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The map label for this gene is capL [H]

Identifier: 187932407

GI number: 187932407

Start: 3553018

End: 3554334

Strand: Reverse

Name: capL [H]

Synonym: CLL_A3370

Alternate gene names: 187932407

Gene position: 3554334-3553018 (Counterclockwise)

Preceding gene: 187934623

Following gene: 187935176

Centisome position: 93.53

GC content: 29.92

Gene sequence:

>1317_bases
ATGTCAGGATTAAAGCAACAATTATTAGAAAAAATAAATAATAGAACTGCTAAAGTAGGCGTAGTGGGATTAGGATACGT
TGGTTTACCATTAGCTGTAGAAAAAGCAAGTGCAGGATATGAAACCATTGGATTTGATGTTCAAGACCAAAAAGTTAAAA
TGGTTAATGAAGGTAATAATTACATAGGTGATGTAGTAGACGAAAAATTAAAAATGTTAGTTAATGATAAAATATTAAGA
GCTACTACAGATTTCAGTTTTGTAAAAGATGTAGATACTATTTGTATTTGTGTACCTACACCACTTGATTTATACAAACA
ACCAGATTTATCATACGTTGTAGAATCAACAAAAAGTGTTGCAAAATACATGCACAAAGGTATGTTAATAGTTCTTGAAA
GTACAACTTATCCAGGAACAACAGAAGAAGTTCTTAAACCTATCTTAGAAGAAAATGGATTAAAATGTGGAGTAGACTTT
TTCTTAGCATTCTCACCAGAAAGAGTTGATCCAGGTAATAAAAACTTTAACACTAAAAATACACCTAAAGTTGTTGGTGG
ATGTAGTGAAGACTGTACAGAAGTTGCAGCAGCATTATATAGAAATATTTTAGAAGGTGAAATACATACTGTTTCATCAC
CAGCAGTAGCTGAAATGGAAAAGATATTAGAAAACACATTCAGAAATATTAATATTGGATTAGCTAATGAAATGGCTATA
CTATGCAACAGAATGGGAATAGACGTGTGGGAAGTTATAGATGCAGCTAAAACTAAGCCATATGGATTTATGCCATTTTA
CCCAGGTCCAGGTTTAGGCGGACACTGTATACCACTTGATCCATTTTATTTAGAATGGAAAGCGAAGGAATATGATTATC
ATACAAGATTAATAGAAACTTCAGGAGAAATAAATGATTCAATGCCTGAATTTGTATTAGATAATGTAATGAAAATATTA
AATAAACATAAAAAAGCACTTAATGGATCAAAAGTTCTTATATTAGGTGTTGCTTATAAGAATGATATTGATGATTATAG
AGAATCACCAGCATTCAAAGTTATTGAACTTCTAGAAAAGAATGGAGCAGAAGTTATCGTAAATGATCCGTATTGTGAAG
TTTCTAAATACAAAAACAAAGTTTACAATTCTGTAGATTGGAAAGATGTAATTGATGATAGTGACATTGCTATAGTAACA
ACTAATCATAGCTGTTATGATTATGAAGATATAGTAAGTAAAGCTAAAGTTGTTTATGATACAAGAAATGCAACTAAAAA
TGTAGTTAATAATAGAGATAAGATTTATAAATTATAA

Upstream 100 bases:

>100_bases
AGATTTTAAAAACAATAAAGCAATTTGTGAAAGTTGTAATGAAGAATATATAAAATCTGATGAAAAAGTTGAGTGTGTAG
ATTTAGGAGGTATAAAATAG

Downstream 100 bases:

>100_bases
TATGTATTAATTCACATATTTTAAGTATGATTTATTATAGGATTTAGTGCTCAGTAAGCATTAAGTCCTATAATTTTTCT
AAAAATAGGCATATTTATTT

Product: UDP-glucose 6-dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MSGLKQQLLEKINNRTAKVGVVGLGYVGLPLAVEKASAGYETIGFDVQDQKVKMVNEGNNYIGDVVDEKLKMLVNDKILR
ATTDFSFVKDVDTICICVPTPLDLYKQPDLSYVVESTKSVAKYMHKGMLIVLESTTYPGTTEEVLKPILEENGLKCGVDF
FLAFSPERVDPGNKNFNTKNTPKVVGGCSEDCTEVAAALYRNILEGEIHTVSSPAVAEMEKILENTFRNINIGLANEMAI
LCNRMGIDVWEVIDAAKTKPYGFMPFYPGPGLGGHCIPLDPFYLEWKAKEYDYHTRLIETSGEINDSMPEFVLDNVMKIL
NKHKKALNGSKVLILGVAYKNDIDDYRESPAFKVIELLEKNGAEVIVNDPYCEVSKYKNKVYNSVDWKDVIDDSDIAIVT
TNHSCYDYEDIVSKAKVVYDTRNATKNVVNNRDKIYKL

Sequences:

>Translated_438_residues
MSGLKQQLLEKINNRTAKVGVVGLGYVGLPLAVEKASAGYETIGFDVQDQKVKMVNEGNNYIGDVVDEKLKMLVNDKILR
ATTDFSFVKDVDTICICVPTPLDLYKQPDLSYVVESTKSVAKYMHKGMLIVLESTTYPGTTEEVLKPILEENGLKCGVDF
FLAFSPERVDPGNKNFNTKNTPKVVGGCSEDCTEVAAALYRNILEGEIHTVSSPAVAEMEKILENTFRNINIGLANEMAI
LCNRMGIDVWEVIDAAKTKPYGFMPFYPGPGLGGHCIPLDPFYLEWKAKEYDYHTRLIETSGEINDSMPEFVLDNVMKIL
NKHKKALNGSKVLILGVAYKNDIDDYRESPAFKVIELLEKNGAEVIVNDPYCEVSKYKNKVYNSVDWKDVIDDSDIAIVT
TNHSCYDYEDIVSKAKVVYDTRNATKNVVNNRDKIYKL
>Mature_437_residues
SGLKQQLLEKINNRTAKVGVVGLGYVGLPLAVEKASAGYETIGFDVQDQKVKMVNEGNNYIGDVVDEKLKMLVNDKILRA
TTDFSFVKDVDTICICVPTPLDLYKQPDLSYVVESTKSVAKYMHKGMLIVLESTTYPGTTEEVLKPILEENGLKCGVDFF
LAFSPERVDPGNKNFNTKNTPKVVGGCSEDCTEVAAALYRNILEGEIHTVSSPAVAEMEKILENTFRNINIGLANEMAIL
CNRMGIDVWEVIDAAKTKPYGFMPFYPGPGLGGHCIPLDPFYLEWKAKEYDYHTRLIETSGEINDSMPEFVLDNVMKILN
KHKKALNGSKVLILGVAYKNDIDDYRESPAFKVIELLEKNGAEVIVNDPYCEVSKYKNKVYNSVDWKDVIDDSDIAIVTT
NHSCYDYEDIVSKAKVVYDTRNATKNVVNNRDKIYKL

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=370, Percent_Identity=24.3243243243243, Blast_Score=76, Evalue=8e-14,
Organism=Escherichia coli, GI48994968, Length=406, Percent_Identity=33.4975369458128, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1788340, Length=408, Percent_Identity=24.5098039215686, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17560350, Length=405, Percent_Identity=25.679012345679, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI17136908, Length=384, Percent_Identity=22.3958333333333, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 49003; Mature: 48871

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGLKQQLLEKINNRTAKVGVVGLGYVGLPLAVEKASAGYETIGFDVQDQKVKMVNEGNN
CCHHHHHHHHHHCCCEEEEEEEEECCCCCCEEEECCCCCCEEECCCCCCCCEEEECCCCC
YIGDVVDEKLKMLVNDKILRATTDFSFVKDVDTICICVPTPLDLYKQPDLSYVVESTKSV
HHHHHHHHHHHHHHCCHHHEEECCHHHHHCCCEEEEEECCCHHHHCCCCHHHHHHHHHHH
AKYMHKGMLIVLESTTYPGTTEEVLKPILEENGLKCGVDFFLAFSPERVDPGNKNFNTKN
HHHHHCCEEEEEECCCCCCCHHHHHHHHHHHCCCEECEEEEEEECCCCCCCCCCCCCCCC
TPKVVGGCSEDCTEVAAALYRNILEGEIHTVSSPAVAEMEKILENTFRNINIGLANEMAI
CCCEECCCCHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHEEECCCHHHHHH
LCNRMGIDVWEVIDAAKTKPYGFMPFYPGPGLGGHCIPLDPFYLEWKAKEYDYHTRLIET
HHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCEEEEEECCCCCHHHEEEEC
SGEINDSMPEFVLDNVMKILNKHKKALNGSKVLILGVAYKNDIDDYRESPAFKVIELLEK
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHCCCHHHHHHHHHC
NGAEVIVNDPYCEVSKYKNKVYNSVDWKDVIDDSDIAIVTTNHSCYDYEDIVSKAKVVYD
CCCEEEEECCCHHHHHHHHHHCCCCCHHHHCCCCCEEEEECCCCCCCHHHHHHHHHEEEE
TRNATKNVVNNRDKIYKL
CCHHHHHHHCCCHHEECC
>Mature Secondary Structure 
SGLKQQLLEKINNRTAKVGVVGLGYVGLPLAVEKASAGYETIGFDVQDQKVKMVNEGNN
CHHHHHHHHHHCCCEEEEEEEEECCCCCCEEEECCCCCCEEECCCCCCCCEEEECCCCC
YIGDVVDEKLKMLVNDKILRATTDFSFVKDVDTICICVPTPLDLYKQPDLSYVVESTKSV
HHHHHHHHHHHHHHCCHHHEEECCHHHHHCCCEEEEEECCCHHHHCCCCHHHHHHHHHHH
AKYMHKGMLIVLESTTYPGTTEEVLKPILEENGLKCGVDFFLAFSPERVDPGNKNFNTKN
HHHHHCCEEEEEECCCCCCCHHHHHHHHHHHCCCEECEEEEEEECCCCCCCCCCCCCCCC
TPKVVGGCSEDCTEVAAALYRNILEGEIHTVSSPAVAEMEKILENTFRNINIGLANEMAI
CCCEECCCCHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHEEECCCHHHHHH
LCNRMGIDVWEVIDAAKTKPYGFMPFYPGPGLGGHCIPLDPFYLEWKAKEYDYHTRLIET
HHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCEEEEEECCCCCHHHEEEEC
SGEINDSMPEFVLDNVMKILNKHKKALNGSKVLILGVAYKNDIDDYRESPAFKVIELLEK
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHCCCHHHHHHHHHC
NGAEVIVNDPYCEVSKYKNKVYNSVDWKDVIDDSDIAIVTTNHSCYDYEDIVSKAKVVYD
CCCEEEEECCCHHHHHHHHHHCCCCCHHHHCCCCCEEEEECCCCCCCHHHHHHHHHEEEE
TRNATKNVVNNRDKIYKL
CCHHHHHHHCCCHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]