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The map label for this gene is cusR [H]

Identifier: 187928801

GI number: 187928801

Start: 1812149

End: 1812835

Strand: Reverse

Name: cusR [H]

Synonym: Rpic_1718

Alternate gene names: 187928801

Gene position: 1812835-1812149 (Counterclockwise)

Preceding gene: 187928807

Following gene: 187928800

Centisome position: 45.98

GC content: 62.74

Gene sequence:

>687_bases
ATGAAACTGTTGGTCGTCGAGGACGAGCCCAAAACCGGAGAGTATCTGCAGCAAGGCCTGACCGAAGCCGGCTTTGTGGT
CGATCTGGCACGCAACGGTACTGACGGCCGCCATCTGGCCATGTCGGGCGACTACGACTTGCTGTTGCTGGACGTGATGC
TGCCTGACGTGGATGGCTGGCAGATCGTCCAATCGTTGCGCGCTGCGGAACAGGCGGTGCCGGTGTTGTTCTTGACCGCC
CGCGACAGCGTGGCCGACCGCGTCAAAGGCCTTGAAATGGGCGCCGACGACTACTTGGTGAAGCCATTCGCGTTTGCTGA
GTTGCTAGCCCGGGTCCGCACGCTGCTGCGCCGGGGAACCGGTGCCGTCTCGTCCGACCGAATCCAAGTGGCCGACCTTG
TGCTGGATTTGGCTCGCCGTCGTGCCTCACGCGGAGGCCAGAAGATCCCGCTGACGAGCAAGGAGTTCTCCCTGCTGGAG
CTGCTGGTCCGCCGCCGTGGCGAGGTCTTGCCTCGCTCCCTGATCGCCTCGCAGGTCTGGGACATGAACTTCGACAGTGA
TACCAATGTGATCGACGTCGCCATTCGCCGGTTGCGCGCCAAGATCGACGACCACTTCGAGCCGAAGCTGATCCAAACGG
TACGCGGCATGGGTTATGTACTGGAAGCGCCCGAGGACGCGGCCTGA

Upstream 100 bases:

>100_bases
GACCTGACTGAAACATTACAAATCCGTCATCTTGGTGTGATGCCGCCTGCAGCGCGGTACTCTACAGCCCATAAATCATA
GGAAGTGATTCAGGCGCGAT

Downstream 100 bases:

>100_bases
TGGGGCAGTTCTCCCTGACCACTCGGCTCACCGCGTATTTCTCGCTGTGTTCGGCAGCCGTCTTGCTGGGCCTGGGCGTG
GTGATTGCGCTGGCCATGGA

Product: winged helix family two component heavy metal response transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MKLLVVEDEPKTGEYLQQGLTEAGFVVDLARNGTDGRHLAMSGDYDLLLLDVMLPDVDGWQIVQSLRAAEQAVPVLFLTA
RDSVADRVKGLEMGADDYLVKPFAFAELLARVRTLLRRGTGAVSSDRIQVADLVLDLARRRASRGGQKIPLTSKEFSLLE
LLVRRRGEVLPRSLIASQVWDMNFDSDTNVIDVAIRRLRAKIDDHFEPKLIQTVRGMGYVLEAPEDAA

Sequences:

>Translated_228_residues
MKLLVVEDEPKTGEYLQQGLTEAGFVVDLARNGTDGRHLAMSGDYDLLLLDVMLPDVDGWQIVQSLRAAEQAVPVLFLTA
RDSVADRVKGLEMGADDYLVKPFAFAELLARVRTLLRRGTGAVSSDRIQVADLVLDLARRRASRGGQKIPLTSKEFSLLE
LLVRRRGEVLPRSLIASQVWDMNFDSDTNVIDVAIRRLRAKIDDHFEPKLIQTVRGMGYVLEAPEDAA
>Mature_228_residues
MKLLVVEDEPKTGEYLQQGLTEAGFVVDLARNGTDGRHLAMSGDYDLLLLDVMLPDVDGWQIVQSLRAAEQAVPVLFLTA
RDSVADRVKGLEMGADDYLVKPFAFAELLARVRTLLRRGTGAVSSDRIQVADLVLDLARRRASRGGQKIPLTSKEFSLLE
LLVRRRGEVLPRSLIASQVWDMNFDSDTNVIDVAIRRLRAKIDDHFEPKLIQTVRGMGYVLEAPEDAA

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=70.6666666666667, Blast_Score=336, Evalue=7e-94,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=56.0538116591928, Blast_Score=252, Evalue=1e-68,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=40.7239819004525, Blast_Score=167, Evalue=7e-43,
Organism=Escherichia coli, GI1790552, Length=230, Percent_Identity=39.1304347826087, Blast_Score=152, Evalue=1e-38,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=35.1351351351351, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=38.3259911894273, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=38.9140271493213, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=35, Blast_Score=127, Evalue=9e-31,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=36.3636363636364, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=34.061135371179, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI1788394, Length=227, Percent_Identity=35.2422907488987, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=38.5964912280702, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1790863, Length=232, Percent_Identity=32.7586206896552, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=30.2127659574468, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=33.6448598130841, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=35.9649122807018, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788713, Length=115, Percent_Identity=31.304347826087, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1788191, Length=121, Percent_Identity=30.5785123966942, Blast_Score=60, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25344; Mature: 25344

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLVVEDEPKTGEYLQQGLTEAGFVVDLARNGTDGRHLAMSGDYDLLLLDVMLPDVDGW
CEEEEECCCCCCHHHHHHCCCCCCEEEEECCCCCCCCEEEECCCCCEEEEEECCCCCCHH
QIVQSLRAAEQAVPVLFLTARDSVADRVKGLEMGADDYLVKPFAFAELLARVRTLLRRGT
HHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHHHCC
GAVSSDRIQVADLVLDLARRRASRGGQKIPLTSKEFSLLELLVRRRGEVLPRSLIASQVW
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
DMNFDSDTNVIDVAIRRLRAKIDDHFEPKLIQTVRGMGYVLEAPEDAA
CCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEECCCCCC
>Mature Secondary Structure
MKLLVVEDEPKTGEYLQQGLTEAGFVVDLARNGTDGRHLAMSGDYDLLLLDVMLPDVDGW
CEEEEECCCCCCHHHHHHCCCCCCEEEEECCCCCCCCEEEECCCCCEEEEEECCCCCCHH
QIVQSLRAAEQAVPVLFLTARDSVADRVKGLEMGADDYLVKPFAFAELLARVRTLLRRGT
HHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHHHCC
GAVSSDRIQVADLVLDLARRRASRGGQKIPLTSKEFSLLELLVRRRGEVLPRSLIASQVW
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
DMNFDSDTNVIDVAIRRLRAKIDDHFEPKLIQTVRGMGYVLEAPEDAA
CCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]