Click here to switch to the map view.

The map label for this gene is rocD [H]

Identifier: 187927162

GI number: 187927162

Start: 64147

End: 65373

Strand: Reverse

Name: rocD [H]

Synonym: Rpic_0052

Alternate gene names: 187927162

Gene position: 65373-64147 (Counterclockwise)

Preceding gene: 187927169

Following gene: 187927161

Centisome position: 1.66

GC content: 67.32

Gene sequence:

>1227_bases
ATGACGACCGCAATGCAACATCCGAGCTATGCATTGGAAGACCGTTACGGCGCACGCAACTACGCGCCCTTGCCGGTCAT
GCTGGAACGCGGCGAAGGCGTGTGGCTCTTCGATACCGACGGCCGGCGCTACCTCGACATGATGTCTGCGTACTCGGCCG
TCAGCTTTGGGCATTCGCATCCGAAGCTCGTGGCCGCGCTGACGGAACAGGCCGGCCGGCTGACGCTCACGTCGCGCGCA
TTCCACAACACCGAGCTGGGGCCCTTCCTGGCCGACGTCTGCCGCATCACGCGCATGGACCGCGCGCTGCCCATGAACAC
CGGCGCGGAAGCCGTCGAAACCGCCATCAAGGCGGCACGCAAGTGGGCGCGCGACGTAAAGGGCCTGCCGCCCGAGGCGG
CCGAAATCATCGTCTTCGACAACAATTTCCACGGCCGCACGACGACCATCGTCGGGTTCTCCTCACACGATCAATATCGC
TACGGATTCGGACCCTTCGCGGCGGGCTTCCGGCGCATTCCGTTCGGCGACGCCGATGCACTGCGTGCGGCGATCGGGCC
CAACACGGGCGCCATCCTGATGGAGCCCGTGCAAGGCGAAGGCGGCATCGTCGAACCGCCTGCGGGCTACCTCAAGCTCG
CGCGTGAACTTGCCACCCGGCACAACGTGCTCCTCGTCTGCGACGAGGTGCAAACGGGCCTAGGCCGCACCGGCGATGTG
CTGGCGAGCTGGCACGAAGGCGTTGACGCCGATCTGGTGGTGCTGGGCAAGGCGCTCGGCGGCGGCATGGTGCCCGTATC
GGCCATTGCCGGGCGCGAGGCGGTCATCGGCGTGTTCCACCCGGGCGACCACGGCTCCACGTTTGGCGGCAACCCGCTCG
CAGCGCACATCGGACGCGCGGCACTTGCCTTGCTGATGGAAGAACAACTGCCACAGCGTGCCGCGCGCGTGGGCGCAGCG
TTCATCAACGAACTGAAAACGCTGGTCGGCCACGGCGTTCGGCAGGTGCGTGGACGCGGCTTGATGATCGGCCTGCAGCT
CGACGCCGACATCGATGCACACGACTTCGCCTTCGCGCTGGCCGAGCGCGGCGTGCTGACCAAGGACACCTACGGCAACG
TGGTTCGCCTGACACCGCCGCTGGTCATTGGCGAGGCCGAACTGGCGCTGGCGCTGGACGCCATCCGCCAGACGCTGGCC
GGCTGGCCGCGGCGCAAGGTGGCGTGA

Upstream 100 bases:

>100_bases
ATTTTTGGATCGAAAAACGAAAAACATTCGATTTGATTTCAAGTCTGTCAGATCGCACAATCCGCCGCAAGTGAACGACC
GATCCAGGCAGGAGGCCATC

Downstream 100 bases:

>100_bases
GGAAGAACTCGCAAGGGGAGTGACATGACCATCATTGATCTGATCGGCGCGGCCATCGGCTGCGGAGCGCAAGACGACGG
CTGCAAGGACGGCCCGCGCG

Product: ornithine aminotransferase

Products: NA

Alternate protein names: OAT; Ornithine--oxo-acid aminotransferase [H]

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MTTAMQHPSYALEDRYGARNYAPLPVMLERGEGVWLFDTDGRRYLDMMSAYSAVSFGHSHPKLVAALTEQAGRLTLTSRA
FHNTELGPFLADVCRITRMDRALPMNTGAEAVETAIKAARKWARDVKGLPPEAAEIIVFDNNFHGRTTTIVGFSSHDQYR
YGFGPFAAGFRRIPFGDADALRAAIGPNTGAILMEPVQGEGGIVEPPAGYLKLARELATRHNVLLVCDEVQTGLGRTGDV
LASWHEGVDADLVVLGKALGGGMVPVSAIAGREAVIGVFHPGDHGSTFGGNPLAAHIGRAALALLMEEQLPQRAARVGAA
FINELKTLVGHGVRQVRGRGLMIGLQLDADIDAHDFAFALAERGVLTKDTYGNVVRLTPPLVIGEAELALALDAIRQTLA
GWPRRKVA

Sequences:

>Translated_408_residues
MTTAMQHPSYALEDRYGARNYAPLPVMLERGEGVWLFDTDGRRYLDMMSAYSAVSFGHSHPKLVAALTEQAGRLTLTSRA
FHNTELGPFLADVCRITRMDRALPMNTGAEAVETAIKAARKWARDVKGLPPEAAEIIVFDNNFHGRTTTIVGFSSHDQYR
YGFGPFAAGFRRIPFGDADALRAAIGPNTGAILMEPVQGEGGIVEPPAGYLKLARELATRHNVLLVCDEVQTGLGRTGDV
LASWHEGVDADLVVLGKALGGGMVPVSAIAGREAVIGVFHPGDHGSTFGGNPLAAHIGRAALALLMEEQLPQRAARVGAA
FINELKTLVGHGVRQVRGRGLMIGLQLDADIDAHDFAFALAERGVLTKDTYGNVVRLTPPLVIGEAELALALDAIRQTLA
GWPRRKVA
>Mature_407_residues
TTAMQHPSYALEDRYGARNYAPLPVMLERGEGVWLFDTDGRRYLDMMSAYSAVSFGHSHPKLVAALTEQAGRLTLTSRAF
HNTELGPFLADVCRITRMDRALPMNTGAEAVETAIKAARKWARDVKGLPPEAAEIIVFDNNFHGRTTTIVGFSSHDQYRY
GFGPFAAGFRRIPFGDADALRAAIGPNTGAILMEPVQGEGGIVEPPAGYLKLARELATRHNVLLVCDEVQTGLGRTGDVL
ASWHEGVDADLVVLGKALGGGMVPVSAIAGREAVIGVFHPGDHGSTFGGNPLAAHIGRAALALLMEEQLPQRAARVGAAF
INELKTLVGHGVRQVRGRGLMIGLQLDADIDAHDFAFALAERGVLTKDTYGNVVRLTPPLVIGEAELALALDAIRQTLAG
WPRRKVA

Specific function: Catalyzes the interconversion of ornithine to glutamate semialdehyde [H]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. OAT subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=390, Percent_Identity=47.6923076923077, Blast_Score=359, Evalue=3e-99,
Organism=Homo sapiens, GI284507298, Length=298, Percent_Identity=46.3087248322148, Blast_Score=252, Evalue=5e-67,
Organism=Homo sapiens, GI13994255, Length=440, Percent_Identity=27.0454545454545, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI37574042, Length=435, Percent_Identity=26.2068965517241, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI24119277, Length=425, Percent_Identity=27.7647058823529, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI226442705, Length=435, Percent_Identity=25.5172413793103, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI226442709, Length=400, Percent_Identity=26, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1788044, Length=377, Percent_Identity=38.7267904509284, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI1789759, Length=372, Percent_Identity=36.8279569892473, Blast_Score=231, Evalue=4e-62,
Organism=Escherichia coli, GI145693181, Length=385, Percent_Identity=31.9480519480519, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1789016, Length=417, Percent_Identity=29.7362110311751, Blast_Score=164, Evalue=9e-42,
Organism=Escherichia coli, GI1787560, Length=410, Percent_Identity=30.7317073170732, Blast_Score=161, Evalue=8e-41,
Organism=Escherichia coli, GI1786991, Length=397, Percent_Identity=29.7229219143577, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1786349, Length=293, Percent_Identity=29.6928327645051, Blast_Score=107, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI25144271, Length=394, Percent_Identity=44.1624365482233, Blast_Score=368, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI25144274, Length=280, Percent_Identity=40.7142857142857, Blast_Score=228, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI32564660, Length=446, Percent_Identity=29.372197309417, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71981843, Length=170, Percent_Identity=45.2941176470588, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71992977, Length=439, Percent_Identity=26.6514806378132, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17541228, Length=431, Percent_Identity=23.6658932714617, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323470, Length=407, Percent_Identity=43.4889434889435, Blast_Score=334, Evalue=1e-92,
Organism=Saccharomyces cerevisiae, GI6324432, Length=406, Percent_Identity=26.8472906403941, Blast_Score=152, Evalue=9e-38,
Organism=Saccharomyces cerevisiae, GI6324386, Length=433, Percent_Identity=23.3256351039261, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21357415, Length=391, Percent_Identity=48.5933503836317, Blast_Score=380, Evalue=1e-106,
Organism=Drosophila melanogaster, GI28574759, Length=444, Percent_Identity=28.8288288288288, Blast_Score=164, Evalue=8e-41,
Organism=Drosophila melanogaster, GI161085790, Length=440, Percent_Identity=27.7272727272727, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI21356575, Length=427, Percent_Identity=26.463700234192, Blast_Score=124, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR010164
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.13 [H]

Molecular weight: Translated: 43756; Mature: 43624

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAMQHPSYALEDRYGARNYAPLPVMLERGEGVWLFDTDGRRYLDMMSAYSAVSFGHSH
CCCCCCCCCCHHHHCCCCCCCCCCCEEEECCCEEEEEECCCHHHHHHHHHHHHHHCCCCC
PKLVAALTEQAGRLTLTSRAFHNTELGPFLADVCRITRMDRALPMNTGAEAVETAIKAAR
HHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
KWARDVKGLPPEAAEIIVFDNNFHGRTTTIVGFSSHDQYRYGFGPFAAGFRRIPFGDADA
HHHHHHCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCCCHHHHCCEECCCCCHHH
LRAAIGPNTGAILMEPVQGEGGIVEPPAGYLKLARELATRHNVLLVCDEVQTGLGRTGDV
HHHHCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCHHHCCCCCHHH
LASWHEGVDADLVVLGKALGGGMVPVSAIAGREAVIGVFHPGDHGSTFGGNPLAAHIGRA
HHHHHCCCCCCCEEEEHHHCCCCCCHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHH
ALALLMEEQLPQRAARVGAAFINELKTLVGHGVRQVRGRGLMIGLQLDADIDAHDFAFAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCEEEEEEEECCCCCHHHHHHHH
AERGVLTKDTYGNVVRLTPPLVIGEAELALALDAIRQTLAGWPRRKVA
HHCCCEEECCCCCEEEECCCEEECCHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TTAMQHPSYALEDRYGARNYAPLPVMLERGEGVWLFDTDGRRYLDMMSAYSAVSFGHSH
CCCCCCCCCHHHHCCCCCCCCCCCEEEECCCEEEEEECCCHHHHHHHHHHHHHHCCCCC
PKLVAALTEQAGRLTLTSRAFHNTELGPFLADVCRITRMDRALPMNTGAEAVETAIKAAR
HHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
KWARDVKGLPPEAAEIIVFDNNFHGRTTTIVGFSSHDQYRYGFGPFAAGFRRIPFGDADA
HHHHHHCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCCCHHHHCCEECCCCCHHH
LRAAIGPNTGAILMEPVQGEGGIVEPPAGYLKLARELATRHNVLLVCDEVQTGLGRTGDV
HHHHCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCHHHCCCCCHHH
LASWHEGVDADLVVLGKALGGGMVPVSAIAGREAVIGVFHPGDHGSTFGGNPLAAHIGRA
HHHHHCCCCCCCEEEEHHHCCCCCCHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHH
ALALLMEEQLPQRAARVGAAFINELKTLVGHGVRQVRGRGLMIGLQLDADIDAHDFAFAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCEEEEEEEECCCCCHHHHHHHH
AERGVLTKDTYGNVVRLTPPLVIGEAELALALDAIRQTLAGWPRRKVA
HHCCCEEECCCCCEEEECCCEEECCHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]