Click here to switch to the map view.

The map label for this gene is blaI [H]

Identifier: 187935527

GI number: 187935527

Start: 2245929

End: 2246312

Strand: Reverse

Name: blaI [H]

Synonym: CLL_A2155

Alternate gene names: 187935527

Gene position: 2246312-2245929 (Counterclockwise)

Preceding gene: 187933751

Following gene: 187934087

Centisome position: 59.11

GC content: 26.04

Gene sequence:

>384_bases
ATGAATGAAATTCCTAAAATATCAAACGCTGAATGGGAAATTATGAAAGTAATATGGAGTCATACTGAAATTACATCAGT
CAATATTATATGTGAACTAAAAGATAAAGTAGAATGGAAACCATCTACAATAAAGAGCTTAATAAATAGATTACTAAAAA
AGAAGGTAATAGGGTTTAAAAGATTAAGTAACGAATACTTATATTTTCCTTTGATATCAGAAGATGAGTGCATAAAGATA
GAAAGCAAATCTTTTATTAATAAAGTCTTCAATGGTTCTGTCAAATCTATGCTTTTAAACTTTGTTGAATCAAAAGAAAT
ATCTGAAACAGACATAGAAGAATTAAAGAACATACTCAAACAATCAAATAAAAAGAAAGGTTGA

Upstream 100 bases:

>100_bases
TATATACAAAATATTCCAGAAAACCTATTGATATTTATTAATTACAAGTGTAAACTGAAAATAGAAATTACATTTGTAAT
CAGAAAGGGGGTAAAGAATA

Downstream 100 bases:

>100_bases
AGTGTATGAATTTTTTCGAGACTACTATAGTTTCTTCTTTCATTGGAAGCATAATAGTATTAATTATATTAAGCATAAAT
AGCATATTTAGATATAAGTT

Product: penicillinase repressor

Products: NA

Alternate protein names: Beta-lactamase repressor protein; Regulatory protein BlaI [H]

Number of amino acids: Translated: 127; Mature: 127

Protein sequence:

>127_residues
MNEIPKISNAEWEIMKVIWSHTEITSVNIICELKDKVEWKPSTIKSLINRLLKKKVIGFKRLSNEYLYFPLISEDECIKI
ESKSFINKVFNGSVKSMLLNFVESKEISETDIEELKNILKQSNKKKG

Sequences:

>Translated_127_residues
MNEIPKISNAEWEIMKVIWSHTEITSVNIICELKDKVEWKPSTIKSLINRLLKKKVIGFKRLSNEYLYFPLISEDECIKI
ESKSFINKVFNGSVKSMLLNFVESKEISETDIEELKNILKQSNKKKG
>Mature_127_residues
MNEIPKISNAEWEIMKVIWSHTEITSVNIICELKDKVEWKPSTIKSLINRLLKKKVIGFKRLSNEYLYFPLISEDECIKI
ESKSFINKVFNGSVKSMLLNFVESKEISETDIEELKNILKQSNKKKG

Specific function: Transcriptional repressor that constitutively blocks expression of beta-lactamase. Regulates genes involved in antibiotic resistance. Binds DNA as a dimer [H]

COG id: COG3682

COG function: function code K; Predicted transcriptional regulator

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BlaI transcriptional regulatory family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005650
- InterPro:   IPR011991 [H]

Pfam domain/function: PF03965 Pencillinase_R [H]

EC number: NA

Molecular weight: Translated: 14823; Mature: 14823

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEIPKISNAEWEIMKVIWSHTEITSVNIICELKDKVEWKPSTIKSLINRLLKKKVIGFK
CCCCCCCCCCHHHHHHHHHHCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
RLSNEYLYFPLISEDECIKIESKSFINKVFNGSVKSMLLNFVESKEISETDIEELKNILK
HHCCCEEEEEECCCCCEEEEHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
QSNKKKG
HCCCCCC
>Mature Secondary Structure
MNEIPKISNAEWEIMKVIWSHTEITSVNIICELKDKVEWKPSTIKSLINRLLKKKVIGFK
CCCCCCCCCCHHHHHHHHHHCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
RLSNEYLYFPLISEDECIKIESKSFINKVFNGSVKSMLLNFVESKEISETDIEELKNILK
HHCCCEEEEEECCCCCEEEEHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
QSNKKKG
HCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3096969; 3305074; 3260234; 3040663; 3498148 [H]