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The map label for this gene is pbpA [H]

Identifier: 187933516

GI number: 187933516

Start: 3523940

End: 3525418

Strand: Reverse

Name: pbpA [H]

Synonym: CLL_A3345

Alternate gene names: 187933516

Gene position: 3525418-3523940 (Counterclockwise)

Preceding gene: 187932344

Following gene: 187934936

Centisome position: 92.77

GC content: 31.37

Gene sequence:

>1479_bases
ATGAAAGATATTTCAGATAGCATAAAAAAAGTAATGATAGTTTTTCTATTTTGTTTCGTAGCACTTATTTCGTATATAGC
GTATTTTCAAGTCTTTAATGCTCCAGCAATAGCTGAACAACAAGGCAATAAAAGATTAAGTGCAAGAAGAAATGAAGTAC
TTAGAGGAACTATATATGATAGAAATCAGGTTGCTTTAACTAAAAGCGAAAGAAAGAATGCTCTTACTCAAAAAAGAGAA
TATATATATGGTGATTTATATACTCATGCTTTAGGATATGTAGATCCAATATATAGAGCGACAGGTCTAGAAGCAGCATA
TGATAAAGAACTGTCTCAGTATAGTTCTATTAGCAATACATTTTTAAATTTAACTAAAGATTTTTCAATGGATAATTTAA
AGGATGCTTTTAAGCAGAGAAAAGAAGAAGAAAATAAAATAGGTAACAGTATAATAACTACTTTAAATACAAATATTCAA
CAAGTTGCTTATGATGCTCTTGGGAATAATAAGGGTGCAGTGGTTGCATTAGATCCTAAAACAGGAGAAGTTCTTGCAAT
GGTATCAAAACCAACATACGATCCAAATAATTTAGAGGCTGCAATGAAAGCTGCTAATGAAGGAAGTGCGGATGATAGTC
CACTTATAAACAGAGCAACTGGAGGATTATATCCACCAGGATCAACTTTTAAGACAGTAACTCTTACAAGTGCTTTAGAA
AATATAGCGGGAATAACTAATAGACAATTCCAAGATGATGGTAAGCTTGTATTTAATGATAGTCATTCATTAAGTAATGC
AGGTGGAGCAGTTTATGGAAGCTTGGATTTAAAAAATGCATTTAGAGTATCAAGTAATGTTGTCTTTGGTGGTTTAGCAA
TGGAATTAGGCAATGATAAATTGAAATCTACAGCAGAAAAATTTGGATTTAATAATTCTATAGAAGCTGATGGATTTACA
ATACAAAAAAGTCAATTTCCAACACTTAAAAGTTATGAAGTTGGAAGTATAGCACAAACAGGAATAGGTCAAAGTAGTAT
ATTATCTACACCTATGCAAATGGCTTTAGTATCTAGCACAATAGCTAATGATGGGGTTATGATGAAACCCAAATTAGTTA
ATAAAGTTATTGATAAAGATGGAAATACAGTAAAAACAGTAAATCCTGAAAAATTAAAACAAGTTATGGCTGCAAATGAA
GCTGCTATAATAACAGATTACATGAAAAATTTAGTTGATTCTAAAATAAATAGTACTTGGAGTATATTTAGAGGTACAGA
AACTTGTGGTAAAACAGGAACAGCAGATTATCAGTTACCAAATGGTCAAGATGCTAAACCACATTCATGGTTTATAGGTT
TTGCACCTGAAAATAATCCTAAAGTTGCAATAGCTGTTATTGTTGAAAATGGTGGTTATGGATCAGGAGTAGCAGCCCAA
GTTGCAGGTGAAGTTATACAATCTGCATTATCAAATTAA

Upstream 100 bases:

>100_bases
CAGGTATAACTTTACCACTTATTAGTTATGGTGGTTCTTCAGTTATAACCATGTTTTTTGCGCTTTCAATATTGCAAAAA
ATATCAGAGGAGGACTAACT

Downstream 100 bases:

>100_bases
AAATAAAGATTTGTTTTAAGTGTATGTCGATATAGGAATAAGTATAGTCCCATTTTACCTATTACATAATTAACACATAT
TTAAAATAAAGCTAAAATTA

Product: penicillin-binding protein

Products: NA

Alternate protein names: PBPA [H]

Number of amino acids: Translated: 492; Mature: 492

Protein sequence:

>492_residues
MKDISDSIKKVMIVFLFCFVALISYIAYFQVFNAPAIAEQQGNKRLSARRNEVLRGTIYDRNQVALTKSERKNALTQKRE
YIYGDLYTHALGYVDPIYRATGLEAAYDKELSQYSSISNTFLNLTKDFSMDNLKDAFKQRKEEENKIGNSIITTLNTNIQ
QVAYDALGNNKGAVVALDPKTGEVLAMVSKPTYDPNNLEAAMKAANEGSADDSPLINRATGGLYPPGSTFKTVTLTSALE
NIAGITNRQFQDDGKLVFNDSHSLSNAGGAVYGSLDLKNAFRVSSNVVFGGLAMELGNDKLKSTAEKFGFNNSIEADGFT
IQKSQFPTLKSYEVGSIAQTGIGQSSILSTPMQMALVSSTIANDGVMMKPKLVNKVIDKDGNTVKTVNPEKLKQVMAANE
AAIITDYMKNLVDSKINSTWSIFRGTETCGKTGTADYQLPNGQDAKPHSWFIGFAPENNPKVAIAVIVENGGYGSGVAAQ
VAGEVIQSALSN

Sequences:

>Translated_492_residues
MKDISDSIKKVMIVFLFCFVALISYIAYFQVFNAPAIAEQQGNKRLSARRNEVLRGTIYDRNQVALTKSERKNALTQKRE
YIYGDLYTHALGYVDPIYRATGLEAAYDKELSQYSSISNTFLNLTKDFSMDNLKDAFKQRKEEENKIGNSIITTLNTNIQ
QVAYDALGNNKGAVVALDPKTGEVLAMVSKPTYDPNNLEAAMKAANEGSADDSPLINRATGGLYPPGSTFKTVTLTSALE
NIAGITNRQFQDDGKLVFNDSHSLSNAGGAVYGSLDLKNAFRVSSNVVFGGLAMELGNDKLKSTAEKFGFNNSIEADGFT
IQKSQFPTLKSYEVGSIAQTGIGQSSILSTPMQMALVSSTIANDGVMMKPKLVNKVIDKDGNTVKTVNPEKLKQVMAANE
AAIITDYMKNLVDSKINSTWSIFRGTETCGKTGTADYQLPNGQDAKPHSWFIGFAPENNPKVAIAVIVENGGYGSGVAAQ
VAGEVIQSALSN
>Mature_492_residues
MKDISDSIKKVMIVFLFCFVALISYIAYFQVFNAPAIAEQQGNKRLSARRNEVLRGTIYDRNQVALTKSERKNALTQKRE
YIYGDLYTHALGYVDPIYRATGLEAAYDKELSQYSSISNTFLNLTKDFSMDNLKDAFKQRKEEENKIGNSIITTLNTNIQ
QVAYDALGNNKGAVVALDPKTGEVLAMVSKPTYDPNNLEAAMKAANEGSADDSPLINRATGGLYPPGSTFKTVTLTSALE
NIAGITNRQFQDDGKLVFNDSHSLSNAGGAVYGSLDLKNAFRVSSNVVFGGLAMELGNDKLKSTAEKFGFNNSIEADGFT
IQKSQFPTLKSYEVGSIAQTGIGQSSILSTPMQMALVSSTIANDGVMMKPKLVNKVIDKDGNTVKTVNPEKLKQVMAANE
AAIITDYMKNLVDSKINSTWSIFRGTETCGKTGTADYQLPNGQDAKPHSWFIGFAPENNPKVAIAVIVENGGYGSGVAAQ
VAGEVIQSALSN

Specific function: Cell wall formation. Plays an important role in cell division and cell shape maintenance by cross-linking adjacent peptidoglycan chains through transpeptidation [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Probable). Note=Localized to the division site (septum) along with newly synthesized peptidoglycan, between segregated nucleoids (Probable) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=442, Percent_Identity=28.0542986425339, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1786272, Length=432, Percent_Identity=23.3796296296296, Blast_Score=91, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 53299; Mature: 53299

Theoretical pI: Translated: 7.48; Mature: 7.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDISDSIKKVMIVFLFCFVALISYIAYFQVFNAPAIAEQQGNKRLSARRNEVLRGTIYD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHEEEEEC
RNQVALTKSERKNALTQKREYIYGDLYTHALGYVDPIYRATGLEAAYDKELSQYSSISNT
CCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
FLNLTKDFSMDNLKDAFKQRKEEENKIGNSIITTLNTNIQQVAYDALGNNKGAVVALDPK
HHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHCCCCCEEEEECCC
TGEVLAMVSKPTYDPNNLEAAMKAANEGSADDSPLINRATGGLYPPGSTFKTVTLTSALE
CCCEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHH
NIAGITNRQFQDDGKLVFNDSHSLSNAGGAVYGSLDLKNAFRVSSNVVFGGLAMELGNDK
HHHCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEEECCHHHHHCCCEEEEEEEEECCCHH
LKSTAEKFGFNNSIEADGFTIQKSQFPTLKSYEVGSIAQTGIGQSSILSTPMQMALVSST
HHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHH
IANDGVMMKPKLVNKVIDKDGNTVKTVNPEKLKQVMAANEAAIITDYMKNLVDSKINSTW
HCCCCEEECHHHHHHHHCCCCCEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCE
SIFRGTETCGKTGTADYQLPNGQDAKPHSWFIGFAPENNPKVAIAVIVENGGYGSGVAAQ
EEEECCHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCCHHHH
VAGEVIQSALSN
HHHHHHHHHHCC
>Mature Secondary Structure
MKDISDSIKKVMIVFLFCFVALISYIAYFQVFNAPAIAEQQGNKRLSARRNEVLRGTIYD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHEEEEEC
RNQVALTKSERKNALTQKREYIYGDLYTHALGYVDPIYRATGLEAAYDKELSQYSSISNT
CCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
FLNLTKDFSMDNLKDAFKQRKEEENKIGNSIITTLNTNIQQVAYDALGNNKGAVVALDPK
HHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHCCCCCEEEEECCC
TGEVLAMVSKPTYDPNNLEAAMKAANEGSADDSPLINRATGGLYPPGSTFKTVTLTSALE
CCCEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHH
NIAGITNRQFQDDGKLVFNDSHSLSNAGGAVYGSLDLKNAFRVSSNVVFGGLAMELGNDK
HHHCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEEECCHHHHHCCCEEEEEEEEECCCHH
LKSTAEKFGFNNSIEADGFTIQKSQFPTLKSYEVGSIAQTGIGQSSILSTPMQMALVSST
HHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHH
IANDGVMMKPKLVNKVIDKDGNTVKTVNPEKLKQVMAANEAAIITDYMKNLVDSKINSTW
HCCCCEEECHHHHHHHHCCCCCEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCE
SIFRGTETCGKTGTADYQLPNGQDAKPHSWFIGFAPENNPKVAIAVIVENGGYGSGVAAQ
EEEECCHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCCHHHH
VAGEVIQSALSN
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA