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The map label for this gene is trx [H]

Identifier: 187932849

GI number: 187932849

Start: 3341543

End: 3341854

Strand: Reverse

Name: trx [H]

Synonym: CLL_A3209

Alternate gene names: 187932849

Gene position: 3341854-3341543 (Counterclockwise)

Preceding gene: 187934034

Following gene: 187934913

Centisome position: 87.94

GC content: 26.28

Gene sequence:

>312_bases
ATGTCAAAAATATTAAAAGTTAATGAATTCGATGATGCAATAAAAGAAGGAATTGTAATAGTAGACTTTTTTGCGGATTG
GTGTGGGCCTTGTAAGATGTTAGCACCTATATTTGAAGAATTAGAAGAAGAAATGAAGGATAAAGTTAAATTCTTTAAAG
TTAATGTAGATGAAAGTGGTGAATTAGCTAGTAAGTTTAGCGTATTTAGTATTCCAACTATGATAATATTTAAAGATGGT
AAAGATGTAAGTACTGAAGTAGGATTTTTACCAAAAGAAAAAATAAAAATGAATTTAGAAAAATACATATAA

Upstream 100 bases:

>100_bases
CTATGTTAAAGATTATAAATGATTATACTCTATAAGTGAATTTATATATTCAAAAACAAACTGTTATAAAAAATAATAAA
ATAAAGTGAGGTAATAAGTT

Downstream 100 bases:

>100_bases
TAAAATTTTGGCTATGTTTTAAAACATAGCCAAAATTAATTATGTTATTTTAATTCGCATAGGTATTCTTCAAAGCATAT
ACCTTCATGTACTGAAATAT

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 103; Mature: 102

Protein sequence:

>103_residues
MSKILKVNEFDDAIKEGIVIVDFFADWCGPCKMLAPIFEELEEEMKDKVKFFKVNVDESGELASKFSVFSIPTMIIFKDG
KDVSTEVGFLPKEKIKMNLEKYI

Sequences:

>Translated_103_residues
MSKILKVNEFDDAIKEGIVIVDFFADWCGPCKMLAPIFEELEEEMKDKVKFFKVNVDESGELASKFSVFSIPTMIIFKDG
KDVSTEVGFLPKEKIKMNLEKYI
>Mature_102_residues
SKILKVNEFDDAIKEGIVIVDFFADWCGPCKMLAPIFEELEEEMKDKVKFFKVNVDESGELASKFSVFSIPTMIIFKDGK
DVSTEVGFLPKEKIKMNLEKYI

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI42794771, Length=87, Percent_Identity=42.5287356321839, Blast_Score=74, Evalue=2e-14,
Organism=Homo sapiens, GI224493972, Length=87, Percent_Identity=42.5287356321839, Blast_Score=73, Evalue=5e-14,
Organism=Homo sapiens, GI21361403, Length=97, Percent_Identity=36.0824742268041, Blast_Score=69, Evalue=8e-13,
Organism=Homo sapiens, GI50592994, Length=92, Percent_Identity=39.1304347826087, Blast_Score=66, Evalue=6e-12,
Organism=Homo sapiens, GI21361657, Length=90, Percent_Identity=34.4444444444444, Blast_Score=64, Evalue=4e-11,
Organism=Escherichia coli, GI87082331, Length=81, Percent_Identity=43.2098765432099, Blast_Score=89, Evalue=4e-20,
Organism=Escherichia coli, GI1788936, Length=74, Percent_Identity=50, Blast_Score=86, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI212646193, Length=77, Percent_Identity=42.8571428571429, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17507705, Length=66, Percent_Identity=39.3939393939394, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71980565, Length=98, Percent_Identity=38.7755102040816, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71980562, Length=86, Percent_Identity=41.8604651162791, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71998175, Length=81, Percent_Identity=41.9753086419753, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17509965, Length=62, Percent_Identity=41.9354838709677, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI25144092, Length=82, Percent_Identity=39.0243902439024, Blast_Score=62, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=104, Percent_Identity=42.3076923076923, Blast_Score=91, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6323072, Length=96, Percent_Identity=44.7916666666667, Blast_Score=88, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319925, Length=92, Percent_Identity=36.9565217391304, Blast_Score=72, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28573567, Length=85, Percent_Identity=40, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24639826, Length=85, Percent_Identity=40, Blast_Score=76, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17648013, Length=63, Percent_Identity=44.4444444444444, Blast_Score=69, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24583090, Length=63, Percent_Identity=44.4444444444444, Blast_Score=69, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21358065, Length=96, Percent_Identity=38.5416666666667, Blast_Score=68, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24664269, Length=69, Percent_Identity=42.0289855072464, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11822; Mature: 11691

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKILKVNEFDDAIKEGIVIVDFFADWCGPCKMLAPIFEELEEEMKDKVKFFKVNVDESG
CCCCCCCCCHHHHHHCCEEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCC
ELASKFSVFSIPTMIIFKDGKDVSTEVGFLPKEKIKMNLEKYI
CHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SKILKVNEFDDAIKEGIVIVDFFADWCGPCKMLAPIFEELEEEMKDKVKFFKVNVDESG
CCCCCCCCHHHHHHCCEEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCC
ELASKFSVFSIPTMIIFKDGKDVSTEVGFLPKEKIKMNLEKYI
CHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2559145; 8969504; 9384377; 8755892 [H]