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The map label for this gene is lytA [H]

Identifier: 187933867

GI number: 187933867

Start: 2315979

End: 2317277

Strand: Reverse

Name: lytA [H]

Synonym: CLL_A2231

Alternate gene names: 187933867

Gene position: 2317277-2315979 (Counterclockwise)

Preceding gene: 187934366

Following gene: 187932931

Centisome position: 60.98

GC content: 31.56

Gene sequence:

>1299_bases
ATGTTACTAAGTTTAAATTCAATAACAGCATATGCTGCATGGCAAAAAGATTCACAAAACAGGTGGAGTTGGATTGAAAA
TGAGACTAAGGCAACTGGATGGAAAAATATCGATAATTCTTGGTATTATTTCAATATGAATGGTCTTATGAATACAGGAT
GGTTAAAAGATAATGATGAGAAGTGGTATTACTTAGCAAGTAGTGGAACAATGCAAATTGGATGGTTTAAGGATAATGAT
AATAAATGGTATCACTTATCTAGAAGTGGAGCAATGGATATAAGTTGGCTTAAAGATGAAGATAATAAATGGTATTATCT
TTCAAATAGTGGTGTTATGCTTACTGGATGGTTAAAAGATAAAAATGAAAAATGGTATTACTTATCTAATAATGGCTCAA
TGGATATTGGTTGGTTAGAAGATAAAGGCAATATTTATTATCTTAATTCTGGTGGTGAAATGGTAACTGGAAAATTAACA
ATTGATGGAGATGTATATATATTCTCTGAAAATGGCCAATTACTAAGTAAAGAAATATCCAATTCAATTGAAAGTGATGA
GACAAGTTCTGATGAAATTAGAAAAGGATATGTTATAACAGAAAGTTCACCATTAAATGTAAGAGAAGAACCATCAGCTT
CATCAAATATATTGGGAACTGTACCTAAGAAAAACAAAGTAAAGGTTATAGGCAATGAAGTAAATGGTTTCTATAAAATT
TCATATAATGATTTAACAGGATGGTCAAGTAGTGAGTGGATAAAACTTATAAGTGATGACGATGAGATCGTGAATGATGA
TAATGAAGATTTAGATGAAGGGTTAAACGTAGAACTTGGTGAAGAAAGAACAGCACCGCCAGCTTCGGATAACAAATATT
ATTATTCTAATAATAATATATTTTATAAAGTAAAACTTTCACCGCCATTTTTAAAGGATGATGGAAGTCCTATTGTAGGA
AACTGCACATGGTATGCATGGGGACGCATATGGGAACTTACGGGACAAGCACCGGTTGATGCAAAATTTTTAGGCAATGG
TTATGAATGGTGGCAATCTAATCTTAATACTGGTAAATATAAAACTGGAGATAAACCTAGAGTAGGAGCGTTAGCAGTAT
GGAAACCATCTTTAGTAGGTTCAGGTGGATTTGGTCATGTTGCGGTAATTGAAAAAATAGAAAATGGTAAAGTATATATA
TCAGAATCATCTTGGCATGGATCACTGTTTAAGTATAGAGAATTATATAATACACAAGATTTATATGGATATATATATCT
AGATGAACCGAACTATTAA

Upstream 100 bases:

>100_bases
TTCAAATGACAAAAGACATTAATAATTGACTTAAGGGGAGAAAAAATAGGTGAAAAAAAGATATCTAACGAAGATAATAC
TAACATCGTTAACAATTACT

Downstream 100 bases:

>100_bases
TTAACAAAATATATATAATGTAAACTGCCCTAAATAGAGTATTAATAATCATTTTAGGGCAGTTTTTATATTATTTTTAG
TATTCCCAAGTTCAAATACT

Product: surface protective antigen SpaB

Products: NA

Alternate protein names: Cell wall hydrolase; Mucopeptide aminohydrolase; Murein hydrolase; N-acetylmuramoyl-L-alanine amidase [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MLLSLNSITAYAAWQKDSQNRWSWIENETKATGWKNIDNSWYYFNMNGLMNTGWLKDNDEKWYYLASSGTMQIGWFKDND
NKWYHLSRSGAMDISWLKDEDNKWYYLSNSGVMLTGWLKDKNEKWYYLSNNGSMDIGWLEDKGNIYYLNSGGEMVTGKLT
IDGDVYIFSENGQLLSKEISNSIESDETSSDEIRKGYVITESSPLNVREEPSASSNILGTVPKKNKVKVIGNEVNGFYKI
SYNDLTGWSSSEWIKLISDDDEIVNDDNEDLDEGLNVELGEERTAPPASDNKYYYSNNNIFYKVKLSPPFLKDDGSPIVG
NCTWYAWGRIWELTGQAPVDAKFLGNGYEWWQSNLNTGKYKTGDKPRVGALAVWKPSLVGSGGFGHVAVIEKIENGKVYI
SESSWHGSLFKYRELYNTQDLYGYIYLDEPNY

Sequences:

>Translated_432_residues
MLLSLNSITAYAAWQKDSQNRWSWIENETKATGWKNIDNSWYYFNMNGLMNTGWLKDNDEKWYYLASSGTMQIGWFKDND
NKWYHLSRSGAMDISWLKDEDNKWYYLSNSGVMLTGWLKDKNEKWYYLSNNGSMDIGWLEDKGNIYYLNSGGEMVTGKLT
IDGDVYIFSENGQLLSKEISNSIESDETSSDEIRKGYVITESSPLNVREEPSASSNILGTVPKKNKVKVIGNEVNGFYKI
SYNDLTGWSSSEWIKLISDDDEIVNDDNEDLDEGLNVELGEERTAPPASDNKYYYSNNNIFYKVKLSPPFLKDDGSPIVG
NCTWYAWGRIWELTGQAPVDAKFLGNGYEWWQSNLNTGKYKTGDKPRVGALAVWKPSLVGSGGFGHVAVIEKIENGKVYI
SESSWHGSLFKYRELYNTQDLYGYIYLDEPNY
>Mature_432_residues
MLLSLNSITAYAAWQKDSQNRWSWIENETKATGWKNIDNSWYYFNMNGLMNTGWLKDNDEKWYYLASSGTMQIGWFKDND
NKWYHLSRSGAMDISWLKDEDNKWYYLSNSGVMLTGWLKDKNEKWYYLSNNGSMDIGWLEDKGNIYYLNSGGEMVTGKLT
IDGDVYIFSENGQLLSKEISNSIESDETSSDEIRKGYVITESSPLNVREEPSASSNILGTVPKKNKVKVIGNEVNGFYKI
SYNDLTGWSSSEWIKLISDDDEIVNDDNEDLDEGLNVELGEERTAPPASDNKYYYSNNNIFYKVKLSPPFLKDDGSPIVG
NCTWYAWGRIWELTGQAPVDAKFLGNGYEWWQSNLNTGKYKTGDKPRVGALAVWKPSLVGSGGFGHVAVIEKIENGKVYI
SESSWHGSLFKYRELYNTQDLYGYIYLDEPNY

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella and sporulation. Autolysin strictly depends on the presence of choline-containing

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 6 cell wall-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002502
- InterPro:   IPR018337 [H]

Pfam domain/function: PF01510 Amidase_2; PF01473 CW_binding_1 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 49501; Mature: 49501

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: PS50911 CHAP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLSLNSITAYAAWQKDSQNRWSWIENETKATGWKNIDNSWYYFNMNGLMNTGWLKDNDE
CEEEECCEEEEEEECCCCCCCCEEECCCCCCCCCCCCCCCEEEEECCCCEECCCCCCCCC
KWYYLASSGTMQIGWFKDNDNKWYHLSRSGAMDISWLKDEDNKWYYLSNSGVMLTGWLKD
EEEEEECCCEEEEEEEECCCCCEEEEECCCCEEEEEEECCCCCEEEEECCCEEEEEEEEC
KNEKWYYLSNNGSMDIGWLEDKGNIYYLNSGGEMVTGKLTIDGDVYIFSENGQLLSKEIS
CCCEEEEECCCCCEEEEEEECCCCEEEECCCCCEEEEEEEECCEEEEECCCCCCHHHHHH
NSIESDETSSDEIRKGYVITESSPLNVREEPSASSNILGTVPKKNKVKVIGNEVNGFYKI
CCCCCCCCCCCHHHCCEEEECCCCCCCCCCCCCCCCEEEECCCCCEEEEEEECCCEEEEE
SYNDLTGWSSSEWIKLISDDDEIVNDDNEDLDEGLNVELGEERTAPPASDNKYYYSNNNI
EECCCCCCCCCCEEEEECCCHHHCCCCCHHHHCCCCEEECCCCCCCCCCCCEEEECCCCE
FYKVKLSPPFLKDDGSPIVGNCTWYAWGRIWELTGQAPVDAKFLGNGYEWWQSNLNTGKY
EEEEECCCCEECCCCCEEEECEEEEEEEEEEEECCCCCCCCEEECCCHHHHHCCCCCCCC
KTGDKPRVGALAVWKPSLVGSGGFGHVAVIEKIENGKVYISESSWHGSLFKYRELYNTQD
CCCCCCCCCEEEEECCCEECCCCCCEEEEEEEECCCEEEEECCCCCCCHHHHHHHCCCCC
LYGYIYLDEPNY
EEEEEEEECCCC
>Mature Secondary Structure
MLLSLNSITAYAAWQKDSQNRWSWIENETKATGWKNIDNSWYYFNMNGLMNTGWLKDNDE
CEEEECCEEEEEEECCCCCCCCEEECCCCCCCCCCCCCCCEEEEECCCCEECCCCCCCCC
KWYYLASSGTMQIGWFKDNDNKWYHLSRSGAMDISWLKDEDNKWYYLSNSGVMLTGWLKD
EEEEEECCCEEEEEEEECCCCCEEEEECCCCEEEEEEECCCCCEEEEECCCEEEEEEEEC
KNEKWYYLSNNGSMDIGWLEDKGNIYYLNSGGEMVTGKLTIDGDVYIFSENGQLLSKEIS
CCCEEEEECCCCCEEEEEEECCCCEEEECCCCCEEEEEEEECCEEEEECCCCCCHHHHHH
NSIESDETSSDEIRKGYVITESSPLNVREEPSASSNILGTVPKKNKVKVIGNEVNGFYKI
CCCCCCCCCCCHHHCCEEEECCCCCCCCCCCCCCCCEEEECCCCCEEEEEEECCCEEEEE
SYNDLTGWSSSEWIKLISDDDEIVNDDNEDLDEGLNVELGEERTAPPASDNKYYYSNNNI
EECCCCCCCCCCEEEEECCCHHHCCCCCHHHHCCCCEEECCCCCCCCCCCCEEEECCCCE
FYKVKLSPPFLKDDGSPIVGNCTWYAWGRIWELTGQAPVDAKFLGNGYEWWQSNLNTGKY
EEEEECCCCEECCCCCEEEECEEEEEEEEEEEECCCCCCCCEEECCCHHHHHCCCCCCCC
KTGDKPRVGALAVWKPSLVGSGGFGHVAVIEKIENGKVYISESSWHGSLFKYRELYNTQD
CCCCCCCCCEEEEECCCEECCCCCCEEEEEEEECCCEEEEECCCCCCCHHHHHHHCCCCC
LYGYIYLDEPNY
EEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2875013; 11463916 [H]