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The map label for this gene is pyrC [H]

Identifier: 187933599

GI number: 187933599

Start: 2689549

End: 2690745

Strand: Reverse

Name: pyrC [H]

Synonym: CLL_A2579

Alternate gene names: 187933599

Gene position: 2690745-2689549 (Counterclockwise)

Preceding gene: 187932380

Following gene: 187933897

Centisome position: 70.8

GC content: 30.91

Gene sequence:

>1197_bases
GTGGAACTTTTAATTAAAAATGCAAGAATTATAGATGCGATTCAAGATTTTAAAGGTGATATTTATATAAAAGATGGAGT
AATAAATGAAATTGCTCAGGAAATAAAAAAAGATAATGTTGAAGTGCTTAATTGTGAAGAAAAGATATTAATGCCAGCAT
TTATTGATACACATGCTCATTTTAGAGATCCAGGTCTTACGTGTAAAGAAGATCTAGAAAGTGGATCAAAAGCAGCTTTA
AGAGGTGGTTACACAGGTGTATGCTTGATGGCAAATACAAAACCTATATGTTCATCTAAAGAAGTAGTACAGTATGTTAG
AGATAAATCAAAAGAATTAGATTTAATTGATATACATCAATGCATTTCAGTAACTCAGAATTTTGATGGAAAAACTTTAG
ATCATTTAAATGAATTTAAAGATGATAATGAAGTCAAGGCAATTTCAGATGATGGAGTTGGAGTATCCAATTCTAATATT
ATGCTTGAGGCAATGAAAATTGCAAAAGAAAATAACTGGGTGCTTATGTCACATGCTGAAAGCCCAGAGTTTTCTAAAAG
TGATATGAGAATAGCTGAAAATATGATGACTATCAGAGATGTAGAATTAGCAAAACTAAGTGGAGCCCATGTTCATATGT
GTCATGTTAGTACTAAAGAAGCATTAAAATGCATTATTGCTGCTAAGGATGAAGGTGCAAATATTACTTTAGAAGTAACA
CCTCATCATATAGGTTTAACTAAGGAAATAAATGATTATAGAGTTAATCCACCTATAAGGGAAAAAGAAGATGTAGAAGA
AATTATAAAAGCAATTAAGATGGGGAATGTTGATACAATAGGGACGGATCATGCACCGCATACATTAGAAGAAAAATCTA
AGGGATCTCCAGGAATGGTAGGATTGGAAACAGCTTTTCCAATATGTTATACAAAACTAGTTAGAGAAAATGGAGTTTCA
TTAAATGAACTAAGCAAACTTATGTCACTTAATCCAGCTAGGTTATTGGGAATGAATAAAGGAAGAATCAGCATAGGAGT
AGAAGCAGATTTAGTTTTAATAGATATAGATAAAAAAATAAAAGTAGATTCTAATGAATTTGTATCAAAGGGTAGAAATA
CACCCTTTGAAGGCATGGAGTATTATGGAGAAGTTCTTGCTACAATAAAAAGCGGAAAAATTAAATATAAGAAGTAA

Upstream 100 bases:

>100_bases
TTTGTACTATTAGATAAGGAAAAAGGCACTTATAGATGTGAATACTGTGATGAAATAACAAAATTATCTGAAGTGTAATA
AGTGTAAGGGAGTGAACTTA

Downstream 100 bases:

>100_bases
AAAATATATATTTTAGTGGCATGTTTATATATGCATAAGCAAAGTGGACTGAGTAATTGAACTTAGGAATGCTACAATAA
TTTTTAATATATAAATATTT

Product: dihydroorotase, multifunctional complex type

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MELLIKNARIIDAIQDFKGDIYIKDGVINEIAQEIKKDNVEVLNCEEKILMPAFIDTHAHFRDPGLTCKEDLESGSKAAL
RGGYTGVCLMANTKPICSSKEVVQYVRDKSKELDLIDIHQCISVTQNFDGKTLDHLNEFKDDNEVKAISDDGVGVSNSNI
MLEAMKIAKENNWVLMSHAESPEFSKSDMRIAENMMTIRDVELAKLSGAHVHMCHVSTKEALKCIIAAKDEGANITLEVT
PHHIGLTKEINDYRVNPPIREKEDVEEIIKAIKMGNVDTIGTDHAPHTLEEKSKGSPGMVGLETAFPICYTKLVRENGVS
LNELSKLMSLNPARLLGMNKGRISIGVEADLVLIDIDKKIKVDSNEFVSKGRNTPFEGMEYYGEVLATIKSGKIKYKK

Sequences:

>Translated_398_residues
MELLIKNARIIDAIQDFKGDIYIKDGVINEIAQEIKKDNVEVLNCEEKILMPAFIDTHAHFRDPGLTCKEDLESGSKAAL
RGGYTGVCLMANTKPICSSKEVVQYVRDKSKELDLIDIHQCISVTQNFDGKTLDHLNEFKDDNEVKAISDDGVGVSNSNI
MLEAMKIAKENNWVLMSHAESPEFSKSDMRIAENMMTIRDVELAKLSGAHVHMCHVSTKEALKCIIAAKDEGANITLEVT
PHHIGLTKEINDYRVNPPIREKEDVEEIIKAIKMGNVDTIGTDHAPHTLEEKSKGSPGMVGLETAFPICYTKLVRENGVS
LNELSKLMSLNPARLLGMNKGRISIGVEADLVLIDIDKKIKVDSNEFVSKGRNTPFEGMEYYGEVLATIKSGKIKYKK
>Mature_398_residues
MELLIKNARIIDAIQDFKGDIYIKDGVINEIAQEIKKDNVEVLNCEEKILMPAFIDTHAHFRDPGLTCKEDLESGSKAAL
RGGYTGVCLMANTKPICSSKEVVQYVRDKSKELDLIDIHQCISVTQNFDGKTLDHLNEFKDDNEVKAISDDGVGVSNSNI
MLEAMKIAKENNWVLMSHAESPEFSKSDMRIAENMMTIRDVELAKLSGAHVHMCHVSTKEALKCIIAAKDEGANITLEVT
PHHIGLTKEINDYRVNPPIREKEDVEEIIKAIKMGNVDTIGTDHAPHTLEEKSKGSPGMVGLETAFPICYTKLVRENGVS
LNELSKLMSLNPARLLGMNKGRISIGVEADLVLIDIDKKIKVDSNEFVSKGRNTPFEGMEYYGEVLATIKSGKIKYKK

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=369, Percent_Identity=29.2682926829268, Blast_Score=148, Evalue=9e-36,
Organism=Homo sapiens, GI4503051, Length=441, Percent_Identity=24.0362811791383, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI62422571, Length=441, Percent_Identity=24.0362811791383, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI4503379, Length=438, Percent_Identity=25.1141552511416, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI4503377, Length=451, Percent_Identity=24.6119733924612, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI19923821, Length=446, Percent_Identity=23.7668161434978, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI190194363, Length=446, Percent_Identity=22.4215246636771, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1786722, Length=435, Percent_Identity=27.5862068965517, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI87082175, Length=450, Percent_Identity=21.5555555555556, Blast_Score=99, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI193204318, Length=351, Percent_Identity=27.3504273504274, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI86575075, Length=432, Percent_Identity=24.0740740740741, Blast_Score=90, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6322218, Length=416, Percent_Identity=25.2403846153846, Blast_Score=104, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24642586, Length=374, Percent_Identity=29.6791443850267, Blast_Score=147, Evalue=9e-36,
Organism=Drosophila melanogaster, GI18859883, Length=222, Percent_Identity=25.6756756756757, Blast_Score=96, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 44230; Mature: 44230

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELLIKNARIIDAIQDFKGDIYIKDGVINEIAQEIKKDNVEVLNCEEKILMPAFIDTHAH
CCEEECCCHHHHHHHHCCCCEEEECCHHHHHHHHHHHCCCEEEECCHHEECHHHHCCCCC
FRDPGLTCKEDLESGSKAALRGGYTGVCLMANTKPICSSKEVVQYVRDKSKELDLIDIHQ
CCCCCCCCHHHHCCCCCHHHCCCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCCEEHHHH
CISVTQNFDGKTLDHLNEFKDDNEVKAISDDGVGVSNSNIMLEAMKIAKENNWVLMSHAE
HHHHHCCCCCCHHHHHHHHCCCCCEEEECCCCCCCCCCCEEEEEHHHHCCCCEEEEECCC
SPEFSKSDMRIAENMMTIRDVELAKLSGAHVHMCHVSTKEALKCIIAAKDEGANITLEVT
CCCCCHHHHHHHHHHHHHHCCHHHHCCCCEEEEEECCHHHHHEEEEEECCCCCEEEEEEC
PHHIGLTKEINDYRVNPPIREKEDVEEIIKAIKMGNVDTIGTDHAPHTLEEKSKGSPGMV
CCEECCCCCCCCEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCCEE
GLETAFPICYTKLVRENGVSLNELSKLMSLNPARLLGMNKGRISIGVEADLVLIDIDKKI
EHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHEECCCCEEEEEEEEEEEEEECCCCE
KVDSNEFVSKGRNTPFEGMEYYGEVLATIKSGKIKYKK
EECCHHHHHCCCCCCHHHHHHHHHHHHHHHCCEEEECC
>Mature Secondary Structure
MELLIKNARIIDAIQDFKGDIYIKDGVINEIAQEIKKDNVEVLNCEEKILMPAFIDTHAH
CCEEECCCHHHHHHHHCCCCEEEECCHHHHHHHHHHHCCCEEEECCHHEECHHHHCCCCC
FRDPGLTCKEDLESGSKAALRGGYTGVCLMANTKPICSSKEVVQYVRDKSKELDLIDIHQ
CCCCCCCCHHHHCCCCCHHHCCCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCCEEHHHH
CISVTQNFDGKTLDHLNEFKDDNEVKAISDDGVGVSNSNIMLEAMKIAKENNWVLMSHAE
HHHHHCCCCCCHHHHHHHHCCCCCEEEECCCCCCCCCCCEEEEEHHHHCCCCEEEEECCC
SPEFSKSDMRIAENMMTIRDVELAKLSGAHVHMCHVSTKEALKCIIAAKDEGANITLEVT
CCCCCHHHHHHHHHHHHHHCCHHHHCCCCEEEEEECCHHHHHEEEEEECCCCCEEEEEEC
PHHIGLTKEINDYRVNPPIREKEDVEEIIKAIKMGNVDTIGTDHAPHTLEEKSKGSPGMV
CCEECCCCCCCCEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCCEE
GLETAFPICYTKLVRENGVSLNELSKLMSLNPARLLGMNKGRISIGVEADLVLIDIDKKI
EHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHEECCCCEEEEEEEEEEEEEECCCCE
KVDSNEFVSKGRNTPFEGMEYYGEVLATIKSGKIKYKK
EECCHHHHHCCCCCCHHHHHHHHHHHHHHHCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA