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The map label for this gene is hofD [H]

Identifier: 187934585

GI number: 187934585

Start: 3472991

End: 3473749

Strand: Reverse

Name: hofD [H]

Synonym: CLL_A3303

Alternate gene names: 187934585

Gene position: 3473749-3472991 (Counterclockwise)

Preceding gene: 187934046

Following gene: 187935462

Centisome position: 91.41

GC content: 25.96

Gene sequence:

>759_bases
TTGAATTGTATATTGGTAATTATAATAGGATTAGTAATAGGTAGTTTTTTAAATGTATGTGTTTATAGAATTCCACTTGG
ACAATCAATTTCTTATCCACCATCTCACTGTGGAACTTGTAATCATAACTTAAAACCTATGGACTTAATACCAGTTTTAA
GTTATTTATTCTTAAGGGGAAAATGTAGGTATTGTAAGGGGAAAATCTCAATAAGGTATCCTTTAATAGAGATACTTAAC
TCTATTTTATACATTGTTATATTTTTAAATTATGGATTAACTTTAGAATTTTTTAAATATAGTATATTAAGTTCATTATT
AATTGTAATAGGAATAATAGATTATAAAACTCAAGATATATATACAGTGACAATAATATTTGGAATAATATGTAGCATAA
TATTTATGGCAGTAGATTTTTTTGTCAATAAAAATACAATTTCAACTTATGTTTTAGGGGGATTAATTGGATTTGCAGCA
TTAGCAATCATAGTAATTATAACTAAAGGGATGGGTATTGGAGATGCAGAAATTACACTAGTTTGTGGTTTATTTTTAGG
AATAAAGGGAGTAATTGTGACTTTATTTTTAGGAATCATAATAGGAGGAATAGTTGCAATTATTATTTTAGCTTTAAAAC
TAAAAGATGCAAAAGATGCCATGGCATTTGGTCCATGTTTATCTATAGGCGCAATTATGTACATACTATGGGGAGATACA
ATAATAAATGCTTATTTAAAAATGGTAGGTATAATATAA

Upstream 100 bases:

>100_bases
ATAAGAAATCTACAATCCAAAGTTATTATTATGATGTATTTATATACAAATATATAAAGAAAAGTAATATAATGTAATTA
AAGTTAGGAGTATGTGAATT

Downstream 100 bases:

>100_bases
AAATTAGTATATGTGGGAGAGGTTGTAACATAAGAAATAAAAGAGAGTGGTGAGTATTTAATGGCTATAGAAAAGAAAAG
ATTAGGGAATATCCTTATAA

Product: leader peptidase

Products: NA

Alternate protein names: Leader peptidase; Prepilin peptidase; N-methyltransferase [H]

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MNCILVIIIGLVIGSFLNVCVYRIPLGQSISYPPSHCGTCNHNLKPMDLIPVLSYLFLRGKCRYCKGKISIRYPLIEILN
SILYIVIFLNYGLTLEFFKYSILSSLLIVIGIIDYKTQDIYTVTIIFGIICSIIFMAVDFFVNKNTISTYVLGGLIGFAA
LAIIVIITKGMGIGDAEITLVCGLFLGIKGVIVTLFLGIIIGGIVAIIILALKLKDAKDAMAFGPCLSIGAIMYILWGDT
IINAYLKMVGII

Sequences:

>Translated_252_residues
MNCILVIIIGLVIGSFLNVCVYRIPLGQSISYPPSHCGTCNHNLKPMDLIPVLSYLFLRGKCRYCKGKISIRYPLIEILN
SILYIVIFLNYGLTLEFFKYSILSSLLIVIGIIDYKTQDIYTVTIIFGIICSIIFMAVDFFVNKNTISTYVLGGLIGFAA
LAIIVIITKGMGIGDAEITLVCGLFLGIKGVIVTLFLGIIIGGIVAIIILALKLKDAKDAMAFGPCLSIGAIMYILWGDT
IINAYLKMVGII
>Mature_252_residues
MNCILVIIIGLVIGSFLNVCVYRIPLGQSISYPPSHCGTCNHNLKPMDLIPVLSYLFLRGKCRYCKGKISIRYPLIEILN
SILYIVIFLNYGLTLEFFKYSILSSLLIVIGIIDYKTQDIYTVTIIFGIICSIIFMAVDFFVNKNTISTYVLGGLIGFAA
LAIIVIITKGMGIGDAEITLVCGLFLGIKGVIVTLFLGIIIGGIVAIIILALKLKDAKDAMAFGPCLSIGAIMYILWGDT
IINAYLKMVGII

Specific function: Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue [H]

COG id: COG1989

COG function: function code NOU; Type II secretory pathway, prepilin signal peptidase PulO and related peptidases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A24 family [H]

Homologues:

Organism=Escherichia coli, GI87082194, Length=254, Percent_Identity=31.496062992126, Blast_Score=100, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010627
- InterPro:   IPR014032
- InterPro:   IPR000045 [H]

Pfam domain/function: PF06750 DiS_P_DiS; PF01478 Peptidase_A24 [H]

EC number: =3.4.23.43 [H]

Molecular weight: Translated: 27523; Mature: 27523

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHCCC
>Mature Secondary Structure
MNCILVIIIGLVIGSFLNVCVYRIPLGQSISYPPSHCGTCNHNLKPMDLIPVLSYLFLRG
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
KCRYCKGKISIRYPLIEILNSILYIVIFLNYGLTLEFFKYSILSSLLIVIGIIDYKTQDI
CCHHCCCCEEEECHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCH
YTVTIIFGIICSIIFMAVDFFVNKNTISTYVLGGLIGFAALAIIVIITKGMGIGDAEITL
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
VCGLFLGIKGVIVTLFLGIIIGGIVAIIILALKLKDAKDAMAFGPCLSIGAIMYILWGDT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
IINAYLKMVGII
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]