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The map label for this gene is pepD [H]

Identifier: 187918469

GI number: 187918469

Start: 641466

End: 642887

Strand: Direct

Name: pepD [H]

Synonym: BH0608

Alternate gene names: 187918469

Gene position: 641466-642887 (Clockwise)

Preceding gene: 187918468

Following gene: 187918470

Centisome position: 69.55

GC content: 32.42

Gene sequence:

>1422_bases
ATGGAAAATGTTGTAATTCGTTATTTTAAGCAAATATCTCAAATTCCTAGATGTTCAAAAAATTTAAAAGGTATTAGTAA
TTTTATTAAGGAAGAAGCTAAAAAATTTGGATATTCCTTTAAGGAAGATGGTATAGGCAATATTGTAGTTGGGGTTAAGG
CTAATGGCTGTAGCAATATGTTGCCTATTATTTTGCAAGCCCATACAGATATGGTTTGTGAAAAAAATGAATCTGTTATG
CATGATTTTGAAAAAGATCCGATCAACATCATTGAAGATAATGGATATTTTGTTGCATCAGGTACTACTCTTGGTGCTGA
TGATGGGATTGGGGTTGCTATGATGCTTGCCATTATGAGTGAGTCTTTGACTTTTAAACATCCTGATTTGGAACTTCTTT
TTACTGTTGATGAGGAAATAGGGCTAATAGGCGCTATTGGACTTGATCCTAATTTATGTAGTGGGAAGATGTTGATTAAT
CTTGATGGAGAAGAAGAGGGTTATTTTTTAGTTGGTTGTGCTGGCTCTCGACTTGTTCATATTAACTTTGAACCGCAATA
TAGACAAAGTAGAAAAAAAACAGGTGTTGAGATTTTTTTTACAGGTCTTAAAGGGGGCCATTCTGGTGCGGATATTCATA
TTGATTTAGCAAATTCTTTGAAATTGATGTTTTTTGCTTTAAATACCCTTAGAGCAAACATGGAATTTGAGATTGGATAT
ATATCTGGTGGAGATAAAAGTAATGCGATTCCTAGGGAGGCAAAAGCATTAATATTAATTGAAGCTGAGCATTATGTTTT
ATTGGAGAGAGAATTAAAGTCATTTAAGCGTCATGCACAAGAGATGTATACTCTTGATTCTGATTTTGAAATTCTTTTAA
GGAGAGTAAATTTTTCTGGTAATGTTTTGGATGATATGTCTCAAGATAAGCTTTTAAATATGGGCATGGCATTTTTGCAT
GGGGTTCAAAAGGTTGAAAATTATGATGAAAAACTTATTAGAACGTCTCTAAATTTTGCTAGTCTTTTAAAGGTTGGTAA
TGAGTATCAGTTTATATTTACAATAAGGTCTTTGTTAGATATTGAGAAGGAATATATCTTTAATCATTTAAAGGCTATTA
GTGATCTTTCTGGTGCTAATTTAAGAATAGTTTATGATTATTCTTCCTGGAAGCCAGCTGAGAATAGTAAACTTTTAAAT
CATCTTAAGAATGTGTATAAAGATATGTATTTAAAAGAGGCTAAAACTGTAGTGATTCATGCTGGTCTTGAGACTGGAAT
AATATCTGCAAAATTTGGAGGAATAGATTCAGTTACAATTGGACCTTGGATTAAGTCTCCCCATACACCACGGGAACGGG
TTGATATTGCTTCAACTATTAGGGTTTATAATTTCTTGAAGAGAAGTTTAGAGACTTTATAA

Upstream 100 bases:

>100_bases
TCTTACTTAATTTATTAGAAATTAAGTTTTGAAGTATGTTATGATGGTAGCATGTAATAAATATGTTTAATGATAAGTTT
GGTTTTATTAGAGGATAAGG

Downstream 100 bases:

>100_bases
ATTTTGTGTTTTATATTGCTTGATTTTGAATATATGTTTCAGTTGACTTACTCTTTGAATATATATAAAATAAGTTTACA
TGTAATTGAGTATAGTTGAG

Product: aminoacyl-histidine dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MENVVIRYFKQISQIPRCSKNLKGISNFIKEEAKKFGYSFKEDGIGNIVVGVKANGCSNMLPIILQAHTDMVCEKNESVM
HDFEKDPINIIEDNGYFVASGTTLGADDGIGVAMMLAIMSESLTFKHPDLELLFTVDEEIGLIGAIGLDPNLCSGKMLIN
LDGEEEGYFLVGCAGSRLVHINFEPQYRQSRKKTGVEIFFTGLKGGHSGADIHIDLANSLKLMFFALNTLRANMEFEIGY
ISGGDKSNAIPREAKALILIEAEHYVLLERELKSFKRHAQEMYTLDSDFEILLRRVNFSGNVLDDMSQDKLLNMGMAFLH
GVQKVENYDEKLIRTSLNFASLLKVGNEYQFIFTIRSLLDIEKEYIFNHLKAISDLSGANLRIVYDYSSWKPAENSKLLN
HLKNVYKDMYLKEAKTVVIHAGLETGIISAKFGGIDSVTIGPWIKSPHTPRERVDIASTIRVYNFLKRSLETL

Sequences:

>Translated_473_residues
MENVVIRYFKQISQIPRCSKNLKGISNFIKEEAKKFGYSFKEDGIGNIVVGVKANGCSNMLPIILQAHTDMVCEKNESVM
HDFEKDPINIIEDNGYFVASGTTLGADDGIGVAMMLAIMSESLTFKHPDLELLFTVDEEIGLIGAIGLDPNLCSGKMLIN
LDGEEEGYFLVGCAGSRLVHINFEPQYRQSRKKTGVEIFFTGLKGGHSGADIHIDLANSLKLMFFALNTLRANMEFEIGY
ISGGDKSNAIPREAKALILIEAEHYVLLERELKSFKRHAQEMYTLDSDFEILLRRVNFSGNVLDDMSQDKLLNMGMAFLH
GVQKVENYDEKLIRTSLNFASLLKVGNEYQFIFTIRSLLDIEKEYIFNHLKAISDLSGANLRIVYDYSSWKPAENSKLLN
HLKNVYKDMYLKEAKTVVIHAGLETGIISAKFGGIDSVTIGPWIKSPHTPRERVDIASTIRVYNFLKRSLETL
>Mature_473_residues
MENVVIRYFKQISQIPRCSKNLKGISNFIKEEAKKFGYSFKEDGIGNIVVGVKANGCSNMLPIILQAHTDMVCEKNESVM
HDFEKDPINIIEDNGYFVASGTTLGADDGIGVAMMLAIMSESLTFKHPDLELLFTVDEEIGLIGAIGLDPNLCSGKMLIN
LDGEEEGYFLVGCAGSRLVHINFEPQYRQSRKKTGVEIFFTGLKGGHSGADIHIDLANSLKLMFFALNTLRANMEFEIGY
ISGGDKSNAIPREAKALILIEAEHYVLLERELKSFKRHAQEMYTLDSDFEILLRRVNFSGNVLDDMSQDKLLNMGMAFLH
GVQKVENYDEKLIRTSLNFASLLKVGNEYQFIFTIRSLLDIEKEYIFNHLKAISDLSGANLRIVYDYSSWKPAENSKLLN
HLKNVYKDMYLKEAKTVVIHAGLETGIISAKFGGIDSVTIGPWIKSPHTPRERVDIASTIRVYNFLKRSLETL

Specific function: Dipeptidase with broad substrate specificity [H]

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=472, Percent_Identity=34.3220338983051, Blast_Score=263, Evalue=2e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 53139; Mature: 53139

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENVVIRYFKQISQIPRCSKNLKGISNFIKEEAKKFGYSFKEDGIGNIVVGVKANGCSNM
CCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCC
LPIILQAHTDMVCEKNESVMHDFEKDPINIIEDNGYFVASGTTLGADDGIGVAMMLAIMS
HHHHHHHHCCHHHCCCCHHHHHCCCCCCEEEECCCEEEECCCEECCCCCHHHHHHHHHHH
ESLTFKHPDLELLFTVDEEIGLIGAIGLDPNLCSGKMLINLDGEEEGYFLVGCAGSRLVH
CCCEECCCCEEEEEEECCCCCEEEEECCCCCCCCCEEEEEECCCCCCEEEEEECCCEEEE
INFEPQYRQSRKKTGVEIFFTGLKGGHSGADIHIDLANSLKLMFFALNTLRANMEFEIGY
EECCHHHHHHHHCCCEEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEE
ISGGDKSNAIPREAKALILIEAEHYVLLERELKSFKRHAQEMYTLDSDFEILLRRVNFSG
ECCCCCCCCCCCCCCEEEEEECCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCC
NVLDDMSQDKLLNMGMAFLHGVQKVENYDEKLIRTSLNFASLLKVGNEYQFIFTIRSLLD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEEHHHHHHHH
IEKEYIFNHLKAISDLSGANLRIVYDYSSWKPAENSKLLNHLKNVYKDMYLKEAKTVVIH
HHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEE
AGLETGIISAKFGGIDSVTIGPWIKSPHTPRERVDIASTIRVYNFLKRSLETL
CCCCCCEEEEECCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MENVVIRYFKQISQIPRCSKNLKGISNFIKEEAKKFGYSFKEDGIGNIVVGVKANGCSNM
CCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCC
LPIILQAHTDMVCEKNESVMHDFEKDPINIIEDNGYFVASGTTLGADDGIGVAMMLAIMS
HHHHHHHHCCHHHCCCCHHHHHCCCCCCEEEECCCEEEECCCEECCCCCHHHHHHHHHHH
ESLTFKHPDLELLFTVDEEIGLIGAIGLDPNLCSGKMLINLDGEEEGYFLVGCAGSRLVH
CCCEECCCCEEEEEEECCCCCEEEEECCCCCCCCCEEEEEECCCCCCEEEEEECCCEEEE
INFEPQYRQSRKKTGVEIFFTGLKGGHSGADIHIDLANSLKLMFFALNTLRANMEFEIGY
EECCHHHHHHHHCCCEEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEE
ISGGDKSNAIPREAKALILIEAEHYVLLERELKSFKRHAQEMYTLDSDFEILLRRVNFSG
ECCCCCCCCCCCCCCEEEEEECCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCC
NVLDDMSQDKLLNMGMAFLHGVQKVENYDEKLIRTSLNFASLLKVGNEYQFIFTIRSLLD
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEEHHHHHHHH
IEKEYIFNHLKAISDLSGANLRIVYDYSSWKPAENSKLLNHLKNVYKDMYLKEAKTVVIH
HHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEE
AGLETGIISAKFGGIDSVTIGPWIKSPHTPRERVDIASTIRVYNFLKRSLETL
CCCCCCEEEEECCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]