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The map label for this gene is gyrA [H]

Identifier: 188584650

GI number: 188584650

Start: 7594

End: 10017

Strand: Direct

Name: gyrA [H]

Synonym: Nther_0008

Alternate gene names: 188584650

Gene position: 7594-10017 (Clockwise)

Preceding gene: 188584649

Following gene: 188584651

Centisome position: 0.24

GC content: 35.52

Gene sequence:

>2424_bases
ATGAGCGATACTATGCGAGGGAAAGTAGTGCCGATTGATATCCAAGAAGAGATGGAAAATTCTTTTCTTGATTATGCTAT
GAGCGTAATTGTCAGTAGGGCCTTACCTGATGTCCGGGATGGTTTAAAACCGGTTCATCGTCGAATTTTATTTGCTATGC
ACGATCTAGGAATCACACCAGAAAAACCTTATAAAAAATCTGCCCGTGTTGTTGGAGAAGTGCTAGGTAAATATCATCCT
CATGGTGATGTAGCACTTTACGATGCTATGGTACGCATGGCTCAAGACTTTTCAACCCGATATCCTTTGGTGGATGGTCA
CGGCAACTTTGGGTCAGTTGACGGTGATAGTGCTGCTGCCATGCGTTACACTGAAGTTCGAATGGCTAAGATCAGTACAG
AATTATTGAAGGATATCGATAAAGAAACTATTGATTATCAACAAAACTTTGACGAAACTTTAGAGGAACCTGTCGTACTA
CCTTCTAGATTTCCTAACTTACTTGTCAATGGTTCAGCTGGTATAGCAGTTGGTATGGCAACTAATATTCCTCCTCACAA
TTTAGACGAGGTTATCGACGGGATAGTGGCCATGATAGAGAATCCTGAGATTGCCGATGAGGATTTAATGAATTATATTA
AAGGTCCCGATTTTCCCACTGGAGGAATTATCCTTGGCAGAAATGGAATTAAAGACGCTTATTCAACTGGAAGAGGAAAA
CTTAAAATTAGAGCAAAAACAGAAATTGAAAATTTAAAAGGAAATAAGCATAGAATTTTAGTAACAGAAATCCCTTATCA
GGTAAATAAAGCCAAACTTATAGAATCAATTGCATCTTTAGTTAGGGAAAAGAAAATTGAAGGAATTAGTGATCTCAGGG
ATGAATCTGATAGAGATGGTCTCAGAGTTGTAATAGAACTCAAGAGGGATGTAAATCCTAATGTCCTATTAAATCAGCTA
TATAAATACACTACTTTAGAACAATCTTTCGGAATTATCTTACTAGCCCTGGTTAATGGAGAGCCCAAAGTACTTTCGCT
TAGAGAAATCCTGGATCATTATCTGGAATTTCAAAAAGAAGTTATTATCAGACGAACCAAATATTTATTGAGAAAAGCCG
AAGCAAGGGCTCATATTTTAGAAGGACTTAAGATAGCTTTAAATAATTTAGATGCTGTGATCAAATTGATTAGACAATCT
AAAACTGTTAAAGAGGCAAAAGAAGGTCTTATGAACAATTTTTCATTATCAGATAAACAAGCCCAAGCAATTTTAGATAT
GAGACTTCAAAAGCTAACTGCTTTGGAACGAGATAAAATAGAGGAAGAATACAGTGAACTATTAAAGAAGATTGACTACT
ACAACAGAGTATTAGGGGATGAACAATTAGTCTTAAATATTATTAAAGAAGAAATCCAGGAAATAAAAGAGAAATACAGT
GATAGTAGAAGAACTTTAATTACTAATAAGACCGATGAACTTGATGAAGAAGATTTAATCCCTGATGAAGAAGTAATTAT
CACATTAACGCATCAAGGATATGTCAAACGAGTACCACTGTCCACTTACCGTAATCAAAAACGGGGTGGTCGAGGTATTA
GTGGGATGACTACTAAAAACGATGATTTTGTAGAACATCTTTTTGCAACTTCAACTCATAATTATATTTTATTCTTTACC
AATAAAGGCAAGGTTTATAGACTTAAAGTATATGAAATCCCGGAAGCTTCACGACAAGCCAGAGGTACAGCTATTGTTAA
TCTACTTGCAATAGATCCTGATGAACACATTACTGCAGTTATACCGATTCAAGAATTTACTGAAGATGACTATCTGTTTT
TCGTAACGAAGCAGGGAGTTGCTAAAAAAGTTATCTTAAGCGAATTAAAAGCTTATCGAAAAGATGGTTTGATTGCAATA
AACTTAAATGAAGATGATGAATTGATTGATGTTCATCTAACTGACGGAAAACAAGAAATAATTTTAGGAACGGAGCAAGG
ATTAGCAATTAAATTTTCAGAAGAAGAAGTTAGAAGTATGGGAAGAAATTCTCGCGGTGTAAAAGGTATTTCATTGAAAG
ATAATGATCGAGTAATTGGAATGGATATTGCCCAAGAAAATTCTGATTTACTAATTGTCAGTGAAAACGGCTATGGAAAG
AGGACTCCAGTTTCAGAATATAGGACACAATCAAGAGGCGGAAAAGGTATCTATACCTTTAAACCATCAGAAAAATCCGG
GAATCTAGCGGGTTGTATAGTAGTTAATGAAGATGAAGAAATTATACTGGTGACTGCACAAGGTGTGATTAACAGGCAGC
AAGTTGAAGGCATATCACAAATGAGTAGGAGAACTCAAGGAGTGAGATTAATTAAATTAAAAGATGACGATCAAGTGGTA
TCACTGGCGATTCCAGAAAGTTAA

Upstream 100 bases:

>100_bases
AAATTTGGATGTTTAAAAAATATGTTTAATTTTTAGCAGATCTTTTAACAGATTGATAATAAGATAACAAGCTTTGAAAA
GAAAAGGAAGGGAAGCTATT

Downstream 100 bases:

>100_bases
GCGTATTTTCTAACCGGAGCCTAGCTAAAGGCTCCGGTTTTTTGCTTCTATTAAATTGACGCTGTTAAATTTAGTTGTTG
ATAGTGAAACTTCGTGCTTA

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 807; Mature: 806

Protein sequence:

>807_residues
MSDTMRGKVVPIDIQEEMENSFLDYAMSVIVSRALPDVRDGLKPVHRRILFAMHDLGITPEKPYKKSARVVGEVLGKYHP
HGDVALYDAMVRMAQDFSTRYPLVDGHGNFGSVDGDSAAAMRYTEVRMAKISTELLKDIDKETIDYQQNFDETLEEPVVL
PSRFPNLLVNGSAGIAVGMATNIPPHNLDEVIDGIVAMIENPEIADEDLMNYIKGPDFPTGGIILGRNGIKDAYSTGRGK
LKIRAKTEIENLKGNKHRILVTEIPYQVNKAKLIESIASLVREKKIEGISDLRDESDRDGLRVVIELKRDVNPNVLLNQL
YKYTTLEQSFGIILLALVNGEPKVLSLREILDHYLEFQKEVIIRRTKYLLRKAEARAHILEGLKIALNNLDAVIKLIRQS
KTVKEAKEGLMNNFSLSDKQAQAILDMRLQKLTALERDKIEEEYSELLKKIDYYNRVLGDEQLVLNIIKEEIQEIKEKYS
DSRRTLITNKTDELDEEDLIPDEEVIITLTHQGYVKRVPLSTYRNQKRGGRGISGMTTKNDDFVEHLFATSTHNYILFFT
NKGKVYRLKVYEIPEASRQARGTAIVNLLAIDPDEHITAVIPIQEFTEDDYLFFVTKQGVAKKVILSELKAYRKDGLIAI
NLNEDDELIDVHLTDGKQEIILGTEQGLAIKFSEEEVRSMGRNSRGVKGISLKDNDRVIGMDIAQENSDLLIVSENGYGK
RTPVSEYRTQSRGGKGIYTFKPSEKSGNLAGCIVVNEDEEIILVTAQGVINRQQVEGISQMSRRTQGVRLIKLKDDDQVV
SLAIPES

Sequences:

>Translated_807_residues
MSDTMRGKVVPIDIQEEMENSFLDYAMSVIVSRALPDVRDGLKPVHRRILFAMHDLGITPEKPYKKSARVVGEVLGKYHP
HGDVALYDAMVRMAQDFSTRYPLVDGHGNFGSVDGDSAAAMRYTEVRMAKISTELLKDIDKETIDYQQNFDETLEEPVVL
PSRFPNLLVNGSAGIAVGMATNIPPHNLDEVIDGIVAMIENPEIADEDLMNYIKGPDFPTGGIILGRNGIKDAYSTGRGK
LKIRAKTEIENLKGNKHRILVTEIPYQVNKAKLIESIASLVREKKIEGISDLRDESDRDGLRVVIELKRDVNPNVLLNQL
YKYTTLEQSFGIILLALVNGEPKVLSLREILDHYLEFQKEVIIRRTKYLLRKAEARAHILEGLKIALNNLDAVIKLIRQS
KTVKEAKEGLMNNFSLSDKQAQAILDMRLQKLTALERDKIEEEYSELLKKIDYYNRVLGDEQLVLNIIKEEIQEIKEKYS
DSRRTLITNKTDELDEEDLIPDEEVIITLTHQGYVKRVPLSTYRNQKRGGRGISGMTTKNDDFVEHLFATSTHNYILFFT
NKGKVYRLKVYEIPEASRQARGTAIVNLLAIDPDEHITAVIPIQEFTEDDYLFFVTKQGVAKKVILSELKAYRKDGLIAI
NLNEDDELIDVHLTDGKQEIILGTEQGLAIKFSEEEVRSMGRNSRGVKGISLKDNDRVIGMDIAQENSDLLIVSENGYGK
RTPVSEYRTQSRGGKGIYTFKPSEKSGNLAGCIVVNEDEEIILVTAQGVINRQQVEGISQMSRRTQGVRLIKLKDDDQVV
SLAIPES
>Mature_806_residues
SDTMRGKVVPIDIQEEMENSFLDYAMSVIVSRALPDVRDGLKPVHRRILFAMHDLGITPEKPYKKSARVVGEVLGKYHPH
GDVALYDAMVRMAQDFSTRYPLVDGHGNFGSVDGDSAAAMRYTEVRMAKISTELLKDIDKETIDYQQNFDETLEEPVVLP
SRFPNLLVNGSAGIAVGMATNIPPHNLDEVIDGIVAMIENPEIADEDLMNYIKGPDFPTGGIILGRNGIKDAYSTGRGKL
KIRAKTEIENLKGNKHRILVTEIPYQVNKAKLIESIASLVREKKIEGISDLRDESDRDGLRVVIELKRDVNPNVLLNQLY
KYTTLEQSFGIILLALVNGEPKVLSLREILDHYLEFQKEVIIRRTKYLLRKAEARAHILEGLKIALNNLDAVIKLIRQSK
TVKEAKEGLMNNFSLSDKQAQAILDMRLQKLTALERDKIEEEYSELLKKIDYYNRVLGDEQLVLNIIKEEIQEIKEKYSD
SRRTLITNKTDELDEEDLIPDEEVIITLTHQGYVKRVPLSTYRNQKRGGRGISGMTTKNDDFVEHLFATSTHNYILFFTN
KGKVYRLKVYEIPEASRQARGTAIVNLLAIDPDEHITAVIPIQEFTEDDYLFFVTKQGVAKKVILSELKAYRKDGLIAIN
LNEDDELIDVHLTDGKQEIILGTEQGLAIKFSEEEVRSMGRNSRGVKGISLKDNDRVIGMDIAQENSDLLIVSENGYGKR
TPVSEYRTQSRGGKGIYTFKPSEKSGNLAGCIVVNEDEEIILVTAQGVINRQQVEGISQMSRRTQGVRLIKLKDDDQVVS
LAIPES

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=177, Percent_Identity=27.683615819209, Blast_Score=73, Evalue=1e-12,
Organism=Homo sapiens, GI19913408, Length=174, Percent_Identity=28.1609195402299, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1788562, Length=837, Percent_Identity=50.8960573476703, Blast_Score=857, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=699, Percent_Identity=37.1959942775393, Blast_Score=438, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI212645845, Length=468, Percent_Identity=25.2136752136752, Blast_Score=89, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17535065, Length=367, Percent_Identity=24.2506811989101, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI212645657, Length=423, Percent_Identity=23.6406619385343, Blast_Score=76, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=187, Percent_Identity=31.5508021390374, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17136538, Length=361, Percent_Identity=25.207756232687, Blast_Score=85, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR010235
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV; PF08780 NTase_sub_bind [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 91029; Mature: 90897

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTMRGKVVPIDIQEEMENSFLDYAMSVIVSRALPDVRDGLKPVHRRILFAMHDLGITP
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
EKPYKKSARVVGEVLGKYHPHGDVALYDAMVRMAQDFSTRYPLVDGHGNFGSVDGDSAAA
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCHHH
MRYTEVRMAKISTELLKDIDKETIDYQQNFDETLEEPVVLPSRFPNLLVNGSAGIAVGMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCEEEECCCCEEEEEE
TNIPPHNLDEVIDGIVAMIENPEIADEDLMNYIKGPDFPTGGIILGRNGIKDAYSTGRGK
CCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEECCCCCCHHHHCCCCE
LKIRAKTEIENLKGNKHRILVTEIPYQVNKAKLIESIASLVREKKIEGISDLRDESDRDG
EEEEEECHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCC
LRVVIELKRDVNPNVLLNQLYKYTTLEQSFGIILLALVNGEPKVLSLREILDHYLEFQKE
EEEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEHHHHHHHHHHHHHHH
VIIRRTKYLLRKAEARAHILEGLKIALNNLDAVIKLIRQSKTVKEAKEGLMNNFSLSDKQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
AQAILDMRLQKLTALERDKIEEEYSELLKKIDYYNRVLGDEQLVLNIIKEEIQEIKEKYS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHC
DSRRTLITNKTDELDEEDLIPDEEVIITLTHQGYVKRVPLSTYRNQKRGGRGISGMTTKN
CCCEEEEECCCCCCCCHHCCCCCCEEEEEECCCCEEECCHHHHHCCCCCCCCCCCCCCCC
DDFVEHLFATSTHNYILFFTNKGKVYRLKVYEIPEASRQARGTAIVNLLAIDPDEHITAV
HHHHHHHHHCCCCCEEEEEECCCCEEEEEEEECCCHHHHCCCEEEEEEEEECCCCCEEEE
IPIQEFTEDDYLFFVTKQGVAKKVILSELKAYRKDGLIAINLNEDDELIDVHLTDGKQEI
EEHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEECCCCEEE
ILGTEQGLAIKFSEEEVRSMGRNSRGVKGISLKDNDRVIGMDIAQENSDLLIVSENGYGK
EEECCCCEEEEECHHHHHHCCCCCCCCEEEEECCCCEEEEEEEECCCCCEEEEECCCCCC
RTPVSEYRTQSRGGKGIYTFKPSEKSGNLAGCIVVNEDEEIILVTAQGVINRQQVEGISQ
CCCHHHHHHHCCCCCEEEEECCCCCCCCEEEEEEECCCCCEEEEECCCCCCHHHHHHHHH
MSRRTQGVRLIKLKDDDQVVSLAIPES
HHHHHCCEEEEEECCCCCEEEEECCCC
>Mature Secondary Structure 
SDTMRGKVVPIDIQEEMENSFLDYAMSVIVSRALPDVRDGLKPVHRRILFAMHDLGITP
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
EKPYKKSARVVGEVLGKYHPHGDVALYDAMVRMAQDFSTRYPLVDGHGNFGSVDGDSAAA
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCHHH
MRYTEVRMAKISTELLKDIDKETIDYQQNFDETLEEPVVLPSRFPNLLVNGSAGIAVGMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCEEEECCCCEEEEEE
TNIPPHNLDEVIDGIVAMIENPEIADEDLMNYIKGPDFPTGGIILGRNGIKDAYSTGRGK
CCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEECCCCCCHHHHCCCCE
LKIRAKTEIENLKGNKHRILVTEIPYQVNKAKLIESIASLVREKKIEGISDLRDESDRDG
EEEEEECHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCC
LRVVIELKRDVNPNVLLNQLYKYTTLEQSFGIILLALVNGEPKVLSLREILDHYLEFQKE
EEEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEHHHHHHHHHHHHHHH
VIIRRTKYLLRKAEARAHILEGLKIALNNLDAVIKLIRQSKTVKEAKEGLMNNFSLSDKQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
AQAILDMRLQKLTALERDKIEEEYSELLKKIDYYNRVLGDEQLVLNIIKEEIQEIKEKYS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHC
DSRRTLITNKTDELDEEDLIPDEEVIITLTHQGYVKRVPLSTYRNQKRGGRGISGMTTKN
CCCEEEEECCCCCCCCHHCCCCCCEEEEEECCCCEEECCHHHHHCCCCCCCCCCCCCCCC
DDFVEHLFATSTHNYILFFTNKGKVYRLKVYEIPEASRQARGTAIVNLLAIDPDEHITAV
HHHHHHHHHCCCCCEEEEEECCCCEEEEEEEECCCHHHHCCCEEEEEEEEECCCCCEEEE
IPIQEFTEDDYLFFVTKQGVAKKVILSELKAYRKDGLIAINLNEDDELIDVHLTDGKQEI
EEHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEECCCCEEE
ILGTEQGLAIKFSEEEVRSMGRNSRGVKGISLKDNDRVIGMDIAQENSDLLIVSENGYGK
EEECCCCEEEEECHHHHHHCCCCCCCCEEEEECCCCEEEEEEEECCCCCEEEEECCCCCC
RTPVSEYRTQSRGGKGIYTFKPSEKSGNLAGCIVVNEDEEIILVTAQGVINRQQVEGISQ
CCCHHHHHHHCCCCCEEEEECCCCCCCCEEEEEEECCCCCEEEEECCCCCCHHHHHHHHH
MSRRTQGVRLIKLKDDDQVVSLAIPES
HHHHHCCEEEEEECCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10427704; 11058132 [H]