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The map label for this gene is ldh [H]

Identifier: 187934898

GI number: 187934898

Start: 2678443

End: 2679393

Strand: Reverse

Name: ldh [H]

Synonym: CLL_A2569

Alternate gene names: 187934898

Gene position: 2679393-2678443 (Counterclockwise)

Preceding gene: 187935671

Following gene: 187934619

Centisome position: 70.5

GC content: 30.28

Gene sequence:

>951_bases
ATGGCAAGAGAGAGAAAACGTAAGATATCAATTATAGGTGCAGGATTTGTAGGATCTACAACAGCATTTGCGTTAATGAA
TAGTGGCGTAGCTACAGAAATTTGTATATGTGACATAAATATGGATAAAGCTATGGGAGAAGTTATGGATTTAGTTCATG
GAACTTCATTTGTGAAACCAGTTAATATATATGCTGGAAGCATAGCAGAAACTAAAGATTCTGATATAGTTATAATTACA
GCAGGAGCTGCACAAAAAGATGGTGAAACTAGATTAGATTTAATTGAAAAAAATTATAATATATTCAAGGGATTTATTCC
TGAAATAGCAAAAGTGAGCCCAGATGCTATATTATTAGTTGCATCTAATCCAGTGGATATCTTAGCATATATTACATATA
AATTATCAGGATTTCCTAAAGAAAGAGTGATAGGAACAGGTACTGTATTAGATACATCAAGACTAAAATATGTTATAGGC
AAATATTTAAATGTAAATAATAACAATGTTCATGCATATGTTTTAGGCGAACATGGTGATAGTGAAGTTGTAAGTTGGAG
TACTGCAAGTATTGCTGGAGAAGGATTTGATGATTACACAAAGAAGTTTTCATTAGAATGGGATGAAGAAATAAGAAGTG
TTATTGAAAGTGATGTTAAAAATGCAGCATACGAAATAATAAGTAGAAAAAAAGCCACTTATTATGCAATTGGATTAGCA
ATAACTAAAATAGCAGAGTCAATACTTAGAGATGAAAATGCTATTTTAACTGTTTCATCATTAATGCAAGGAGAGTATGG
TATAAGTGATATGTACTTAGCTATACCTACTATAATTAATAGAAATGGAGCAGTAAGAATAGTAGAACCAAATATAACTG
AAGAGGAAATAGAAAAATTACAGAATTCAGCTAATGTATTAAAAGAACACGTGTCAAAATGTCAAATTTAA

Upstream 100 bases:

>100_bases
AGGGAACAATTTTAGAAATATGTTTATGAAGTTGTTAAATAATAATTTATAAACGTTTTGATAATAATATATTAGAATAG
AATATTTAGGAGGACTAGAT

Downstream 100 bases:

>100_bases
ATTTTATTTGACAAGTTATTATTAATTTATTATACTGAGTTAGTGAAATACGGATGTTTAGGAGGTCAAGTATGCAAATG
CATTCTAAGGCCTCCTTTTT

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: L-LDH [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MARERKRKISIIGAGFVGSTTAFALMNSGVATEICICDINMDKAMGEVMDLVHGTSFVKPVNIYAGSIAETKDSDIVIIT
AGAAQKDGETRLDLIEKNYNIFKGFIPEIAKVSPDAILLVASNPVDILAYITYKLSGFPKERVIGTGTVLDTSRLKYVIG
KYLNVNNNNVHAYVLGEHGDSEVVSWSTASIAGEGFDDYTKKFSLEWDEEIRSVIESDVKNAAYEIISRKKATYYAIGLA
ITKIAESILRDENAILTVSSLMQGEYGISDMYLAIPTIINRNGAVRIVEPNITEEEIEKLQNSANVLKEHVSKCQI

Sequences:

>Translated_316_residues
MARERKRKISIIGAGFVGSTTAFALMNSGVATEICICDINMDKAMGEVMDLVHGTSFVKPVNIYAGSIAETKDSDIVIIT
AGAAQKDGETRLDLIEKNYNIFKGFIPEIAKVSPDAILLVASNPVDILAYITYKLSGFPKERVIGTGTVLDTSRLKYVIG
KYLNVNNNNVHAYVLGEHGDSEVVSWSTASIAGEGFDDYTKKFSLEWDEEIRSVIESDVKNAAYEIISRKKATYYAIGLA
ITKIAESILRDENAILTVSSLMQGEYGISDMYLAIPTIINRNGAVRIVEPNITEEEIEKLQNSANVLKEHVSKCQI
>Mature_315_residues
ARERKRKISIIGAGFVGSTTAFALMNSGVATEICICDINMDKAMGEVMDLVHGTSFVKPVNIYAGSIAETKDSDIVIITA
GAAQKDGETRLDLIEKNYNIFKGFIPEIAKVSPDAILLVASNPVDILAYITYKLSGFPKERVIGTGTVLDTSRLKYVIGK
YLNVNNNNVHAYVLGEHGDSEVVSWSTASIAGEGFDDYTKKFSLEWDEEIRSVIESDVKNAAYEIISRKKATYYAIGLAI
TKIAESILRDENAILTVSSLMQGEYGISDMYLAIPTIINRNGAVRIVEPNITEEEIEKLQNSANVLKEHVSKCQI

Specific function: Catalyzes The Reversible Oxidation Of Malate To Oxaloacetate. [C]

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. LDH family [H]

Homologues:

Organism=Homo sapiens, GI5031857, Length=309, Percent_Identity=42.3948220064725, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI260099723, Length=304, Percent_Identity=41.4473684210526, Blast_Score=251, Evalue=4e-67,
Organism=Homo sapiens, GI15082234, Length=311, Percent_Identity=41.8006430868167, Blast_Score=249, Evalue=2e-66,
Organism=Homo sapiens, GI47059044, Length=304, Percent_Identity=42.4342105263158, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI221136809, Length=304, Percent_Identity=42.4342105263158, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI291575128, Length=302, Percent_Identity=39.4039735099338, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI4557032, Length=302, Percent_Identity=39.4039735099338, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI9257228, Length=302, Percent_Identity=41.3907284768212, Blast_Score=240, Evalue=1e-63,
Organism=Homo sapiens, GI4504973, Length=302, Percent_Identity=41.3907284768212, Blast_Score=240, Evalue=1e-63,
Organism=Homo sapiens, GI260099727, Length=217, Percent_Identity=44.2396313364055, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI260099725, Length=224, Percent_Identity=44.1964285714286, Blast_Score=188, Evalue=6e-48,
Organism=Homo sapiens, GI207028494, Length=194, Percent_Identity=41.2371134020619, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI103472011, Length=300, Percent_Identity=29.3333333333333, Blast_Score=151, Evalue=6e-37,
Organism=Homo sapiens, GI103472015, Length=180, Percent_Identity=32.7777777777778, Blast_Score=112, Evalue=3e-25,
Organism=Escherichia coli, GI1789632, Length=300, Percent_Identity=24, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17535107, Length=291, Percent_Identity=40.2061855670103, Blast_Score=247, Evalue=4e-66,
Organism=Saccharomyces cerevisiae, GI6320125, Length=330, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17136226, Length=305, Percent_Identity=40.9836065573771, Blast_Score=262, Evalue=2e-70,
Organism=Drosophila melanogaster, GI45550422, Length=318, Percent_Identity=33.9622641509434, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24647881, Length=323, Percent_Identity=24.4582043343653, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24663599, Length=329, Percent_Identity=23.1003039513678, Blast_Score=64, Evalue=1e-10,

Paralogues:

None

Copy number: 2640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 260 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2380 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). 260 Molecules/Cell In: Stationary Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001557
- InterPro:   IPR011304
- InterPro:   IPR018177
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N [H]

EC number: =1.1.1.27 [H]

Molecular weight: Translated: 34631; Mature: 34500

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00064 L_LDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARERKRKISIIGAGFVGSTTAFALMNSGVATEICICDINMDKAMGEVMDLVHGTSFVKP
CCCCCCCEEEEEECCCCCHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHHHHCCCCCCE
VNIYAGSIAETKDSDIVIITAGAAQKDGETRLDLIEKNYNIFKGFIPEIAKVSPDAILLV
EEEEECCCCCCCCCCEEEEECCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEE
ASNPVDILAYITYKLSGFPKERVIGTGTVLDTSRLKYVIGKYLNVNNNNVHAYVLGEHGD
ECCCCEEEEEEEHHHCCCCHHHEEECCCEEEHHHHHHHHHHHEECCCCCEEEEEEECCCC
SEVVSWSTASIAGEGFDDYTKKFSLEWDEEIRSVIESDVKNAAYEIISRKKATYYAIGLA
CCEEEEEEHHCCCCCCHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHH
ITKIAESILRDENAILTVSSLMQGEYGISDMYLAIPTIINRNGAVRIVEPNITEEEIEKL
HHHHHHHHHCCCCCEEEHHHHHCCCCCCCHHHEEHHHHCCCCCEEEEECCCCCHHHHHHH
QNSANVLKEHVSKCQI
HHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ARERKRKISIIGAGFVGSTTAFALMNSGVATEICICDINMDKAMGEVMDLVHGTSFVKP
CCCCCCEEEEEECCCCCHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHHHHCCCCCCE
VNIYAGSIAETKDSDIVIITAGAAQKDGETRLDLIEKNYNIFKGFIPEIAKVSPDAILLV
EEEEECCCCCCCCCCEEEEECCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEE
ASNPVDILAYITYKLSGFPKERVIGTGTVLDTSRLKYVIGKYLNVNNNNVHAYVLGEHGD
ECCCCEEEEEEEHHHCCCCHHHEEECCCEEEHHHHHHHHHHHEECCCCCEEEEEEECCCC
SEVVSWSTASIAGEGFDDYTKKFSLEWDEEIRSVIESDVKNAAYEIISRKKATYYAIGLA
CCEEEEEEHHCCCCCCHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHH
ITKIAESILRDENAILTVSSLMQGEYGISDMYLAIPTIINRNGAVRIVEPNITEEEIEKL
HHHHHHHHHCCCCCEEEHHHHHCCCCCCCHHHEEHHHHCCCCCEEEEECCCCCHHHHHHH
QNSANVLKEHVSKCQI
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA