0083

Alternate gene names: 188584725

Gene position: 100248-101918 (Clockwise)

Preceding gene: 188584724

Following gene: 188584727

Centisome position: 3.17

GC content: 39.86

Gene sequence:

>1671_bases
GTGAAAAGTGATATCGAAATAGCTCGAGGGGCACCCATGCGGCCAATCAAGGACATCGCTTCAGAAGTTGGCATCAAGGA
TGAAGAGCTGGAATTATACGGTGATTACAAGGCTAAAATAACTTTTGATGCATGGAAAAGGCTTAAAGACAAACCAGATG
GCAATCTGATATTGGTTACTGCCATCACTCCCACTCCAGCCGGTGAAGGTAAATCTACAACCACTGTAGGTTTGGGTCAG
GCTTTAAAGCGATTGGGCAAGAACACTATGGTAGCCTTAAGGGAACCTTCTTTAGGTCCAAGTTTTGGTGTTAAAGGCGG
TGCTGCAGGTGGGGGCTACTCACAGGTAGTACCTATGGAAGACATCAACTTACATTTTACTGGTGATATTCATGCTATTA
CTACCGCACATAATTTACTCTCGGCAGCCATTGACAACCATATTCATCAAGGTAATAATCTTGATATTGATGCACGAAGA
ATTAACTGGCGAAGGGTAGTTGATTTGAATGATCGAGCTTTAAGAAACACAGTTGTAGCCTTAGGTGGTAGAGGTAATGG
CTTCCCTAGGGAAGATGGCTTTGATATTACTGTTGCTAGTGAGATAATGGCGATCTTATGCTTGGCAACAGATATTAAAG
ATCTAAAAGAAAGGTTAAGCAAAATAATAATTGGCTATACCAGGGATAGACAGCCTGTAACAGTTGCTGATCTAAAGATG
CAGGGATCCATGGCAGTATTATTAAAAGATGCAATTAAGCCAAACCTTGTGCAAACTTATGAAAATGTGCCTGCTTTTGT
ACATGGCGGTCCTTTTGCTAATATTGCACATGGCTGCAATTCGGCCATGGCAACTCAAATGGGAGTGAAAATGTCAGATT
ATCTAGTGACTGAAGCTGGATTTGGAGCTGATTTGGGAGCAGAAAAATTCTTTAATATAAAATGTCGATTTGCAGGTTTA
AATCCAGATGCGGCTGTTGTGGTGGCTACTGCCCGTGCTTTGAAAATGCATGGTGGAGTCGAAAAAGACAATTTAAAAGA
AGAGAATTTAGAAGCATTAGAAAAAGGGTTTGAAAACTTAGAAAAACATATGGAAAACATAAATAAATTTGGTGTGCCAG
CAGTAGTTGCAGTGAATAGATTCCCAACAGATACAGAAAAAGAACTAGAACTACTTATCAATAAGTGTCAAGAGAAAGGC
TATCGAGTGGCATTGAGTGAAGTTTTTGCTAAAGGTGGAGAAGGTGGCGAAGAAGTCGCCAAAGAAGTATTAGACATAAT
TGACAGTAAAGAGTCCAATTTTAAATACTTATATGATGTTGACAAATCTATGGAAGAAAAAATAGAAACTATTGCTAAAG
AAATTTATGGAGCTTCCGATGTTGAGTTTACTCCGACTGCCAGAAGAAATATTAAACAACTAGCTCAAAAAGGTCTGGAT
CAGGTGCCAGTATGTATGGCTAAAACCCAGTTCTCTTTTTCTGATGATCCTAAGCTATTGGGAAGGCCCAAGGATTTTAG
CATAACTGTTAAACGAGTACGGATTTCAGCAGGGGCTGGCTTTGCTGTAGCCATGACTGGGGACATTATGACTATGCCAG
GTTTACCCAAACAACCAGCTGCAGAAGAAATTGATATTGATGATGATGGACAAATTACAGGTCTATTTTAA

Upstream 100 bases:

>100_bases
TGTATTAATTTATTGAATTAATATTAAATGTTAGTTGTATTAAACTAGTGTGGTAACAATTTTTTAAAATATCTGAAAAT
ACTGAAGGAGGGGTTAACTC

Downstream 100 bases:

>100_bases
GTAATCCGGGTGATATAGTTAGTTAATATGATACAGTTTATAGAAGGCTGCTCATTCGATGTCGAGCAGCCTTTTTTTGG
TGTGCTTTTGCTTTGATATA

Product: Formate-tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 556; Mature: 556

Protein sequence:

>556_residues
MKSDIEIARGAPMRPIKDIASEVGIKDEELELYGDYKAKITFDAWKRLKDKPDGNLILVTAITPTPAGEGKSTTTVGLGQ
ALKRLGKNTMVALREPSLGPSFGVKGGAAGGGYSQVVPMEDINLHFTGDIHAITTAHNLLSAAIDNHIHQGNNLDIDARR
INWRRVVDLNDRALRNTVVALGGRGNGFPREDGFDITVASEIMAILCLATDIKDLKERLSKIIIGYTRDRQPVTVADLKM
QGSMAVLLKDAIKPNLVQTYENVPAFVHGGPFANIAHGCNSAMATQMGVKMSDYLVTEAGFGADLGAEKFFNIKCRFAGL
NPDAAVVVATARALKMHGGVEKDNLKEENLEALEKGFENLEKHMENINKFGVPAVVAVNRFPTDTEKELELLINKCQEKG
YRVALSEVFAKGGEGGEEVAKEVLDIIDSKESNFKYLYDVDKSMEEKIETIAKEIYGASDVEFTPTARRNIKQLAQKGLD
QVPVCMAKTQFSFSDDPKLLGRPKDFSITVKRVRISAGAGFAVAMTGDIMTMPGLPKQPAAEEIDIDDDGQITGLF

Sequences:

>Translated_556_residues
MKSDIEIARGAPMRPIKDIASEVGIKDEELELYGDYKAKITFDAWKRLKDKPDGNLILVTAITPTPAGEGKSTTTVGLGQ
ALKRLGKNTMVALREPSLGPSFGVKGGAAGGGYSQVVPMEDINLHFTGDIHAITTAHNLLSAAIDNHIHQGNNLDIDARR
INWRRVVDLNDRALRNTVVALGGRGNGFPREDGFDITVASEIMAILCLATDIKDLKERLSKIIIGYTRDRQPVTVADLKM
QGSMAVLLKDAIKPNLVQTYENVPAFVHGGPFANIAHGCNSAMATQMGVKMSDYLVTEAGFGADLGAEKFFNIKCRFAGL
NPDAAVVVATARALKMHGGVEKDNLKEENLEALEKGFENLEKHMENINKFGVPAVVAVNRFPTDTEKELELLINKCQEKG
YRVALSEVFAKGGEGGEEVAKEVLDIIDSKESNFKYLYDVDKSMEEKIETIAKEIYGASDVEFTPTARRNIKQLAQKGLD
QVPVCMAKTQFSFSDDPKLLGRPKDFSITVKRVRISAGAGFAVAMTGDIMTMPGLPKQPAAEEIDIDDDGQITGLF
>Mature_556_residues
MKSDIEIARGAPMRPIKDIASEVGIKDEELELYGDYKAKITFDAWKRLKDKPDGNLILVTAITPTPAGEGKSTTTVGLGQ
ALKRLGKNTMVALREPSLGPSFGVKGGAAGGGYSQVVPMEDINLHFTGDIHAITTAHNLLSAAIDNHIHQGNNLDIDARR
INWRRVVDLNDRALRNTVVALGGRGNGFPREDGFDITVASEIMAILCLATDIKDLKERLSKIIIGYTRDRQPVTVADLKM
QGSMAVLLKDAIKPNLVQTYENVPAFVHGGPFANIAHGCNSAMATQMGVKMSDYLVTEAGFGADLGAEKFFNIKCRFAGL
NPDAAVVVATARALKMHGGVEKDNLKEENLEALEKGFENLEKHMENINKFGVPAVVAVNRFPTDTEKELELLINKCQEKG
YRVALSEVFAKGGEGGEEVAKEVLDIIDSKESNFKYLYDVDKSMEEKIETIAKEIYGASDVEFTPTARRNIKQLAQKGLD
QVPVCMAKTQFSFSDDPKLLGRPKDFSITVKRVRISAGAGFAVAMTGDIMTMPGLPKQPAAEEIDIDDDGQITGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=620, Percent_Identity=45.3225806451613, Blast_Score=509, Evalue=1e-144,
Organism=Homo sapiens, GI36796743, Length=619, Percent_Identity=44.7495961227787, Blast_Score=486, Evalue=1e-137,
Organism=Homo sapiens, GI310124614, Length=82, Percent_Identity=43.9024390243902, Blast_Score=80, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17568737, Length=622, Percent_Identity=45.016077170418, Blast_Score=502, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17568739, Length=622, Percent_Identity=45.016077170418, Blast_Score=502, Evalue=1e-142,
Organism=Saccharomyces cerevisiae, GI6319558, Length=632, Percent_Identity=43.5126582278481, Blast_Score=483, Evalue=1e-137,
Organism=Saccharomyces cerevisiae, GI6321643, Length=626, Percent_Identity=43.1309904153355, Blast_Score=472, Evalue=1e-134,
Organism=Drosophila melanogaster, GI62472483, Length=620, Percent_Identity=43.5483870967742, Blast_Score=479, Evalue=1e-135,
Organism=Drosophila melanogaster, GI45551871, Length=620, Percent_Identity=43.5483870967742, Blast_Score=479, Evalue=1e-135,
Organism=Drosophila melanogaster, GI24645718, Length=620, Percent_Identity=43.5483870967742, Blast_Score=479, Evalue=1e-135,
Organism=Drosophila melanogaster, GI17137370, Length=620, Percent_Identity=43.5483870967742, Blast_Score=479, Evalue=1e-135,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_NATTJ (B2A3Q6)

Other databases:

- EMBL:   CP001034
- RefSeq:   YP_001916270.1
- ProteinModelPortal:   B2A3Q6
- SMR:   B2A3Q6
- GeneID:   6316276
- GenomeReviews:   CP001034_GR
- KEGG:   nth:Nther_0083
- HOGENOM:   HBG677721
- OMA:   EIMAVLC
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 60471; Mature: 60471

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSDIEIARGAPMRPIKDIASEVGIKDEELELYGDYKAKITFDAWKRLKDKPDGNLILVT
CCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEECEEEEEEHHHHHHHCCCCCCCEEEEE
AITPTPAGEGKSTTTVGLGQALKRLGKNTMVALREPSLGPSFGVKGGAAGGGYSQVVPME
EECCCCCCCCCCCEEHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCEECCCC
DINLHFTGDIHAITTAHNLLSAAIDNHIHQGNNLDIDARRINWRRVVDLNDRALRNTVVA
CCCEEECCCEEEHHHHHHHHHHHHHHHHCCCCCCCEEEEECCEEEEEECCCHHHHCEEEE
LGGRGNGFPREDGFDITVASEIMAILCLATDIKDLKERLSKIIIGYTRDRQPVTVADLKM
ECCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCEEEEEEEE
QGSMAVLLKDAIKPNLVQTYENVPAFVHGGPFANIAHGCNSAMATQMGVKMSDYLVTEAG
CCCHHHHHHHHCCCHHHHHHHCCCCEEECCCCHHHHHHCCHHHHHHHCCCHHHHEEECCC
FGADLGAEKFFNIKCRFAGLNPDAAVVVATARALKMHGGVEKDNLKEENLEALEKGFENL
CCCCCCCCCEEEEEEEEECCCCCCEEEEEHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
EKHMENINKFGVPAVVAVNRFPTDTEKELELLINKCQEKGYRVALSEVFAKGGEGGEEVA
HHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEHHHHHHCCCCCHHHHH
KEVLDIIDSKESNFKYLYDVDKSMEEKIETIAKEIYGASDVEFTPTARRNIKQLAQKGLD
HHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHCCCC
QVPVCMAKTQFSFSDDPKLLGRPKDFSITVKRVRISAGAGFAVAMTGDIMTMPGLPKQPA
CCCEEHEECCCCCCCCHHHCCCCCCCEEEEEEEEEECCCCEEEEEECCEEECCCCCCCCC
AEEIDIDDDGQITGLF
CCCCCCCCCCCEEECC
>Mature Secondary Structure
MKSDIEIARGAPMRPIKDIASEVGIKDEELELYGDYKAKITFDAWKRLKDKPDGNLILVT
CCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEECEEEEEEHHHHHHHCCCCCCCEEEEE
AITPTPAGEGKSTTTVGLGQALKRLGKNTMVALREPSLGPSFGVKGGAAGGGYSQVVPME
EECCCCCCCCCCCEEHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCEECCCC
DINLHFTGDIHAITTAHNLLSAAIDNHIHQGNNLDIDARRINWRRVVDLNDRALRNTVVA
CCCEEECCCEEEHHHHHHHHHHHHHHHHCCCCCCCEEEEECCEEEEEECCCHHHHCEEEE
LGGRGNGFPREDGFDITVASEIMAILCLATDIKDLKERLSKIIIGYTRDRQPVTVADLKM
ECCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCEEEEEEEE
QGSMAVLLKDAIKPNLVQTYENVPAFVHGGPFANIAHGCNSAMATQMGVKMSDYLVTEAG
CCCHHHHHHHHCCCHHHHHHHCCCCEEECCCCHHHHHHCCHHHHHHHCCCHHHHEEECCC
FGADLGAEKFFNIKCRFAGLNPDAAVVVATARALKMHGGVEKDNLKEENLEALEKGFENL
CCCCCCCCCEEEEEEEEECCCCCCEEEEEHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
EKHMENINKFGVPAVVAVNRFPTDTEKELELLINKCQEKGYRVALSEVFAKGGEGGEEVA
HHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEHHHHHHCCCCCHHHHH
KEVLDIIDSKESNFKYLYDVDKSMEEKIETIAKEIYGASDVEFTPTARRNIKQLAQKGLD
HHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHCCCC
QVPVCMAKTQFSFSDDPKLLGRPKDFSITVKRVRISAGAGFAVAMTGDIMTMPGLPKQPA
CCCEEHEECCCCCCCCHHHCCCCCCCEEEEEEEEEECCCCEEEEEECCEEECCCCCCCCC
AEEIDIDDDGQITGLF
CCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA