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The map label for this gene is groEL [H]

Identifier: 187918505

GI number: 187918505

Start: 694552

End: 696216

Strand: Direct

Name: groEL [H]

Synonym: BH0649

Alternate gene names: 187918505

Gene position: 694552-696216 (Clockwise)

Preceding gene: 187918501

Following gene: 187918506

Centisome position: 75.31

GC content: 36.34

Gene sequence:

>1665_bases
TTGTTATACTTAAAAGGAGTAAAATTTATGGCTAAGGACATATATTTTAATGAAGATGCGAGAAAGAGTCTGCTCAGCGG
CATTGAAAAATTATCAAATGCTGTAAAGGTGACTCTTGGTCCTAAGGGGAGAAATGTTTTAATTGATAAAAAATTTGGTT
CTCCTACTGTTACAAAAGATGGAGTGAGTGTTGCTCGTGAAATTGAGCTTGAAAATGCGTTTGAAAATATGGGAGCACAA
CTTTTAAAAGAAGTTGCAATTAAGACAAATGATTTAGCTGGAGATGGAACTACTACAGCTACTGTACTTGCTTATGCAAT
TGCAAGAGAGGGACTTAAAAATGTTTCTTCTGGGATTAATCCAATTGGAATAAAAAAAGGGATAGATCGTGCGGTGACTT
TGGCTGCTGAAAAGATTCGTAAATCTGCTAAGAAAATTACTACTAAGGAAGAAATTGCACAGGTAGCATCTATTTCTGCA
AACAATGATACTTCGATAGGTGAAAAAATTGCTGAAGCAATGGACAGAGTTGGAAAAGATGGGGTTATTACTGTTGAAGA
GTCAAAGACTTTTGATACTACAATCTCTTATGTTGAAGGAATGCAATTCGATAGAGGATATTTGTCCCCTTATTTTTCTA
CAAATAAAGAAAATATGAGTGTAAGCTTTGATGATGCTTATATTTTAATATGTGAGAAAAAAATTAGTACAATTAAAGAA
CTCTTACCAGTGCTTGAAAAAGTTTTAAACACAAATAAACCTTTGTTAATTATTGCTGAGGATATTGAGGGAGAAGCTCT
TGCTGCACTTGTTCTAAATAGTGTTCGTGGGGCTTTAAAGGTTTGTGCAATTAAAGCTCCTGGATTTGGTGACAGACGCA
AGGCAATGCTTGAAGACATTGCGATACTTACTGGAGGAGTACTTGTCAGTGAGGAATTGGGACTTACTCTTGAAAATGTT
GAGCTTGAGCAACTTGGCCAGGCTAAATCAATAAGAGTTGATAAAGATAATACTACAATTATTAATACTGGAAATAAAGA
GCCAATAAAAGAGCGTGCGGAGCTTATTAAAAAACAAATTGAAGAGACAAGTTCTGAGTATGATAGAGAAAAACTTCAAG
AGCGTCTTGCAAAACTTGTTGGTGGAGTTGCTGTTATTAATGTTGGTGCTGTTACTGAAGTGGAACTTAAAGAGAAAAAA
CATAGGGTTGAGGATGCTTTATCTGCAACTCGTGCCGCTGTTGAGGAAGGTGTTGTTCCTGGTGGTGGATCAACTCTTAT
TGAAGTTGCTATGTATCTTGATACAGTTGATACAAGTAAACTTAGCTATGAGGAGAAGCAAGGTTTTGAGATTGTGAAGA
GAAGCCTTGAAGAACCAATGAGACAAATAATTGCTAATGCTGGATTTGAGAGTTCTATTTATATTCATCAGATTAAAACT
GACAAGAAAGGACTCGGTTTTGATGCAGCTAGTTTTAAATGGGTAAATATGATTGAGAGTGGCATAATTGATCCTGCCAA
AGTTACAAGAAGCGCTCTTCAGAATGCAGCTTCAATTGTAGGATTGCTCTTGACAACAGAGTGTGCTATTACTGAAGTTA
AAGAAGAGAAGAGTAATGCTGGTGGTGGCGGTTACCCTATGGATCCTGGAATGGGGATGATGTAA

Upstream 100 bases:

>100_bases
ATTTTGGCTTGATTAATGAATAAAAAAAAATTATATTTTTATAGTGATCTGTATGAAGTTCATGCTAACTTTATGATGTG
CTATTTAATTTAACTTTAAA

Downstream 100 bases:

>100_bases
GTTAGTCTTACTTGCAGATTTTTCATTTATGAGGATTTATATTGTGCTAAGGAGCTAGATTTGAGTGAAAATGAGTTTGT
CTTTTGCATAGGTTATGATG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 554; Mature: 554

Protein sequence:

>554_residues
MLYLKGVKFMAKDIYFNEDARKSLLSGIEKLSNAVKVTLGPKGRNVLIDKKFGSPTVTKDGVSVAREIELENAFENMGAQ
LLKEVAIKTNDLAGDGTTTATVLAYAIAREGLKNVSSGINPIGIKKGIDRAVTLAAEKIRKSAKKITTKEEIAQVASISA
NNDTSIGEKIAEAMDRVGKDGVITVEESKTFDTTISYVEGMQFDRGYLSPYFSTNKENMSVSFDDAYILICEKKISTIKE
LLPVLEKVLNTNKPLLIIAEDIEGEALAALVLNSVRGALKVCAIKAPGFGDRRKAMLEDIAILTGGVLVSEELGLTLENV
ELEQLGQAKSIRVDKDNTTIINTGNKEPIKERAELIKKQIEETSSEYDREKLQERLAKLVGGVAVINVGAVTEVELKEKK
HRVEDALSATRAAVEEGVVPGGGSTLIEVAMYLDTVDTSKLSYEEKQGFEIVKRSLEEPMRQIIANAGFESSIYIHQIKT
DKKGLGFDAASFKWVNMIESGIIDPAKVTRSALQNAASIVGLLLTTECAITEVKEEKSNAGGGGYPMDPGMGMM

Sequences:

>Translated_554_residues
MLYLKGVKFMAKDIYFNEDARKSLLSGIEKLSNAVKVTLGPKGRNVLIDKKFGSPTVTKDGVSVAREIELENAFENMGAQ
LLKEVAIKTNDLAGDGTTTATVLAYAIAREGLKNVSSGINPIGIKKGIDRAVTLAAEKIRKSAKKITTKEEIAQVASISA
NNDTSIGEKIAEAMDRVGKDGVITVEESKTFDTTISYVEGMQFDRGYLSPYFSTNKENMSVSFDDAYILICEKKISTIKE
LLPVLEKVLNTNKPLLIIAEDIEGEALAALVLNSVRGALKVCAIKAPGFGDRRKAMLEDIAILTGGVLVSEELGLTLENV
ELEQLGQAKSIRVDKDNTTIINTGNKEPIKERAELIKKQIEETSSEYDREKLQERLAKLVGGVAVINVGAVTEVELKEKK
HRVEDALSATRAAVEEGVVPGGGSTLIEVAMYLDTVDTSKLSYEEKQGFEIVKRSLEEPMRQIIANAGFESSIYIHQIKT
DKKGLGFDAASFKWVNMIESGIIDPAKVTRSALQNAASIVGLLLTTECAITEVKEEKSNAGGGGYPMDPGMGMM
>Mature_554_residues
MLYLKGVKFMAKDIYFNEDARKSLLSGIEKLSNAVKVTLGPKGRNVLIDKKFGSPTVTKDGVSVAREIELENAFENMGAQ
LLKEVAIKTNDLAGDGTTTATVLAYAIAREGLKNVSSGINPIGIKKGIDRAVTLAAEKIRKSAKKITTKEEIAQVASISA
NNDTSIGEKIAEAMDRVGKDGVITVEESKTFDTTISYVEGMQFDRGYLSPYFSTNKENMSVSFDDAYILICEKKISTIKE
LLPVLEKVLNTNKPLLIIAEDIEGEALAALVLNSVRGALKVCAIKAPGFGDRRKAMLEDIAILTGGVLVSEELGLTLENV
ELEQLGQAKSIRVDKDNTTIINTGNKEPIKERAELIKKQIEETSSEYDREKLQERLAKLVGGVAVINVGAVTEVELKEKK
HRVEDALSATRAAVEEGVVPGGGSTLIEVAMYLDTVDTSKLSYEEKQGFEIVKRSLEEPMRQIIANAGFESSIYIHQIKT
DKKGLGFDAASFKWVNMIESGIIDPAKVTRSALQNAASIVGLLLTTECAITEVKEEKSNAGGGGYPMDPGMGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=530, Percent_Identity=49.811320754717, Blast_Score=504, Evalue=1e-142,
Organism=Homo sapiens, GI31542947, Length=530, Percent_Identity=49.811320754717, Blast_Score=504, Evalue=1e-142,
Organism=Homo sapiens, GI24307939, Length=196, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1790586, Length=524, Percent_Identity=59.1603053435115, Blast_Score=614, Evalue=1e-177,
Organism=Caenorhabditis elegans, GI17555558, Length=536, Percent_Identity=47.0149253731343, Blast_Score=492, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI193210679, Length=214, Percent_Identity=45.7943925233645, Blast_Score=179, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=51.5209125475285, Blast_Score=522, Evalue=1e-149,
Organism=Saccharomyces cerevisiae, GI6322524, Length=153, Percent_Identity=32.0261437908497, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=48.4848484848485, Blast_Score=510, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=48.4848484848485, Blast_Score=510, Evalue=1e-144,
Organism=Drosophila melanogaster, GI45550936, Length=529, Percent_Identity=45.7466918714556, Blast_Score=484, Evalue=1e-137,
Organism=Drosophila melanogaster, GI45550132, Length=529, Percent_Identity=45.7466918714556, Blast_Score=484, Evalue=1e-137,
Organism=Drosophila melanogaster, GI45550935, Length=529, Percent_Identity=45.7466918714556, Blast_Score=484, Evalue=1e-137,
Organism=Drosophila melanogaster, GI17864606, Length=558, Percent_Identity=41.0394265232975, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24584129, Length=530, Percent_Identity=36.2264150943396, Blast_Score=319, Evalue=3e-87,
Organism=Drosophila melanogaster, GI19921262, Length=530, Percent_Identity=36.2264150943396, Blast_Score=319, Evalue=3e-87,
Organism=Drosophila melanogaster, GI24645179, Length=475, Percent_Identity=22.1052631578947, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17647245, Length=535, Percent_Identity=23.3644859813084, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 59995; Mature: 59995

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYLKGVKFMAKDIYFNEDARKSLLSGIEKLSNAVKVTLGPKGRNVLIDKKFGSPTVTKD
CEEECCHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCCCCCCCC
GVSVAREIELENAFENMGAQLLKEVAIKTNDLAGDGTTTATVLAYAIAREGLKNVSSGIN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
PIGIKKGIDRAVTLAAEKIRKSAKKITTKEEIAQVASISANNDTSIGEKIAEAMDRVGKD
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCC
GVITVEESKTFDTTISYVEGMQFDRGYLSPYFSTNKENMSVSFDDAYILICEKKISTIKE
CEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCEEEEEECHHHHHHHH
LLPVLEKVLNTNKPLLIIAEDIEGEALAALVLNSVRGALKVCAIKAPGFGDRRKAMLEDI
HHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHH
AILTGGVLVSEELGLTLENVELEQLGQAKSIRVDKDNTTIINTGNKEPIKERAELIKKQI
HHHHCCEEEEHHHCCEEECCCHHHCCCCCCEEEECCCCEEEECCCCCHHHHHHHHHHHHH
EETSSEYDREKLQERLAKLVGGVAVINVGAVTEVELKEKKHRVEDALSATRAAVEEGVVP
HHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GGGSTLIEVAMYLDTVDTSKLSYEEKQGFEIVKRSLEEPMRQIIANAGFESSIYIHQIKT
CCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEC
DKKGLGFDAASFKWVNMIESGIIDPAKVTRSALQNAASIVGLLLTTECAITEVKEEKSNA
CCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GGGGYPMDPGMGMM
CCCCCCCCCCCCCC
>Mature Secondary Structure
MLYLKGVKFMAKDIYFNEDARKSLLSGIEKLSNAVKVTLGPKGRNVLIDKKFGSPTVTKD
CEEECCHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCCEEEEECCCCCCCCCCC
GVSVAREIELENAFENMGAQLLKEVAIKTNDLAGDGTTTATVLAYAIAREGLKNVSSGIN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
PIGIKKGIDRAVTLAAEKIRKSAKKITTKEEIAQVASISANNDTSIGEKIAEAMDRVGKD
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCC
GVITVEESKTFDTTISYVEGMQFDRGYLSPYFSTNKENMSVSFDDAYILICEKKISTIKE
CEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCEEEEEECHHHHHHHH
LLPVLEKVLNTNKPLLIIAEDIEGEALAALVLNSVRGALKVCAIKAPGFGDRRKAMLEDI
HHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHH
AILTGGVLVSEELGLTLENVELEQLGQAKSIRVDKDNTTIINTGNKEPIKERAELIKKQI
HHHHCCEEEEHHHCCEEECCCHHHCCCCCCEEEECCCCEEEECCCCCHHHHHHHHHHHHH
EETSSEYDREKLQERLAKLVGGVAVINVGAVTEVELKEKKHRVEDALSATRAAVEEGVVP
HHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GGGSTLIEVAMYLDTVDTSKLSYEEKQGFEIVKRSLEEPMRQIIANAGFESSIYIHQIKT
CCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEC
DKKGLGFDAASFKWVNMIESGIIDPAKVTRSALQNAASIVGLLLTTECAITEVKEEKSNA
CCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GGGGYPMDPGMGMM
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA