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The map label for this gene is ctfA [H]

Identifier: 187934410

GI number: 187934410

Start: 2231959

End: 2232612

Strand: Reverse

Name: ctfA [H]

Synonym: CLL_A2133

Alternate gene names: 187934410

Gene position: 2232612-2231959 (Counterclockwise)

Preceding gene: 187934965

Following gene: 187933378

Centisome position: 58.75

GC content: 32.11

Gene sequence:

>654_bases
ATGAATAAAATAGTTAAGCTTGAAGATCTAAAGTCTATTTTTAAAGATGGAATGACAATTATGATCGGTGGCTTCTTAGA
TTGTGGAAGTCCTGAAACCATAATTGATATGTTGGTAAATTTAAATGTAAAAAATCTAACTATAATAGGAAACGATACCG
GATACCCAGATAAAGGCATAGGTAAATTAGTTGTAAATGGTCAGGTAAAAAAGGTAATAGCTTCTCATATAGGGACAAAT
CCTGAGACCGGAAGGAGAATGAATAGTGGGGAAATGGAGGTGGAACTTTCTCCACAAGGAACATTAATTGAAAGAATACG
TGCGGCAGGTTCTGGTTTAGGTGGAGTACTAACATCAACAGGAATAGGAACAATTGTAGAAAAGGGAAAACGTAAGATTT
TAATTGATGATAAAGAATATTTATTAGAACTTCCATTAAAAGCAGATGTTTCACTAGTAAAGGGAAGTATAGTAGATGAA
TTCGGAAATACTTGTTATAAAGGAACTACAAAAAACTTTAATCCTTATATTGCAATGGCGGCTGATACTGTAATAATGGA
AGCTGAAAATTTAGTTGAATTTGAAGAATTAAATAGGGAAGATATAATGACTCCAGGTGTATTAGTAAATTATATAATAA
GGGAGGAAATTTAA

Upstream 100 bases:

>100_bases
GTACTTGCAGGTTAGATGATAGATCAAGACAATTATTTCAATATATTTAGCAGTTTTATATGAAGTATTATATATTCTAA
AAAAAGAAGGAGATATTAAC

Downstream 100 bases:

>100_bases
GTGATTACAGATAGTAAATTAGCAAGACAAATAATTGCAAAAAGGGTTGCAAAGGAATTAGAGGACGGACAACTTGTGAA
CCTTGGAATAGGACTTCCAA

Product: 3-oxoacid CoA-transferase, A subunit

Products: NA

Alternate protein names: Coat A; Acetoacetyl-CoA:acetate/butyrate:CoA transferase subunit A [H]

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MNKIVKLEDLKSIFKDGMTIMIGGFLDCGSPETIIDMLVNLNVKNLTIIGNDTGYPDKGIGKLVVNGQVKKVIASHIGTN
PETGRRMNSGEMEVELSPQGTLIERIRAAGSGLGGVLTSTGIGTIVEKGKRKILIDDKEYLLELPLKADVSLVKGSIVDE
FGNTCYKGTTKNFNPYIAMAADTVIMEAENLVEFEELNREDIMTPGVLVNYIIREEI

Sequences:

>Translated_217_residues
MNKIVKLEDLKSIFKDGMTIMIGGFLDCGSPETIIDMLVNLNVKNLTIIGNDTGYPDKGIGKLVVNGQVKKVIASHIGTN
PETGRRMNSGEMEVELSPQGTLIERIRAAGSGLGGVLTSTGIGTIVEKGKRKILIDDKEYLLELPLKADVSLVKGSIVDE
FGNTCYKGTTKNFNPYIAMAADTVIMEAENLVEFEELNREDIMTPGVLVNYIIREEI
>Mature_217_residues
MNKIVKLEDLKSIFKDGMTIMIGGFLDCGSPETIIDMLVNLNVKNLTIIGNDTGYPDKGIGKLVVNGQVKKVIASHIGTN
PETGRRMNSGEMEVELSPQGTLIERIRAAGSGLGGVLTSTGIGTIVEKGKRKILIDDKEYLLELPLKADVSLVKGSIVDE
FGNTCYKGTTKNFNPYIAMAADTVIMEAENLVEFEELNREDIMTPGVLVNYIIREEI

Specific function: Involved in solventogenic switch which allows C.acetobutylicum to uptake acid and produce solvents. Acts mainly to detoxify the medium by removing the acetate and butyrate excreted earlier in the fermentation [H]

COG id: COG1788

COG function: function code I; Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-oxoacid CoA-transferase subunit A family [H]

Homologues:

Organism=Homo sapiens, GI4557817, Length=228, Percent_Identity=36.8421052631579, Blast_Score=153, Evalue=1e-37,
Organism=Homo sapiens, GI11545841, Length=217, Percent_Identity=36.8663594470046, Blast_Score=139, Evalue=2e-33,
Organism=Escherichia coli, GI1788551, Length=212, Percent_Identity=53.7735849056604, Blast_Score=246, Evalue=7e-67,
Organism=Escherichia coli, GI1787985, Length=192, Percent_Identity=23.9583333333333, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17531517, Length=226, Percent_Identity=34.070796460177, Blast_Score=129, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24655794, Length=218, Percent_Identity=36.2385321100917, Blast_Score=140, Evalue=6e-34,
Organism=Drosophila melanogaster, GI21358325, Length=218, Percent_Identity=36.2385321100917, Blast_Score=140, Evalue=7e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012792
- InterPro:   IPR004165
- InterPro:   IPR004163 [H]

Pfam domain/function: PF01144 CoA_trans [H]

EC number: =2.8.3.9 [H]

Molecular weight: Translated: 23637; Mature: 23637

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS01273 COA_TRANSF_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKIVKLEDLKSIFKDGMTIMIGGFLDCGSPETIIDMLVNLNVKNLTIIGNDTGYPDKGI
CCCCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCC
GKLVVNGQVKKVIASHIGTNPETGRRMNSGEMEVELSPQGTLIERIRAAGSGLGGVLTST
CEEEECCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCHHHHC
GIGTIVEKGKRKILIDDKEYLLELPLKADVSLVKGSIVDEFGNTCYKGTTKNFNPYIAMA
CHHHHHHCCCCEEEECCHHHEEECCCCCCHHHHHHHHHHHHCCCEECCCCCCCCCEEEEE
ADTVIMEAENLVEFEELNREDIMTPGVLVNYIIREEI
HHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MNKIVKLEDLKSIFKDGMTIMIGGFLDCGSPETIIDMLVNLNVKNLTIIGNDTGYPDKGI
CCCCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCC
GKLVVNGQVKKVIASHIGTNPETGRRMNSGEMEVELSPQGTLIERIRAAGSGLGGVLTST
CEEEECCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCHHHHC
GIGTIVEKGKRKILIDDKEYLLELPLKADVSLVKGSIVDEFGNTCYKGTTKNFNPYIAMA
CHHHHHHCCCCEEEECCHHHEEECCCCCCHHHHHHHHHHHHCCCEECCCCCCCCCEEEEE
ADTVIMEAENLVEFEELNREDIMTPGVLVNYIIREEI
HHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8226639; 8423010; 11466286; 8300540; 2383002 [H]