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The map label for this gene is ffh [H]

Identifier: 187918549

GI number: 187918549

Start: 741650

End: 742999

Strand: Direct

Name: ffh [H]

Synonym: BH0694

Alternate gene names: 187918549

Gene position: 741650-742999 (Clockwise)

Preceding gene: 187918548

Following gene: 187918550

Centisome position: 80.41

GC content: 35.41

Gene sequence:

>1350_bases
GTGTTTGAGAAGTTAGGTGCAGGTTTTAGAGATTTTGTTAAGTATGTATCTGGGAAATCTGTGATAAATGAAAAAAATAT
TGAAGATGCTATTGACACTATTAAGGATGCCTTAATTGAAGCTGATGTTAATTTAAGAGTTGTAAGACGTTTTGTAAATT
CTGTTGCCGAAGAGGCAAAGGGAATTAAGGTTTTAAGAGATGTTGATCCCAAGTCTCAGTTTGTTAAGATTGTTAATGAT
AAACTTGTAAATTTTCTGGGTGATAAGCATTCCGAGCTCATTTTAAACCCCGTTAACAAATTGTCATGTATTCTGATGCT
TGGTCTTCAGGGTTCTGGTAAGACTACAACATGTGCAAAACTTGCGATGCGGCTTAAATCAGAGAATCGAAAAGTTCTTC
TTGTCGCTGCAGATACTTTTAGAGCAGCAGCAGTTGATCAGCTAAGAGTTTTGGGTGAGCAAATTGGTATTTCTGTTTTT
GCTATTGAGAGTGAGAATGATCCTATTAAGGTTGTAAAAAAGTCCATTGAATATGCCAAAGTGGAGCTTTTTGATACTGT
AATAGTAGATACTAGAGGGCGTCTTGAGGTTGAAGATTTATTGCTAAAAGAGATAAAAAAGATTAAGGATATTGTGACCC
CTACGGAAACAATATTAGTTGCAGATGCAATGACAGGTCAGGTGGCTGTAAATATTGCTAAAGAATTTAATGAGAGTGTT
GGGATTACGGGTGTAATTTTTACAAAATTTGATTCTGATGCTAGGGGCGGTGCAATACTTTCGCTTAAGACTATTTGTGG
AGCTCCCATTAAATTTGTTGGAGTTGGAGAGAGGCCTGAGGATCTTGATATTTTTTATCCAGATAGAGTTGCTTCACGAA
TTCTTGGCATGGGAGATGTTGTTAGTCTTGTTGAGAAAGCCCAAAGTGTTATAGATAAAGAAGAAGCCTTAAGACTTGAA
GAGAAAATTAGAAAAGCTAATTTTAGTTTTGAAGATTATTTAAATCAATTTAAGTATATGCGTAATATGGGTGGGATTTC
TAGTTTGATGGGAATGCTTCCAGGCGTTTCACCAGAAATGTTAGGTCGTGGTATCAATGAGAGAGAACTTAAAAGGGAAG
AGGCAATCATCCTTTCTATGACTAAAAAAGAGAGGGTAAATCCTGTCATTTTAAATAGTCCTTCAAGGAAGAAAAGAATA
GCTTTGGGAAGTGGGACAACAGTTTTTGAGGTAAATAAGCTTATGAAAAAATTTAGCCAGACGATTTTGATGATGAAAAA
AATGAAAAATAAGAGCTTTCAAAATAAGATAACATCTCTTTTGGGAGGTAAAGGAGGAATGGTAAATTGA

Upstream 100 bases:

>100_bases
TATTCAATAAATTCTATTTGACAGGGGGAGATATTGATTAATATTTCCTTTTTTTGTATTGTATATTTTGTAGGATTTTG
ACAAATGAAGGTGATTTTTA

Downstream 100 bases:

>100_bases
GTGTTAGAATAAGATTAAAAAGGATGGGGGCAAAAAAGAGGCCTTATTATCGAATTGTAGTAATGGATTCTGCTTCGCCT
AGAGATGGACGAGCCATTGA

Product: signal recognition particle, subunit FFH/SRP54

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MFEKLGAGFRDFVKYVSGKSVINEKNIEDAIDTIKDALIEADVNLRVVRRFVNSVAEEAKGIKVLRDVDPKSQFVKIVND
KLVNFLGDKHSELILNPVNKLSCILMLGLQGSGKTTTCAKLAMRLKSENRKVLLVAADTFRAAAVDQLRVLGEQIGISVF
AIESENDPIKVVKKSIEYAKVELFDTVIVDTRGRLEVEDLLLKEIKKIKDIVTPTETILVADAMTGQVAVNIAKEFNESV
GITGVIFTKFDSDARGGAILSLKTICGAPIKFVGVGERPEDLDIFYPDRVASRILGMGDVVSLVEKAQSVIDKEEALRLE
EKIRKANFSFEDYLNQFKYMRNMGGISSLMGMLPGVSPEMLGRGINERELKREEAIILSMTKKERVNPVILNSPSRKKRI
ALGSGTTVFEVNKLMKKFSQTILMMKKMKNKSFQNKITSLLGGKGGMVN

Sequences:

>Translated_449_residues
MFEKLGAGFRDFVKYVSGKSVINEKNIEDAIDTIKDALIEADVNLRVVRRFVNSVAEEAKGIKVLRDVDPKSQFVKIVND
KLVNFLGDKHSELILNPVNKLSCILMLGLQGSGKTTTCAKLAMRLKSENRKVLLVAADTFRAAAVDQLRVLGEQIGISVF
AIESENDPIKVVKKSIEYAKVELFDTVIVDTRGRLEVEDLLLKEIKKIKDIVTPTETILVADAMTGQVAVNIAKEFNESV
GITGVIFTKFDSDARGGAILSLKTICGAPIKFVGVGERPEDLDIFYPDRVASRILGMGDVVSLVEKAQSVIDKEEALRLE
EKIRKANFSFEDYLNQFKYMRNMGGISSLMGMLPGVSPEMLGRGINERELKREEAIILSMTKKERVNPVILNSPSRKKRI
ALGSGTTVFEVNKLMKKFSQTILMMKKMKNKSFQNKITSLLGGKGGMVN
>Mature_449_residues
MFEKLGAGFRDFVKYVSGKSVINEKNIEDAIDTIKDALIEADVNLRVVRRFVNSVAEEAKGIKVLRDVDPKSQFVKIVND
KLVNFLGDKHSELILNPVNKLSCILMLGLQGSGKTTTCAKLAMRLKSENRKVLLVAADTFRAAAVDQLRVLGEQIGISVF
AIESENDPIKVVKKSIEYAKVELFDTVIVDTRGRLEVEDLLLKEIKKIKDIVTPTETILVADAMTGQVAVNIAKEFNESV
GITGVIFTKFDSDARGGAILSLKTICGAPIKFVGVGERPEDLDIFYPDRVASRILGMGDVVSLVEKAQSVIDKEEALRLE
EKIRKANFSFEDYLNQFKYMRNMGGISSLMGMLPGVSPEMLGRGINERELKREEAIILSMTKKERVNPVILNSPSRKKRI
ALGSGTTVFEVNKLMKKFSQTILMMKKMKNKSFQNKITSLLGGKGGMVN

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=433, Percent_Identity=32.7944572748268, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI226371618, Length=338, Percent_Identity=36.3905325443787, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI295424842, Length=307, Percent_Identity=27.6872964169381, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI23308697, Length=307, Percent_Identity=27.6872964169381, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI89061728, Length=155, Percent_Identity=36.7741935483871, Blast_Score=103, Evalue=3e-22,
Organism=Escherichia coli, GI1788963, Length=422, Percent_Identity=45.260663507109, Blast_Score=366, Evalue=1e-102,
Organism=Escherichia coli, GI1789874, Length=261, Percent_Identity=39.463601532567, Blast_Score=163, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17539958, Length=453, Percent_Identity=32.2295805739514, Blast_Score=237, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI193206261, Length=304, Percent_Identity=30.9210526315789, Blast_Score=115, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6325345, Length=420, Percent_Identity=36.1904761904762, Blast_Score=238, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6320498, Length=206, Percent_Identity=33.0097087378641, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17647949, Length=430, Percent_Identity=33.4883720930233, Blast_Score=214, Evalue=7e-56,
Organism=Drosophila melanogaster, GI24641198, Length=305, Percent_Identity=26.8852459016393, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49742; Mature: 49742

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEKLGAGFRDFVKYVSGKSVINEKNIEDAIDTIKDALIEADVNLRVVRRFVNSVAEEAK
CCCCCCCCHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
GIKVLRDVDPKSQFVKIVNDKLVNFLGDKHSELILNPVNKLSCILMLGLQGSGKTTTCAK
CCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHCHHHHHEEEHEEECCCCCCCHHHHH
LAMRLKSENRKVLLVAADTFRAAAVDQLRVLGEQIGISVFAIESENDPIKVVKKSIEYAK
HHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHHH
VELFDTVIVDTRGRLEVEDLLLKEIKKIKDIVTPTETILVADAMTGQVAVNIAKEFNESV
HHHHHHHEECCCCCCCHHHHHHHHHHHHHHHCCCCHHEEEEECCCCHHHHHHHHHHCCCC
GITGVIFTKFDSDARGGAILSLKTICGAPIKFVGVGERPEDLDIFYPDRVASRILGMGDV
CCEEEEEEECCCCCCCCEEEEEHHHCCCCEEEEECCCCCCCCCEECCHHHHHHHHCCHHH
VSLVEKAQSVIDKEEALRLEEKIRKANFSFEDYLNQFKYMRNMGGISSLMGMLPGVSPEM
HHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHH
LGRGINERELKREEAIILSMTKKERVNPVILNSPSRKKRIALGSGTTVFEVNKLMKKFSQ
HCCCCCHHHHHHHHHHEEEEHHHHCCCEEEECCCCCCCEEEECCCCHHHHHHHHHHHHHH
TILMMKKMKNKSFQNKITSLLGGKGGMVN
HHHHHHHHHCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MFEKLGAGFRDFVKYVSGKSVINEKNIEDAIDTIKDALIEADVNLRVVRRFVNSVAEEAK
CCCCCCCCHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
GIKVLRDVDPKSQFVKIVNDKLVNFLGDKHSELILNPVNKLSCILMLGLQGSGKTTTCAK
CCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHCHHHHHEEEHEEECCCCCCCHHHHH
LAMRLKSENRKVLLVAADTFRAAAVDQLRVLGEQIGISVFAIESENDPIKVVKKSIEYAK
HHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHHH
VELFDTVIVDTRGRLEVEDLLLKEIKKIKDIVTPTETILVADAMTGQVAVNIAKEFNESV
HHHHHHHEECCCCCCCHHHHHHHHHHHHHHHCCCCHHEEEEECCCCHHHHHHHHHHCCCC
GITGVIFTKFDSDARGGAILSLKTICGAPIKFVGVGERPEDLDIFYPDRVASRILGMGDV
CCEEEEEEECCCCCCCCEEEEEHHHCCCCEEEEECCCCCCCCCEECCHHHHHHHHCCHHH
VSLVEKAQSVIDKEEALRLEEKIRKANFSFEDYLNQFKYMRNMGGISSLMGMLPGVSPEM
HHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHH
LGRGINERELKREEAIILSMTKKERVNPVILNSPSRKKRIALGSGTTVFEVNKLMKKFSQ
HCCCCCHHHHHHHHHHEEEEHHHHCCCEEEECCCCCCCEEEECCCCHHHHHHHHHHHHHH
TILMMKKMKNKSFQNKITSLLGGKGGMVN
HHHHHHHHHCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]