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The map label for this gene is adk

Identifier: 188527534

GI number: 188527534

Start: 727240

End: 727815

Strand: Reverse

Name: adk

Synonym: HPSH_03780

Alternate gene names: 188527534

Gene position: 727815-727240 (Counterclockwise)

Preceding gene: 188527535

Following gene: 188527533

Centisome position: 45.25

GC content: 40.62

Gene sequence:

>576_bases
ATGAAACAACTATTTTTGATTATTGGAGCCCCAGGGAGTGGTAAAACCACTGATGCAGAGCTTATCGCTAAGAATAACAG
CGAAAAAATCGCTCATTTTTCTACCGGGGATTTACTAAGGGCTGAGAGCGCTAAAAAGACCGAGCGAGGCTTATTGATTG
AGAAATTCACTTCTCAAGGCGAATTAGTGCCTTTAGAAATTGTGGTAGAAACGATCCTTTCAGCGATTAAAAGCTCTGAT
AAAGGGATCATTTTAATTGATGGCTATCCTAGGAGCGTGGAACAGATGCAGGCTTTGGATAAGGAATTGAGCGCTCAAAA
TGAAGTGGTTTTAAAAAGCGTGATTGAAGTGGAAGTGAGTGAAAACACCGCTAAAGAAAGGGTTTTAGGGCGCTCTAGGG
GGGCTGATGATAATGAGATGGTGTTTCATAACCGCATGCGGGTGTTTTTGGATCCGTTGGGTGAGATCCAAAATTTTTAC
AAGAATAAGAAGGTGTATAAAGCGATCAATGGCGAAAGAAGCATTGAAGAAATCGTGCATGAAATGCAAGAGTATATTTT
GTCTTTTGGGAATTAA

Upstream 100 bases:

>100_bases
AAAGCTTCATGTTTATTGACTGACGCTCCTAGCCCCATTAATGAAGAGCAACTAAGAGAATTACACATTCGCTTAAGAAA
ATAATTTGAAAGGATAAGAT

Downstream 100 bases:

>100_bases
AATGCACCACAAAGAGAATGAGCTGTGATTTGTGTCTATATCATTTCTTTAAAAGAAAGTCAAAGGCGTTTGGATACTGA
AAAACTCGTTTTAGAATCTA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 191; Mature: 191

Protein sequence:

>191_residues
MKQLFLIIGAPGSGKTTDAELIAKNNSEKIAHFSTGDLLRAESAKKTERGLLIEKFTSQGELVPLEIVVETILSAIKSSD
KGIILIDGYPRSVEQMQALDKELSAQNEVVLKSVIEVEVSENTAKERVLGRSRGADDNEMVFHNRMRVFLDPLGEIQNFY
KNKKVYKAINGERSIEEIVHEMQEYILSFGN

Sequences:

>Translated_191_residues
MKQLFLIIGAPGSGKTTDAELIAKNNSEKIAHFSTGDLLRAESAKKTERGLLIEKFTSQGELVPLEIVVETILSAIKSSD
KGIILIDGYPRSVEQMQALDKELSAQNEVVLKSVIEVEVSENTAKERVLGRSRGADDNEMVFHNRMRVFLDPLGEIQNFY
KNKKVYKAINGERSIEEIVHEMQEYILSFGN
>Mature_191_residues
MKQLFLIIGAPGSGKTTDAELIAKNNSEKIAHFSTGDLLRAESAKKTERGLLIEKFTSQGELVPLEIVVETILSAIKSSD
KGIILIDGYPRSVEQMQALDKELSAQNEVVLKSVIEVEVSENTAKERVLGRSRGADDNEMVFHNRMRVFLDPLGEIQNFY
KNKKVYKAINGERSIEEIVHEMQEYILSFGN

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI4502011, Length=190, Percent_Identity=30, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI28144899, Length=185, Percent_Identity=32.4324324324324, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI28144897, Length=185, Percent_Identity=32.4324324324324, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI7706497, Length=192, Percent_Identity=29.6875, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI4502013, Length=200, Percent_Identity=27.5, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI7524346, Length=200, Percent_Identity=27.5, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI19923437, Length=126, Percent_Identity=34.1269841269841, Blast_Score=75, Evalue=3e-14,
Organism=Escherichia coli, GI1786680, Length=140, Percent_Identity=32.1428571428571, Blast_Score=62, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17567503, Length=183, Percent_Identity=36.0655737704918, Blast_Score=101, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17533833, Length=187, Percent_Identity=28.3422459893048, Blast_Score=84, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17550688, Length=186, Percent_Identity=30.1075268817204, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17552384, Length=215, Percent_Identity=25.5813953488372, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322828, Length=190, Percent_Identity=28.9473684210526, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320432, Length=132, Percent_Identity=37.8787878787879, Blast_Score=74, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321018, Length=202, Percent_Identity=27.2277227722772, Blast_Score=73, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221459597, Length=193, Percent_Identity=27.979274611399, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21356893, Length=193, Percent_Identity=27.979274611399, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17737899, Length=161, Percent_Identity=35.4037267080745, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24645822, Length=161, Percent_Identity=35.4037267080745, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24663208, Length=191, Percent_Identity=30.3664921465969, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17647141, Length=191, Percent_Identity=30.3664921465969, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI22026816, Length=127, Percent_Identity=36.2204724409449, Blast_Score=74, Evalue=4e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000850 [H]

Pfam domain/function: PF00406 ADK [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 21370; Mature: 21370

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQLFLIIGAPGSGKTTDAELIAKNNSEKIAHFSTGDLLRAESAKKTERGLLIEKFTSQG
CCEEEEEEECCCCCCCCCHHHEECCCCCCEEEECCCCHHHHHHHHHHHHCHHHHHHCCCC
ELVPLEIVVETILSAIKSSDKGIILIDGYPRSVEQMQALDKELSAQNEVVLKSVIEVEVS
CEEHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCC
ENTAKERVLGRSRGADDNEMVFHNRMRVFLDPLGEIQNFYKNKKVYKAINGERSIEEIVH
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCHHHHHHHH
EMQEYILSFGN
HHHHHHHHCCC
>Mature Secondary Structure
MKQLFLIIGAPGSGKTTDAELIAKNNSEKIAHFSTGDLLRAESAKKTERGLLIEKFTSQG
CCEEEEEEECCCCCCCCCHHHEECCCCCCEEEECCCCHHHHHHHHHHHHCHHHHHHCCCC
ELVPLEIVVETILSAIKSSDKGIILIDGYPRSVEQMQALDKELSAQNEVVLKSVIEVEVS
CEEHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCC
ENTAKERVLGRSRGADDNEMVFHNRMRVFLDPLGEIQNFYKNKKVYKAINGERSIEEIVH
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCHHHHHHHH
EMQEYILSFGN
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA