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The map label for this gene is dnaA

Identifier: 188584643

GI number: 188584643

Start: 146

End: 1507

Strand: Direct

Name: dnaA

Synonym: Nther_0001

Alternate gene names: 188584643

Gene position: 146-1507 (Clockwise)

Preceding gene: NA

Following gene: 188584644

Centisome position: 0.0

GC content: 33.99

Gene sequence:

>1362_bases
ATGTCAGAAAACATGGAAGAATTATGGTCTAAAACTCTAGAAGAATTAAAACAGCAACTTAGCAAACCAAGCTTTGAGAC
CTGGTTTCAATCCACTGAGCCTGTAGAAATGAGTAGTACGGATTTATATATAAGTGTTCCTAACGAATTCACTAAAGACT
GGCTCAATTCCAGGTATAAAAATTCAATTGAAAATTCATTAAAAAAAATATCAGGAAAACAGCTAAAAATTAAATTTTTA
TTACCTGGAGAAAAAATAAAAATGGAAGAACAAAACAATGAAAATGAAGAAAAACCAGAATCTACTTCTAAAAAGTCTTC
CCAGGGAAGCGAACATACAACTTGGTTAAATCCCAAATATACCTTTGATACATTTGTTATAGGAAATGCCAATAGATTTG
CTCATGCTGCCTCTTTGGCAGTGGCAGAAGCTCCAGCCAAGGCATATAATCCTCTATTTATATACGGGGGAGTAGGCTTA
GGTAAGACTCACTTAATGCATGCAATTGGTCATTATGTACTCAGTCATCAACCAAACTATCGGGTTGTCTACATTTCATC
GGAAAAGTTTACAAATGAATTTATCAACGCTATCAGAGATAACAAAACAGTTAATTTCCGTAATAAATACAGAAATGTTG
ATATCCTTTTAGTTGACGATATTCAATTTTTAGCAGGAAAAGAACAAACTCAAGAAGAGTTTTTCCACACTTTTAATACG
CTTCACGAAAATGATAAGCAAATCATTATCTCAAGTGACCGTCCTCCTAAAGAAATTCCCACATTAGAAGACAGGCTTAG
ATCACGATTTGAATGGGGTTTGATCACAGATATTCAAGCACCAGATTTAGAAACTAGAATAGCTATCTTGAGAAAGAAAG
CATATCTAGAAAAGCTTGATATCCCCAATGATGTAATTGTTTATATTGCCAATCAAATAGATACTAATATAAGGGAATTA
GAAGGTGGCTTAATTAGGGTTATTGCCTATTCATCAATGGCTAATAAAAAAATAACCAAAGAAACAGCAGAAGAGGCGTT
AAAGGATATTTTACCTAATAAACAACCTAAAAAAATGACAGTGGAGCATATCCAAAAGACGGTAGCACAATATTTTGGAT
TAAAGGTTGATGATCTCAAAGCTAAGAAGCGTACACGTTCAGTAGCTTTCCCTCGACAGATAGCAATGTATCTAGCAAGG
GAATTAACCGACAGTTCACTACCTAAAATAGGAGACGAGTTTGGTGGACGCGATCATACTACAGTTATGCATGCTCATGA
CAAAATAGCAAGTGACCTTAAAAAAGAATCTCATTTAAATGAAACTATAGATGAAATCAAGAATCTATTACATGGTGATT
AA

Upstream 100 bases:

>100_bases
TCTTAAATTTGAATGTTGTAATTGCAAAACATCAATTAAAAATGACTACATTTAAATAACAAGCTCATATGTAAGATTTT
TCCCAAAGGGGGATATATTT

Downstream 100 bases:

>100_bases
AGGAGTTATTTTAGTGGATAAGTCTCGGAAAAACTGTGGACAACATTAGGGACTATCTGTGTATATTCTTCGGGATAACT
TAAGACACTTATACCAATTG

Product: chromosomal replication initiator protein DnaA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MSENMEELWSKTLEELKQQLSKPSFETWFQSTEPVEMSSTDLYISVPNEFTKDWLNSRYKNSIENSLKKISGKQLKIKFL
LPGEKIKMEEQNNENEEKPESTSKKSSQGSEHTTWLNPKYTFDTFVIGNANRFAHAASLAVAEAPAKAYNPLFIYGGVGL
GKTHLMHAIGHYVLSHQPNYRVVYISSEKFTNEFINAIRDNKTVNFRNKYRNVDILLVDDIQFLAGKEQTQEEFFHTFNT
LHENDKQIIISSDRPPKEIPTLEDRLRSRFEWGLITDIQAPDLETRIAILRKKAYLEKLDIPNDVIVYIANQIDTNIREL
EGGLIRVIAYSSMANKKITKETAEEALKDILPNKQPKKMTVEHIQKTVAQYFGLKVDDLKAKKRTRSVAFPRQIAMYLAR
ELTDSSLPKIGDEFGGRDHTTVMHAHDKIASDLKKESHLNETIDEIKNLLHGD

Sequences:

>Translated_453_residues
MSENMEELWSKTLEELKQQLSKPSFETWFQSTEPVEMSSTDLYISVPNEFTKDWLNSRYKNSIENSLKKISGKQLKIKFL
LPGEKIKMEEQNNENEEKPESTSKKSSQGSEHTTWLNPKYTFDTFVIGNANRFAHAASLAVAEAPAKAYNPLFIYGGVGL
GKTHLMHAIGHYVLSHQPNYRVVYISSEKFTNEFINAIRDNKTVNFRNKYRNVDILLVDDIQFLAGKEQTQEEFFHTFNT
LHENDKQIIISSDRPPKEIPTLEDRLRSRFEWGLITDIQAPDLETRIAILRKKAYLEKLDIPNDVIVYIANQIDTNIREL
EGGLIRVIAYSSMANKKITKETAEEALKDILPNKQPKKMTVEHIQKTVAQYFGLKVDDLKAKKRTRSVAFPRQIAMYLAR
ELTDSSLPKIGDEFGGRDHTTVMHAHDKIASDLKKESHLNETIDEIKNLLHGD
>Mature_452_residues
SENMEELWSKTLEELKQQLSKPSFETWFQSTEPVEMSSTDLYISVPNEFTKDWLNSRYKNSIENSLKKISGKQLKIKFLL
PGEKIKMEEQNNENEEKPESTSKKSSQGSEHTTWLNPKYTFDTFVIGNANRFAHAASLAVAEAPAKAYNPLFIYGGVGLG
KTHLMHAIGHYVLSHQPNYRVVYISSEKFTNEFINAIRDNKTVNFRNKYRNVDILLVDDIQFLAGKEQTQEEFFHTFNTL
HENDKQIIISSDRPPKEIPTLEDRLRSRFEWGLITDIQAPDLETRIAILRKKAYLEKLDIPNDVIVYIANQIDTNIRELE
GGLIRVIAYSSMANKKITKETAEEALKDILPNKQPKKMTVEHIQKTVAQYFGLKVDDLKAKKRTRSVAFPRQIAMYLARE
LTDSSLPKIGDEFGGRDHTTVMHAHDKIASDLKKESHLNETIDEIKNLLHGD

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family

Homologues:

Organism=Escherichia coli, GI2367267, Length=451, Percent_Identity=45.2328159645233, Blast_Score=397, Evalue=1e-112,
Organism=Escherichia coli, GI226510964, Length=229, Percent_Identity=26.6375545851528, Blast_Score=75, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAA_NATTJ (B2A2Y6)

Other databases:

- EMBL:   CP001034
- RefSeq:   YP_001916188.1
- ProteinModelPortal:   B2A2Y6
- GeneID:   6315755
- GenomeReviews:   CP001034_GR
- KEGG:   nth:Nther_0001
- HOGENOM:   HBG695666
- OMA:   CHTLNAL
- GO:   GO:0005737
- HAMAP:   MF_00377
- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1750.10
- PRINTS:   PR00051
- SMART:   SM00382
- SMART:   SM00760
- TIGRFAMs:   TIGR00362

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 52092; Mature: 51961

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSENMEELWSKTLEELKQQLSKPSFETWFQSTEPVEMSSTDLYISVPNEFTKDWLNSRYK
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCEECCCEEEEECCCHHHHHHHHHHHH
NSIENSLKKISGKQLKIKFLLPGEKIKMEEQNNENEEKPESTSKKSSQGSEHTTWLNPKY
HHHHHHHHHCCCCEEEEEEEECCCEEEECCCCCCCCCCCCHHHHHCCCCCCCCEECCCCE
TFDTFVIGNANRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHLMHAIGHYVLSHQPNY
EEEEEEEECCHHHHHHHHHHHHHCCHHHCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCE
RVVYISSEKFTNEFINAIRDNKTVNFRNKYRNVDILLVDDIQFLAGKEQTQEEFFHTFNT
EEEEEECHHHHHHHHHHHHCCCCEEEHHHHCCEEEEEECCHHHHHCCHHHHHHHHHHHHH
LHENDKQIIISSDRPPKEIPTLEDRLRSRFEWGLITDIQAPDLETRIAILRKKAYLEKLD
HCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHCC
IPNDVIVYIANQIDTNIRELEGGLIRVIAYSSMANKKITKETAEEALKDILPNKQPKKMT
CCCCEEEEEEHHHCCHHHHHCCCEEEEEEHHHHHCHHHHHHHHHHHHHHHCCCCCCCHHH
VEHIQKTVAQYFGLKVDDLKAKKRTRSVAFPRQIAMYLARELTDSSLPKIGDEFGGRDHT
HHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHCCCCCC
TVMHAHDKIASDLKKESHLNETIDEIKNLLHGD
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SENMEELWSKTLEELKQQLSKPSFETWFQSTEPVEMSSTDLYISVPNEFTKDWLNSRYK
CCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCEECCCEEEEECCCHHHHHHHHHHHH
NSIENSLKKISGKQLKIKFLLPGEKIKMEEQNNENEEKPESTSKKSSQGSEHTTWLNPKY
HHHHHHHHHCCCCEEEEEEEECCCEEEECCCCCCCCCCCCHHHHHCCCCCCCCEECCCCE
TFDTFVIGNANRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHLMHAIGHYVLSHQPNY
EEEEEEEECCHHHHHHHHHHHHHCCHHHCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCE
RVVYISSEKFTNEFINAIRDNKTVNFRNKYRNVDILLVDDIQFLAGKEQTQEEFFHTFNT
EEEEEECHHHHHHHHHHHHCCCCEEEHHHHCCEEEEEECCHHHHHCCHHHHHHHHHHHHH
LHENDKQIIISSDRPPKEIPTLEDRLRSRFEWGLITDIQAPDLETRIAILRKKAYLEKLD
HCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHCC
IPNDVIVYIANQIDTNIRELEGGLIRVIAYSSMANKKITKETAEEALKDILPNKQPKKMT
CCCCEEEEEEHHHCCHHHHHCCCEEEEEEHHHHHCHHHHHHHHHHHHHHHCCCCCCCHHH
VEHIQKTVAQYFGLKVDDLKAKKRTRSVAFPRQIAMYLARELTDSSLPKIGDEFGGRDHT
HHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHCCCCCC
TVMHAHDKIASDLKKESHLNETIDEIKNLLHGD
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA