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The map label for this gene is ilvE [H]

Identifier: 187935225

GI number: 187935225

Start: 1112778

End: 1113806

Strand: Reverse

Name: ilvE [H]

Synonym: CLL_A1088

Alternate gene names: 187935225

Gene position: 1113806-1112778 (Counterclockwise)

Preceding gene: 187934473

Following gene: 187934441

Centisome position: 29.31

GC content: 33.43

Gene sequence:

>1029_bases
ATGGGGAAAAAAGTTGATATGGATTGGGGTAAACTAGGATTTAGTTACATAAAAACGGATTATCGTTATATTTCAACTTG
GAAAGATGGTAAATGGGATGATGGCAAGCTTATAGAAGATAATATGCTTAAAATGAGTGAAGCTTCTACTGTTCTTCATT
ATGGTCAAAGCTCTTTTGAAGGATTAAAAGCTTATACAACGAAAGAAGGGAAAATACAATTATTCAGACCTAATAGAAAT
GCTGCTCGTATGAATGAAAGTTGTGATAAACTTCTTATGCCAAATATTCCTGAAGAAAAGTTTATAGACGCATGTATGCA
AGTTGTTAAAGCTAATGAACATTTTGTTCCACCATATGGCACTGGTGCAACTTTATATATTAGACCTGTTATAATGGGGG
TTGGAGATAATATAGGTGTAAAACCAGCATCTGAATATATTTTTACAGTATTTTGTATGCCAGTAGGACCTTACTTCTCT
GGTGGATTAAAACCTTGTAACTTTATCGTTCAAGATGAATTTGATAGAGCCGCTCCACATGGTACTGGAAAACAAAAAGT
TGGTGGTAATTATGCGGCCTCTCTTGAAGCTCATAAAAAAGCTACTGATGCTGGATATGCAGATTGTATTTATTTAGATC
CTACTACCCACACAAAAATCGATGAAGTTGGTGCTGCAAACTTTATAGGAATAACTAAAAAGGGTGAATTTATAACACCT
AAGTCTTCATCAATATTACCTAGTATAACAAAATATTCTTTACTTTATATAGCTGAACATTATTTAAATATGCCAGTATA
TGAAAGAGAAGTTTTTGTTAATCAATTAGATGAATTTGCAGAAGCTGGTGCTTGTGGTACTGCTGCTGTAATAACTCCAA
TTGGAGCTATAGATTACAATGGAAAGAGATTTGTGTTCCATAGTGAAACTGAAGTTGGACCTACAATAAAGAAATTATAT
GAAATACTTTCTGGAATCCAAACAGGTGATGTAGAAGCTCCTGAAGGATGGATATACGAAGTTAAATAA

Upstream 100 bases:

>100_bases
TATACTTTTTATGCTTAACTATAGAATTTTTGTTTTGATAGTGTTAGAATAAAAGGTATTAAGTAAAGGCAATAAGCCTA
TAGATATGGAGGAATGTAAA

Downstream 100 bases:

>100_bases
ATCTTTAATTTATACTATATTTTAAACAAGTTTTGATATTATAGCATAAAACTTTTAAAGTAAAGAAGCTTACTTTAAAA
ATAATAAAATTAATAAAAAG

Product: branched-chain amino acid aminotransferase

Products: NA

Alternate protein names: BCAT [H]

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MGKKVDMDWGKLGFSYIKTDYRYISTWKDGKWDDGKLIEDNMLKMSEASTVLHYGQSSFEGLKAYTTKEGKIQLFRPNRN
AARMNESCDKLLMPNIPEEKFIDACMQVVKANEHFVPPYGTGATLYIRPVIMGVGDNIGVKPASEYIFTVFCMPVGPYFS
GGLKPCNFIVQDEFDRAAPHGTGKQKVGGNYAASLEAHKKATDAGYADCIYLDPTTHTKIDEVGAANFIGITKKGEFITP
KSSSILPSITKYSLLYIAEHYLNMPVYEREVFVNQLDEFAEAGACGTAAVITPIGAIDYNGKRFVFHSETEVGPTIKKLY
EILSGIQTGDVEAPEGWIYEVK

Sequences:

>Translated_342_residues
MGKKVDMDWGKLGFSYIKTDYRYISTWKDGKWDDGKLIEDNMLKMSEASTVLHYGQSSFEGLKAYTTKEGKIQLFRPNRN
AARMNESCDKLLMPNIPEEKFIDACMQVVKANEHFVPPYGTGATLYIRPVIMGVGDNIGVKPASEYIFTVFCMPVGPYFS
GGLKPCNFIVQDEFDRAAPHGTGKQKVGGNYAASLEAHKKATDAGYADCIYLDPTTHTKIDEVGAANFIGITKKGEFITP
KSSSILPSITKYSLLYIAEHYLNMPVYEREVFVNQLDEFAEAGACGTAAVITPIGAIDYNGKRFVFHSETEVGPTIKKLY
EILSGIQTGDVEAPEGWIYEVK
>Mature_341_residues
GKKVDMDWGKLGFSYIKTDYRYISTWKDGKWDDGKLIEDNMLKMSEASTVLHYGQSSFEGLKAYTTKEGKIQLFRPNRNA
ARMNESCDKLLMPNIPEEKFIDACMQVVKANEHFVPPYGTGATLYIRPVIMGVGDNIGVKPASEYIFTVFCMPVGPYFSG
GLKPCNFIVQDEFDRAAPHGTGKQKVGGNYAASLEAHKKATDAGYADCIYLDPTTHTKIDEVGAANFIGITKKGEFITPK
SSSILPSITKYSLLYIAEHYLNMPVYEREVFVNQLDEFAEAGACGTAAVITPIGAIDYNGKRFVFHSETEVGPTIKKLYE
ILSGIQTGDVEAPEGWIYEVK

Specific function: Acts on leucine, isoleucine and valine [H]

COG id: COG0115

COG function: function code EH; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI296010904, Length=341, Percent_Identity=33.1378299120235, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI38176287, Length=341, Percent_Identity=33.1378299120235, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI296010906, Length=341, Percent_Identity=33.1378299120235, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI50658084, Length=349, Percent_Identity=30.6590257879656, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI258614015, Length=302, Percent_Identity=31.1258278145695, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI296010902, Length=250, Percent_Identity=33.6, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI296010900, Length=250, Percent_Identity=33.6, Blast_Score=116, Evalue=3e-26,
Organism=Escherichia coli, GI48994963, Length=317, Percent_Identity=29.3375394321767, Blast_Score=110, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17568601, Length=355, Percent_Identity=29.5774647887324, Blast_Score=154, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17565728, Length=357, Percent_Identity=29.6918767507003, Blast_Score=112, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6322608, Length=341, Percent_Identity=31.0850439882698, Blast_Score=159, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6322002, Length=340, Percent_Identity=31.7647058823529, Blast_Score=157, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24641779, Length=338, Percent_Identity=29.8816568047337, Blast_Score=155, Evalue=3e-38,

Paralogues:

None

Copy number: 2342 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 11,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001544
- InterPro:   IPR018300
- InterPro:   IPR005786 [H]

Pfam domain/function: PF01063 Aminotran_4 [H]

EC number: =2.6.1.42 [H]

Molecular weight: Translated: 37941; Mature: 37809

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKKVDMDWGKLGFSYIKTDYRYISTWKDGKWDDGKLIEDNMLKMSEASTVLHYGQSSFE
CCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCHHC
GLKAYTTKEGKIQLFRPNRNAARMNESCDKLLMPNIPEEKFIDACMQVVKANEHFVPPYG
CCEEEECCCCCEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCC
TGATLYIRPVIMGVGDNIGVKPASEYIFTVFCMPVGPYFSGGLKPCNFIVQDEFDRAAPH
CCCEEEEEEEEEECCCCCCCCCCHHEEEEEEEEECCHHHCCCCCCCEEEEECCCHHCCCC
GTGKQKVGGNYAASLEAHKKATDAGYADCIYLDPTTHTKIDEVGAANFIGITKKGEFITP
CCCCCCCCCCEEEHHHHHHHHCCCCCCEEEEECCCCCCCHHHCCCCCEEEECCCCCEECC
KSSSILPSITKYSLLYIAEHYLNMPVYEREVFVNQLDEFAEAGACGTAAVITPIGAIDYN
CCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHCCCCCEEECC
GKRFVFHSETEVGPTIKKLYEILSGIQTGDVEAPEGWIYEVK
CCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEC
>Mature Secondary Structure 
GKKVDMDWGKLGFSYIKTDYRYISTWKDGKWDDGKLIEDNMLKMSEASTVLHYGQSSFE
CCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCHHC
GLKAYTTKEGKIQLFRPNRNAARMNESCDKLLMPNIPEEKFIDACMQVVKANEHFVPPYG
CCEEEECCCCCEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCC
TGATLYIRPVIMGVGDNIGVKPASEYIFTVFCMPVGPYFSGGLKPCNFIVQDEFDRAAPH
CCCEEEEEEEEEECCCCCCCCCCHHEEEEEEEEECCHHHCCCCCCCEEEEECCCHHCCCC
GTGKQKVGGNYAASLEAHKKATDAGYADCIYLDPTTHTKIDEVGAANFIGITKKGEFITP
CCCCCCCCCCEEEHHHHHHHHCCCCCCEEEEECCCCCCCHHHCCCCCEEEECCCCCEECC
KSSSILPSITKYSLLYIAEHYLNMPVYEREVFVNQLDEFAEAGACGTAAVITPIGAIDYN
CCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHCCCCCEEECC
GKRFVFHSETEVGPTIKKLYEILSGIQTGDVEAPEGWIYEVK
CCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]