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The map label for this gene is zwf [H]

Identifier: 187918493

GI number: 187918493

Start: 679965

End: 681398

Strand: Direct

Name: zwf [H]

Synonym: BH0636

Alternate gene names: 187918493

Gene position: 679965-681398 (Clockwise)

Preceding gene: 187918488

Following gene: 187918494

Centisome position: 73.72

GC content: 30.75

Gene sequence:

>1434_bases
ATGAGAGAAAAGAATGTATCTAATTTTGATGTTGTAATATTTGGTGTTACTGGCAATTTGTCTAGAAGAAAACTTATCCC
TTCTCTTTTTAATTTATATAAGGATGGCCATATTAGTAATTTTAGGATTATTGGATTCTCACGAAGAAGCTTTACTGATG
AGGAACTTAATATTTATGTTAAAGACTCTTTGTGGCAAGAAGAGTCTACTGTTTTAGTTGATGATTTTTTAAAATTTTTT
GTTTATTTGTCAGGAGATTTTAGAGAAAAGGATGCTTATGTAAAATTATCGTCTCTTTTAGATAATAGAGAGAGGATATA
TTACCTCTCAACATCTCCTGAGTTTTATGAGGCTATAATTGAGAATTTAAAGCCATATTCATTTAATAATACTTCTTACT
TGTCTAAGATTATTCTTGAAAAGCCTTTTGGTAGTAGTCTTGATACAGCCAGGTGTTTAAACTCTCTTCTTTATTCTGTG
TTTAAAGAAGAACAAATTTACAGGATAGACCATTATTTAGGTAAAGAAACCGTTCAAAATATTTTTACATTTAGATTTGG
GAATTCTATTTTTGAGAATATTTGGAACAATCGTTATGTGGATTTTGTTCAAATTACCGTGGCAGAGGAGGCCGGTATTG
ATGGTAGGGCTGAGTATTATGATTCTGTTGGCGCCTTAAGAGATATGGTTCAGAATCATATCTTGCAACTTTTAAGTTTA
ATTGCAATGGAACCTCCCATTGGATTTAATGCTGATTTTATTCATGACGAAAAGGTGAAGGTTTTAAAAAGTTTAAAAAA
ATTAAATAGAAAGACCATGCAAAATTATATTGTTAAAGGACAATATGTGTGTTCTCAGGTACAAGGGATTTTAAAAAAAG
GATATAGAGAAGAAGCTGAGTTTTTAAGTACTTCAAATACTGAGACTTATTTGGCTATGAAATTGTTTATTGATAACTGG
CGTTGGTCTGGGGTTCCTTTTTATATTAGGACGGGAAAAGCACTTGTGAGGAAATTTTCAGAAATATATATTCAGTTTAA
AAAGCCCGGGTTTACTATTTTTAATACTGAGTTAAATAATCTTTCAAATGCTTTGATTTTTAGAATTCAACCAAGAGATG
GTATTGAAATTAAGTTTAATACTAAGCGCCCGGGATATAATTATGAGATTCAAGAAGCTAATATGGAATTTTCTTATCAT
GCTTCATTTAACAAATTTTTTGGTGAATCTTATGAGAGATTACTTTTTGATGCTTTTTTGGGCGATAGAACCTTGTATGC
TCGTAATGATGAGATTGATAGTTCTTGGGAATTTGTATCAGATATTCTTGATAAGTGGTCAGACATTAAGAATTGGGATT
ATTTTTATGGTTCAGAAGGACCAGTTGAAGCAAATATGGTTTTAGAAAAGGATCATTTTTGGCGTAAGATGTAG

Upstream 100 bases:

>100_bases
TGTGATTAAATTTAAGTTAGGTATAGCTATTTTAGCAAGGGAATTGCAACATAGTTTTTGATGTGACAATAATAGTATAA
TTACCTGTTGGAGATCTTTT

Downstream 100 bases:

>100_bases
TAGGTATTGAAGATATTAGGTTTACAATTACTAAATTGATAAGATCAAATATTATATTTACTTTATTTTTTGTTGTAGAT
GTTTAATGCTATTTTGGATG

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MREKNVSNFDVVIFGVTGNLSRRKLIPSLFNLYKDGHISNFRIIGFSRRSFTDEELNIYVKDSLWQEESTVLVDDFLKFF
VYLSGDFREKDAYVKLSSLLDNRERIYYLSTSPEFYEAIIENLKPYSFNNTSYLSKIILEKPFGSSLDTARCLNSLLYSV
FKEEQIYRIDHYLGKETVQNIFTFRFGNSIFENIWNNRYVDFVQITVAEEAGIDGRAEYYDSVGALRDMVQNHILQLLSL
IAMEPPIGFNADFIHDEKVKVLKSLKKLNRKTMQNYIVKGQYVCSQVQGILKKGYREEAEFLSTSNTETYLAMKLFIDNW
RWSGVPFYIRTGKALVRKFSEIYIQFKKPGFTIFNTELNNLSNALIFRIQPRDGIEIKFNTKRPGYNYEIQEANMEFSYH
ASFNKFFGESYERLLFDAFLGDRTLYARNDEIDSSWEFVSDILDKWSDIKNWDYFYGSEGPVEANMVLEKDHFWRKM

Sequences:

>Translated_477_residues
MREKNVSNFDVVIFGVTGNLSRRKLIPSLFNLYKDGHISNFRIIGFSRRSFTDEELNIYVKDSLWQEESTVLVDDFLKFF
VYLSGDFREKDAYVKLSSLLDNRERIYYLSTSPEFYEAIIENLKPYSFNNTSYLSKIILEKPFGSSLDTARCLNSLLYSV
FKEEQIYRIDHYLGKETVQNIFTFRFGNSIFENIWNNRYVDFVQITVAEEAGIDGRAEYYDSVGALRDMVQNHILQLLSL
IAMEPPIGFNADFIHDEKVKVLKSLKKLNRKTMQNYIVKGQYVCSQVQGILKKGYREEAEFLSTSNTETYLAMKLFIDNW
RWSGVPFYIRTGKALVRKFSEIYIQFKKPGFTIFNTELNNLSNALIFRIQPRDGIEIKFNTKRPGYNYEIQEANMEFSYH
ASFNKFFGESYERLLFDAFLGDRTLYARNDEIDSSWEFVSDILDKWSDIKNWDYFYGSEGPVEANMVLEKDHFWRKM
>Mature_477_residues
MREKNVSNFDVVIFGVTGNLSRRKLIPSLFNLYKDGHISNFRIIGFSRRSFTDEELNIYVKDSLWQEESTVLVDDFLKFF
VYLSGDFREKDAYVKLSSLLDNRERIYYLSTSPEFYEAIIENLKPYSFNNTSYLSKIILEKPFGSSLDTARCLNSLLYSV
FKEEQIYRIDHYLGKETVQNIFTFRFGNSIFENIWNNRYVDFVQITVAEEAGIDGRAEYYDSVGALRDMVQNHILQLLSL
IAMEPPIGFNADFIHDEKVKVLKSLKKLNRKTMQNYIVKGQYVCSQVQGILKKGYREEAEFLSTSNTETYLAMKLFIDNW
RWSGVPFYIRTGKALVRKFSEIYIQFKKPGFTIFNTELNNLSNALIFRIQPRDGIEIKFNTKRPGYNYEIQEANMEFSYH
ASFNKFFGESYERLLFDAFLGDRTLYARNDEIDSSWEFVSDILDKWSDIKNWDYFYGSEGPVEANMVLEKDHFWRKM

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=474, Percent_Identity=34.5991561181435, Blast_Score=303, Evalue=3e-82,
Organism=Homo sapiens, GI109389365, Length=474, Percent_Identity=34.5991561181435, Blast_Score=302, Evalue=4e-82,
Organism=Homo sapiens, GI52145310, Length=491, Percent_Identity=26.4765784114053, Blast_Score=166, Evalue=7e-41,
Organism=Escherichia coli, GI1788158, Length=489, Percent_Identity=39.8773006134969, Blast_Score=367, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17538218, Length=476, Percent_Identity=35.2941176470588, Blast_Score=314, Evalue=6e-86,
Organism=Saccharomyces cerevisiae, GI6324088, Length=472, Percent_Identity=34.3220338983051, Blast_Score=281, Evalue=1e-76,
Organism=Drosophila melanogaster, GI24643350, Length=479, Percent_Identity=36.7432150313152, Blast_Score=298, Evalue=5e-81,
Organism=Drosophila melanogaster, GI24643352, Length=479, Percent_Identity=36.7432150313152, Blast_Score=298, Evalue=5e-81,
Organism=Drosophila melanogaster, GI221513548, Length=489, Percent_Identity=27.6073619631902, Blast_Score=204, Evalue=1e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 56249; Mature: 56249

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREKNVSNFDVVIFGVTGNLSRRKLIPSLFNLYKDGHISNFRIIGFSRRSFTDEELNIYV
CCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEEEE
KDSLWQEESTVLVDDFLKFFVYLSGDFREKDAYVKLSSLLDNRERIYYLSTSPEFYEAII
ECCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHEEHHHHHCCCCEEEEEECCHHHHHHHH
ENLKPYSFNNTSYLSKIILEKPFGSSLDTARCLNSLLYSVFKEEQIYRIDHYLGKETVQN
HCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
IFTFRFGNSIFENIWNNRYVDFVQITVAEEAGIDGRAEYYDSVGALRDMVQNHILQLLSL
HHHHHCCCHHHHHHCCCCCEEEEEEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IAMEPPIGFNADFIHDEKVKVLKSLKKLNRKTMQNYIVKGQYVCSQVQGILKKGYREEAE
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
FLSTSNTETYLAMKLFIDNWRWSGVPFYIRTGKALVRKFSEIYIQFKKPGFTIFNTELNN
HHHCCCCCEEEEEEEEEECCCCCCCCEEEECCHHHHHHHHHHEEEECCCCCEEEECCHHC
LSNALIFRIQPRDGIEIKFNTKRPGYNYEIQEANMEFSYHASFNKFFGESYERLLFDAFL
CCCEEEEEECCCCCEEEEEECCCCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHH
GDRTLYARNDEIDSSWEFVSDILDKWSDIKNWDYFYGSEGPVEANMVLEKDHFWRKM
CCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEECCCCCCEEEEEEEECHHHHCCC
>Mature Secondary Structure
MREKNVSNFDVVIFGVTGNLSRRKLIPSLFNLYKDGHISNFRIIGFSRRSFTDEELNIYV
CCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEEEE
KDSLWQEESTVLVDDFLKFFVYLSGDFREKDAYVKLSSLLDNRERIYYLSTSPEFYEAII
ECCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHEEHHHHHCCCCEEEEEECCHHHHHHHH
ENLKPYSFNNTSYLSKIILEKPFGSSLDTARCLNSLLYSVFKEEQIYRIDHYLGKETVQN
HCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
IFTFRFGNSIFENIWNNRYVDFVQITVAEEAGIDGRAEYYDSVGALRDMVQNHILQLLSL
HHHHHCCCHHHHHHCCCCCEEEEEEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IAMEPPIGFNADFIHDEKVKVLKSLKKLNRKTMQNYIVKGQYVCSQVQGILKKGYREEAE
HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
FLSTSNTETYLAMKLFIDNWRWSGVPFYIRTGKALVRKFSEIYIQFKKPGFTIFNTELNN
HHHCCCCCEEEEEEEEEECCCCCCCCEEEECCHHHHHHHHHHEEEECCCCCEEEECCHHC
LSNALIFRIQPRDGIEIKFNTKRPGYNYEIQEANMEFSYHASFNKFFGESYERLLFDAFL
CCCEEEEEECCCCCEEEEEECCCCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHH
GDRTLYARNDEIDSSWEFVSDILDKWSDIKNWDYFYGSEGPVEANMVLEKDHFWRKM
CCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEECCCCCCEEEEEEEECHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9403685 [H]