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The map label for this gene is lysA [H]

Identifier: 188527096

GI number: 188527096

Start: 291655

End: 292872

Strand: Direct

Name: lysA [H]

Synonym: HPSH_01505

Alternate gene names: 188527096

Gene position: 291655-292872 (Clockwise)

Preceding gene: 188527095

Following gene: 188527097

Centisome position: 18.13

GC content: 41.05

Gene sequence:

>1218_bases
ATGTTTAATTATGAAGAGCTGTTTCAAACTCACAAAACCCCTTTTTACCTCTATGATTTTGACAAAATCAAACAGGCTTT
TTTGAATTATAAAGAAGCGTTTAAGGGGCGTAAGTCTTTGATTTGTTACGCTTTAAAGGCGAATTCCAATTTGAGTATCC
TCTCTTTATTAGCCCATTTAGAGAGCGGGGCAGATTGCGTTTCCATAGGCGAGATATATAGGGCTTTAAAAGCCGGGATC
AAGCCTTATAGGATCGTGTTTAGCGGGGTGGGTAAGAGCGAATTTGAAATAGAGCAAGCCCTAAAACTCAACATTTTATT
TTTGAATGTAGAAAGTTTTATGGAATTGCAAACGATTGAAAAAATCGCCCAATCTTTAGGGATAAAGGCTAGGATCTCTA
TTAGGATCAACCCCAACATTGACGCTAAAACGCACCCCTATATTTCTACCGGTTTGAAAGAAAATAAGTTTGGCGTGGGA
GAAAAAGAAGCTTTAGAAATGTTTCTTTGGGCTAAAAAAAGCGCGTTTTTGGAGCCTATTAGCGTGCATTTTCATATCGG
CTCACAGCTATTAGATTTAGAGCCGATTATAGAAGCGAGCCAAAAGGTGGCTAAAATCGCTAAATCTTTGATAGCGCTAG
GGATAGATTTGCGTTTTTTTGATGTGGGTGGAGGGATTGGCGTGAGCTATGAAAATGAAGAGACTATCAAGCTTTATGAT
TACGCGCAAAGGATCTTAAACGCGCTTCAAGGCTTGGATTTGACGATCATTTGTGAGCCGGGCCGATCCATCGTGGCTGA
GAGTGGGGAATTGATCACGCAGGTTTTATATGAAAAAAAGGCTCAAAACAAGCGTTTTGTGATTGTGGATGCGGGCATGA
ATGATTTTTTACGCCCCAGTTTGTATCATGCTAAGCATGCCATAAGGGTTATAACGCCTTCTAAGGGGCGTAAGATCTCG
CCTTGTGATGTGGTAGGGCCTGTGTGTGAGAGCAGCGACACTTTTTTAAAAGGTGTGAATTTGCCAGAATTAGAGCCAGG
CGATAAATTAGTCATAGAAAAGGTTGGGGCTTATGGCTCTAGCATGGCCAGTCAATACAATTCACGCCCCAAACTCTTAG
AATTAGCCCTAGAAGATCACCAAATCAGGGTGATAAGAAAAAGAGAGGCTTTAGAAGATTTATGGCGGTTAGAAGAAGAA
GGCTTAAAAGGGGTTTGA

Upstream 100 bases:

>100_bases
AATACCAAGACATTAATATAACCGGGAATGTGGGCATGCGAGTGGCGTTTTAGCTTTTTTGCTATAATGCTTCGTTCAAA
TTTTATAGTTAGGTTTTTCT

Downstream 100 bases:

>100_bases
CCAGATGCAAAAGAATTTGGATAGTCTTTTAGAAAATTTAAGGGCTGAAATTGATGTGTTGGATAATGAATTGAGCGATC
TTTTAGACAAACGCTTAGAA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MFNYEELFQTHKTPFYLYDFDKIKQAFLNYKEAFKGRKSLICYALKANSNLSILSLLAHLESGADCVSIGEIYRALKAGI
KPYRIVFSGVGKSEFEIEQALKLNILFLNVESFMELQTIEKIAQSLGIKARISIRINPNIDAKTHPYISTGLKENKFGVG
EKEALEMFLWAKKSAFLEPISVHFHIGSQLLDLEPIIEASQKVAKIAKSLIALGIDLRFFDVGGGIGVSYENEETIKLYD
YAQRILNALQGLDLTIICEPGRSIVAESGELITQVLYEKKAQNKRFVIVDAGMNDFLRPSLYHAKHAIRVITPSKGRKIS
PCDVVGPVCESSDTFLKGVNLPELEPGDKLVIEKVGAYGSSMASQYNSRPKLLELALEDHQIRVIRKREALEDLWRLEEE
GLKGV

Sequences:

>Translated_405_residues
MFNYEELFQTHKTPFYLYDFDKIKQAFLNYKEAFKGRKSLICYALKANSNLSILSLLAHLESGADCVSIGEIYRALKAGI
KPYRIVFSGVGKSEFEIEQALKLNILFLNVESFMELQTIEKIAQSLGIKARISIRINPNIDAKTHPYISTGLKENKFGVG
EKEALEMFLWAKKSAFLEPISVHFHIGSQLLDLEPIIEASQKVAKIAKSLIALGIDLRFFDVGGGIGVSYENEETIKLYD
YAQRILNALQGLDLTIICEPGRSIVAESGELITQVLYEKKAQNKRFVIVDAGMNDFLRPSLYHAKHAIRVITPSKGRKIS
PCDVVGPVCESSDTFLKGVNLPELEPGDKLVIEKVGAYGSSMASQYNSRPKLLELALEDHQIRVIRKREALEDLWRLEEE
GLKGV
>Mature_405_residues
MFNYEELFQTHKTPFYLYDFDKIKQAFLNYKEAFKGRKSLICYALKANSNLSILSLLAHLESGADCVSIGEIYRALKAGI
KPYRIVFSGVGKSEFEIEQALKLNILFLNVESFMELQTIEKIAQSLGIKARISIRINPNIDAKTHPYISTGLKENKFGVG
EKEALEMFLWAKKSAFLEPISVHFHIGSQLLDLEPIIEASQKVAKIAKSLIALGIDLRFFDVGGGIGVSYENEETIKLYD
YAQRILNALQGLDLTIICEPGRSIVAESGELITQVLYEKKAQNKRFVIVDAGMNDFLRPSLYHAKHAIRVITPSKGRKIS
PCDVVGPVCESSDTFLKGVNLPELEPGDKLVIEKVGAYGSSMASQYNSRPKLLELALEDHQIRVIRKREALEDLWRLEEE
GLKGV

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=388, Percent_Identity=24.7422680412371, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI16506287, Length=344, Percent_Identity=26.1627906976744, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI22538418, Length=423, Percent_Identity=23.6406619385343, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI21361583, Length=423, Percent_Identity=23.6406619385343, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1789203, Length=401, Percent_Identity=32.4189526184539, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1789307, Length=277, Percent_Identity=25.9927797833935, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562780, Length=385, Percent_Identity=23.3766233766234, Blast_Score=89, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6322664, Length=394, Percent_Identity=26.9035532994924, Blast_Score=100, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24586472, Length=337, Percent_Identity=24.3323442136499, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24586474, Length=338, Percent_Identity=23.6686390532544, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45450; Mature: 45450

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNYEELFQTHKTPFYLYDFDKIKQAFLNYKEAFKGRKSLICYALKANSNLSILSLLAHL
CCCHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHH
ESGADCVSIGEIYRALKAGIKPYRIVFSGVGKSEFEIEQALKLNILFLNVESFMELQTIE
HCCCCEEHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHEEEEEEEEEHHHHHHHHHHH
KIAQSLGIKARISIRINPNIDAKTHPYISTGLKENKFGVGEKEALEMFLWAKKSAFLEPI
HHHHHCCCEEEEEEEECCCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEE
SVHFHIGSQLLDLEPIIEASQKVAKIAKSLIALGIDLRFFDVGGGIGVSYENEETIKLYD
EEEEEECCHHHCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCHHHH
YAQRILNALQGLDLTIICEPGRSIVAESGELITQVLYEKKAQNKRFVIVDAGMNDFLRPS
HHHHHHHHHCCCCEEEEECCCCHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHCHH
LYHAKHAIRVITPSKGRKISPCDVVGPVCESSDTFLKGVNLPELEPGDKLVIEKVGAYGS
HHHHHCEEEEEECCCCCCCCCHHHHCCCCCCCCCCEECCCCCCCCCCCHHHHHHHCCCHH
SMASQYNSRPKLLELALEDHQIRVIRKREALEDLWRLEEEGLKGV
HHHHHHCCCCCEEEEECCCCCEEEHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFNYEELFQTHKTPFYLYDFDKIKQAFLNYKEAFKGRKSLICYALKANSNLSILSLLAHL
CCCHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHH
ESGADCVSIGEIYRALKAGIKPYRIVFSGVGKSEFEIEQALKLNILFLNVESFMELQTIE
HCCCCEEHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHEEEEEEEEEHHHHHHHHHHH
KIAQSLGIKARISIRINPNIDAKTHPYISTGLKENKFGVGEKEALEMFLWAKKSAFLEPI
HHHHHCCCEEEEEEEECCCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEE
SVHFHIGSQLLDLEPIIEASQKVAKIAKSLIALGIDLRFFDVGGGIGVSYENEETIKLYD
EEEEEECCHHHCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCHHHH
YAQRILNALQGLDLTIICEPGRSIVAESGELITQVLYEKKAQNKRFVIVDAGMNDFLRPS
HHHHHHHHHCCCCEEEEECCCCHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHCHH
LYHAKHAIRVITPSKGRKISPCDVVGPVCESSDTFLKGVNLPELEPGDKLVIEKVGAYGS
HHHHHCEEEEEECCCCCCCCCHHHHCCCCCCCCCCEECCCCCCCCCCCHHHHHHHCCCHH
SMASQYNSRPKLLELALEDHQIRVIRKREALEDLWRLEEEGLKGV
HHHHHHCCCCCEEEEECCCCCEEEHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]