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The map label for this gene is iscS [H]

Identifier: 188527025

GI number: 188527025

Start: 213286

End: 214449

Strand: Direct

Name: iscS [H]

Synonym: HPSH_01140

Alternate gene names: 188527025

Gene position: 213286-214449 (Clockwise)

Preceding gene: 188527024

Following gene: 188527026

Centisome position: 13.26

GC content: 44.76

Gene sequence:

>1164_bases
TTGTTACAACGAATTTATTTAGACAATAACGCTACAACTAGGATTGATCCTAAAGTCAAAGAGATCATGGATCCGTTTTT
AAGGGATCATTACGGGAATCCTAGCTCGTTGCACCAGTTTGGCACAGAAACCCACCCAGCCATTGCAGAAGCGCTAGACA
AGCTTTATAAGGGCATTAACGCTAGGGATATAGATGACGTGATCATCACTTCTTGCGCGACAGAAAGCAATAATTGGGTT
TTAAAGGGCGTGTATTTTGATGAATGCTTGAAAAAAGGCAAAAACCATATTGTAACCACGGTTACAGAGCATCCGGCGGT
GCGATCCACTTGCAATTTTTTAGAAAGCTTGGGGGTGGAAGTTACTTACTTGCCCATTAATGAGCATGGGAGTATCACCG
CAGAGCAAGTCAAAGAAGCGATCACAGAAAAAACCGCTTTAGTGAGCGTGATGTGGGCGAATAATGAAACCGGTCTCATT
TTCCCTATTGAAGAAATTGGGGCTATTTGTAAAGAAAAGGGCGTGTTGTTCCATACCGATGCGGTGCAAGCGATTGGTAA
GATCCCTGTAGATGTGTTAAAAGCGAATGTGGATTTCCTTTCTTTTAGCGCGCACAAGTTTCATGGGCCTAAAGGCATTG
GGGGGTTGTATATTAGAAGTGGGGTGGGATTGACCCCTCTTTTTCATGGCGGGGAACATATGAATGGCAGGCGTAGCGGG
ACTTTGAATGTGCCTTATATCGTGGGCATGGGCGAAGCGATGAAATTAGCCGTAGAGCATTTAGACTATGAAAAAGAAGT
GGTAGGGAAATTGCGCGACAAATTAGAAGAAGCGCTTTTGAAAATCCCTGATGTGATGGTGGTGGGGGATCGAATCCATC
GTGTGCCTAACACGACTTTAATCAGCGTGAGAGGGATTGAAGGAGAGGCCATGCTGTGGGATTTGAATCGCTCTAATATC
GCCGCTTCCACAGGGAGCGCGTGCGCGAGTGAGGATTTAGAGGCTAATCCTGTCATGGTGGCGATTGGAGCGAGTAAGGA
ATTAGCTCATACCGCTATCAGGCTTTCATTGAGCCGTTTTAACACGGAAGCTGAAATTGATAAAACGATTGAAGTTTTCT
CTCAAGCGGCTACAAGGTTGAGAAACATTTCAAGTTCTTATTAA

Upstream 100 bases:

>100_bases
CATCTTATTTTAAGTTAAAATTAAGAAAATATCTTGTATTTAATCATAATTTAGACCTAGATAAGAAAATCTATGTAAAG
TTTTTAAGGAGAACACTCAT

Downstream 100 bases:

>100_bases
AAAGGATATAAAGGAATCAAAATGGCAAAACATGATTTAGTGGGATCAGCCCTTTGGGACGCGTATTCTAAAGAAGTTCA
AAGGCGCATGGATAACCCTA

Product: cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MLQRIYLDNNATTRIDPKVKEIMDPFLRDHYGNPSSLHQFGTETHPAIAEALDKLYKGINARDIDDVIITSCATESNNWV
LKGVYFDECLKKGKNHIVTTVTEHPAVRSTCNFLESLGVEVTYLPINEHGSITAEQVKEAITEKTALVSVMWANNETGLI
FPIEEIGAICKEKGVLFHTDAVQAIGKIPVDVLKANVDFLSFSAHKFHGPKGIGGLYIRSGVGLTPLFHGGEHMNGRRSG
TLNVPYIVGMGEAMKLAVEHLDYEKEVVGKLRDKLEEALLKIPDVMVVGDRIHRVPNTTLISVRGIEGEAMLWDLNRSNI
AASTGSACASEDLEANPVMVAIGASKELAHTAIRLSLSRFNTEAEIDKTIEVFSQAATRLRNISSSY

Sequences:

>Translated_387_residues
MLQRIYLDNNATTRIDPKVKEIMDPFLRDHYGNPSSLHQFGTETHPAIAEALDKLYKGINARDIDDVIITSCATESNNWV
LKGVYFDECLKKGKNHIVTTVTEHPAVRSTCNFLESLGVEVTYLPINEHGSITAEQVKEAITEKTALVSVMWANNETGLI
FPIEEIGAICKEKGVLFHTDAVQAIGKIPVDVLKANVDFLSFSAHKFHGPKGIGGLYIRSGVGLTPLFHGGEHMNGRRSG
TLNVPYIVGMGEAMKLAVEHLDYEKEVVGKLRDKLEEALLKIPDVMVVGDRIHRVPNTTLISVRGIEGEAMLWDLNRSNI
AASTGSACASEDLEANPVMVAIGASKELAHTAIRLSLSRFNTEAEIDKTIEVFSQAATRLRNISSSY
>Mature_387_residues
MLQRIYLDNNATTRIDPKVKEIMDPFLRDHYGNPSSLHQFGTETHPAIAEALDKLYKGINARDIDDVIITSCATESNNWV
LKGVYFDECLKKGKNHIVTTVTEHPAVRSTCNFLESLGVEVTYLPINEHGSITAEQVKEAITEKTALVSVMWANNETGLI
FPIEEIGAICKEKGVLFHTDAVQAIGKIPVDVLKANVDFLSFSAHKFHGPKGIGGLYIRSGVGLTPLFHGGEHMNGRRSG
TLNVPYIVGMGEAMKLAVEHLDYEKEVVGKLRDKLEEALLKIPDVMVVGDRIHRVPNTTLISVRGIEGEAMLWDLNRSNI
AASTGSACASEDLEANPVMVAIGASKELAHTAIRLSLSRFNTEAEIDKTIEVFSQAATRLRNISSSY

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=388, Percent_Identity=42.7835051546392, Blast_Score=305, Evalue=5e-83,
Organism=Homo sapiens, GI156713448, Length=423, Percent_Identity=34.0425531914894, Blast_Score=201, Evalue=8e-52,
Organism=Escherichia coli, GI48994898, Length=385, Percent_Identity=43.6363636363636, Blast_Score=297, Evalue=8e-82,
Organism=Escherichia coli, GI1787970, Length=396, Percent_Identity=25.7575757575758, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1789175, Length=392, Percent_Identity=25, Blast_Score=98, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI25143064, Length=387, Percent_Identity=42.3772609819121, Blast_Score=300, Evalue=7e-82,
Organism=Caenorhabditis elegans, GI17533177, Length=328, Percent_Identity=34.7560975609756, Blast_Score=162, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6319831, Length=383, Percent_Identity=44.6475195822454, Blast_Score=297, Evalue=2e-81,
Organism=Drosophila melanogaster, GI20129463, Length=387, Percent_Identity=42.6356589147287, Blast_Score=292, Evalue=2e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010240
- InterPro:   IPR017773
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 42478; Mature: 42478

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQRIYLDNNATTRIDPKVKEIMDPFLRDHYGNPSSLHQFGTETHPAIAEALDKLYKGIN
CCEEEEECCCCCEEECCHHHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHCCCC
ARDIDDVIITSCATESNNWVLKGVYFDECLKKGKNHIVTTVTEHPAVRSTCNFLESLGVE
CCCCHHHHHHHCCCCCCCEEEEEEEHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCE
VTYLPINEHGSITAEQVKEAITEKTALVSVMWANNETGLIFPIEEIGAICKEKGVLFHTD
EEEEEECCCCCCCHHHHHHHHHHHHEEEEEEEECCCCCEEEEHHHHHHHHHHCCCEEECH
AVQAIGKIPVDVLKANVDFLSFSAHKFHGPKGIGGLYIRSGVGLTPLFHGGEHMNGRRSG
HHHHHHCCCHHHHHCCCCEEEECHHHCCCCCCCCCEEEECCCCCCCEECCCCCCCCCCCC
TLNVPYIVGMGEAMKLAVEHLDYEKEVVGKLRDKLEEALLKIPDVMVVGDRIHRVPNTTL
CCCCCEEEECCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHCCCCCEE
ISVRGIEGEAMLWDLNRSNIAASTGSACASEDLEANPVMVAIGASKELAHTAIRLSLSRF
EEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHC
NTEAEIDKTIEVFSQAATRLRNISSSY
CCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLQRIYLDNNATTRIDPKVKEIMDPFLRDHYGNPSSLHQFGTETHPAIAEALDKLYKGIN
CCEEEEECCCCCEEECCHHHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHCCCC
ARDIDDVIITSCATESNNWVLKGVYFDECLKKGKNHIVTTVTEHPAVRSTCNFLESLGVE
CCCCHHHHHHHCCCCCCCEEEEEEEHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCE
VTYLPINEHGSITAEQVKEAITEKTALVSVMWANNETGLIFPIEEIGAICKEKGVLFHTD
EEEEEECCCCCCCHHHHHHHHHHHHEEEEEEEECCCCCEEEEHHHHHHHHHHCCCEEECH
AVQAIGKIPVDVLKANVDFLSFSAHKFHGPKGIGGLYIRSGVGLTPLFHGGEHMNGRRSG
HHHHHHCCCHHHHHCCCCEEEECHHHCCCCCCCCCEEEECCCCCCCEECCCCCCCCCCCC
TLNVPYIVGMGEAMKLAVEHLDYEKEVVGKLRDKLEEALLKIPDVMVVGDRIHRVPNTTL
CCCCCEEEECCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHCCCCCEE
ISVRGIEGEAMLWDLNRSNIAASTGSACASEDLEANPVMVAIGASKELAHTAIRLSLSRF
EEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHC
NTEAEIDKTIEVFSQAATRLRNISSSY
CCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA