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The map label for this gene is cdr [H]

Identifier: 187932636

GI number: 187932636

Start: 1954433

End: 1956913

Strand: Reverse

Name: cdr [H]

Synonym: CLL_A1858

Alternate gene names: 187932636

Gene position: 1956913-1954433 (Counterclockwise)

Preceding gene: 187934523

Following gene: 187933153

Centisome position: 51.49

GC content: 29.99

Gene sequence:

>2481_bases
ATGGCTAAAAAAATTATTATTGTTGGTGGGGTTGCAGGTGGAGCATCTACTGCAGCTAGACTTAGAAGGTTAGATGAAAA
TTTAGATATAATTATGTTTGAAAAAGGAGAATATATATCATTTGCTAATTGCGGACTTCCATATTATATAGGAGGGGCCA
TTAATGATAGAGAAAAACTTATAGTTCAAACTGTAGAAGAAATGAGTAAGAAATTCAATTTAGATATAAGAAATTTAAGT
GAAGTTATAAAAATAGACAAGGAAAATAAAAAAGTCAGTATAAAAGATTACAGAAAAAATAAAGTTTATGAAGAAGACTA
TGATATTTTAGTATTATCTCCAGGAGCAAGTCCTTTAAAACCTGAAATATCAGGAATTGATAAATGTGATAATTTATTTA
CACTTAGAAATATACCAGATACAGATAAAATAAAAGAATTTGTTGATAATAAAAATCCTAAAAAAGCAGTTGTAATAGGT
GGGGGATTTATAGGACTTGAAATGGCTGAAAATCTAAAGGAAAGAGGCATTGATGTAGCGTTAGTAGAAGCTAGTGATCA
AGTGATGGCTCCAATTGATATAGAAATGGCAAGTATAGTACATGACCATTTAATTGATAAAAATGTAGAATTAATATTAA
AAGATGGTGTAGATTCTTTTGAAGATAAAGGAAAGAAAATCGTTTTGAAAAGTGGAAGAAAAATTAATACTGATATGATA
ATTTTATCAATAGGTGTTAAACCAGAAACTAGAATAGCTAAGGAAGCAGGCATTAAATTAAATGAAAGAGGAGCTATTAT
AGTAGATAAATATATGAAAACTTCTGATTCAAACATTTTTGCACTAGGAGATGCAATTGAAGTTATGGATTTTGTAAATA
AAAAGCCTACAATGATTCCTCTAGCTTGGCCTGCAAATCGTCAAGGTAGATTAGTTGCTAATAATATAATTGGAAGAAAT
GAAGAGTATAAAGGAAGCCTTGGTTCATCAGTAGCCAAAGTATTTGACTATACAGTAGCTGCAACTGGCAATAATGAAAA
AATGCTTAAAAGACTAGGTATTGACTATAAAGCAATTCATATACATCCAGGTTCTAATGCAGGATATTATCCAGGATCTT
TTCCAATAGCAATTAAGATGTTATTTAGTCCTGATGATGGAAGAATATTTGGAGCTCAAGCTGTAGGAATGAGTGGTGTT
GAAAAACGTATAGATATATTAGCTACAGCTATTAAGGGGAATTTTACTGTTTTTGATTTACAAGATATTGAAGTGTGTTA
TGCACCACCATACAATTCAGCAAAAGATCCAGTTAATATGTTAGGTTACTATGCAGCAAATATTATAGAAGGAATAGTGG
ATACAATACAGTGGGATGAAATAGATAATATAGATAAAAATAATTCTATAATTTTAGATATAAGGGAAGAATTTGAATTA
GTTACTGGGAAATTTGATAATTCAATTAACATTCCCCTTGGTGATTTGAGAAATAGATTAAATGAGATACCAAAAGATAA
ACATATATATGTTACATGTCAAGTTGGGTTACGTGGATATGTAGCTTGTAGAATATTAAAACAAAAAGGAATAAAGTGCA
CTAACATAGATGGTGGTTTAAAGACTTACATGTATGTAAAAAGAGCAGAAGAAAGTTTGAAAAATCAATATGAAAAACTT
AATGAGATAAAAGAAGAGGTAGCAGCTATGAGTTTAGAAGATTTAGATATAACAGAAATAAATGCAAAAGTTACGTTAGA
TGCTTGTGGACTTCAATGTCCAGGACCGATAAGAAGAGTATTTGAAGAAATTAATAAAATGGAAGAAGGTCAAATTTTAG
AGGCAAAAGCAAGTGATGTTGGATTTAGTAAGGATATAAAAGCATGGTGTGAAAAAACTAATAATACTTTACTTAAATCA
GAATTTGATAAAAGTAAAAATGCTTTTGTAGCTTATATACAAAAAGGAACAAAGAAAGATGAAGCGATATCTTTAAGTTC
AACTGTAGATAAAAATGGAGCAACTTTGGTAGTGTTTAGTGGAGAGTTTGATAAAGCTATAGCATCATTTATAATAGCCA
CAGGAGCAGCTTCTATGGGAAAAGAAGTTACTATGTTCTTTACTTTTTGGGGACTTAATATATTAAAAAGCAAAAATAAG
CCCAAAGTAAATAAGGATACTATGGAGAAGATGTTTGATATTATGTTGCCAGGACATCCAGAAAAGTTACCATTATCTAA
AATGAATATGATGGGAATGGGACCTGCAATGATAAAACAAATAATGAAAAAGCATAACGTTGACGATTTAGAAAGTTTGA
TAACTAACGCAATAAATATGGGAGTTAAGGTTGTTGCATGTGCTATGAGTATGGATCTTATGGGAATAAAAAAAGAAGAA
TTCATTGATGGAGTTGAAATAGGGGGAGTTGCATCATATTTAGGTGCTACTGAAGATTCAGGATTAAATTTATTTATATA
A

Upstream 100 bases:

>100_bases
TAAAGACTTGTAGCATTTGAATAAATACAGAAAGCAATATTAGAGAATACTACTTTATATAAATGTTTATGTTAGAAATA
ATAAAGTAAGGAGAGATAAC

Downstream 100 bases:

>100_bases
TTTATAAAAGAGCTATATCTTAGAGTATTCTAATATATGGCTCTTTTGTTCTACAAAAAAATTAAAAATTCATAATTATT
AAGTTTAATGGGAAGGAGAA

Product: FAD-dependent pyridine nucleotide-disulphide oxidoreductase

Products: NA

Alternate protein names: CoA-disulfide reductase; CoADR [H]

Number of amino acids: Translated: 826; Mature: 825

Protein sequence:

>826_residues
MAKKIIIVGGVAGGASTAARLRRLDENLDIIMFEKGEYISFANCGLPYYIGGAINDREKLIVQTVEEMSKKFNLDIRNLS
EVIKIDKENKKVSIKDYRKNKVYEEDYDILVLSPGASPLKPEISGIDKCDNLFTLRNIPDTDKIKEFVDNKNPKKAVVIG
GGFIGLEMAENLKERGIDVALVEASDQVMAPIDIEMASIVHDHLIDKNVELILKDGVDSFEDKGKKIVLKSGRKINTDMI
ILSIGVKPETRIAKEAGIKLNERGAIIVDKYMKTSDSNIFALGDAIEVMDFVNKKPTMIPLAWPANRQGRLVANNIIGRN
EEYKGSLGSSVAKVFDYTVAATGNNEKMLKRLGIDYKAIHIHPGSNAGYYPGSFPIAIKMLFSPDDGRIFGAQAVGMSGV
EKRIDILATAIKGNFTVFDLQDIEVCYAPPYNSAKDPVNMLGYYAANIIEGIVDTIQWDEIDNIDKNNSIILDIREEFEL
VTGKFDNSINIPLGDLRNRLNEIPKDKHIYVTCQVGLRGYVACRILKQKGIKCTNIDGGLKTYMYVKRAEESLKNQYEKL
NEIKEEVAAMSLEDLDITEINAKVTLDACGLQCPGPIRRVFEEINKMEEGQILEAKASDVGFSKDIKAWCEKTNNTLLKS
EFDKSKNAFVAYIQKGTKKDEAISLSSTVDKNGATLVVFSGEFDKAIASFIIATGAASMGKEVTMFFTFWGLNILKSKNK
PKVNKDTMEKMFDIMLPGHPEKLPLSKMNMMGMGPAMIKQIMKKHNVDDLESLITNAINMGVKVVACAMSMDLMGIKKEE
FIDGVEIGGVASYLGATEDSGLNLFI

Sequences:

>Translated_826_residues
MAKKIIIVGGVAGGASTAARLRRLDENLDIIMFEKGEYISFANCGLPYYIGGAINDREKLIVQTVEEMSKKFNLDIRNLS
EVIKIDKENKKVSIKDYRKNKVYEEDYDILVLSPGASPLKPEISGIDKCDNLFTLRNIPDTDKIKEFVDNKNPKKAVVIG
GGFIGLEMAENLKERGIDVALVEASDQVMAPIDIEMASIVHDHLIDKNVELILKDGVDSFEDKGKKIVLKSGRKINTDMI
ILSIGVKPETRIAKEAGIKLNERGAIIVDKYMKTSDSNIFALGDAIEVMDFVNKKPTMIPLAWPANRQGRLVANNIIGRN
EEYKGSLGSSVAKVFDYTVAATGNNEKMLKRLGIDYKAIHIHPGSNAGYYPGSFPIAIKMLFSPDDGRIFGAQAVGMSGV
EKRIDILATAIKGNFTVFDLQDIEVCYAPPYNSAKDPVNMLGYYAANIIEGIVDTIQWDEIDNIDKNNSIILDIREEFEL
VTGKFDNSINIPLGDLRNRLNEIPKDKHIYVTCQVGLRGYVACRILKQKGIKCTNIDGGLKTYMYVKRAEESLKNQYEKL
NEIKEEVAAMSLEDLDITEINAKVTLDACGLQCPGPIRRVFEEINKMEEGQILEAKASDVGFSKDIKAWCEKTNNTLLKS
EFDKSKNAFVAYIQKGTKKDEAISLSSTVDKNGATLVVFSGEFDKAIASFIIATGAASMGKEVTMFFTFWGLNILKSKNK
PKVNKDTMEKMFDIMLPGHPEKLPLSKMNMMGMGPAMIKQIMKKHNVDDLESLITNAINMGVKVVACAMSMDLMGIKKEE
FIDGVEIGGVASYLGATEDSGLNLFI
>Mature_825_residues
AKKIIIVGGVAGGASTAARLRRLDENLDIIMFEKGEYISFANCGLPYYIGGAINDREKLIVQTVEEMSKKFNLDIRNLSE
VIKIDKENKKVSIKDYRKNKVYEEDYDILVLSPGASPLKPEISGIDKCDNLFTLRNIPDTDKIKEFVDNKNPKKAVVIGG
GFIGLEMAENLKERGIDVALVEASDQVMAPIDIEMASIVHDHLIDKNVELILKDGVDSFEDKGKKIVLKSGRKINTDMII
LSIGVKPETRIAKEAGIKLNERGAIIVDKYMKTSDSNIFALGDAIEVMDFVNKKPTMIPLAWPANRQGRLVANNIIGRNE
EYKGSLGSSVAKVFDYTVAATGNNEKMLKRLGIDYKAIHIHPGSNAGYYPGSFPIAIKMLFSPDDGRIFGAQAVGMSGVE
KRIDILATAIKGNFTVFDLQDIEVCYAPPYNSAKDPVNMLGYYAANIIEGIVDTIQWDEIDNIDKNNSIILDIREEFELV
TGKFDNSINIPLGDLRNRLNEIPKDKHIYVTCQVGLRGYVACRILKQKGIKCTNIDGGLKTYMYVKRAEESLKNQYEKLN
EIKEEVAAMSLEDLDITEINAKVTLDACGLQCPGPIRRVFEEINKMEEGQILEAKASDVGFSKDIKAWCEKTNNTLLKSE
FDKSKNAFVAYIQKGTKKDEAISLSSTVDKNGATLVVFSGEFDKAIASFIIATGAASMGKEVTMFFTFWGLNILKSKNKP
KVNKDTMEKMFDIMLPGHPEKLPLSKMNMMGMGPAMIKQIMKKHNVDDLESLITNAINMGVKVVACAMSMDLMGIKKEEF
IDGVEIGGVASYLGATEDSGLNLFI

Specific function: Catalyzes specifically the NADPH-dependent reduction of coenzyme A disulfide [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI21389617, Length=326, Percent_Identity=26.9938650306748, Blast_Score=121, Evalue=3e-27,
Organism=Homo sapiens, GI226437568, Length=326, Percent_Identity=26.9938650306748, Blast_Score=121, Evalue=3e-27,
Organism=Homo sapiens, GI65787454, Length=326, Percent_Identity=26.9938650306748, Blast_Score=121, Evalue=3e-27,
Organism=Escherichia coli, GI1789065, Length=327, Percent_Identity=26.9113149847095, Blast_Score=118, Evalue=2e-27,
Organism=Escherichia coli, GI1788892, Length=295, Percent_Identity=25.4237288135593, Blast_Score=78, Evalue=3e-15,
Organism=Escherichia coli, GI1789765, Length=387, Percent_Identity=25.8397932816537, Blast_Score=77, Evalue=5e-15,
Organism=Escherichia coli, GI1786307, Length=259, Percent_Identity=29.3436293436293, Blast_Score=76, Evalue=9e-15,
Organism=Escherichia coli, GI87082354, Length=310, Percent_Identity=23.5483870967742, Blast_Score=70, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17559934, Length=228, Percent_Identity=28.9473684210526, Blast_Score=86, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6325166, Length=193, Percent_Identity=31.0880829015544, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI281359715, Length=288, Percent_Identity=24.3055555555556, Blast_Score=71, Evalue=4e-12,
Organism=Drosophila melanogaster, GI281359713, Length=288, Percent_Identity=24.3055555555556, Blast_Score=71, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24639250, Length=288, Percent_Identity=24.3055555555556, Blast_Score=71, Evalue=4e-12,
Organism=Drosophila melanogaster, GI18543267, Length=288, Percent_Identity=24.3055555555556, Blast_Score=71, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24639252, Length=288, Percent_Identity=24.3055555555556, Blast_Score=71, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24639257, Length=290, Percent_Identity=24.1379310344828, Blast_Score=70, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24585130, Length=295, Percent_Identity=22.0338983050847, Blast_Score=66, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017758
- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.14 [H]

Molecular weight: Translated: 91416; Mature: 91285

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKKIIIVGGVAGGASTAARLRRLDENLDIIMFEKGEYISFANCGLPYYIGGAINDREKL
CCCEEEEEEECCCCHHHHHHHHHHCCCCCEEEEECCCEEEEECCCCCEEECCCCCCHHHH
IVQTVEEMSKKFNLDIRNLSEVIKIDKENKKVSIKDYRKNKVYEEDYDILVLSPGASPLK
HHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEEHHHCCCCCCCCCCEEEECCCCCCCC
PEISGIDKCDNLFTLRNIPDTDKIKEFVDNKNPKKAVVIGGGFIGLEMAENLKERGIDVA
CCCCCCCCCCCEEEECCCCCHHHHHHHHCCCCCCEEEEEECCEEHHHHHHHHHHCCCEEE
LVEASDQVMAPIDIEMASIVHDHLIDKNVELILKDGVDSFEDKGKKIVLKSGRKINTDMI
EEECCCCEECCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHCCCEEEEECCCEECCCEE
ILSIGVKPETRIAKEAGIKLNERGAIIVDKYMKTSDSNIFALGDAIEVMDFVNKKPTMIP
EEEECCCCCHHHHHHCCCEECCCCCEEEEEHHCCCCCCEEEECHHHHHHHHHCCCCCEEE
LAWPANRQGRLVANNIIGRNEEYKGSLGSSVAKVFDYTVAATGNNEKMLKRLGIDYKAIH
EECCCCCCCCEEEHHHCCCCCCCCCCHHHHHHHHHHEEEEECCCCHHHHHHHCCCEEEEE
IHPGSNAGYYPGSFPIAIKMLFSPDDGRIFGAQAVGMSGVEKRIDILATAIKGNFTVFDL
EECCCCCCCCCCCCCEEEEEEEECCCCCEEEEHHCCCCHHHHHHHHHHHEECCCEEEEEE
QDIEVCYAPPYNSAKDPVNMLGYYAANIIEGIVDTIQWDEIDNIDKNNSIILDIREEFEL
CCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHE
VTGKFDNSINIPLGDLRNRLNEIPKDKHIYVTCQVGLRGYVACRILKQKGIKCTNIDGGL
EECCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHCCCEEECCCCCH
KTYMYVKRAEESLKNQYEKLNEIKEEVAAMSLEDLDITEINAKVTLDACGLQCPGPIRRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECEEEEEEECCCCCCHHHHHH
FEEINKMEEGQILEAKASDVGFSKDIKAWCEKTNNTLLKSEFDKSKNAFVAYIQKGTKKD
HHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCEEHHHHCCCCCCEEEEEECCCCCC
EAISLSSTVDKNGATLVVFSGEFDKAIASFIIATGAASMGKEVTMFFTFWGLNILKSKNK
CEEEEHHCCCCCCCEEEEECCCHHHHHHHHHHHHCCHHCCCEEEEEEEECCHHHHCCCCC
PKVNKDTMEKMFDIMLPGHPEKLPLSKMNMMGMGPAMIKQIMKKHNVDDLESLITNAINM
CCCCHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHC
GVKVVACAMSMDLMGIKKEEFIDGVEIGGVASYLGATEDSGLNLFI
CHHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHCCCCCCCCEEEC
>Mature Secondary Structure 
AKKIIIVGGVAGGASTAARLRRLDENLDIIMFEKGEYISFANCGLPYYIGGAINDREKL
CCEEEEEEECCCCHHHHHHHHHHCCCCCEEEEECCCEEEEECCCCCEEECCCCCCHHHH
IVQTVEEMSKKFNLDIRNLSEVIKIDKENKKVSIKDYRKNKVYEEDYDILVLSPGASPLK
HHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEEHHHCCCCCCCCCCEEEECCCCCCCC
PEISGIDKCDNLFTLRNIPDTDKIKEFVDNKNPKKAVVIGGGFIGLEMAENLKERGIDVA
CCCCCCCCCCCEEEECCCCCHHHHHHHHCCCCCCEEEEEECCEEHHHHHHHHHHCCCEEE
LVEASDQVMAPIDIEMASIVHDHLIDKNVELILKDGVDSFEDKGKKIVLKSGRKINTDMI
EEECCCCEECCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHCCCEEEEECCCEECCCEE
ILSIGVKPETRIAKEAGIKLNERGAIIVDKYMKTSDSNIFALGDAIEVMDFVNKKPTMIP
EEEECCCCCHHHHHHCCCEECCCCCEEEEEHHCCCCCCEEEECHHHHHHHHHCCCCCEEE
LAWPANRQGRLVANNIIGRNEEYKGSLGSSVAKVFDYTVAATGNNEKMLKRLGIDYKAIH
EECCCCCCCCEEEHHHCCCCCCCCCCHHHHHHHHHHEEEEECCCCHHHHHHHCCCEEEEE
IHPGSNAGYYPGSFPIAIKMLFSPDDGRIFGAQAVGMSGVEKRIDILATAIKGNFTVFDL
EECCCCCCCCCCCCCEEEEEEEECCCCCEEEEHHCCCCHHHHHHHHHHHEECCCEEEEEE
QDIEVCYAPPYNSAKDPVNMLGYYAANIIEGIVDTIQWDEIDNIDKNNSIILDIREEFEL
CCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHE
VTGKFDNSINIPLGDLRNRLNEIPKDKHIYVTCQVGLRGYVACRILKQKGIKCTNIDGGL
EECCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHCCCEEECCCCCH
KTYMYVKRAEESLKNQYEKLNEIKEEVAAMSLEDLDITEINAKVTLDACGLQCPGPIRRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECEEEEEEECCCCCCHHHHHH
FEEINKMEEGQILEAKASDVGFSKDIKAWCEKTNNTLLKSEFDKSKNAFVAYIQKGTKKD
HHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCEEHHHHCCCCCCEEEEEECCCCCC
EAISLSSTVDKNGATLVVFSGEFDKAIASFIIATGAASMGKEVTMFFTFWGLNILKSKNK
CEEEEHHCCCCCCCEEEEECCCHHHHHHHHHHHHCCHHCCCEEEEEEEECCHHHHCCCCC
PKVNKDTMEKMFDIMLPGHPEKLPLSKMNMMGMGPAMIKQIMKKHNVDDLESLITNAINM
CCCCHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHC
GVKVVACAMSMDLMGIKKEEFIDGVEIGGVASYLGATEDSGLNLFI
CHHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHCCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA