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The map label for this gene is lon2 [H]

Identifier: 187928773

GI number: 187928773

Start: 1781426

End: 1782646

Strand: Reverse

Name: lon2 [H]

Synonym: Rpic_1690

Alternate gene names: 187928773

Gene position: 1782646-1781426 (Counterclockwise)

Preceding gene: 187928777

Following gene: 187928772

Centisome position: 45.22

GC content: 60.36

Gene sequence:

>1221_bases
ATGTCTGCTCCCCGGCAACCTTCGGAGCACCCACCTGGATTTGTTCCTTTAGGGGATCTGTCCGAGCAGCGTAGTGCGGC
GGCATGGCATCTGCTCATCCCCTCGAACACGCACACCGTCCTTGAGGCTGCCCGACAAGCCAAACTGGACCTTGCGGTGA
TAAAAGAAGATGAGCATGAATCCTCATCTGCTGGACCGGCTGTGGCGACGCCGGCAGAAGTGGTTCCCGCTCCTCGCCGT
GCTCGGCCCCGGCATATTCAGGTTTTTGGGCCTGAAGCGCTGGCGCTCGCCAACGAGCACATGCAAGGTGCAGACCGCAG
CCAGCGGCGGTGCGCCGAGACATTGTTGGAGCGAGCCGGGAGCAATGAGGGCTACCGCGCACTACCTCGTGTTCGATCTG
CCCTGAAGAAGCTCGAAACGGCGCGGAGCGTGTTCGGCAACCTGAGTGAGCCGATTGAGAAGCTCAGGATTGATCTCACG
TTGAACAGTGCGATGCGGACAAAGGATTTCCGGATTCGGCCGATCCTGCTGACAGGACCACCAGGCATTGGAAAAACGCA
CTTTGCGCTGAAGTTGGCAGAGCTTCTGAATGTGCCAATGCGGAAGTGGTCCGCTGGAAGTGCCCAGGCAAGCTTCCAAC
TGACGGGCGGCGATAGCGCCTGGCACAGCGCTCGACCTGGGATGGTTATTGAGATGCTCGCCCGTGGCAGCTCGGCGACG
CCTGTGCTCATCTTGGACGAAGTGGACAAGATTGGTAGCGATGTCCGCTACCCGGTAACTCCTGTACTGCTGGATCTACT
TGAGTCCGAGACAGCAAGCACATTCCAAGACATGTTCTTGCATATGGCGTTTGACGCCAGTCGGATCATCTACGTCCTGA
CGGCCAATGATCTCAACGCTGTGCCTTCCCCGCTATTGAGCCGCGTAGAGGTGTTTGACATCCCGGCACCTGAGCCCGAG
CAGCGGTTGCTGCTTGTTTTGGCGGAGGTGCAGCGGCTGCAGCGTGCCACCGGCAAGCGCATTGAGTTGGACGCCAGCGC
GGCAGAAGCCTTGGCAGGACGGAGCGACCTAGATCTGCGCGCAACACATCGTTTGGTCCAGGATGCTTTTGCGACTGCGA
TGGCATCAGGAAAGCACGTCGCCGCGCCCAAGATGCCGCGGCGCGCCGGGCGGCAGGCGATCGGCTTCGTGGCAGACCGA
CAATCTGGTGAGCGGGCCTAG

Upstream 100 bases:

>100_bases
CTCGCGAATAGCTGACTGACCTCGGGCTTCTTCGGCTCCCGGCGTTGCCGGGTTCGATGGCTGCGGCTGCAAGCCATTGA
TTCGCGTATGGAGAATCATC

Downstream 100 bases:

>100_bases
GGGCAATGAATCACCATGCCCGCGACCTACGCTATTGCAATCGCCCTGTGGAGAGACGCGCTGCCGCGAAGGCGTGGACG
GAGTAATCTGGGGGGCAGGA

Product: AAA ATPase central domain-containing protein

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MSAPRQPSEHPPGFVPLGDLSEQRSAAAWHLLIPSNTHTVLEAARQAKLDLAVIKEDEHESSSAGPAVATPAEVVPAPRR
ARPRHIQVFGPEALALANEHMQGADRSQRRCAETLLERAGSNEGYRALPRVRSALKKLETARSVFGNLSEPIEKLRIDLT
LNSAMRTKDFRIRPILLTGPPGIGKTHFALKLAELLNVPMRKWSAGSAQASFQLTGGDSAWHSARPGMVIEMLARGSSAT
PVLILDEVDKIGSDVRYPVTPVLLDLLESETASTFQDMFLHMAFDASRIIYVLTANDLNAVPSPLLSRVEVFDIPAPEPE
QRLLLVLAEVQRLQRATGKRIELDASAAEALAGRSDLDLRATHRLVQDAFATAMASGKHVAAPKMPRRAGRQAIGFVADR
QSGERA

Sequences:

>Translated_406_residues
MSAPRQPSEHPPGFVPLGDLSEQRSAAAWHLLIPSNTHTVLEAARQAKLDLAVIKEDEHESSSAGPAVATPAEVVPAPRR
ARPRHIQVFGPEALALANEHMQGADRSQRRCAETLLERAGSNEGYRALPRVRSALKKLETARSVFGNLSEPIEKLRIDLT
LNSAMRTKDFRIRPILLTGPPGIGKTHFALKLAELLNVPMRKWSAGSAQASFQLTGGDSAWHSARPGMVIEMLARGSSAT
PVLILDEVDKIGSDVRYPVTPVLLDLLESETASTFQDMFLHMAFDASRIIYVLTANDLNAVPSPLLSRVEVFDIPAPEPE
QRLLLVLAEVQRLQRATGKRIELDASAAEALAGRSDLDLRATHRLVQDAFATAMASGKHVAAPKMPRRAGRQAIGFVADR
QSGERA
>Mature_405_residues
SAPRQPSEHPPGFVPLGDLSEQRSAAAWHLLIPSNTHTVLEAARQAKLDLAVIKEDEHESSSAGPAVATPAEVVPAPRRA
RPRHIQVFGPEALALANEHMQGADRSQRRCAETLLERAGSNEGYRALPRVRSALKKLETARSVFGNLSEPIEKLRIDLTL
NSAMRTKDFRIRPILLTGPPGIGKTHFALKLAELLNVPMRKWSAGSAQASFQLTGGDSAWHSARPGMVIEMLARGSSATP
VLILDEVDKIGSDVRYPVTPVLLDLLESETASTFQDMFLHMAFDASRIIYVLTANDLNAVPSPLLSRVEVFDIPAPEPEQ
RLLLVLAEVQRLQRATGKRIELDASAAEALAGRSDLDLRATHRLVQDAFATAMASGKHVAAPKMPRRAGRQAIGFVADRQ
SGERA

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=149, Percent_Identity=30.8724832214765, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI31377667, Length=200, Percent_Identity=30, Blast_Score=96, Evalue=5e-20,
Organism=Escherichia coli, GI1786643, Length=195, Percent_Identity=29.2307692307692, Blast_Score=96, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17556486, Length=189, Percent_Identity=30.1587301587302, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17505831, Length=150, Percent_Identity=32, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319449, Length=150, Percent_Identity=32, Blast_Score=97, Evalue=3e-21,
Organism=Drosophila melanogaster, GI221513036, Length=239, Percent_Identity=27.1966527196653, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24666867, Length=239, Percent_Identity=27.1966527196653, Blast_Score=99, Evalue=4e-21,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 44131; Mature: 44000

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPRQPSEHPPGFVPLGDLSEQRSAAAWHLLIPSNTHTVLEAARQAKLDLAVIKEDEHE
CCCCCCCCCCCCCEEECCCCCHHHCCCEEEEEECCCHHHHHHHHHHHCCEEEEEECCCCC
SSSAGPAVATPAEVVPAPRRARPRHIQVFGPEALALANEHMQGADRSQRRCAETLLERAG
CCCCCCCCCCCHHHCCCCCCCCCCEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
SNEGYRALPRVRSALKKLETARSVFGNLSEPIEKLRIDLTLNSAMRTKDFRIRPILLTGP
CCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEEEEEECCHHCCCCCEEEEEEEECC
PGIGKTHFALKLAELLNVPMRKWSAGSAQASFQLTGGDSAWHSARPGMVIEMLARGSSAT
CCCCCHHHHHHHHHHHCCCHHHCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHCCCCCC
PVLILDEVDKIGSDVRYPVTPVLLDLLESETASTFQDMFLHMAFDASRIIYVLTANDLNA
CEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCC
VPSPLLSRVEVFDIPAPEPEQRLLLVLAEVQRLQRATGKRIELDASAAEALAGRSDLDLR
CCHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHCCCCCCHHH
ATHRLVQDAFATAMASGKHVAAPKMPRRAGRQAIGFVADRQSGERA
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHCHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SAPRQPSEHPPGFVPLGDLSEQRSAAAWHLLIPSNTHTVLEAARQAKLDLAVIKEDEHE
CCCCCCCCCCCCEEECCCCCHHHCCCEEEEEECCCHHHHHHHHHHHCCEEEEEECCCCC
SSSAGPAVATPAEVVPAPRRARPRHIQVFGPEALALANEHMQGADRSQRRCAETLLERAG
CCCCCCCCCCCHHHCCCCCCCCCCEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
SNEGYRALPRVRSALKKLETARSVFGNLSEPIEKLRIDLTLNSAMRTKDFRIRPILLTGP
CCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEEEEEECCHHCCCCCEEEEEEEECC
PGIGKTHFALKLAELLNVPMRKWSAGSAQASFQLTGGDSAWHSARPGMVIEMLARGSSAT
CCCCCHHHHHHHHHHHCCCHHHCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHCCCCCC
PVLILDEVDKIGSDVRYPVTPVLLDLLESETASTFQDMFLHMAFDASRIIYVLTANDLNA
CEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCC
VPSPLLSRVEVFDIPAPEPEQRLLLVLAEVQRLQRATGKRIELDASAAEALAGRSDLDLR
CCHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHCCCCCCHHH
ATHRLVQDAFATAMASGKHVAAPKMPRRAGRQAIGFVADRQSGERA
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHCHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA