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The map label for this gene is pbp [H]

Identifier: 187935490

GI number: 187935490

Start: 2258554

End: 2260644

Strand: Reverse

Name: pbp [H]

Synonym: CLL_A2172

Alternate gene names: 187935490

Gene position: 2260644-2258554 (Counterclockwise)

Preceding gene: 187932722

Following gene: 187934685

Centisome position: 59.49

GC content: 28.89

Gene sequence:

>2091_bases
ATGAAAAAATTTTCAAAACTGTTAGCATTACTTCTAGCAACGCAACTTATTTTAGTATGTGGAAATAGAATTAAATCTGT
CCATGCTGCGGCAAATCCATCAGAAAAAATTAATTCCAATTATTCTACTGTAAATGAAAAAATTAAAGAAAAAGCAAACA
TTCTTGTTGAAAAGTATGGTGTAACAAGTGTGCAATATGCAATGATGGATGATGGTAATATAATATCATCAGGAAATAGT
GGCGTGTATAGTAAAAATAATAATAGGAGTATAACTAGTGATACCATGTATGGTATTGGTTCAACATCTAAGACTTTTAC
AGCAACTGCTATAATGAAGTTAGTAGATATGAAAAAAATTGATTTAGACAAGCCTATTGTAAATTATATTCCAGAGTTTG
TAATGAAAGATGAGAGATATAAAAAAATAACAACTAGAATGTTACTTAATCATTCATCAGGACTTATGGGGACTGCATAT
TCAAGAACAATGTTATGGGATGATAATGATACAATCGCGCATGATAAATTATTAGAGCAATTAAAAACTCAAAGATTGAA
AGCTGAACCAGGTAAATTTTCTGTATACTGTAATGATGGATTTACACTTGCAGAAATATTGGTTGAAAAGGTAAGTGGAG
AAAGCTTTACAAATTTTGTTCATGAAAACATAACAATACCATTAAAAATGGATAATACAAAGACTTCACAAGATGGTTTT
AATAGAGAGAAGCTTGCAAAAACTTATAGTCCAATTGCACCTACAATAGAAACACCACCAGACAGTGCAAATATAATTGG
TGCAGGTGGTATATATTCAACAGCACAGGATTTATGTAAATTTGGAAATATATTTACAAAGAATGGTACATTACTTTCAT
CAAACTCTGTTAATCAAATGATAAGTGGTGAATACAAAAATGGTTTGTGGTTAGATAACATAGATAATACTGAAACTATT
TTTAATTATGGACTTGGTTTTGATGGAACAGAGATATTTCCATTTAGCCAATATGGTATAAAAGCTATTGCAAAAGGTGG
AGATACATTACTTTATCACAATTCTACTGTTATATTACCAGAGTACAATATGATTGCAGCAGTATCTTCAGCAGATGGAA
GCAGCTTATATAATGAAGTTTTAGCTTGCAATATGTTACTTGATGCTTTAAAAGAAAAAGGCATTATTAAAGAAATAAAA
AGTGATAAATCTTTTGAAATACCAACTAAAACCTTAATAAATGATGATATTAAAAAATATGAAGGAACATATGGGGCATC
AGGACAAATTATTAATGTAAAAATGAATGAAAATGGTATAATGGCAATTTCAAATACATCATTATTATCAAAAGTACAAG
ATAGGGAATATCTTTATAATGGCAACGGAGTATTTTTGAAGCAAGATGGCAGTGAAAAAATCACTTTCGAAAATAAGGAT
GGTAAGATTTATTTAAGATTTGATTCATATATAAAATTACCAGGAGTGGGACAAACAGCCATAGCACAATATATGGGGCA
AAAATTAGAAGAAAACAAGTTAATAGCAGAAGTAAATAAAGCTTGGGAAAATAGAAATAATAAAAAATATTTTAATATAA
CAGATAAGTATAATTCTCAAATACTTAGCAGTGCACCACCTTTTATCGCTATTAATTTTAATAATGGTTATGAAATGTCT
AACAAAATTATAGATGCAAATAATTCTATTAACATTATTGAAATCCCTGTGATGGCAGGACGGGATACTTATGATTGCAC
TTTCTTTAAAGAAAGTGATATCGAATATATGAAAGTAGCTGAAAATATATTAATTAATCAAGATGGTCTAAAAGAAATAT
CAGAAGGAAACAGTGTTTGCGCTGTGGAAGAGAATGGATACAATGTATGGTATAAGATTAATGATAATTTAGAAGGAAAA
AAGATTACAGTAAAATTACCTGAAAATAGCGGATTTTTAGTATATACAAAAGATGGTGTATGTACAAATCAAAGCGCATT
AACTAAAAATAATACTGCAACATTATCAGGTGGTGGTTATATAATGTTTGGTGGTGAAAAAGGTAGCAAAATTGATATTA
CAATAGAGTAA

Upstream 100 bases:

>100_bases
TTTTAAATTCAAATTACTTAAACTAATTGAATATTAAATAAATACAATTATTAAAATTAAATGACAAATTAAACATATAG
AAAGTCCGGAGGTAAACTTA

Downstream 100 bases:

>100_bases
GAATAGATAGTAAATGAAATGGTTGATAAATGAAATGTTGAGTTAACTGTACACAAATATGTAAATGGTGATAGTGCATT
TTTAGCACTATCACCATTTA

Product: cell surface protein

Products: NA

Alternate protein names: PBP-4 [H]

Number of amino acids: Translated: 696; Mature: 696

Protein sequence:

>696_residues
MKKFSKLLALLLATQLILVCGNRIKSVHAAANPSEKINSNYSTVNEKIKEKANILVEKYGVTSVQYAMMDDGNIISSGNS
GVYSKNNNRSITSDTMYGIGSTSKTFTATAIMKLVDMKKIDLDKPIVNYIPEFVMKDERYKKITTRMLLNHSSGLMGTAY
SRTMLWDDNDTIAHDKLLEQLKTQRLKAEPGKFSVYCNDGFTLAEILVEKVSGESFTNFVHENITIPLKMDNTKTSQDGF
NREKLAKTYSPIAPTIETPPDSANIIGAGGIYSTAQDLCKFGNIFTKNGTLLSSNSVNQMISGEYKNGLWLDNIDNTETI
FNYGLGFDGTEIFPFSQYGIKAIAKGGDTLLYHNSTVILPEYNMIAAVSSADGSSLYNEVLACNMLLDALKEKGIIKEIK
SDKSFEIPTKTLINDDIKKYEGTYGASGQIINVKMNENGIMAISNTSLLSKVQDREYLYNGNGVFLKQDGSEKITFENKD
GKIYLRFDSYIKLPGVGQTAIAQYMGQKLEENKLIAEVNKAWENRNNKKYFNITDKYNSQILSSAPPFIAINFNNGYEMS
NKIIDANNSINIIEIPVMAGRDTYDCTFFKESDIEYMKVAENILINQDGLKEISEGNSVCAVEENGYNVWYKINDNLEGK
KITVKLPENSGFLVYTKDGVCTNQSALTKNNTATLSGGGYIMFGGEKGSKIDITIE

Sequences:

>Translated_696_residues
MKKFSKLLALLLATQLILVCGNRIKSVHAAANPSEKINSNYSTVNEKIKEKANILVEKYGVTSVQYAMMDDGNIISSGNS
GVYSKNNNRSITSDTMYGIGSTSKTFTATAIMKLVDMKKIDLDKPIVNYIPEFVMKDERYKKITTRMLLNHSSGLMGTAY
SRTMLWDDNDTIAHDKLLEQLKTQRLKAEPGKFSVYCNDGFTLAEILVEKVSGESFTNFVHENITIPLKMDNTKTSQDGF
NREKLAKTYSPIAPTIETPPDSANIIGAGGIYSTAQDLCKFGNIFTKNGTLLSSNSVNQMISGEYKNGLWLDNIDNTETI
FNYGLGFDGTEIFPFSQYGIKAIAKGGDTLLYHNSTVILPEYNMIAAVSSADGSSLYNEVLACNMLLDALKEKGIIKEIK
SDKSFEIPTKTLINDDIKKYEGTYGASGQIINVKMNENGIMAISNTSLLSKVQDREYLYNGNGVFLKQDGSEKITFENKD
GKIYLRFDSYIKLPGVGQTAIAQYMGQKLEENKLIAEVNKAWENRNNKKYFNITDKYNSQILSSAPPFIAINFNNGYEMS
NKIIDANNSINIIEIPVMAGRDTYDCTFFKESDIEYMKVAENILINQDGLKEISEGNSVCAVEENGYNVWYKINDNLEGK
KITVKLPENSGFLVYTKDGVCTNQSALTKNNTATLSGGGYIMFGGEKGSKIDITIE
>Mature_696_residues
MKKFSKLLALLLATQLILVCGNRIKSVHAAANPSEKINSNYSTVNEKIKEKANILVEKYGVTSVQYAMMDDGNIISSGNS
GVYSKNNNRSITSDTMYGIGSTSKTFTATAIMKLVDMKKIDLDKPIVNYIPEFVMKDERYKKITTRMLLNHSSGLMGTAY
SRTMLWDDNDTIAHDKLLEQLKTQRLKAEPGKFSVYCNDGFTLAEILVEKVSGESFTNFVHENITIPLKMDNTKTSQDGF
NREKLAKTYSPIAPTIETPPDSANIIGAGGIYSTAQDLCKFGNIFTKNGTLLSSNSVNQMISGEYKNGLWLDNIDNTETI
FNYGLGFDGTEIFPFSQYGIKAIAKGGDTLLYHNSTVILPEYNMIAAVSSADGSSLYNEVLACNMLLDALKEKGIIKEIK
SDKSFEIPTKTLINDDIKKYEGTYGASGQIINVKMNENGIMAISNTSLLSKVQDREYLYNGNGVFLKQDGSEKITFENKD
GKIYLRFDSYIKLPGVGQTAIAQYMGQKLEENKLIAEVNKAWENRNNKKYFNITDKYNSQILSSAPPFIAINFNNGYEMS
NKIIDANNSINIIEIPVMAGRDTYDCTFFKESDIEYMKVAENILINQDGLKEISEGNSVCAVEENGYNVWYKINDNLEGK
KITVKLPENSGFLVYTKDGVCTNQSALTKNNTATLSGGGYIMFGGEKGSKIDITIE

Specific function: Involved in cell wall biosynthesis and may also act as a sensor of external penicillins [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-lactamase family [H]

Homologues:

Organism=Escherichia coli, GI1786574, Length=301, Percent_Identity=26.578073089701, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI115533026, Length=263, Percent_Identity=28.5171102661597, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: NA

Molecular weight: Translated: 77243; Mature: 77243

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKFSKLLALLLATQLILVCGNRIKSVHAAANPSEKINSNYSTVNEKIKEKANILVEKYG
CCHHHHHHHHHHHHHHHHHHCCHHHEEECCCCCHHHHCCCHHHHHHHHHHHHHEEEEECC
VTSVQYAMMDDGNIISSGNSGVYSKNNNRSITSDTMYGIGSTSKTFTATAIMKLVDMKKI
CCEEEEEEECCCCEEECCCCCCEECCCCCCEECCCEEECCCCCCHHHHHHHHHHHHHHHC
DLDKPIVNYIPEFVMKDERYKKITTRMLLNHSSGLMGTAYSRTMLWDDNDTIAHDKLLEQ
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEECCCCEEEEECCCCCHHHHHHHHH
LKTQRLKAEPGKFSVYCNDGFTLAEILVEKVSGESFTNFVHENITIPLKMDNTKTSQDGF
HHHHHHCCCCCCEEEEECCCCHHHHHHHHHHCCCHHHHHHHCCEEEEEEECCCCCCCCCC
NREKLAKTYSPIAPTIETPPDSANIIGAGGIYSTAQDLCKFGNIFTKNGTLLSSNSVNQM
CHHHHHHHCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHCCEEECCCEEEECCCHHHH
ISGEYKNGLWLDNIDNTETIFNYGLGFDGTEIFPFSQYGIKAIAKGGDTLLYHNSTVILP
HCCCCCCCEEECCCCCCHHHEEECCCCCCCEEEEEHHHCHHEEECCCCEEEEECCEEEEE
EYNMIAAVSSADGSSLYNEVLACNMLLDALKEKGIIKEIKSDKSFEIPTKTLINDDIKKY
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHHHHH
EGTYGASGQIINVKMNENGIMAISNTSLLSKVQDREYLYNGNGVFLKQDGSEKITFENKD
CCCCCCCCEEEEEEECCCCEEEEECHHHHHHHCCCCEEECCCEEEEEECCCCEEEEECCC
GKIYLRFDSYIKLPGVGQTAIAQYMGQKLEENKLIAEVNKAWENRNNKKYFNITDKYNSQ
CEEEEEEECEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCHHCCH
ILSSAPPFIAINFNNGYEMSNKIIDANNSINIIEIPVMAGRDTYDCTFFKESDIEYMKVA
HHHCCCCEEEEECCCCCCCCCEEEECCCCEEEEEEEEEECCCCCEEEEEECCCCHHHHHH
ENILINQDGLKEISEGNSVCAVEENGYNVWYKINDNLEGKKITVKLPENSGFLVYTKDGV
HHHEECCCCHHHHHCCCCEEEEECCCCEEEEEECCCCCCCEEEEEECCCCCEEEEECCCC
CTNQSALTKNNTATLSGGGYIMFGGEKGSKIDITIE
CCCCCCCCCCCCEEEECCEEEEECCCCCCEEEEEEC
>Mature Secondary Structure
MKKFSKLLALLLATQLILVCGNRIKSVHAAANPSEKINSNYSTVNEKIKEKANILVEKYG
CCHHHHHHHHHHHHHHHHHHCCHHHEEECCCCCHHHHCCCHHHHHHHHHHHHHEEEEECC
VTSVQYAMMDDGNIISSGNSGVYSKNNNRSITSDTMYGIGSTSKTFTATAIMKLVDMKKI
CCEEEEEEECCCCEEECCCCCCEECCCCCCEECCCEEECCCCCCHHHHHHHHHHHHHHHC
DLDKPIVNYIPEFVMKDERYKKITTRMLLNHSSGLMGTAYSRTMLWDDNDTIAHDKLLEQ
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEECCCCEEEEECCCCCHHHHHHHHH
LKTQRLKAEPGKFSVYCNDGFTLAEILVEKVSGESFTNFVHENITIPLKMDNTKTSQDGF
HHHHHHCCCCCCEEEEECCCCHHHHHHHHHHCCCHHHHHHHCCEEEEEEECCCCCCCCCC
NREKLAKTYSPIAPTIETPPDSANIIGAGGIYSTAQDLCKFGNIFTKNGTLLSSNSVNQM
CHHHHHHHCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHCCEEECCCEEEECCCHHHH
ISGEYKNGLWLDNIDNTETIFNYGLGFDGTEIFPFSQYGIKAIAKGGDTLLYHNSTVILP
HCCCCCCCEEECCCCCCHHHEEECCCCCCCEEEEEHHHCHHEEECCCCEEEEECCEEEEE
EYNMIAAVSSADGSSLYNEVLACNMLLDALKEKGIIKEIKSDKSFEIPTKTLINDDIKKY
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHHHHH
EGTYGASGQIINVKMNENGIMAISNTSLLSKVQDREYLYNGNGVFLKQDGSEKITFENKD
CCCCCCCCEEEEEEECCCCEEEEECHHHHHHHCCCCEEECCCEEEEEECCCCEEEEECCC
GKIYLRFDSYIKLPGVGQTAIAQYMGQKLEENKLIAEVNKAWENRNNKKYFNITDKYNSQ
CEEEEEEECEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCHHCCH
ILSSAPPFIAINFNNGYEMSNKIIDANNSINIIEIPVMAGRDTYDCTFFKESDIEYMKVA
HHHCCCCEEEEECCCCCCCCCEEEECCCCEEEEEEEEEECCCCCEEEEEECCCCHHHHHH
ENILINQDGLKEISEGNSVCAVEENGYNVWYKINDNLEGKKITVKLPENSGFLVYTKDGV
HHHEECCCCHHHHHCCCCEEEEECCCCEEEEEECCCCCCCEEEEEECCCCCEEEEECCCC
CTNQSALTKNNTATLSGGGYIMFGGEKGSKIDITIE
CCCCCCCCCCCCEEEECCEEEEECCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8440253 [H]