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The map label for this gene is lacR [H]

Identifier: 187935145

GI number: 187935145

Start: 1569810

End: 1570574

Strand: Reverse

Name: lacR [H]

Synonym: CLL_A1511

Alternate gene names: 187935145

Gene position: 1570574-1569810 (Counterclockwise)

Preceding gene: 187935705

Following gene: 187933931

Centisome position: 41.33

GC content: 21.83

Gene sequence:

>765_bases
ATGTTTCAAGAAGAAAGATTACAAGAAATAATAGATATAGTTAATAAGGAAGGCAAAGTTTTTGTTAAAAATCTTAGTGA
AAAGTTTGATGTATCTAATGGAATGATACGTAAAGATCTTCAAAAATTAGAAAGTCTAGGCAAGTTAACAAGAACCTATG
GAGGAGCAATAGCAAATAATGAAATTAAAAAAACTCTAAATATTGATACTAGAATGCATAAAAATATTGAAAATAAACAT
ATAATTGCAAAAAAAGCATTTAATATAATAAAAGATTCTGATACATTATTTTTTGATATCTCTAGCATAAATTTTTTATT
AGCAGAGTTAATTGCAAATAGTGATAAAAAAATAACCCTAATAACAAATATGTCATCTATCCCTGAATTATTTAAAAATA
ATTCTAACTGTAAATTAATCCTTGTTGGTGGAATTTATAATAAAGAATTAGGTGGAACAGTTGGTTCAGAAACTATTAGT
ACATTAAAAAAGTATAGATTTGATAAAGCCTTTATAGGAAGTTCAGGCATAAATTTAGAAAATGGAGATATTTATAATTT
TGATTTAGAAGAAGGTAATACAAAACAAGTAATAATTAATTCAAGTAATAATTCATATATATTAATGGAAAATGAAAAAT
TTTATTCTCATGGTATATATACTTTTTCAAATCTAAATGACATTAATGGAATAGTTACAGATAAAATTCCAAATAAAAAT
ATAATAAAAACATTAAAAAATTTTAATGTTGAGTTATATAATTAA

Upstream 100 bases:

>100_bases
ATATTAATCTACTTTAAAACTTGGAAATGCAAATAAAGTAACTGTTTTATATTTTAAATACTAAAAATTCTCAGTTTTAT
TTAAGGAAGGAAATAACAAA

Downstream 100 bases:

>100_bases
ATTTTTGTTAATATCTTATAGGCTGCATTAAAAATATATTTTCAAAAAAGAACCTACTGAAATAGCCCATTTATAGTCTA
TTCAGTAGGTTTTATTTTAT

Product: transcriptional regulator, DeoR family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MFQEERLQEIIDIVNKEGKVFVKNLSEKFDVSNGMIRKDLQKLESLGKLTRTYGGAIANNEIKKTLNIDTRMHKNIENKH
IIAKKAFNIIKDSDTLFFDISSINFLLAELIANSDKKITLITNMSSIPELFKNNSNCKLILVGGIYNKELGGTVGSETIS
TLKKYRFDKAFIGSSGINLENGDIYNFDLEEGNTKQVIINSSNNSYILMENEKFYSHGIYTFSNLNDINGIVTDKIPNKN
IIKTLKNFNVELYN

Sequences:

>Translated_254_residues
MFQEERLQEIIDIVNKEGKVFVKNLSEKFDVSNGMIRKDLQKLESLGKLTRTYGGAIANNEIKKTLNIDTRMHKNIENKH
IIAKKAFNIIKDSDTLFFDISSINFLLAELIANSDKKITLITNMSSIPELFKNNSNCKLILVGGIYNKELGGTVGSETIS
TLKKYRFDKAFIGSSGINLENGDIYNFDLEEGNTKQVIINSSNNSYILMENEKFYSHGIYTFSNLNDINGIVTDKIPNKN
IIKTLKNFNVELYN
>Mature_254_residues
MFQEERLQEIIDIVNKEGKVFVKNLSEKFDVSNGMIRKDLQKLESLGKLTRTYGGAIANNEIKKTLNIDTRMHKNIENKH
IIAKKAFNIIKDSDTLFFDISSINFLLAELIANSDKKITLITNMSSIPELFKNNSNCKLILVGGIYNKELGGTVGSETIS
TLKKYRFDKAFIGSSGINLENGDIYNFDLEEGNTKQVIINSSNNSYILMENEKFYSHGIYTFSNLNDINGIVTDKIPNKN
IIKTLKNFNVELYN

Specific function: Repressor of the lactose catabolism operon. Galactose-6- phosphate is the inducer [H]

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787540, Length=229, Percent_Identity=30.5676855895196, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1789829, Length=252, Percent_Identity=27.7777777777778, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1788069, Length=253, Percent_Identity=30.4347826086957, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1789059, Length=235, Percent_Identity=28.5106382978723, Blast_Score=94, Evalue=6e-21,
Organism=Escherichia coli, GI226510968, Length=234, Percent_Identity=24.3589743589744, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI87082344, Length=247, Percent_Identity=22.2672064777328, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI1789519, Length=250, Percent_Identity=23.6, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1789170, Length=234, Percent_Identity=25.6410256410256, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790635, Length=256, Percent_Identity=23.4375, Blast_Score=71, Evalue=8e-14,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 28812; Mature: 28812

Theoretical pI: Translated: 8.83; Mature: 8.83

Prosite motif: PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQEERLQEIIDIVNKEGKVFVKNLSEKFDVSNGMIRKDLQKLESLGKLTRTYGGAIANN
CCHHHHHHHHHHHHCCCCCEEEEHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
EIKKTLNIDTRMHKNIENKHIIAKKAFNIIKDSDTLFFDISSINFLLAELIANSDKKITL
HHHHHHCCCHHHHCCCCCCEEHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHCCCCCEEEE
ITNMSSIPELFKNNSNCKLILVGGIYNKELGGTVGSETISTLKKYRFDKAFIGSSGINLE
EECCHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCHHEECCCCCCCC
NGDIYNFDLEEGNTKQVIINSSNNSYILMENEKFYSHGIYTFSNLNDINGIVTDKIPNKN
CCCEEEEECCCCCCEEEEEECCCCEEEEEECCCCHHCCCEEECCCCCCCCEEECCCCCHH
IIKTLKNFNVELYN
HHHHHHHCCEEEEC
>Mature Secondary Structure
MFQEERLQEIIDIVNKEGKVFVKNLSEKFDVSNGMIRKDLQKLESLGKLTRTYGGAIANN
CCHHHHHHHHHHHHCCCCCEEEEHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
EIKKTLNIDTRMHKNIENKHIIAKKAFNIIKDSDTLFFDISSINFLLAELIANSDKKITL
HHHHHHCCCHHHHCCCCCCEEHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHCCCCCEEEE
ITNMSSIPELFKNNSNCKLILVGGIYNKELGGTVGSETISTLKKYRFDKAFIGSSGINLE
EECCHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCHHEECCCCCCCC
NGDIYNFDLEEGNTKQVIINSSNNSYILMENEKFYSHGIYTFSNLNDINGIVTDKIPNKN
CCCEEEEECCCCCCEEEEEECCCCEEEEEECCCCHHCCCEEECCCCCCCCEEECCCCCHH
IIKTLKNFNVELYN
HHHHHHHCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2120234; 1901863 [H]