Click here to switch to the map view.

The map label for this gene is iclR [H]

Identifier: 187927262

GI number: 187927262

Start: 171953

End: 172831

Strand: Reverse

Name: iclR [H]

Synonym: Rpic_0154

Alternate gene names: 187927262

Gene position: 172831-171953 (Counterclockwise)

Preceding gene: 187927264

Following gene: 187927261

Centisome position: 4.38

GC content: 67.46

Gene sequence:

>879_bases
ATGACCATGCCACCGCTGCCCGCCGACACCGATCTCGACCTGGAGCCCGATGCCGACGGTGAATTGGATGCGCCCGCGCG
CTCGGGCATCCAGTCCATCGAAGTCGGCTTCCGGCTGCTGGAAGTGCTCACGCACACCACCGGCCCGATGATGCTGCGCG
ACCTCGCGCGTGCCGCGCCCATGAACCCCGCCAAGGCGCACCGTTATCTGGTGAGCTTTGCGCGCCTGGGGCTTGTCACG
CAAACGCCCGAAGGCCGTTACGATCTGGGTCCGTTCGCGCTGGAAATGGGGCTGGTGAGCCTGAACCGACAAGACCCGAT
GCGCCGCGCCCGGCCCGCCGCCGCCGCGCTGCGCGACGAGATCGATCACACTGTCGGCCTGGCCGTCTGGGGCAACCAGG
GCCCGGCCATCGTCCACTGGGAAGAAGCCAGCCATCCCGTGACGGTCAGCTTGCGCCTGGGGGATGTGATGCCGATGCTG
AACTCGGCCACCGGCCGCGTGTTCGGCGCGTACTTGCCGCGCGCGCAGACGCGCTCGTTCATCCAGCGCGAACTCGATCG
CATTGCGGCCCAGGGCGAGTCCGCCGACTCCGAGAACCCGGAGCTACCGCAAACGCTCGAAGCCTACGATGCGATCTGCG
CCGACGTGCGCCTGCGTGGCGTCTCGCGCATCCACGGTGGCGTGCTGCCCGGCATCAACGCGATGTCGCTGCCGGTGTTC
GACGCCAACGGCCAATTGTGTCTCGTGCTGATCGCGTTGGGCGCACAAAGCACCTTCGACACCACTTGGAGCAGCCCGCT
GGAGCGGCGCTTGCGGCTGGCCGCACAACAACTTTCCGCCGATCTTGGATACGTTGCACCCAACGCCCCGCAATGCTGA

Upstream 100 bases:

>100_bases
ATCCTTGAGGGTGGCGAGTTTCATGTGCGTTGTGTGGAGAAAAGCTGCGCGGATGGTACACCTTGCATCGGCTAAACTGG
CCCGAACCGATCCATCGCCC

Downstream 100 bases:

>100_bases
CGAACTGAATACCGACCGCGTGCAACCCCGCAGGCGTCGCTTCTATCGGCTTGGCCGGTTCGGGCTCGTGCTGCTGGCCG
TGCTCGTGCTGCACGTCGTT

Product: IclR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MTMPPLPADTDLDLEPDADGELDAPARSGIQSIEVGFRLLEVLTHTTGPMMLRDLARAAPMNPAKAHRYLVSFARLGLVT
QTPEGRYDLGPFALEMGLVSLNRQDPMRRARPAAAALRDEIDHTVGLAVWGNQGPAIVHWEEASHPVTVSLRLGDVMPML
NSATGRVFGAYLPRAQTRSFIQRELDRIAAQGESADSENPELPQTLEAYDAICADVRLRGVSRIHGGVLPGINAMSLPVF
DANGQLCLVLIALGAQSTFDTTWSSPLERRLRLAAQQLSADLGYVAPNAPQC

Sequences:

>Translated_292_residues
MTMPPLPADTDLDLEPDADGELDAPARSGIQSIEVGFRLLEVLTHTTGPMMLRDLARAAPMNPAKAHRYLVSFARLGLVT
QTPEGRYDLGPFALEMGLVSLNRQDPMRRARPAAAALRDEIDHTVGLAVWGNQGPAIVHWEEASHPVTVSLRLGDVMPML
NSATGRVFGAYLPRAQTRSFIQRELDRIAAQGESADSENPELPQTLEAYDAICADVRLRGVSRIHGGVLPGINAMSLPVF
DANGQLCLVLIALGAQSTFDTTWSSPLERRLRLAAQQLSADLGYVAPNAPQC
>Mature_291_residues
TMPPLPADTDLDLEPDADGELDAPARSGIQSIEVGFRLLEVLTHTTGPMMLRDLARAAPMNPAKAHRYLVSFARLGLVTQ
TPEGRYDLGPFALEMGLVSLNRQDPMRRARPAAAALRDEIDHTVGLAVWGNQGPAIVHWEEASHPVTVSLRLGDVMPMLN
SATGRVFGAYLPRAQTRSFIQRELDRIAAQGESADSENPELPQTLEAYDAICADVRLRGVSRIHGGVLPGINAMSLPVFD
ANGQLCLVLIALGAQSTFDTTWSSPLERRLRLAAQQLSADLGYVAPNAPQC

Specific function: Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyr

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=164, Percent_Identity=28.0487804878049, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1789999, Length=276, Percent_Identity=24.2753623188406, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 31577; Mature: 31446

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMPPLPADTDLDLEPDADGELDAPARSGIQSIEVGFRLLEVLTHTTGPMMLRDLARAAP
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
MNPAKAHRYLVSFARLGLVTQTPEGRYDLGPFALEMGLVSLNRQDPMRRARPAAAALRDE
CCHHHHHHHHHHHHHHCCEECCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
IDHTVGLAVWGNQGPAIVHWEEASHPVTVSLRLGDVMPMLNSATGRVFGAYLPRAQTRSF
HHHHEEEEEECCCCCEEEEECCCCCCEEEEEECCHHHHHHHHHCHHHHHHHCCCHHHHHH
IQRELDRIAAQGESADSENPELPQTLEAYDAICADVRLRGVSRIHGGVLPGINAMSLPVF
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEE
DANGQLCLVLIALGAQSTFDTTWSSPLERRLRLAAQQLSADLGYVAPNAPQC
CCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TMPPLPADTDLDLEPDADGELDAPARSGIQSIEVGFRLLEVLTHTTGPMMLRDLARAAP
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
MNPAKAHRYLVSFARLGLVTQTPEGRYDLGPFALEMGLVSLNRQDPMRRARPAAAALRDE
CCHHHHHHHHHHHHHHCCEECCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
IDHTVGLAVWGNQGPAIVHWEEASHPVTVSLRLGDVMPMLNSATGRVFGAYLPRAQTRSF
HHHHEEEEEECCCCCEEEEECCCCCCEEEEEECCHHHHHHHHHCHHHHHHHCCCHHHHHH
IQRELDRIAAQGESADSENPELPQTLEAYDAICADVRLRGVSRIHGGVLPGINAMSLPVF
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEE
DANGQLCLVLIALGAQSTFDTTWSSPLERRLRLAAQQLSADLGYVAPNAPQC
CCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185227; 1995431; 8265357; 9278503; 1995429 [H]