Click here to switch to the map view.

The map label for this gene is gpwA [H]

Identifier: 187927270

GI number: 187927270

Start: 180211

End: 180906

Strand: Reverse

Name: gpwA [H]

Synonym: Rpic_0162

Alternate gene names: 187927270

Gene position: 180906-180211 (Counterclockwise)

Preceding gene: 187927273

Following gene: 187927264

Centisome position: 4.59

GC content: 63.79

Gene sequence:

>696_bases
ATGTTGTTTCCCGCCACCGTTTCCATGCGTCGCCCGCGCCTGCAATTGCACGCGTCGGGTGTGCTGCGTCGGCACCATCT
GCTGATGATCGCCATTGCGATTGCCATTGCCGTCATCGCGTTGCTGCTGCCGCGCACGGGGCATGCTGTTACGGCCGGCG
TCGCACCGGCTGCACAAACCCCGACCACCCCGGGCGCCTGCCCCGCGAGCCTGAATTTTCGCGTCAAGCGCCTGCAGGAC
GATGCGCCGCAAGACCTTTGCCAGTACGCCGGCCGCGTCGTGCTGGTGGTCAACACCGCCAGCTATTGCGGCTACACGCA
TCAGTACGAAGGGCTCGAAGCGCTGTACGCAAAGTATCGCGACAAGGGACTGACGGTGCTGGGCTTTCCGTCCAATGACT
TTCAGCAGGAACCCGGCAACAGCAAGCAGATCGCCGACTTTTGCTACAACACGTACGGCGTGAAATTCCCGATGTTCTCG
AAGACGGCAGTGGTGGGTGCGGGCGCATCGCCGCTGTATGCGTGGCTCGCGACGCAGACGGGCCAGCCGCCCAAGTGGAA
CTTCCACAAATACCTGCTGGACCGCACCGGCCGCGTGGCGGCAGTGTTCCCCAGCAGTGTCGAGCCGAGCGACCCAGCGC
TCATCAAACGCATCGACGCACTGCTGGCTGAACCATCGACCCGCTCGTCCCGCTGA

Upstream 100 bases:

>100_bases
CGCATAACGCACATTTCACCCGGTGCGACCCCGGGGCGTTATACCCTAAACTGAAGACACTCCGGTTCGCCGGCTGAGCG
TCCGCTTTTGGAGATTCCCC

Downstream 100 bases:

>100_bases
TCAGGCTGCGCGCATCGTGTCCGGAATCGCGCCGTACAGGAACGCGGCCAGTTCGTCGCGGCGGGCCTGCACATCGCGCT
CGCCCAGGTCGATCAGTTCC

Product: glutathione peroxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MLFPATVSMRRPRLQLHASGVLRRHHLLMIAIAIAIAVIALLLPRTGHAVTAGVAPAAQTPTTPGACPASLNFRVKRLQD
DAPQDLCQYAGRVVLVVNTASYCGYTHQYEGLEALYAKYRDKGLTVLGFPSNDFQQEPGNSKQIADFCYNTYGVKFPMFS
KTAVVGAGASPLYAWLATQTGQPPKWNFHKYLLDRTGRVAAVFPSSVEPSDPALIKRIDALLAEPSTRSSR

Sequences:

>Translated_231_residues
MLFPATVSMRRPRLQLHASGVLRRHHLLMIAIAIAIAVIALLLPRTGHAVTAGVAPAAQTPTTPGACPASLNFRVKRLQD
DAPQDLCQYAGRVVLVVNTASYCGYTHQYEGLEALYAKYRDKGLTVLGFPSNDFQQEPGNSKQIADFCYNTYGVKFPMFS
KTAVVGAGASPLYAWLATQTGQPPKWNFHKYLLDRTGRVAAVFPSSVEPSDPALIKRIDALLAEPSTRSSR
>Mature_231_residues
MLFPATVSMRRPRLQLHASGVLRRHHLLMIAIAIAIAVIALLLPRTGHAVTAGVAPAAQTPTTPGACPASLNFRVKRLQD
DAPQDLCQYAGRVVLVVNTASYCGYTHQYEGLEALYAKYRDKGLTVLGFPSNDFQQEPGNSKQIADFCYNTYGVKFPMFS
KTAVVGAGASPLYAWLATQTGQPPKWNFHKYLLDRTGRVAAVFPSSVEPSDPALIKRIDALLAEPSTRSSR

Specific function: Not Essential For B12 Transport; However, It Is An Auxiliary Component Of The Transport System. [C]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI15618997, Length=146, Percent_Identity=43.1506849315069, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI192455698, Length=136, Percent_Identity=36.7647058823529, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI90903240, Length=167, Percent_Identity=35.9281437125749, Blast_Score=95, Evalue=5e-20,
Organism=Homo sapiens, GI75709200, Length=133, Percent_Identity=41.3533834586466, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI90903238, Length=115, Percent_Identity=42.6086956521739, Blast_Score=84, Evalue=8e-17,
Organism=Homo sapiens, GI4557629, Length=141, Percent_Identity=32.6241134751773, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1788003, Length=164, Percent_Identity=40.2439024390244, Blast_Score=119, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71993584, Length=141, Percent_Identity=39.0070921985816, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17535473, Length=155, Percent_Identity=38.0645161290323, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17506887, Length=159, Percent_Identity=35.2201257861635, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17550320, Length=226, Percent_Identity=27.4336283185841, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI193210707, Length=146, Percent_Identity=35.6164383561644, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI193209493, Length=183, Percent_Identity=28.9617486338798, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319721, Length=143, Percent_Identity=46.1538461538462, Blast_Score=133, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6322228, Length=143, Percent_Identity=45.4545454545455, Blast_Score=132, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6322826, Length=141, Percent_Identity=38.2978723404255, Blast_Score=103, Evalue=2e-23,
Organism=Drosophila melanogaster, GI85726443, Length=144, Percent_Identity=38.1944444444444, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24656772, Length=144, Percent_Identity=38.8888888888889, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24656767, Length=144, Percent_Identity=38.8888888888889, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24656777, Length=144, Percent_Identity=38.8888888888889, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: =1.11.1.9 [H]

Molecular weight: Translated: 25157; Mature: 25157

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: PS00460 GLUTATHIONE_PEROXID_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFPATVSMRRPRLQLHASGVLRRHHLLMIAIAIAIAVIALLLPRTGHAVTAGVAPAAQT
CCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCC
PTTPGACPASLNFRVKRLQDDAPQDLCQYAGRVVLVVNTASYCGYTHQYEGLEALYAKYR
CCCCCCCCCCCCEEEEECCCCCHHHHHHHCCEEEEEEECHHHCCCCCHHHHHHHHHHHHH
DKGLTVLGFPSNDFQQEPGNSKQIADFCYNTYGVKFPMFSKTAVVGAGASPLYAWLATQT
CCCCEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHHCC
GQPPKWNFHKYLLDRTGRVAAVFPSSVEPSDPALIKRIDALLAEPSTRSSR
CCCCCCCHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLFPATVSMRRPRLQLHASGVLRRHHLLMIAIAIAIAVIALLLPRTGHAVTAGVAPAAQT
CCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCC
PTTPGACPASLNFRVKRLQDDAPQDLCQYAGRVVLVVNTASYCGYTHQYEGLEALYAKYR
CCCCCCCCCCCCEEEEECCCCCHHHHHHHCCEEEEEEECHHHCCCCCHHHHHHHHHHHHH
DKGLTVLGFPSNDFQQEPGNSKQIADFCYNTYGVKFPMFSKTAVVGAGASPLYAWLATQT
CCCCEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHHCC
GQPPKWNFHKYLLDRTGRVAAVFPSSVEPSDPALIKRIDALLAEPSTRSSR
CCCCCCCHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA