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The map label for this gene is lysA [H]

Identifier: 187935097

GI number: 187935097

Start: 3449873

End: 3451168

Strand: Reverse

Name: lysA [H]

Synonym: CLL_A3286

Alternate gene names: 187935097

Gene position: 3451168-3449873 (Counterclockwise)

Preceding gene: 187935276

Following gene: 187934098

Centisome position: 90.81

GC content: 29.09

Gene sequence:

>1296_bases
ATGAATTTATTTGGAAGTATGAAAATTGAAAACAATGAATTAACAATTGGGGGCATTAAATCTACTGATTTAGTAAAGGA
ATATGGTACACCATTATATGTTATGGATGAGGGGCTAATAAGACAAAATTGTAATGAGTACTATAAATATTTTAAATGTG
ATAATTCATCAAATAGAGTTGCATATGCAGGTAAAGCATTTTTAACTCTTGAGATGTGTAAGATAATAAATGAAGAAAAT
TTATCATTAGATGTTGTGTCTGGAGGGGAACTTTTTATAGCTCATAAGTCTGGTTTTCCTTTAGATAAAGTGATGTTTCA
TGGAAATAATAAAACATTAGATGAAATTGAGTTAGGTGTTAAACTAGGTGTAGGAAGATTTGTTGTGGATAACTATTATG
AAATGGAAGAATTAAATAGAATAGCAGCAAGTTATAATAAAATTCAAAAAGTATTTTTGAGAATAACACCTGGTATAGAA
GCACATACTCATGAGTATATAAAAACTGGTCAGGTTGATTCAAAATTTGGTTTTGCACCTGTTGGAAATATGATAGAAGA
TGCTATAAACAAATCTATAAATCTTCCTAATATTGAACTATCAGGACTACATTGTCATATAGGATCTCAAATATTTGAAA
TCGAACCATATGAGGATGCAGTAGAAATTATGCTAGGTTTAATAAAAAAAATTAAACAAAATACAGGTTATTTAATAAAA
GAACTAGATTTAGGTGGTGGGTTTGGTATATACTATAATAGAGGAGATAAACCAAAAACAACTAAAGAGTATTGTGAAGC
AATATTAAATAAGGTTGATGAGGTTTGCTCTAGAACAGGTCTATCAAAGCCATCGTTAATAATAGAGCCAGGTAGAAGCA
TAGTTGGAAATTCTGGTATAACTTTATATACTGTAGGATCAATAAAAGATATTCCTGGAGTAAGAAAGTATGTATCAGTA
GATGGTGGTATGTCAGATAATATAAGACCAGCTTTATATCATGCTGAATATGAATGCATGTTAGCAAATAAAGTTGAAAA
AGACCTAAAAGAGACAGTAACTATTTGTGGAAAATGTTGTGAGTCAGGAGATATATTATTAAATGATGTTAATATTTCAA
CACCACAGTCAAATGATATTTTATCAGTTATGACAACAGGGGCGTATGGATATTCAATGTCTAATAATTATAATAAGATT
CCAAGACCACCAGTAGTAATGGTAAAAGATAATAAAGAAAGACTTATATGTAGAAGAGAAACATATGAAGATCTTATACA
AAATGAGATTATCTAA

Upstream 100 bases:

>100_bases
ATAAGCAGTAAGCAACAAAAATCCTAAGTAAGTAGACTCTACCAGTCGCAGATTAATATCTGTGACTTTTGTTTTTAAAC
AAATTTTTGGAGGTAGAAAG

Downstream 100 bases:

>100_bases
TAATTATCTTTTAATAAATTAGCTTTTTATTAATATTCTTTCCCAAGATAATATATATATCTTAGTGTGTATCAAATTGA
TTTATTAATTTTGATACACA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MNLFGSMKIENNELTIGGIKSTDLVKEYGTPLYVMDEGLIRQNCNEYYKYFKCDNSSNRVAYAGKAFLTLEMCKIINEEN
LSLDVVSGGELFIAHKSGFPLDKVMFHGNNKTLDEIELGVKLGVGRFVVDNYYEMEELNRIAASYNKIQKVFLRITPGIE
AHTHEYIKTGQVDSKFGFAPVGNMIEDAINKSINLPNIELSGLHCHIGSQIFEIEPYEDAVEIMLGLIKKIKQNTGYLIK
ELDLGGGFGIYYNRGDKPKTTKEYCEAILNKVDEVCSRTGLSKPSLIIEPGRSIVGNSGITLYTVGSIKDIPGVRKYVSV
DGGMSDNIRPALYHAEYECMLANKVEKDLKETVTICGKCCESGDILLNDVNISTPQSNDILSVMTTGAYGYSMSNNYNKI
PRPPVVMVKDNKERLICRRETYEDLIQNEII

Sequences:

>Translated_431_residues
MNLFGSMKIENNELTIGGIKSTDLVKEYGTPLYVMDEGLIRQNCNEYYKYFKCDNSSNRVAYAGKAFLTLEMCKIINEEN
LSLDVVSGGELFIAHKSGFPLDKVMFHGNNKTLDEIELGVKLGVGRFVVDNYYEMEELNRIAASYNKIQKVFLRITPGIE
AHTHEYIKTGQVDSKFGFAPVGNMIEDAINKSINLPNIELSGLHCHIGSQIFEIEPYEDAVEIMLGLIKKIKQNTGYLIK
ELDLGGGFGIYYNRGDKPKTTKEYCEAILNKVDEVCSRTGLSKPSLIIEPGRSIVGNSGITLYTVGSIKDIPGVRKYVSV
DGGMSDNIRPALYHAEYECMLANKVEKDLKETVTICGKCCESGDILLNDVNISTPQSNDILSVMTTGAYGYSMSNNYNKI
PRPPVVMVKDNKERLICRRETYEDLIQNEII
>Mature_431_residues
MNLFGSMKIENNELTIGGIKSTDLVKEYGTPLYVMDEGLIRQNCNEYYKYFKCDNSSNRVAYAGKAFLTLEMCKIINEEN
LSLDVVSGGELFIAHKSGFPLDKVMFHGNNKTLDEIELGVKLGVGRFVVDNYYEMEELNRIAASYNKIQKVFLRITPGIE
AHTHEYIKTGQVDSKFGFAPVGNMIEDAINKSINLPNIELSGLHCHIGSQIFEIEPYEDAVEIMLGLIKKIKQNTGYLIK
ELDLGGGFGIYYNRGDKPKTTKEYCEAILNKVDEVCSRTGLSKPSLIIEPGRSIVGNSGITLYTVGSIKDIPGVRKYVSV
DGGMSDNIRPALYHAEYECMLANKVEKDLKETVTICGKCCESGDILLNDVNISTPQSNDILSVMTTGAYGYSMSNNYNKI
PRPPVVMVKDNKERLICRRETYEDLIQNEII

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=419, Percent_Identity=28.6396181384248, Blast_Score=142, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 48190; Mature: 48190

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLFGSMKIENNELTIGGIKSTDLVKEYGTPLYVMDEGLIRQNCNEYYKYFKCDNSSNRV
CCCCCCEEEECCEEEECCCCCHHHHHHHCCCEEEECCCHHHHHHHHHHHEEECCCCCCEE
AYAGKAFLTLEMCKIINEENLSLDVVSGGELFIAHKSGFPLDKVMFHGNNKTLDEIELGV
EECCCHHHHHHHHHHCCCCCCEEEEECCCEEEEEECCCCCHHHEEEECCCCCHHHHHHCE
KLGVGRFVVDNYYEMEELNRIAASYNKIQKVFLRITPGIEAHTHEYIKTGQVDSKFGFAP
EECCCHHHHCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHCCCCCCCCCCCC
VGNMIEDAINKSINLPNIELSGLHCHIGSQIFEIEPYEDAVEIMLGLIKKIKQNTGYLIK
CHHHHHHHHHCCCCCCCEEEEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHCCCCCEEE
ELDLGGGFGIYYNRGDKPKTTKEYCEAILNKVDEVCSRTGLSKPSLIIEPGRSIVGNSGI
EEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEECCCCE
TLYTVGSIKDIPGVRKYVSVDGGMSDNIRPALYHAEYECMLANKVEKDLKETVTICGKCC
EEEEECCCCCCCCCCEEEEECCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHC
ESGDILLNDVNISTPQSNDILSVMTTGAYGYSMSNNYNKIPRPPVVMVKDNKERLICRRE
CCCCEEEEECCCCCCCCCCEEEEEECCCCCEECCCCCCCCCCCCEEEEECCCCCEEEEHH
TYEDLIQNEII
HHHHHHHHCCC
>Mature Secondary Structure
MNLFGSMKIENNELTIGGIKSTDLVKEYGTPLYVMDEGLIRQNCNEYYKYFKCDNSSNRV
CCCCCCEEEECCEEEECCCCCHHHHHHHCCCEEEECCCHHHHHHHHHHHEEECCCCCCEE
AYAGKAFLTLEMCKIINEENLSLDVVSGGELFIAHKSGFPLDKVMFHGNNKTLDEIELGV
EECCCHHHHHHHHHHCCCCCCEEEEECCCEEEEEECCCCCHHHEEEECCCCCHHHHHHCE
KLGVGRFVVDNYYEMEELNRIAASYNKIQKVFLRITPGIEAHTHEYIKTGQVDSKFGFAP
EECCCHHHHCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHCCCCCCCCCCCC
VGNMIEDAINKSINLPNIELSGLHCHIGSQIFEIEPYEDAVEIMLGLIKKIKQNTGYLIK
CHHHHHHHHHCCCCCCCEEEEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHCCCCCEEE
ELDLGGGFGIYYNRGDKPKTTKEYCEAILNKVDEVCSRTGLSKPSLIIEPGRSIVGNSGI
EEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEECCCCE
TLYTVGSIKDIPGVRKYVSVDGGMSDNIRPALYHAEYECMLANKVEKDLKETVTICGKCC
EEEEECCCCCCCCCCEEEEECCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHC
ESGDILLNDVNISTPQSNDILSVMTTGAYGYSMSNNYNKIPRPPVVMVKDNKERLICRRE
CCCCEEEEECCCCCCCCCCEEEEEECCCCCEECCCCCCCCCCCCEEEEECCCCCEEEEHH
TYEDLIQNEII
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2513554; 7934829; 1368705; 8969508; 9384377 [H]