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The map label for this gene is dus [H]

Identifier: 187918594

GI number: 187918594

Start: 788669

End: 789664

Strand: Direct

Name: dus [H]

Synonym: BH0737

Alternate gene names: 187918594

Gene position: 788669-789664 (Clockwise)

Preceding gene: 187918591

Following gene: 187918595

Centisome position: 85.51

GC content: 31.12

Gene sequence:

>996_bases
ATGAATTTTTTAAGTAATATGAGTCGTCCCATTATGATTTTGGCCCCAATGGAAGATGTCACAGATACTGTTTTTAGAAA
TTTAATTCATTTGATAGGGAATGGAAAGGATGTGCCTGATATTTATTTTACCGAATTTATTTCCGTAAAAGGACTTTTAA
ATAAATCAAAGCAGTCAATGCAACATATTTTGACAAAAAATGATGAACTTAATCGACCATTGATTGCTCAAATTTGGGGA
AAGGAGCCTGATGAATTTTTTAAGGCAATAGAAATTTTAAGTAATTTGGGATTTTGGGGTATTGACCTTAATATGGGTTG
CCCTAAGAAAAAAATAGTTAAAAAGGGAGTTTGTTCCGCTTTAATTAACAATAAATCTTTGGCCCGTGAAATAATTATGG
CAAGTAAAGAGGCGTGTTTGAAATTTGGATTGCCTCTTAGTGTTAAGACAAGACATGGGTTTTTTTATTCTGAGGTTGAA
GATTGGTTAGGATTTTTACTGGAACTAGGCATTGATATGTTGATTGTGCATCCCAGGCTTGCTGTTAATCAGAGTGAAGG
GCCTATAGATGTTGCTGTGTTTCATGAGCTTGTTAAGCTGAGGGATCAAATCAATCCTTCTGCATTAATTATTGGCAATG
GAGGTATTTTAAGTCTAGAGCAAGCACATCAGATTGTAAGGGAGTATTCTATTGATGGAGTAATGTTTGGTTGTGGGATT
TTTAGGAATTTAAACTTATTTAGAAAAGGTTTGTCAAACTTTTTGAGTAATAATTTAAATTATAGATTAAATATATTAAA
ATTGCATATAACAGATTTTCATTCTACTTGGAGTCTTACTAAGGATTTTAATAAACTTAAGAAATACTTCAAAATTTATT
TTAATGAAGATGAAAGACATAGCGAGTATTTTTATAATATTATGAATTCAAGTAATTATGATGAGCTTTTTGAAAATCTA
AGTCGAATGGATATAGGAGATGAGCTTAAGCAATGA

Upstream 100 bases:

>100_bases
ATTGAAAAGTTTTTTATTCCCTTGTAAGGCATACTGATTTCTTTGAAATTCATTTTGTGCATTTCTTTACCATAATGTTG
TCTTATTATATATTTATTTT

Downstream 100 bases:

>100_bases
GCGATGAACTTTCAAAAAATTATAATCCTAAAGTTTTTGAAGATAAAATTTATCAAAAATGGCTAGATAATGGTGTATTT
AGTCCTAATGATGGGATTGA

Product: histidine phosphokinase/phophatase, putative

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MNFLSNMSRPIMILAPMEDVTDTVFRNLIHLIGNGKDVPDIYFTEFISVKGLLNKSKQSMQHILTKNDELNRPLIAQIWG
KEPDEFFKAIEILSNLGFWGIDLNMGCPKKKIVKKGVCSALINNKSLAREIIMASKEACLKFGLPLSVKTRHGFFYSEVE
DWLGFLLELGIDMLIVHPRLAVNQSEGPIDVAVFHELVKLRDQINPSALIIGNGGILSLEQAHQIVREYSIDGVMFGCGI
FRNLNLFRKGLSNFLSNNLNYRLNILKLHITDFHSTWSLTKDFNKLKKYFKIYFNEDERHSEYFYNIMNSSNYDELFENL
SRMDIGDELKQ

Sequences:

>Translated_331_residues
MNFLSNMSRPIMILAPMEDVTDTVFRNLIHLIGNGKDVPDIYFTEFISVKGLLNKSKQSMQHILTKNDELNRPLIAQIWG
KEPDEFFKAIEILSNLGFWGIDLNMGCPKKKIVKKGVCSALINNKSLAREIIMASKEACLKFGLPLSVKTRHGFFYSEVE
DWLGFLLELGIDMLIVHPRLAVNQSEGPIDVAVFHELVKLRDQINPSALIIGNGGILSLEQAHQIVREYSIDGVMFGCGI
FRNLNLFRKGLSNFLSNNLNYRLNILKLHITDFHSTWSLTKDFNKLKKYFKIYFNEDERHSEYFYNIMNSSNYDELFENL
SRMDIGDELKQ
>Mature_331_residues
MNFLSNMSRPIMILAPMEDVTDTVFRNLIHLIGNGKDVPDIYFTEFISVKGLLNKSKQSMQHILTKNDELNRPLIAQIWG
KEPDEFFKAIEILSNLGFWGIDLNMGCPKKKIVKKGVCSALINNKSLAREIIMASKEACLKFGLPLSVKTRHGFFYSEVE
DWLGFLLELGIDMLIVHPRLAVNQSEGPIDVAVFHELVKLRDQINPSALIIGNGGILSLEQAHQIVREYSIDGVMFGCGI
FRNLNLFRKGLSNFLSNNLNYRLNILKLHITDFHSTWSLTKDFNKLKKYFKIYFNEDERHSEYFYNIMNSSNYDELFENL
SRMDIGDELKQ

Specific function: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs [H]

COG id: COG0042

COG function: function code J; tRNA-dihydrouridine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dus family [H]

Homologues:

Organism=Homo sapiens, GI31742496, Length=237, Percent_Identity=24.8945147679325, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1789660, Length=324, Percent_Identity=24.6913580246914, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788462, Length=246, Percent_Identity=28.8617886178862, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25144369, Length=254, Percent_Identity=27.9527559055118, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6323437, Length=242, Percent_Identity=25.2066115702479, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24580595, Length=272, Percent_Identity=25.3676470588235, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19920448, Length=272, Percent_Identity=25.3676470588235, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001269
- InterPro:   IPR018517 [H]

Pfam domain/function: PF01207 Dus [H]

EC number: NA

Molecular weight: Translated: 38081; Mature: 38081

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFLSNMSRPIMILAPMEDVTDTVFRNLIHLIGNGKDVPDIYFTEFISVKGLLNKSKQSM
CCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
QHILTKNDELNRPLIAQIWGKEPDEFFKAIEILSNLGFWGIDLNMGCPKKKIVKKGVCSA
HHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHH
LINNKSLAREIIMASKEACLKFGLPLSVKTRHGFFYSEVEDWLGFLLELGIDMLIVHPRL
HHCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHCCCCEEEECCCC
AVNQSEGPIDVAVFHELVKLRDQINPSALIIGNGGILSLEQAHQIVREYSIDGVMFGCGI
EECCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCEEEHHHHHHHHHHHCCCCEEEHHHH
FRNLNLFRKGLSNFLSNNLNYRLNILKLHITDFHSTWSLTKDFNKLKKYFKIYFNEDERH
HHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCHH
SEYFYNIMNSSNYDELFENLSRMDIGDELKQ
HHHHHHHHCCCCHHHHHHHHHHCCCCHHHCC
>Mature Secondary Structure
MNFLSNMSRPIMILAPMEDVTDTVFRNLIHLIGNGKDVPDIYFTEFISVKGLLNKSKQSM
CCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
QHILTKNDELNRPLIAQIWGKEPDEFFKAIEILSNLGFWGIDLNMGCPKKKIVKKGVCSA
HHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHH
LINNKSLAREIIMASKEACLKFGLPLSVKTRHGFFYSEVEDWLGFLLELGIDMLIVHPRL
HHCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHCCCCEEEECCCC
AVNQSEGPIDVAVFHELVKLRDQINPSALIIGNGGILSLEQAHQIVREYSIDGVMFGCGI
EECCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCEEEHHHHHHHHHHHCCCCEEEHHHH
FRNLNLFRKGLSNFLSNNLNYRLNILKLHITDFHSTWSLTKDFNKLKKYFKIYFNEDERH
HHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCHH
SEYFYNIMNSSNYDELFENLSRMDIGDELKQ
HHHHHHHHCCCCHHHHHHHHHHCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA