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The map label for this gene is mepA [H]

Identifier: 187933879

GI number: 187933879

Start: 1120237

End: 1121616

Strand: Reverse

Name: mepA [H]

Synonym: CLL_A1094

Alternate gene names: 187933879

Gene position: 1121616-1120237 (Counterclockwise)

Preceding gene: 187935418

Following gene: 187934473

Centisome position: 29.51

GC content: 26.38

Gene sequence:

>1380_bases
GTGAATTTAATATTTTCCAAAAACAATAACACTGCTTTAAACAAAGACTTTTTTAAGTATGTAATTCCATCAATTGCTTC
TATGTGGATTTCTGCTTTATATATAATGGTAGATGCTATATTCGTAAGTAAAGGGGTAAGCTCTGAAGCATTAGCCGCTG
TAAATTTAGCTATGCCATACACAAATTTTATTTTTGGATTATCTGTGTTATTTTCAATTGGGTCATCTACTGTTATTTCT
ATAGCTTTAGGTAAAGGAGAAAATAAAAAAGCTAAAGAGTATTTTTCTATTACAATTGTATTACTCACAATAATATCTAG
TATTATTTGCATATTTAGTCTTATATTTTTAGATGAAATATGCTTATTTCTAGGCGCAACTAATTCTATCCTTCCTATGG
TTAAAAGCTATTTAGGTGTAATCATACTTTTTATAGTTTTTTACGTAGTATCTTATGCCCTAGAAGTCCTTATAAAGACA
GATGGTTATCCTCATTTATCTACAATAGGAGTTATCATATCTGCTTTAACTAATGTAGTATTAGACTATGTCTTTGTTAT
GCAATTTAACTGGGGACTTGAAGGTGCTGCTTTAGCAACTGGACTAGCGCGTTTATTTTCTTTTGTGTTTTTTATGATTC
ACTTTTTAGGAAAAAACTCTAACTTAAAATTTTGTAAGTTTAAATTTGAAATGCCATTTATAAAGAGAATAATGTCAATA
GGATTTTCTGACTGTGCTACTGAACTTAGTCTTGGAATTATAATATTGTTATTTAATCAGTGCATATTAATATTTTTAAA
AGAAGATGCTTTAATAACTTATAGTGTTATTTCTTATGTAAATACCATGGTTCTATCTACTATGCTAGGAATATCGCAAG
GTCTTCAACCCTTATGTAGTTATTATTATGGAACACGTGATAAAAAAACTATTAAATATTTATTTTCTCTATCTTTAAAA
GTAGTTTTAGCTTCTTCTGTATCTATATTTTTGATATGTACATTATTCACTGAGCCTATAGTACTTATGTTTATCGATAA
ATCAGATATGAGTCTATTTAACTACACTACTCATACTTTTAAAATTTTTTCTATATCATTTTTAATATTAGGTTTTAATG
TCGTTACATCTGGATTTTTAGCATCTTTAGAAAAAAGTATTGATGCTTGCAAGATTTCTTTAGGACGAGGCTTATTTGTT
CTTTCTATATCTTTATTTCTTATGATATTTTTATTTGGTGGAAATGGAATTTGGATTAGTACAATAATTTCTGAAATTGT
AGTTTTAATATTTTCCTTATTACTTTTGAGAAAAAATTTAAATGTTTTAGAAGATATTAATTATAAAACTAAGTATGAAT
TAAATAAAATAGGGACATAA

Upstream 100 bases:

>100_bases
TAACGCTTCATAAACATTCCCCCCTATTTTTTCTAAAAAGCGTTTGACCTGTGTATTATACCATAGCTTATAGTATTGTT
TGAATAAGGAGGTAAAATAC

Downstream 100 bases:

>100_bases
TATAATTAATCCTTATTTATATATGATAAAAATTTAGTCTCTTAAGTTAGTACTCTTTACTAGTTAATTTTAAAAGGCTC
AATAAATATTTCCACATTTA

Product: Na+ driven multidrug efflux pump

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MNLIFSKNNNTALNKDFFKYVIPSIASMWISALYIMVDAIFVSKGVSSEALAAVNLAMPYTNFIFGLSVLFSIGSSTVIS
IALGKGENKKAKEYFSITIVLLTIISSIICIFSLIFLDEICLFLGATNSILPMVKSYLGVIILFIVFYVVSYALEVLIKT
DGYPHLSTIGVIISALTNVVLDYVFVMQFNWGLEGAALATGLARLFSFVFFMIHFLGKNSNLKFCKFKFEMPFIKRIMSI
GFSDCATELSLGIIILLFNQCILIFLKEDALITYSVISYVNTMVLSTMLGISQGLQPLCSYYYGTRDKKTIKYLFSLSLK
VVLASSVSIFLICTLFTEPIVLMFIDKSDMSLFNYTTHTFKIFSISFLILGFNVVTSGFLASLEKSIDACKISLGRGLFV
LSISLFLMIFLFGGNGIWISTIISEIVVLIFSLLLLRKNLNVLEDINYKTKYELNKIGT

Sequences:

>Translated_459_residues
MNLIFSKNNNTALNKDFFKYVIPSIASMWISALYIMVDAIFVSKGVSSEALAAVNLAMPYTNFIFGLSVLFSIGSSTVIS
IALGKGENKKAKEYFSITIVLLTIISSIICIFSLIFLDEICLFLGATNSILPMVKSYLGVIILFIVFYVVSYALEVLIKT
DGYPHLSTIGVIISALTNVVLDYVFVMQFNWGLEGAALATGLARLFSFVFFMIHFLGKNSNLKFCKFKFEMPFIKRIMSI
GFSDCATELSLGIIILLFNQCILIFLKEDALITYSVISYVNTMVLSTMLGISQGLQPLCSYYYGTRDKKTIKYLFSLSLK
VVLASSVSIFLICTLFTEPIVLMFIDKSDMSLFNYTTHTFKIFSISFLILGFNVVTSGFLASLEKSIDACKISLGRGLFV
LSISLFLMIFLFGGNGIWISTIISEIVVLIFSLLLLRKNLNVLEDINYKTKYELNKIGT
>Mature_459_residues
MNLIFSKNNNTALNKDFFKYVIPSIASMWISALYIMVDAIFVSKGVSSEALAAVNLAMPYTNFIFGLSVLFSIGSSTVIS
IALGKGENKKAKEYFSITIVLLTIISSIICIFSLIFLDEICLFLGATNSILPMVKSYLGVIILFIVFYVVSYALEVLIKT
DGYPHLSTIGVIISALTNVVLDYVFVMQFNWGLEGAALATGLARLFSFVFFMIHFLGKNSNLKFCKFKFEMPFIKRIMSI
GFSDCATELSLGIIILLFNQCILIFLKEDALITYSVISYVNTMVLSTMLGISQGLQPLCSYYYGTRDKKTIKYLFSLSLK
VVLASSVSIFLICTLFTEPIVLMFIDKSDMSLFNYTTHTFKIFSISFLILGFNVVTSGFLASLEKSIDACKISLGRGLFV
LSISLFLMIFLFGGNGIWISTIISEIVVLIFSLLLLRKNLNVLEDINYKTKYELNKIGT

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 51175; Mature: 51175

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLIFSKNNNTALNKDFFKYVIPSIASMWISALYIMVDAIFVSKGVSSEALAAVNLAMPY
CCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCH
TNFIFGLSVLFSIGSSTVISIALGKGENKKAKEYFSITIVLLTIISSIICIFSLIFLDEI
HHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CLFLGATNSILPMVKSYLGVIILFIVFYVVSYALEVLIKTDGYPHLSTIGVIISALTNVV
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LDYVFVMQFNWGLEGAALATGLARLFSFVFFMIHFLGKNSNLKFCKFKFEMPFIKRIMSI
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHC
GFSDCATELSLGIIILLFNQCILIFLKEDALITYSVISYVNTMVLSTMLGISQGLQPLCS
CHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
YYYGTRDKKTIKYLFSLSLKVVLASSVSIFLICTLFTEPIVLMFIDKSDMSLFNYTTHTF
HHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEEECCCCCCHHCCCHHHH
KIFSISFLILGFNVVTSGFLASLEKSIDACKISLGRGLFVLSISLFLMIFLFGGNGIWIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEHH
TIISEIVVLIFSLLLLRKNLNVLEDINYKTKYELNKIGT
HHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCHHCCCC
>Mature Secondary Structure
MNLIFSKNNNTALNKDFFKYVIPSIASMWISALYIMVDAIFVSKGVSSEALAAVNLAMPY
CCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCH
TNFIFGLSVLFSIGSSTVISIALGKGENKKAKEYFSITIVLLTIISSIICIFSLIFLDEI
HHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CLFLGATNSILPMVKSYLGVIILFIVFYVVSYALEVLIKTDGYPHLSTIGVIISALTNVV
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LDYVFVMQFNWGLEGAALATGLARLFSFVFFMIHFLGKNSNLKFCKFKFEMPFIKRIMSI
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHC
GFSDCATELSLGIIILLFNQCILIFLKEDALITYSVISYVNTMVLSTMLGISQGLQPLCS
CHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
YYYGTRDKKTIKYLFSLSLKVVLASSVSIFLICTLFTEPIVLMFIDKSDMSLFNYTTHTF
HHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEEECCCCCCHHCCCHHHH
KIFSISFLILGFNVVTSGFLASLEKSIDACKISLGRGLFVLSISLFLMIFLFGGNGIWIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEHH
TIISEIVVLIFSLLLLRKNLNVLEDINYKTKYELNKIGT
HHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA