Click here to switch to the map view.

The map label for this gene is pdxA [H]

Identifier: 187927496

GI number: 187927496

Start: 419141

End: 420157

Strand: Direct

Name: pdxA [H]

Synonym: Rpic_0393

Alternate gene names: 187927496

Gene position: 419141-420157 (Clockwise)

Preceding gene: 187927495

Following gene: 187927497

Centisome position: 10.63

GC content: 67.75

Gene sequence:

>1017_bases
ATGCTGAACATTGCCATCACCACTGGCGAACCCGCCGGTATCGGCCCCGACATCACCGTGGCCGCTTTGCTGCATTTGGC
GCGGCAGGCATTGCCGCGTTACGCCGATGTGCAGTGGCACGTGATTGGCGATGCCGCGCTGCTGCAGGCACGCGCTGACG
CGATCGCGCAGGGCGATTTCTGGCGCGTTGCCTCGACGGCGCTGACTGTCGTGGAGCGCCCGCTGGGTGCGCCGGTGCGC
GCCGGCGTGCTCGATGCCGCCAACGGCCGCTATGTGCTGGACTTGCTCGACGCTGCCATCGACGGTTGCCAGATCGGCAC
CGAAGATGGCGTCCGTTACGACGCGATGGTCACGGCGCCGGTGCAGAAGAGCACGATCAACGACGCAGGCGTGCCTTTTA
CCGGCCACACCGAGTACCTGGCCGAGCGCAGCCGAACGCCGCGCGTGGTAATGATGCTCGCCGGTCCGCAGCCGGCGCAC
GACAACGCCATGCTGCGCGTGGCGCTGGCGACGACGCACTTGCCGCTGCGCGAGGTGCCGGACGCCATCACCCCCGCGGT
GCTCGACGAAACGCTGGACATCGTGCAGCGTGACCTGCGCATGCGTTTTGGACTGAACGCACCTCGCATCCTCGTGACGG
GGTTGAATCCGCATGCGGGTGAATCCGGCCACCTCGGCCGCGAAGAGATCGAGGTGATCGAGCCCGCCATCGCGCGGGCG
CGTGCACGCGGAATCGATGCCCGCGGTCCGTATCCGGCCGATACGCTGTTCCAGCCGCGCCTGCTGGCCGATGCCGATTG
CGTGCTGGCGATGTACCACGACCAAGGTTTGGCGCCGCTCAAGTACGGCACCTTCGGCCATGGCGTGAACATCACGCTGG
GCTTGCCGTTTGTCCGCACGTCGGTGGACCACGGCACGGCGCTGGACTTGGCCGGCACGGGCCGCGCCGAGTTCGGCAGC
ATGATCGAGGCGATCGATACTGCCATCGCCATGGCGCGGCACACCGCGCGCTCCTGA

Upstream 100 bases:

>100_bases
CGTCAGCAATAAGCTACGGGCATCCGCATCGCTCACGGCCGCCTGCGGGCGGCCGTGGCGTTTCTAGATCGCTCCAGAAA
CCATCGCAGGAAAGCGCTGC

Downstream 100 bases:

>100_bases
GTTTCCTTCACCTCTTCGATTTCGAGTTCGCAATGGCACGATCCACGACCGGCGTTCACCAAGGGCACCAGGCCCGCAAG
CGCTTCGGCCAGAACTTCCT

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MLNIAITTGEPAGIGPDITVAALLHLARQALPRYADVQWHVIGDAALLQARADAIAQGDFWRVASTALTVVERPLGAPVR
AGVLDAANGRYVLDLLDAAIDGCQIGTEDGVRYDAMVTAPVQKSTINDAGVPFTGHTEYLAERSRTPRVVMMLAGPQPAH
DNAMLRVALATTHLPLREVPDAITPAVLDETLDIVQRDLRMRFGLNAPRILVTGLNPHAGESGHLGREEIEVIEPAIARA
RARGIDARGPYPADTLFQPRLLADADCVLAMYHDQGLAPLKYGTFGHGVNITLGLPFVRTSVDHGTALDLAGTGRAEFGS
MIEAIDTAIAMARHTARS

Sequences:

>Translated_338_residues
MLNIAITTGEPAGIGPDITVAALLHLARQALPRYADVQWHVIGDAALLQARADAIAQGDFWRVASTALTVVERPLGAPVR
AGVLDAANGRYVLDLLDAAIDGCQIGTEDGVRYDAMVTAPVQKSTINDAGVPFTGHTEYLAERSRTPRVVMMLAGPQPAH
DNAMLRVALATTHLPLREVPDAITPAVLDETLDIVQRDLRMRFGLNAPRILVTGLNPHAGESGHLGREEIEVIEPAIARA
RARGIDARGPYPADTLFQPRLLADADCVLAMYHDQGLAPLKYGTFGHGVNITLGLPFVRTSVDHGTALDLAGTGRAEFGS
MIEAIDTAIAMARHTARS
>Mature_338_residues
MLNIAITTGEPAGIGPDITVAALLHLARQALPRYADVQWHVIGDAALLQARADAIAQGDFWRVASTALTVVERPLGAPVR
AGVLDAANGRYVLDLLDAAIDGCQIGTEDGVRYDAMVTAPVQKSTINDAGVPFTGHTEYLAERSRTPRVVMMLAGPQPAH
DNAMLRVALATTHLPLREVPDAITPAVLDETLDIVQRDLRMRFGLNAPRILVTGLNPHAGESGHLGREEIEVIEPAIARA
RARGIDARGPYPADTLFQPRLLADADCVLAMYHDQGLAPLKYGTFGHGVNITLGLPFVRTSVDHGTALDLAGTGRAEFGS
MIEAIDTAIAMARHTARS

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=342, Percent_Identity=53.2163742690059, Blast_Score=323, Evalue=1e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 35996; Mature: 35996

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNIAITTGEPAGIGPDITVAALLHLARQALPRYADVQWHVIGDAALLQARADAIAQGDF
CEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHCCCCH
WRVASTALTVVERPLGAPVRAGVLDAANGRYVLDLLDAAIDGCQIGTEDGVRYDAMVTAP
HHHHHHHHHHHHCCCCCCHHCCEEECCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEECC
VQKSTINDAGVPFTGHTEYLAERSRTPRVVMMLAGPQPAHDNAMLRVALATTHLPLREVP
CCCCCCCCCCCCCCCCHHHHHHCCCCCEEEEEEECCCCCCCCCEEEEEEECCCCCHHHCC
DAITPAVLDETLDIVQRDLRMRFGLNAPRILVTGLNPHAGESGHLGREEIEVIEPAIARA
CHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
RARGIDARGPYPADTLFQPRLLADADCVLAMYHDQGLAPLKYGTFGHGVNITLGLPFVRT
HHCCCCCCCCCCCCCCCCCHHHCCCCEEEEEECCCCCCCEECCCCCCCEEEEEECCHHEE
SVDHGTALDLAGTGRAEFGSMIEAIDTAIAMARHTARS
CCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLNIAITTGEPAGIGPDITVAALLHLARQALPRYADVQWHVIGDAALLQARADAIAQGDF
CEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHCCCCH
WRVASTALTVVERPLGAPVRAGVLDAANGRYVLDLLDAAIDGCQIGTEDGVRYDAMVTAP
HHHHHHHHHHHHCCCCCCHHCCEEECCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEECC
VQKSTINDAGVPFTGHTEYLAERSRTPRVVMMLAGPQPAHDNAMLRVALATTHLPLREVP
CCCCCCCCCCCCCCCCHHHHHHCCCCCEEEEEEECCCCCCCCCEEEEEEECCCCCHHHCC
DAITPAVLDETLDIVQRDLRMRFGLNAPRILVTGLNPHAGESGHLGREEIEVIEPAIARA
CHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
RARGIDARGPYPADTLFQPRLLADADCVLAMYHDQGLAPLKYGTFGHGVNITLGLPFVRT
HHCCCCCCCCCCCCCCCCCHHHCCCCEEEEEECCCCCCCEECCCCCCCEEEEEECCHHEE
SVDHGTALDLAGTGRAEFGSMIEAIDTAIAMARHTARS
CCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]