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The map label for this gene is obgE

Identifier: 188527109

GI number: 188527109

Start: 305657

End: 306739

Strand: Direct

Name: obgE

Synonym: HPSH_01570

Alternate gene names: 188527109

Gene position: 305657-306739 (Clockwise)

Preceding gene: 188527108

Following gene: 188527110

Centisome position: 19.0

GC content: 43.86

Gene sequence:

>1083_bases
GTGTTTGTAGATAGCGTGGAAATCATCATCGCTTCGGGTAAGGGGGGGCCTGGAATGGTGAGTTTTAGGCGAGAAAAGTT
TGTCATCAAGGGAGGCCCTGATGGGGGCGATGGAGGCGATGGAGGCGATGTGTATTTTGAAGTGGATAACAATACCGACA
CTCTAGCGAGTTTTAGAGGCACTAAACACCATAAGGCTAAAAACGGGGCTCCAGGAGGCACACGAAATTGTGCGGGCAAA
AAGGGCGAAGACAAGATTATTGTTGTGCCACCAGGAACGCAAGTTTTTGTAGATGATGCTTTGTGGCTTGATTTAGTGGA
GCCTAAAGAAAGGGTGTTAGCCTTAAAAGGAGGCAAGGGGGGGTTAGGGAATGCGCATTTTAAAAGCGCGACCAAACAAC
AACCCACTTACGCGCAAAAAGGCCTAGAGGGGGTTGAAAAATGCGTGCGTTTGGAATTAAAGCTCATCGCTGATATAGGG
TTAGTGGGCTTCCCTAATGCGGGTAAATCCACGCTCATTTCCACAATCTCTAACGCTAAGCCTAAAATCGCTAATTATGA
ATTCACGACTCTAGTGCCTAATTTAGGGGTTGTGAGCGTAGATGAAAAAAGCGAATTTCTAATGGCTGATATTCCTGGCA
TCATTGAAGGGGCTAGTGAGGGAAAAGGCTTAGGGATTAGCTTTTTAAAGCATATTGAGCGCACCAAAGTTTTAGCCTTT
GTTTTAGACGCTTCTAGGCTGGATTTGGGTATTAAAGAGCAATACCAACGCTTGAGATTGGAGTTGGAAAAATTTTCACC
CGCTTTGGCCAATAAGCCTTTTGGGGTGTTGCTCAATAAATGCGATGTTGTAGAAAACATTGATGAGATGGCTAAGGATT
TTTGCACCTTTTTAAACTTAGAAGCGCAAAAATTAGAGGCGTTTGGTTTGGAGCCGTATTTAGGATTTTTACACCCCCAT
TTAACTAGCGATTTTGAAAATAACCCTAATGAAAAATCAGCGCTCTTTGTCTTACCCCTTTCAGCGCTTAGCGCTCTTAA
TACGCATGCACTTAAATTTGTGTTGTTGGAAGCGTTACCATAA

Upstream 100 bases:

>100_bases
GCCCCCAAGCACCCTTATACGCAGAAATTACTCAATGCGGTGCCGCATTTAGAAAAATCCATGCAAAGATTTGCTGAATA
AAAGAAAGGACTTTTAAGCT

Downstream 100 bases:

>100_bases
AACGCTATTTTTAGATCAATCCATTAAAATAAAGGCGAGAAATGAAAAGATTTGTTTTGTTTTTATTGTTCATGGGTGTT
TGCGTTTGCGTTCAAGCTCA

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg [H]

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MFVDSVEIIIASGKGGPGMVSFRREKFVIKGGPDGGDGGDGGDVYFEVDNNTDTLASFRGTKHHKAKNGAPGGTRNCAGK
KGEDKIIVVPPGTQVFVDDALWLDLVEPKERVLALKGGKGGLGNAHFKSATKQQPTYAQKGLEGVEKCVRLELKLIADIG
LVGFPNAGKSTLISTISNAKPKIANYEFTTLVPNLGVVSVDEKSEFLMADIPGIIEGASEGKGLGISFLKHIERTKVLAF
VLDASRLDLGIKEQYQRLRLELEKFSPALANKPFGVLLNKCDVVENIDEMAKDFCTFLNLEAQKLEAFGLEPYLGFLHPH
LTSDFENNPNEKSALFVLPLSALSALNTHALKFVLLEALP

Sequences:

>Translated_360_residues
MFVDSVEIIIASGKGGPGMVSFRREKFVIKGGPDGGDGGDGGDVYFEVDNNTDTLASFRGTKHHKAKNGAPGGTRNCAGK
KGEDKIIVVPPGTQVFVDDALWLDLVEPKERVLALKGGKGGLGNAHFKSATKQQPTYAQKGLEGVEKCVRLELKLIADIG
LVGFPNAGKSTLISTISNAKPKIANYEFTTLVPNLGVVSVDEKSEFLMADIPGIIEGASEGKGLGISFLKHIERTKVLAF
VLDASRLDLGIKEQYQRLRLELEKFSPALANKPFGVLLNKCDVVENIDEMAKDFCTFLNLEAQKLEAFGLEPYLGFLHPH
LTSDFENNPNEKSALFVLPLSALSALNTHALKFVLLEALP
>Mature_360_residues
MFVDSVEIIIASGKGGPGMVSFRREKFVIKGGPDGGDGGDGGDVYFEVDNNTDTLASFRGTKHHKAKNGAPGGTRNCAGK
KGEDKIIVVPPGTQVFVDDALWLDLVEPKERVLALKGGKGGLGNAHFKSATKQQPTYAQKGLEGVEKCVRLELKLIADIG
LVGFPNAGKSTLISTISNAKPKIANYEFTTLVPNLGVVSVDEKSEFLMADIPGIIEGASEGKGLGISFLKHIERTKVLAF
VLDASRLDLGIKEQYQRLRLELEKFSPALANKPFGVLLNKCDVVENIDEMAKDFCTFLNLEAQKLEAFGLEPYLGFLHPH
LTSDFENNPNEKSALFVLPLSALSALNTHALKFVLLEALP

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain [H]

Homologues:

Organism=Homo sapiens, GI24308117, Length=284, Percent_Identity=40.4929577464789, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI111955139, Length=354, Percent_Identity=35.3107344632768, Blast_Score=148, Evalue=7e-36,
Organism=Homo sapiens, GI111955063, Length=210, Percent_Identity=36.6666666666667, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI4758796, Length=126, Percent_Identity=38.8888888888889, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI4557537, Length=120, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789574, Length=306, Percent_Identity=48.0392156862745, Blast_Score=231, Evalue=4e-62,
Organism=Escherichia coli, GI1787454, Length=99, Percent_Identity=37.3737373737374, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17508313, Length=321, Percent_Identity=41.1214953271028, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17552324, Length=330, Percent_Identity=32.1212121212121, Blast_Score=121, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI71981008, Length=117, Percent_Identity=39.3162393162393, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17555344, Length=118, Percent_Identity=37.2881355932203, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6321962, Length=201, Percent_Identity=44.2786069651741, Blast_Score=132, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6321612, Length=124, Percent_Identity=38.7096774193548, Blast_Score=73, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6319281, Length=125, Percent_Identity=35.2, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI20129375, Length=295, Percent_Identity=40.6779661016949, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24585318, Length=368, Percent_Identity=32.8804347826087, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI21356473, Length=90, Percent_Identity=40, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17981711, Length=126, Percent_Identity=37.3015873015873, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917 [H]

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 38808; Mature: 38808

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVDSVEIIIASGKGGPGMVSFRREKFVIKGGPDGGDGGDGGDVYFEVDNNTDTLASFRG
CCCCCEEEEEEECCCCCCCEEEECEEEEEECCCCCCCCCCCCEEEEEECCCCCHHHHHCC
TKHHKAKNGAPGGTRNCAGKKGEDKIIVVPPGTQVFVDDALWLDLVEPKERVLALKGGKG
CCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEECCCEEEEECCCCCEEEEEECCCC
GLGNAHFKSATKQQPTYAQKGLEGVEKCVRLELKLIADIGLVGFPNAGKSTLISTISNAK
CCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHCCC
PKIANYEFTTLVPNLGVVSVDEKSEFLMADIPGIIEGASEGKGLGISFLKHIERTKVLAF
CCCCCEEEEEECCCCCEEEECCCCCEEEECCCHHHCCCCCCCCCCHHHHHHHHHHHHHHE
VLDASRLDLGIKEQYQRLRLELEKFSPALANKPFGVLLNKCDVVENIDEMAKDFCTFLNL
EECHHHCCCCHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
EAQKLEAFGLEPYLGFLHPHLTSDFENNPNEKSALFVLPLSALSALNTHALKFVLLEALP
CHHHHHHCCCCHHHHHHCHHHCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFVDSVEIIIASGKGGPGMVSFRREKFVIKGGPDGGDGGDGGDVYFEVDNNTDTLASFRG
CCCCCEEEEEEECCCCCCCEEEECEEEEEECCCCCCCCCCCCEEEEEECCCCCHHHHHCC
TKHHKAKNGAPGGTRNCAGKKGEDKIIVVPPGTQVFVDDALWLDLVEPKERVLALKGGKG
CCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEECCCEEEEECCCCCEEEEEECCCC
GLGNAHFKSATKQQPTYAQKGLEGVEKCVRLELKLIADIGLVGFPNAGKSTLISTISNAK
CCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHCCC
PKIANYEFTTLVPNLGVVSVDEKSEFLMADIPGIIEGASEGKGLGISFLKHIERTKVLAF
CCCCCEEEEEECCCCCEEEECCCCCEEEECCCHHHCCCCCCCCCCHHHHHHHHHHHHHHE
VLDASRLDLGIKEQYQRLRLELEKFSPALANKPFGVLLNKCDVVENIDEMAKDFCTFLNL
EECHHHCCCCHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
EAQKLEAFGLEPYLGFLHPHLTSDFENNPNEKSALFVLPLSALSALNTHALKFVLLEALP
CHHHHHHCCCCHHHHHHCHHHCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA