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The map label for this gene is pabB [H]

Identifier: 188527099

GI number: 188527099

Start: 294053

End: 295732

Strand: Direct

Name: pabB [H]

Synonym: HPSH_01520

Alternate gene names: 188527099

Gene position: 294053-295732 (Clockwise)

Preceding gene: 188527098

Following gene: 188527100

Centisome position: 18.28

GC content: 36.55

Gene sequence:

>1680_bases
ATGATTTTTGGGGATTTTAAATATCAAAAAAGGATTAAAAAACTCACCGCCACCAATCTTAATGAGCTGAAAAACGCCCT
GGATTTCATCTCTCAAAATAGGGGGAATGGGTATTTTGTGGGGTATCTTTTATACGAAGCGCGCTTAGCGTTTTTAGATG
AAAATTTTCAAAGTCAAACCCCTTTTTTATATTTTGAACAATTTTTAGAAAGAAAAAAATATTCTTTAGAGCCTTTAAAA
GAGCATGCGTTTTACCCCAAAATCCACAGCTCTTTAGATCAAAAAACTTATTTCAAGCAGTTCAAAGCCGTTAAAGAATA
TCTCAAAAACGGCGATACCTATCAAGTGAATCTCACGATGGATTTATTTTTAGACACTAAAGCCAAACTGAAGCGCGTTT
TTAAGGAGGTGATACACAACCAAAACACGCCCTTTAAGGCTTTTATAGAAAATGAGTTTGGGAGCGTTTTAAGTTTTTCG
CCGGAATTGTTTTTTGAATTAGAGTTTTTAGACACAGCGATTAAGATTGTTACAAAACCCATGAAAGGCACGATCGCTCG
CTCAAATAACCCCTTAATAGATGAAAAAAACCGATTGTTTTTGCAAAATGATGACAAAAATAGAAGTGAAAATGTGATGA
TTGTGGATTTACTGCGTAACGATTTGAGCCGCTTGGCCTTAAAAAATAGCGTGAAAGTCAATCAATTGTTTGAAATCATC
AGCTTGCCTAGCGTGTATCAAATGATAAGCGAGATTGAAGCGAAATTGCCCCTAAAAACCAGCTTGTTTGAGATTTTTAA
GGCGTTGTTCCCTTGCGGATCTGTGACCGGATGCCCTAAAATAAAAACCATGCAAATCATTGAAAGTTTAGAAAAACGCC
CTAGGGGGGTGTATTGCGGAGCGATAGGCATGGTTGAAGAAAAAAAAGCCCTTTTTAGCGTGCCTATCCGCACTTTAGAA
AAAAGAGCGCGCGAAGATTTTTTGCATTTAGGGGTAGGGAGTGGGGTAACTTATAAAAGTAAAGCGCCCAAAGAATATGA
AGAGAGCTTTTTAAAATCCTTTTTTGTGATGCCCAAAATAGAATTTGAGATTGTAGAAACGATGAAAATTATCAAAAAGG
ATCAAAAATTAGAGATTAACAATAAAAACGCCCATAAAGAACGCTTAATGAATAGCGCCCAATATTTCAATTTCAAACAT
GATGAAAATCTTTTAGACTTTGAATTAGAAAAAGAAGGGGTTTTAAGGGTTTTACTCAATAAAAAGGGCAAGCTCATTAA
AGAATACAAAGCCTTAGAGCCTTTAAAAAGCCTAGAAATTCGTTTGAGTGAAGCCCCCATTGATAAGCGCAATGATTTTT
TATACCATAAGACCACCTATGCCCCTTTTTATCAAAACGCTCGAGCGCTCATTAAAAAAGGCGTTATTTTTGATGAAATC
TTTTATAACCAGGATCTAGAACTCACTGAGGGCGCTAGGAGCAATCTCATTTTAGAAATCCATAACAGGCTTTTAACCCC
TTATTTTAGTGCGGGCGCGTTAAACGGGACGGGTGTGATGGGATTGTTAAAAAAGAGTCTTGTTGAGCATGCCCCTTTAA
AATTGCAAGACTTGCAAAGAGCGGATAAAATCTATTGCATCAATGCGCTATATGGCTTAGTGGAAGTGAAAATCAAATAA

Upstream 100 bases:

>100_bases
CAGAGAAGAAGATCTAGGATTGGAGGGTTTGAGAAGGTCTAAAATGAGCTATAACCCGGTGTTTTTGATAGACAAATACG
AAGCTGTTGCTAAAAATTAA

Downstream 100 bases:

>100_bases
CCATAAAATAGAGCGGCTAAAACCTCATTTTTTAGAAATAGGCTACTACAAAAAAGTTAAAACTCGCCCACAATAATCAT
AATGATTAAAGTTTTCATAT

Product: para-aminobenzoate synthetase (pabB)

Products: NA

Alternate protein names: ADC synthase; Para-aminobenzoate synthase component I [H]

Number of amino acids: Translated: 559; Mature: 559

Protein sequence:

>559_residues
MIFGDFKYQKRIKKLTATNLNELKNALDFISQNRGNGYFVGYLLYEARLAFLDENFQSQTPFLYFEQFLERKKYSLEPLK
EHAFYPKIHSSLDQKTYFKQFKAVKEYLKNGDTYQVNLTMDLFLDTKAKLKRVFKEVIHNQNTPFKAFIENEFGSVLSFS
PELFFELEFLDTAIKIVTKPMKGTIARSNNPLIDEKNRLFLQNDDKNRSENVMIVDLLRNDLSRLALKNSVKVNQLFEII
SLPSVYQMISEIEAKLPLKTSLFEIFKALFPCGSVTGCPKIKTMQIIESLEKRPRGVYCGAIGMVEEKKALFSVPIRTLE
KRAREDFLHLGVGSGVTYKSKAPKEYEESFLKSFFVMPKIEFEIVETMKIIKKDQKLEINNKNAHKERLMNSAQYFNFKH
DENLLDFELEKEGVLRVLLNKKGKLIKEYKALEPLKSLEIRLSEAPIDKRNDFLYHKTTYAPFYQNARALIKKGVIFDEI
FYNQDLELTEGARSNLILEIHNRLLTPYFSAGALNGTGVMGLLKKSLVEHAPLKLQDLQRADKIYCINALYGLVEVKIK

Sequences:

>Translated_559_residues
MIFGDFKYQKRIKKLTATNLNELKNALDFISQNRGNGYFVGYLLYEARLAFLDENFQSQTPFLYFEQFLERKKYSLEPLK
EHAFYPKIHSSLDQKTYFKQFKAVKEYLKNGDTYQVNLTMDLFLDTKAKLKRVFKEVIHNQNTPFKAFIENEFGSVLSFS
PELFFELEFLDTAIKIVTKPMKGTIARSNNPLIDEKNRLFLQNDDKNRSENVMIVDLLRNDLSRLALKNSVKVNQLFEII
SLPSVYQMISEIEAKLPLKTSLFEIFKALFPCGSVTGCPKIKTMQIIESLEKRPRGVYCGAIGMVEEKKALFSVPIRTLE
KRAREDFLHLGVGSGVTYKSKAPKEYEESFLKSFFVMPKIEFEIVETMKIIKKDQKLEINNKNAHKERLMNSAQYFNFKH
DENLLDFELEKEGVLRVLLNKKGKLIKEYKALEPLKSLEIRLSEAPIDKRNDFLYHKTTYAPFYQNARALIKKGVIFDEI
FYNQDLELTEGARSNLILEIHNRLLTPYFSAGALNGTGVMGLLKKSLVEHAPLKLQDLQRADKIYCINALYGLVEVKIK
>Mature_559_residues
MIFGDFKYQKRIKKLTATNLNELKNALDFISQNRGNGYFVGYLLYEARLAFLDENFQSQTPFLYFEQFLERKKYSLEPLK
EHAFYPKIHSSLDQKTYFKQFKAVKEYLKNGDTYQVNLTMDLFLDTKAKLKRVFKEVIHNQNTPFKAFIENEFGSVLSFS
PELFFELEFLDTAIKIVTKPMKGTIARSNNPLIDEKNRLFLQNDDKNRSENVMIVDLLRNDLSRLALKNSVKVNQLFEII
SLPSVYQMISEIEAKLPLKTSLFEIFKALFPCGSVTGCPKIKTMQIIESLEKRPRGVYCGAIGMVEEKKALFSVPIRTLE
KRAREDFLHLGVGSGVTYKSKAPKEYEESFLKSFFVMPKIEFEIVETMKIIKKDQKLEINNKNAHKERLMNSAQYFNFKH
DENLLDFELEKEGVLRVLLNKKGKLIKEYKALEPLKSLEIRLSEAPIDKRNDFLYHKTTYAPFYQNARALIKKGVIFDEI
FYNQDLELTEGARSNLILEIHNRLLTPYFSAGALNGTGVMGLLKKSLVEHAPLKLQDLQRADKIYCINALYGLVEVKIK

Specific function: Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine [H]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1788114, Length=295, Percent_Identity=35.5932203389831, Blast_Score=191, Evalue=9e-50,
Organism=Escherichia coli, GI1787518, Length=266, Percent_Identity=25.5639097744361, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6320935, Length=265, Percent_Identity=27.1698113207547, Blast_Score=117, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6324361, Length=289, Percent_Identity=28.0276816608997, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR015890
- InterPro:   IPR005802 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =2.6.1.85 [H]

Molecular weight: Translated: 64907; Mature: 64907

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFGDFKYQKRIKKLTATNLNELKNALDFISQNRGNGYFVGYLLYEARLAFLDENFQSQT
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHCCCCCCC
PFLYFEQFLERKKYSLEPLKEHAFYPKIHSSLDQKTYFKQFKAVKEYLKNGDTYQVNLTM
CHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEE
DLFLDTKAKLKRVFKEVIHNQNTPFKAFIENEFGSVLSFSPELFFELEFLDTAIKIVTKP
EEEECCHHHHHHHHHHHHCCCCCCEEEHHHHHCCHHHCCCHHHEEEHHHHHHHHHHHHCC
MKGTIARSNNPLIDEKNRLFLQNDDKNRSENVMIVDLLRNDLSRLALKNSVKVNQLFEII
CCCCEECCCCCCCCCCCEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHCCCCHHHHHHHH
SLPSVYQMISEIEAKLPLKTSLFEIFKALFPCGSVTGCPKIKTMQIIESLEKRPRGVYCG
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEE
AIGMVEEKKALFSVPIRTLEKRAREDFLHLGVGSGVTYKSKAPKEYEESFLKSFFVMPKI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCH
EFEIVETMKIIKKDQKLEINNKNAHKERLMNSAQYFNFKHDENLLDFELEKEGVLRVLLN
HHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHC
KKGKLIKEYKALEPLKSLEIRLSEAPIDKRNDFLYHKTTYAPFYQNARALIKKGVIFDEI
CCCHHHHHHHHHCCHHHHHEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCHHHHH
FYNQDLELTEGARSNLILEIHNRLLTPYFSAGALNGTGVMGLLKKSLVEHAPLKLQDLQR
HCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHH
ADKIYCINALYGLVEVKIK
CCCEEEHHHHHCEEEEEEC
>Mature Secondary Structure
MIFGDFKYQKRIKKLTATNLNELKNALDFISQNRGNGYFVGYLLYEARLAFLDENFQSQT
CCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHCCCCCCC
PFLYFEQFLERKKYSLEPLKEHAFYPKIHSSLDQKTYFKQFKAVKEYLKNGDTYQVNLTM
CHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEE
DLFLDTKAKLKRVFKEVIHNQNTPFKAFIENEFGSVLSFSPELFFELEFLDTAIKIVTKP
EEEECCHHHHHHHHHHHHCCCCCCEEEHHHHHCCHHHCCCHHHEEEHHHHHHHHHHHHCC
MKGTIARSNNPLIDEKNRLFLQNDDKNRSENVMIVDLLRNDLSRLALKNSVKVNQLFEII
CCCCEECCCCCCCCCCCEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHCCCCHHHHHHHH
SLPSVYQMISEIEAKLPLKTSLFEIFKALFPCGSVTGCPKIKTMQIIESLEKRPRGVYCG
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEE
AIGMVEEKKALFSVPIRTLEKRAREDFLHLGVGSGVTYKSKAPKEYEESFLKSFFVMPKI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCH
EFEIVETMKIIKKDQKLEINNKNAHKERLMNSAQYFNFKHDENLLDFELEKEGVLRVLLN
HHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHC
KKGKLIKEYKALEPLKSLEIRLSEAPIDKRNDFLYHKTTYAPFYQNARALIKKGVIFDEI
CCCHHHHHHHHHCCHHHHHEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCHHHHH
FYNQDLELTEGARSNLILEIHNRLLTPYFSAGALNGTGVMGLLKKSLVEHAPLKLQDLQR
HCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHH
ADKIYCINALYGLVEVKIK
CCCEEEHHHHHCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6330050; 9097040; 9278503; 7896119; 2251281; 7592344 [H]