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The map label for this gene is glmS [H]

Identifier: 187927172

GI number: 187927172

Start: 76334

End: 78172

Strand: Direct

Name: glmS [H]

Synonym: Rpic_0062

Alternate gene names: 187927172

Gene position: 76334-78172 (Clockwise)

Preceding gene: 187927171

Following gene: 187927173

Centisome position: 1.94

GC content: 65.42

Gene sequence:

>1839_bases
ATGTGCGGTATCGTTGGCGCGGTTTCCACGCGCAATATCGTTCCCGTCCTGATCGAAGGCCTGCGCCGCCTGGAATACCG
CGGCTATGACTCTTGTGGCGTCGCCATTCAGCGCGATGGCCAGCTCGAGCGCGCGCGCACCGTATCGCGCGTGGCCGATC
TGGATGCCCAGGCACAGACGAGCCACCTGGACGGCGCCATCGGCATCGCCCACACGCGCTGGGCCACGCACGGCCGGCCG
GATACCGTCAACGCGCACCCGCACTTCTCGGGCGACACCATCGCCCTGGTGCACAACGGCATCATCGAAAACTACGAAGC
GCTGCGCGAAGAACTCAAGGCCGTCGGCTACGGCTTTGAATCGCAGACGGATACCGAAGTTGTCGCGCACCTGATCCACC
AAGCCTACACGTACCCGAGCAGCAAGACGCGCGGCGACCTGTTCGCCTCGGTGCGTGCGTCGGTCAAGCGCCTGCACGGC
GCTTATGCGATCGCCGTGTTTGCACGCGACAACCCCGACGTGGTGGTGGGTGCGCGCGCCGGCTCCCCGCTGGTGGTGGC
GATTGGCGAGAACGAATCGTTCCTCGCATCCGACGCGCTGGCCGTGGCCGGTACCGCCAGCCGCATGGCCTACCTGGAAG
AAGGCGACGTGGTGGAACTCACCCGCGACGGCTTCACCGTGGCCGATGCCAACGACAAGATCGTCGCGCGTGAAGTGAAG
GAAGTCGGCACCTACGCTGCCGCTGTGGAACTCGGCCCCTTCCGCCACTTCATGCAGAAGGAAATCTTCGAGCAGCCGCG
CGCCCTGGGCGACACGCTGGAAGGCGTACAAGGCTTTGCGCCTGACCTGTTTGGCCCCGAGGCGGCCCAGGTGCTGCCCA
AGGTCGACAGCGTGCTGATCCTGGCCTGCGGCACGAGCTACTACTCGGGCTGCACGGCCAAGTACTGGCTCGAATCGATC
GCCAAGATCCCGACGCAGGTCGAGGTTGCCAGCGAATACCGCTACCGCGAGACGGTGCCCAACCCGAACGCGCTGGTCGT
CGTGATCTCGCAATCGGGCGAAACCGCCGACACGCTGGCCGCACTGCGCCACGCACGCGAACTCGGCCACACGCATACGC
TCGCCATCTGCAACGTGGCGACCAGCGCCATGGTGCGCGAGACGCAGCTCAAGTTCCTCACGCGCGCCGGCACCGAGATC
GGCGTGGCGTCCACCAAGGCATTCACCACGCAGCTGGCCGCGCTTTACATGCTGGCGCTCACGTTCGCCAAGCTGCGCGG
CCATCTGAACGCCGAACAGGAAGAAGATGCGCTGCGTCATCTGCGTCACCTGCCGTCGGCGCTGAACGCGGTGCTGGCCC
TGGAGCCGCAAATCATCGCGTGGTCGGAAGAGTTTGCCCGCCGTGAAAACGCGCTGTTTCTCGGTCGCGGTCTGCATTAC
CCGATTGCCCTGGAAGGCGCGCTCAAGCTCAAGGAAATTTCGTACATCCACGCCGAGGCCTACCCGGCCGGCGAACTCAA
GCACGGTCCGCTGGCGCTGGTGACCGAGCAGATGCCGGTCGTGACCGTCGCCCCGAACGACGCGCTGCTTGAAAAGCTCA
AGTCGAACATCCAGGAAGTGCGCGCGCGCGGCGGCAAGCTGTACGTGTTTGCCGACGCCGATACGCACATCCAGTCGAGC
GACGGCATCCAGGTGATCCGCATGCCCGAGCACTACGGGCAGCTCTCGCCGATCCTGCACGTGGTGCCGCTGCAGCTGCT
GGCGTATCACACGGCACTGGCGCGCGGCACTGACGTCGACAAGCCGCGCAACCTGGCGAAATCGGTGACTGTCGAATAA

Upstream 100 bases:

>100_bases
CGAACAGCGGATGCCGCTTCGGCACACGAGCATCGATACTGAATTACCGAGTGCGGCGCACATTGAACGTGCGGCCACAC
CCCAAACTGGAGAAATCAAC

Downstream 100 bases:

>100_bases
GTTTCGGCAGGCGCAGAAACAGAAAAGGCCGTCCTTCGGGACGGCCTTTTTTCGTGGTGTGCGCTTCGCCAGGACGAGCG
GTCCAAGGCGCTGAGCGAGA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 612; Mature: 612

Protein sequence:

>612_residues
MCGIVGAVSTRNIVPVLIEGLRRLEYRGYDSCGVAIQRDGQLERARTVSRVADLDAQAQTSHLDGAIGIAHTRWATHGRP
DTVNAHPHFSGDTIALVHNGIIENYEALREELKAVGYGFESQTDTEVVAHLIHQAYTYPSSKTRGDLFASVRASVKRLHG
AYAIAVFARDNPDVVVGARAGSPLVVAIGENESFLASDALAVAGTASRMAYLEEGDVVELTRDGFTVADANDKIVAREVK
EVGTYAAAVELGPFRHFMQKEIFEQPRALGDTLEGVQGFAPDLFGPEAAQVLPKVDSVLILACGTSYYSGCTAKYWLESI
AKIPTQVEVASEYRYRETVPNPNALVVVISQSGETADTLAALRHARELGHTHTLAICNVATSAMVRETQLKFLTRAGTEI
GVASTKAFTTQLAALYMLALTFAKLRGHLNAEQEEDALRHLRHLPSALNAVLALEPQIIAWSEEFARRENALFLGRGLHY
PIALEGALKLKEISYIHAEAYPAGELKHGPLALVTEQMPVVTVAPNDALLEKLKSNIQEVRARGGKLYVFADADTHIQSS
DGIQVIRMPEHYGQLSPILHVVPLQLLAYHTALARGTDVDKPRNLAKSVTVE

Sequences:

>Translated_612_residues
MCGIVGAVSTRNIVPVLIEGLRRLEYRGYDSCGVAIQRDGQLERARTVSRVADLDAQAQTSHLDGAIGIAHTRWATHGRP
DTVNAHPHFSGDTIALVHNGIIENYEALREELKAVGYGFESQTDTEVVAHLIHQAYTYPSSKTRGDLFASVRASVKRLHG
AYAIAVFARDNPDVVVGARAGSPLVVAIGENESFLASDALAVAGTASRMAYLEEGDVVELTRDGFTVADANDKIVAREVK
EVGTYAAAVELGPFRHFMQKEIFEQPRALGDTLEGVQGFAPDLFGPEAAQVLPKVDSVLILACGTSYYSGCTAKYWLESI
AKIPTQVEVASEYRYRETVPNPNALVVVISQSGETADTLAALRHARELGHTHTLAICNVATSAMVRETQLKFLTRAGTEI
GVASTKAFTTQLAALYMLALTFAKLRGHLNAEQEEDALRHLRHLPSALNAVLALEPQIIAWSEEFARRENALFLGRGLHY
PIALEGALKLKEISYIHAEAYPAGELKHGPLALVTEQMPVVTVAPNDALLEKLKSNIQEVRARGGKLYVFADADTHIQSS
DGIQVIRMPEHYGQLSPILHVVPLQLLAYHTALARGTDVDKPRNLAKSVTVE
>Mature_612_residues
MCGIVGAVSTRNIVPVLIEGLRRLEYRGYDSCGVAIQRDGQLERARTVSRVADLDAQAQTSHLDGAIGIAHTRWATHGRP
DTVNAHPHFSGDTIALVHNGIIENYEALREELKAVGYGFESQTDTEVVAHLIHQAYTYPSSKTRGDLFASVRASVKRLHG
AYAIAVFARDNPDVVVGARAGSPLVVAIGENESFLASDALAVAGTASRMAYLEEGDVVELTRDGFTVADANDKIVAREVK
EVGTYAAAVELGPFRHFMQKEIFEQPRALGDTLEGVQGFAPDLFGPEAAQVLPKVDSVLILACGTSYYSGCTAKYWLESI
AKIPTQVEVASEYRYRETVPNPNALVVVISQSGETADTLAALRHARELGHTHTLAICNVATSAMVRETQLKFLTRAGTEI
GVASTKAFTTQLAALYMLALTFAKLRGHLNAEQEEDALRHLRHLPSALNAVLALEPQIIAWSEEFARRENALFLGRGLHY
PIALEGALKLKEISYIHAEAYPAGELKHGPLALVTEQMPVVTVAPNDALLEKLKSNIQEVRARGGKLYVFADADTHIQSS
DGIQVIRMPEHYGQLSPILHVVPLQLLAYHTALARGTDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=687, Percent_Identity=36.9723435225619, Blast_Score=404, Evalue=1e-112,
Organism=Homo sapiens, GI205277386, Length=688, Percent_Identity=36.1918604651163, Blast_Score=395, Evalue=1e-110,
Organism=Escherichia coli, GI1790167, Length=616, Percent_Identity=54.7077922077922, Blast_Score=652, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17532899, Length=726, Percent_Identity=34.7107438016529, Blast_Score=375, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17539970, Length=716, Percent_Identity=35.0558659217877, Blast_Score=370, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17532897, Length=739, Percent_Identity=33.9648173207037, Blast_Score=368, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17554892, Length=248, Percent_Identity=26.6129032258064, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6322745, Length=444, Percent_Identity=36.9369369369369, Blast_Score=265, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6323731, Length=431, Percent_Identity=30.8584686774942, Blast_Score=199, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6323730, Length=207, Percent_Identity=37.6811594202899, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI21357745, Length=688, Percent_Identity=36.1918604651163, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI28573187, Length=256, Percent_Identity=26.171875, Blast_Score=80, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24659598, Length=256, Percent_Identity=23.4375, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24659604, Length=231, Percent_Identity=23.3766233766234, Blast_Score=66, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 66453; Mature: 66453

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGAVSTRNIVPVLIEGLRRLEYRGYDSCGVAIQRDGQLERARTVSRVADLDAQAQT
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCHHHH
SHLDGAIGIAHTRWATHGRPDTVNAHPHFSGDTIALVHNGIIENYEALREELKAVGYGFE
HHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCC
SQTDTEVVAHLIHQAYTYPSSKTRGDLFASVRASVKRLHGAYAIAVFARDNPDVVVGARA
CCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCEEEEECC
GSPLVVAIGENESFLASDALAVAGTASRMAYLEEGDVVELTRDGFTVADANDKIVAREVK
CCCEEEEECCCCCCHHHCHHHHHCCHHHHHEECCCCEEEEECCCEEEECCCCCHHHHHHH
EVGTYAAAVELGPFRHFMQKEIFEQPRALGDTLEGVQGFAPDLFGPEAAQVLPKVDSVLI
HHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCEEE
LACGTSYYSGCTAKYWLESIAKIPTQVEVASEYRYRETVPNPNALVVVISQSGETADTLA
EEECCHHHCCCCHHHHHHHHHHCCCEEEHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHH
ALRHARELGHTHTLAICNVATSAMVRETQLKFLTRAGTEIGVASTKAFTTQLAALYMLAL
HHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
TFAKLRGHLNAEQEEDALRHLRHLPSALNAVLALEPQIIAWSEEFARRENALFLGRGLHY
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHCCCCEEEECCCCC
PIALEGALKLKEISYIHAEAYPAGELKHGPLALVTEQMPVVTVAPNDALLEKLKSNIQEV
CEEECCCEEEHHHHEEEECCCCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHH
RARGGKLYVFADADTHIQSSDGIQVIRMPEHYGQLSPILHVVPLQLLAYHTALARGTDVD
HHCCCEEEEEECCCCCEECCCCEEEEECCHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
KPRNLAKSVTVE
CHHHHHHHCCCC
>Mature Secondary Structure
MCGIVGAVSTRNIVPVLIEGLRRLEYRGYDSCGVAIQRDGQLERARTVSRVADLDAQAQT
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCHHHH
SHLDGAIGIAHTRWATHGRPDTVNAHPHFSGDTIALVHNGIIENYEALREELKAVGYGFE
HHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCC
SQTDTEVVAHLIHQAYTYPSSKTRGDLFASVRASVKRLHGAYAIAVFARDNPDVVVGARA
CCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCEEEEECC
GSPLVVAIGENESFLASDALAVAGTASRMAYLEEGDVVELTRDGFTVADANDKIVAREVK
CCCEEEEECCCCCCHHHCHHHHHCCHHHHHEECCCCEEEEECCCEEEECCCCCHHHHHHH
EVGTYAAAVELGPFRHFMQKEIFEQPRALGDTLEGVQGFAPDLFGPEAAQVLPKVDSVLI
HHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCEEE
LACGTSYYSGCTAKYWLESIAKIPTQVEVASEYRYRETVPNPNALVVVISQSGETADTLA
EEECCHHHCCCCHHHHHHHHHHCCCEEEHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHH
ALRHARELGHTHTLAICNVATSAMVRETQLKFLTRAGTEIGVASTKAFTTQLAALYMLAL
HHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
TFAKLRGHLNAEQEEDALRHLRHLPSALNAVLALEPQIIAWSEEFARRENALFLGRGLHY
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHCCCCEEEECCCCC
PIALEGALKLKEISYIHAEAYPAGELKHGPLALVTEQMPVVTVAPNDALLEKLKSNIQEV
CEEECCCEEEHHHHEEEECCCCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHH
RARGGKLYVFADADTHIQSSDGIQVIRMPEHYGQLSPILHVVPLQLLAYHTALARGTDVD
HHCCCEEEEEECCCCCEECCCCEEEEECCHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
KPRNLAKSVTVE
CHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]