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The map label for this gene is cynR [H]

Identifier: 187927163

GI number: 187927163

Start: 65492

End: 66415

Strand: Direct

Name: cynR [H]

Synonym: Rpic_0053

Alternate gene names: 187927163

Gene position: 65492-66415 (Clockwise)

Preceding gene: 187927160

Following gene: 187927164

Centisome position: 1.66

GC content: 67.53

Gene sequence:

>924_bases
ATGTCGCACTCGCCGCTGCGTTATCTGCATAGCTTCCTGACCGTCGCCAACGAAGGCAGCTTCGTGCGTGCCGCAGACCG
CCTCGCCGTGTCGCAACCGGCGCTGTCGTACCAGATGCGGCAGCTGGAGCAGTGGCTCGGCGTGCCCCTGTTCGAGCGCT
CGGGGCGCAAGCTCGTGCTGACGCGCGCCGGCACGTCGGTGCGTGCGTGGTGCCGCGATGCGTTTGCCGGGCTGGATGAG
CTGCGCGCCGCCTTGCACAGCGGCGAGATGGAGCGGGTATCGCTCAAGCTGGCGAGCGGCTCCAGCTTCGGACGCTATGT
GCTGATGCCGGCGCTGCTGACGCCTTCGCCCGAATCGGAGGCGCCGCTTCTCGACGACGTGCGCCTGGAACTCGTCTTCG
GCAGCGACGAAGAGGTCTTCAGCCATGTCGAATCCGGCCGCGCCGATCTCGGCTTCGTCTACACGCCGCGCACGTCGCGC
CTGTTTGAACACCACGCTGTCTATACCGAAGAGTTCGTGCTGGCCTGCAGCGCCCGGGTACTGCGTGAGCACGCTGCGCC
ACGCACGCTGGCCGACTGCGCGGCGCTGCCCTTTGTCACCTACGACGAATCCGATGCGGTCTACGGGCTGTGGTTCAAGG
CGCTGTTCCGGCGCATGCCGGAGACGACCGTCAGCGCACATCACGTTTCCGATCTGGAAGAAGTGAGCACCTTGGTGGAG
GCCGGCATGGGCTGGTCGGTGCTGCCGCTGCATGCCGTTCAGGAAGCGGTGGAGCGCGGGCGTCTGCAGGTCGTGCGCCC
GATCGCGACGCGGCGCTGCCTGAACACCGTGTTCGCCGTGCGCCGCACATCGAGCTTCCCGAGCGAAGCGCAGGACCGCT
TGCTGGTGCGGCTTGCGCAGCTTGATGCGGCGGCGCGCGTTTAG

Upstream 100 bases:

>100_bases
TCGGTCGTTCACTTGCGGCGGATTGTGCGATCTGACAGACTTGAAATCAAATCGAATGTTTTTCGTTTTTCGATCCAAAA
ATTTGATGAATTGAGGCGCC

Downstream 100 bases:

>100_bases
CCGCGCGGTCGCAATCTTCCCCGTCGATCTACAAGGCGCGACATGTCGCCTTGAAATTAATTAATTAGACAATTAATATT
CGCGGCATGGCAACCTTCGA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MSHSPLRYLHSFLTVANEGSFVRAADRLAVSQPALSYQMRQLEQWLGVPLFERSGRKLVLTRAGTSVRAWCRDAFAGLDE
LRAALHSGEMERVSLKLASGSSFGRYVLMPALLTPSPESEAPLLDDVRLELVFGSDEEVFSHVESGRADLGFVYTPRTSR
LFEHHAVYTEEFVLACSARVLREHAAPRTLADCAALPFVTYDESDAVYGLWFKALFRRMPETTVSAHHVSDLEEVSTLVE
AGMGWSVLPLHAVQEAVERGRLQVVRPIATRRCLNTVFAVRRTSSFPSEAQDRLLVRLAQLDAAARV

Sequences:

>Translated_307_residues
MSHSPLRYLHSFLTVANEGSFVRAADRLAVSQPALSYQMRQLEQWLGVPLFERSGRKLVLTRAGTSVRAWCRDAFAGLDE
LRAALHSGEMERVSLKLASGSSFGRYVLMPALLTPSPESEAPLLDDVRLELVFGSDEEVFSHVESGRADLGFVYTPRTSR
LFEHHAVYTEEFVLACSARVLREHAAPRTLADCAALPFVTYDESDAVYGLWFKALFRRMPETTVSAHHVSDLEEVSTLVE
AGMGWSVLPLHAVQEAVERGRLQVVRPIATRRCLNTVFAVRRTSSFPSEAQDRLLVRLAQLDAAARV
>Mature_306_residues
SHSPLRYLHSFLTVANEGSFVRAADRLAVSQPALSYQMRQLEQWLGVPLFERSGRKLVLTRAGTSVRAWCRDAFAGLDEL
RAALHSGEMERVSLKLASGSSFGRYVLMPALLTPSPESEAPLLDDVRLELVFGSDEEVFSHVESGRADLGFVYTPRTSRL
FEHHAVYTEEFVLACSARVLREHAAPRTLADCAALPFVTYDESDAVYGLWFKALFRRMPETTVSAHHVSDLEEVSTLVEA
GMGWSVLPLHAVQEAVERGRLQVVRPIATRRCLNTVFAVRRTSSFPSEAQDRLLVRLAQLDAAARV

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=172, Percent_Identity=37.2093023255814, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1787879, Length=249, Percent_Identity=31.3253012048193, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87082132, Length=258, Percent_Identity=26.7441860465116, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788481, Length=295, Percent_Identity=26.4406779661017, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788887, Length=277, Percent_Identity=28.5198555956679, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788748, Length=256, Percent_Identity=27.734375, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI145693105, Length=314, Percent_Identity=25.796178343949, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1790399, Length=290, Percent_Identity=27.9310344827586, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1790783, Length=264, Percent_Identity=25.7575757575758, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1788706, Length=245, Percent_Identity=24.0816326530612, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI87081978, Length=213, Percent_Identity=27.2300469483568, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790208, Length=277, Percent_Identity=26.3537906137184, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1786448, Length=215, Percent_Identity=28.8372093023256, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1789492, Length=293, Percent_Identity=26.6211604095563, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34200; Mature: 34069

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS50931 HTH_LYSR ; PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHSPLRYLHSFLTVANEGSFVRAADRLAVSQPALSYQMRQLEQWLGVPLFERSGRKLVL
CCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCEEEE
TRAGTSVRAWCRDAFAGLDELRAALHSGEMERVSLKLASGSSFGRYVLMPALLTPSPESE
EECCCHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEEECCCCCCHHEEEHHHCCCCCCCC
APLLDDVRLELVFGSDEEVFSHVESGRADLGFVYTPRTSRLFEHHAVYTEEFVLACSARV
CCCCCCEEEEEEECCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
LREHAAPRTLADCAALPFVTYDESDAVYGLWFKALFRRMPETTVSAHHVSDLEEVSTLVE
HHHHCCCHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
AGMGWSVLPLHAVQEAVERGRLQVVRPIATRRCLNTVFAVRRTSSFPSEAQDRLLVRLAQ
CCCCCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LDAAARV
HHHHHCC
>Mature Secondary Structure 
SHSPLRYLHSFLTVANEGSFVRAADRLAVSQPALSYQMRQLEQWLGVPLFERSGRKLVL
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCEEEE
TRAGTSVRAWCRDAFAGLDELRAALHSGEMERVSLKLASGSSFGRYVLMPALLTPSPESE
EECCCHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEEECCCCCCHHEEEHHHCCCCCCCC
APLLDDVRLELVFGSDEEVFSHVESGRADLGFVYTPRTSRLFEHHAVYTEEFVLACSARV
CCCCCCEEEEEEECCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
LREHAAPRTLADCAALPFVTYDESDAVYGLWFKALFRRMPETTVSAHHVSDLEEVSTLVE
HHHHCCCHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
AGMGWSVLPLHAVQEAVERGRLQVVRPIATRRCLNTVFAVRRTSSFPSEAQDRLLVRLAQ
CCCCCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LDAAARV
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]