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The map label for this gene is guaB [H]

Identifier: 188584671

GI number: 188584671

Start: 42241

End: 43698

Strand: Direct

Name: guaB [H]

Synonym: Nther_0029

Alternate gene names: 188584671

Gene position: 42241-43698 (Clockwise)

Preceding gene: 188584669

Following gene: 188584672

Centisome position: 1.33

GC content: 38.61

Gene sequence:

>1458_bases
ATGGAATACAATGATAAAATTGTAAATGAAGGGCTTACTTTTGATGATGTGCTTTTGGTCCCTTCTAAATCTCAAATAAT
CCCTAAAGACATTGATATTCAAACCAGGCTAACTAATAAAATTAGATTAAATATTCCCTTGATGAGTGCAGGTATGGATA
CTGTCACTGAAGCTCGCCTTGCCGTAGCCATGGCAAGAGAAGGCGGCATTGGTATCATTCACAAGAATATGTCGATTGAT
AAGCAGGCTACTGAAGTAGATCGGGTTAAGAGATCGGAACACGGTGTAATTACAAATCCTTTCTCTTTATCCCAAAATCA
TAAAATATCCGATGCTGCAGCTTTAATGGAACGCTATCGTATATCAGGGGTTCCTATTACGGAAAGTGGTAAATTAATTG
GTATCATTACCAACCGCGATTTGAGATTTGAAACCGATTTTAACAGACCGATAAAAGAAGTTATGACAGATTCAAATTTA
ATAACAGCTTCTGAAGGAATCTCAATGTCAGAAGCTCAGAAGATTCTTCAGGAAAATAAAGTTGAAAAACTACCTTTAAC
TGATGATGAAGGAAACTTAAAAGGTTTGATAACCATAAAAGATATTGAAAAATCAATTAAGTTTCCCAATGCCGCTAAAG
ATGAAACTGGTCGGTTACTGGCAGGTGCCGCAGTAGGCCCAGGCAAGGATCTGGATGAACGAGTAGCAGCTTTAGTTGAG
GCCAAAGTTGATGTAATTGTTATCGATACTGCCCATGGTCATTCACAGAATGTAATTAAAGCTGTTAGATACGTTAAAGA
AACATATCCTGATGTGGAACTAGTAGCAGGTAATGTAGCCACAACTGAAGGAACTAAAGATTTAATAGAAGCGGGAGCTG
ATGCGGTCAAAGTAGGAGTTGGCCCCGGATCAATATGTACTACTCGAATAGTTTGTGGAGTTGGGGTTCCCCAAATAACA
GCTGTATTAGATTGTGCTAAGGTTGCTAAAGAATACGGAGTACCAATAATTTCTGATGGTGGTATCAAATATTCTGGAGA
TATAGCTAAGGCTTTATCAGTAGGGGCTGATGTTGTCATGATTGGCAGCTTATTTGCTGGTACTGATGAAAGTCCGGGTG
AATTTGAAATTTATCAAGGCCGCAGTTATAAAGTCTATAGAGGAATGGGATCTGAAACCTCAATGAAATTAGGAAGTAAA
GACAGATATTTCCAAGAAGACAAAAGGAAATTCGTTCCAGAAGGGATAGAAGGACGGGTTCCGTATCGTGGAACCTTACA
AGATACAGTTTATCAATTAGTTGGGGGTTTAAGATCCGGTATGGGATATTGTGGTGCTGCTGATATCGAAAGTTTACAAA
AGGATTCTCGTATGGTAAGAATCACTGCTTCGGGGTTAAAGGAAAGTCACCCCCACGATGTTCAAATCACTAAAGAAGCA
CCTAATTATTCATTATAA

Upstream 100 bases:

>100_bases
CACGTGCTAGTTTGATAAGGACTAGGGTCAATAGGACTAGGAAAACTAATTATAAATAATTTTGTTATATGTTTTAATTA
ACCGAGGAGGTGTAATACTC

Downstream 100 bases:

>100_bases
TTAGGTGCTTTTCTTTCAGGGCATACTTTTAAGTTTTGAAATGTTAATTAAATAAAATTTTTTTATTTTTTAAGAAGGAA
TTTTCTTTAACAAATCGAAT

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MEYNDKIVNEGLTFDDVLLVPSKSQIIPKDIDIQTRLTNKIRLNIPLMSAGMDTVTEARLAVAMAREGGIGIIHKNMSID
KQATEVDRVKRSEHGVITNPFSLSQNHKISDAAALMERYRISGVPITESGKLIGIITNRDLRFETDFNRPIKEVMTDSNL
ITASEGISMSEAQKILQENKVEKLPLTDDEGNLKGLITIKDIEKSIKFPNAAKDETGRLLAGAAVGPGKDLDERVAALVE
AKVDVIVIDTAHGHSQNVIKAVRYVKETYPDVELVAGNVATTEGTKDLIEAGADAVKVGVGPGSICTTRIVCGVGVPQIT
AVLDCAKVAKEYGVPIISDGGIKYSGDIAKALSVGADVVMIGSLFAGTDESPGEFEIYQGRSYKVYRGMGSETSMKLGSK
DRYFQEDKRKFVPEGIEGRVPYRGTLQDTVYQLVGGLRSGMGYCGAADIESLQKDSRMVRITASGLKESHPHDVQITKEA
PNYSL

Sequences:

>Translated_485_residues
MEYNDKIVNEGLTFDDVLLVPSKSQIIPKDIDIQTRLTNKIRLNIPLMSAGMDTVTEARLAVAMAREGGIGIIHKNMSID
KQATEVDRVKRSEHGVITNPFSLSQNHKISDAAALMERYRISGVPITESGKLIGIITNRDLRFETDFNRPIKEVMTDSNL
ITASEGISMSEAQKILQENKVEKLPLTDDEGNLKGLITIKDIEKSIKFPNAAKDETGRLLAGAAVGPGKDLDERVAALVE
AKVDVIVIDTAHGHSQNVIKAVRYVKETYPDVELVAGNVATTEGTKDLIEAGADAVKVGVGPGSICTTRIVCGVGVPQIT
AVLDCAKVAKEYGVPIISDGGIKYSGDIAKALSVGADVVMIGSLFAGTDESPGEFEIYQGRSYKVYRGMGSETSMKLGSK
DRYFQEDKRKFVPEGIEGRVPYRGTLQDTVYQLVGGLRSGMGYCGAADIESLQKDSRMVRITASGLKESHPHDVQITKEA
PNYSL
>Mature_485_residues
MEYNDKIVNEGLTFDDVLLVPSKSQIIPKDIDIQTRLTNKIRLNIPLMSAGMDTVTEARLAVAMAREGGIGIIHKNMSID
KQATEVDRVKRSEHGVITNPFSLSQNHKISDAAALMERYRISGVPITESGKLIGIITNRDLRFETDFNRPIKEVMTDSNL
ITASEGISMSEAQKILQENKVEKLPLTDDEGNLKGLITIKDIEKSIKFPNAAKDETGRLLAGAAVGPGKDLDERVAALVE
AKVDVIVIDTAHGHSQNVIKAVRYVKETYPDVELVAGNVATTEGTKDLIEAGADAVKVGVGPGSICTTRIVCGVGVPQIT
AVLDCAKVAKEYGVPIISDGGIKYSGDIAKALSVGADVVMIGSLFAGTDESPGEFEIYQGRSYKVYRGMGSETSMKLGSK
DRYFQEDKRKFVPEGIEGRVPYRGTLQDTVYQLVGGLRSGMGYCGAADIESLQKDSRMVRITASGLKESHPHDVQITKEA
PNYSL

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=453, Percent_Identity=43.046357615894, Blast_Score=355, Evalue=5e-98,
Organism=Homo sapiens, GI34328930, Length=453, Percent_Identity=43.046357615894, Blast_Score=355, Evalue=8e-98,
Organism=Homo sapiens, GI34328928, Length=453, Percent_Identity=43.046357615894, Blast_Score=354, Evalue=1e-97,
Organism=Homo sapiens, GI156616279, Length=453, Percent_Identity=43.046357615894, Blast_Score=354, Evalue=1e-97,
Organism=Homo sapiens, GI66933016, Length=453, Percent_Identity=41.0596026490066, Blast_Score=346, Evalue=2e-95,
Organism=Homo sapiens, GI217035152, Length=447, Percent_Identity=42.9530201342282, Blast_Score=346, Evalue=3e-95,
Organism=Homo sapiens, GI217035148, Length=453, Percent_Identity=42.3841059602649, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI217035150, Length=453, Percent_Identity=40.1766004415011, Blast_Score=318, Evalue=9e-87,
Organism=Homo sapiens, GI156104880, Length=239, Percent_Identity=40.1673640167364, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI50541956, Length=242, Percent_Identity=40.0826446280992, Blast_Score=179, Evalue=7e-45,
Organism=Homo sapiens, GI50541954, Length=242, Percent_Identity=40.0826446280992, Blast_Score=178, Evalue=9e-45,
Organism=Homo sapiens, GI50541952, Length=242, Percent_Identity=40.0826446280992, Blast_Score=178, Evalue=9e-45,
Organism=Homo sapiens, GI50541948, Length=242, Percent_Identity=40.0826446280992, Blast_Score=178, Evalue=9e-45,
Organism=Escherichia coli, GI1788855, Length=484, Percent_Identity=55.3719008264463, Blast_Score=500, Evalue=1e-143,
Organism=Escherichia coli, GI1786293, Length=219, Percent_Identity=40.1826484018265, Blast_Score=172, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI71994385, Length=471, Percent_Identity=37.791932059448, Blast_Score=290, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI71994389, Length=420, Percent_Identity=40.2380952380952, Blast_Score=280, Evalue=9e-76,
Organism=Caenorhabditis elegans, GI17560440, Length=223, Percent_Identity=43.4977578475336, Blast_Score=186, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6323585, Length=490, Percent_Identity=39.1836734693878, Blast_Score=345, Evalue=1e-95,
Organism=Saccharomyces cerevisiae, GI6323464, Length=490, Percent_Identity=39.7959183673469, Blast_Score=339, Evalue=6e-94,
Organism=Saccharomyces cerevisiae, GI6322012, Length=490, Percent_Identity=38.1632653061225, Blast_Score=338, Evalue=9e-94,
Organism=Saccharomyces cerevisiae, GI6319352, Length=347, Percent_Identity=40.0576368876081, Blast_Score=270, Evalue=4e-73,
Organism=Saccharomyces cerevisiae, GI6319353, Length=97, Percent_Identity=41.2371134020619, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24641071, Length=481, Percent_Identity=38.4615384615385, Blast_Score=335, Evalue=5e-92,
Organism=Drosophila melanogaster, GI24641073, Length=481, Percent_Identity=38.4615384615385, Blast_Score=335, Evalue=5e-92,
Organism=Drosophila melanogaster, GI28571163, Length=439, Percent_Identity=38.9521640091116, Blast_Score=303, Evalue=2e-82,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52476; Mature: 52476

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYNDKIVNEGLTFDDVLLVPSKSQIIPKDIDIQTRLTNKIRLNIPLMSAGMDTVTEARL
CCCCCHHHHCCCCCCCEEEECCCCCCCCCCCCEEEEECCEEEEEEEEECCCCHHHHHHHH
AVAMAREGGIGIIHKNMSIDKQATEVDRVKRSEHGVITNPFSLSQNHKISDAAALMERYR
HHEECCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHH
ISGVPITESGKLIGIITNRDLRFETDFNRPIKEVMTDSNLITASEGISMSEAQKILQENK
CCCCCCCCCCCEEEEEECCCEEEECCCCCHHHHHHCCCCEEEECCCCCHHHHHHHHHHCC
VEKLPLTDDEGNLKGLITIKDIEKSIKFPNAAKDETGRLLAGAAVGPGKDLDERVAALVE
CCCCCCCCCCCCEEEEEEEEEHHHHCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHH
AKVDVIVIDTAHGHSQNVIKAVRYVKETYPDVELVAGNVATTEGTKDLIEAGADAVKVGV
CCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCEECCCCHHHHHHCCCCEEEECC
GPGSICTTRIVCGVGVPQITAVLDCAKVAKEYGVPIISDGGIKYSGDIAKALSVGADVVM
CCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCEEEECCCEEECCHHHHHHHCCCCEEE
IGSLFAGTDESPGEFEIYQGRSYKVYRGMGSETSMKLGSKDRYFQEDKRKFVPEGIEGRV
EEHHHCCCCCCCCCEEEEECCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCC
PYRGTLQDTVYQLVGGLRSGMGYCGAADIESLQKDSRMVRITASGLKESHPHDVQITKEA
CCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCEEEEEEECCCCCCCCCCEEEEECC
PNYSL
CCCCC
>Mature Secondary Structure
MEYNDKIVNEGLTFDDVLLVPSKSQIIPKDIDIQTRLTNKIRLNIPLMSAGMDTVTEARL
CCCCCHHHHCCCCCCCEEEECCCCCCCCCCCCEEEEECCEEEEEEEEECCCCHHHHHHHH
AVAMAREGGIGIIHKNMSIDKQATEVDRVKRSEHGVITNPFSLSQNHKISDAAALMERYR
HHEECCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHH
ISGVPITESGKLIGIITNRDLRFETDFNRPIKEVMTDSNLITASEGISMSEAQKILQENK
CCCCCCCCCCCEEEEEECCCEEEECCCCCHHHHHHCCCCEEEECCCCCHHHHHHHHHHCC
VEKLPLTDDEGNLKGLITIKDIEKSIKFPNAAKDETGRLLAGAAVGPGKDLDERVAALVE
CCCCCCCCCCCCEEEEEEEEEHHHHCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHH
AKVDVIVIDTAHGHSQNVIKAVRYVKETYPDVELVAGNVATTEGTKDLIEAGADAVKVGV
CCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCEECCCCHHHHHHCCCCEEEECC
GPGSICTTRIVCGVGVPQITAVLDCAKVAKEYGVPIISDGGIKYSGDIAKALSVGADVVM
CCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCEEEECCCEEECCHHHHHHHCCCCEEE
IGSLFAGTDESPGEFEIYQGRSYKVYRGMGSETSMKLGSKDRYFQEDKRKFVPEGIEGRV
EEHHHCCCCCCCCCEEEEECCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCC
PYRGTLQDTVYQLVGGLRSGMGYCGAADIESLQKDSRMVRITASGLKESHPHDVQITKEA
CCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCEEEEEEECCCCCCCCCCEEEEECC
PNYSL
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]